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Purely electrical detection of electrolyte concentration through microfluidic impedance spectroscopy 通过微流控阻抗能谱对电解质浓度进行纯电检测
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-30 DOI: 10.1016/j.xcrp.2024.102133
{"title":"Purely electrical detection of electrolyte concentration through microfluidic impedance spectroscopy","authors":"","doi":"10.1016/j.xcrp.2024.102133","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102133","url":null,"abstract":"<p>Impedance spectroscopy enables the electrical properties of samples to be probed and is commonly used to characterize solids. Extending this technique to analyze fluids within microfluidic channels could enable the rapid characterization of bodily fluids such as sweat. Here, we present a low-cost microfluidic platform with integrated aerosol-jet printed electrodes for the electrical characterization of fluids via impedance spectroscopy. A novel analysis method is presented to accurately determine the concentration of several aqueous ionic chloride solutions, namely NaCl, KCl, CaCl<sub>2</sub>, and MgCl<sub>2</sub>. Importantly, we identify a key parameter, the turning point frequency of the capacitance-frequency graph, which is found to have a highly linear correlation with the solution concentration for each species spanning at least three orders of magnitude. This linear dependence is highly reproducible across different cationic species, making it useful for accurate fluid characterization. Applying this technique to analyze bodily fluids in real time has implications for remote health monitoring.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"66 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large-scale synthesis of transition metal dichalcogenides at atmospheric pressure in air 在常压空气中大规模合成过渡金属二钙化物
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-30 DOI: 10.1016/j.xcrp.2024.102124
{"title":"Large-scale synthesis of transition metal dichalcogenides at atmospheric pressure in air","authors":"","doi":"10.1016/j.xcrp.2024.102124","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102124","url":null,"abstract":"<p>Transition metal dichalcogenides (TMDs) have received considerable attention in recent years because of their intriguing chemical and physical properties. However, conventional synthesis methods, including chemical vapor deposition and wet-chemical synthesis, still face many challenges in mass production. Here, we develop a dynamic salt capsulation method to massively prepare TMDs (MoS<sub>2</sub>, WS<sub>2</sub>) at atmospheric pressure in air with a high yield of over 95%. With the help of binary salts (KCl, KBr), TMDs can be easily obtained for a short reaction time of 1 h at a relatively low temperature (400°C). The as-synthesized MoS<sub>2</sub> powders show flower-like nanospheres, which exhibit a desired catalytic performance in hydrogen evolution reactions and good electrochemical performance as anode materials in lithium-ion batteries. This work provides a simple method to synthesize high-quality and large quantities of TMDs with low cost and time consumption, which has a great potential to integrate into industrial production.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"45 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluidic control programming for 3D magnetic soft metamaterials with reconfigurable mechanical behaviors 具有可重构机械行为的三维磁性软超材料的流体控制编程
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-29 DOI: 10.1016/j.xcrp.2024.102125
{"title":"Fluidic control programming for 3D magnetic soft metamaterials with reconfigurable mechanical behaviors","authors":"","doi":"10.1016/j.xcrp.2024.102125","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102125","url":null,"abstract":"<p>Active mechanical metamaterials are an attractive proposition for soft robotics, electronic devices, and biomedical devices. However, the utilization of their uncommon physical and mechanical behaviors remains underexplored because existing fabrication processes limit the decoupling of structural frameworks from the responsive mechanisms. Here, we propose a multi-step fluidic control programming strategy by fabricating three-dimensional (3D) magnetic soft materials (MSMs) with reconfigurable mechanical metamaterial behaviors, enabling magnetic-field-driven alteration between three different geometry modes in a single structure. The MSM lattices exhibit fast 3D transitions between positive (ν<sub>max</sub> = 3.41) and negative (ν<sub>max</sub> = −2.64) Poisson’s ratios. We then create MSMs with reconfigurable orthotropic behaviors, which demonstrate the positive and negative Poisson’s effect in perpendicular planes. In further demonstrations, the fast and wireless response is validated by manipulating falling loads and switching the states of electrical circuits. This research provides a controllable workflow for future magnetic soft metamaterials.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"31 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing RNA inhibitory activity using clamp-G-modified nucleobases 利用钳夹-G修饰的核碱基增强 RNA 抑制活性
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-29 DOI: 10.1016/j.xcrp.2024.102120
{"title":"Enhancing RNA inhibitory activity using clamp-G-modified nucleobases","authors":"","doi":"10.1016/j.xcrp.2024.102120","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102120","url":null,"abstract":"<p>We explore the potential of clamp-G nucleobase-modified peptide nucleic acids (cGPNAs) as microRNA and messenger RNA inhibitors. For proof of concept, we target miR-155, which is upregulated in diffuse large B cell lymphoma. cGPNA shows significant downregulation of miR-155 and the upregulation of its downstream targets in multiple lymphoma cell lines. Also, cGPNA treatment <em>in vivo</em> reduced tumor growth and improved survival in the U2932 cell-derived xenograft mouse model. To assess the broad application of cGPNA as an antisense modality, we also target transthyretin (<em>TTR</em>) mRNA. We establish a dose-dependent effect of antisense cGPNA on <em>TTR</em> mRNA levels. For <em>in vivo</em> studies, we conjugated cGPNA-based TTR antisense with lactobionic acid-based targeting ligand for <em>in vivo</em> liver delivery. We establish that cGPNA exhibits significant TTR protein knockdown compared to unmodified peptide nucleic acid (PNA) <em>in vivo</em>. Overall, we confirm that clamp-G-modified PNA analogs are a robust antisense therapy platform.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"262 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-volumetric pseudocapacitive sodium storage in densely packed mesoporous titanium dioxide-carbon composite 在致密介孔二氧化钛-碳复合材料中储存高容积伪电容钠
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-26 DOI: 10.1016/j.xcrp.2024.102123
{"title":"High-volumetric pseudocapacitive sodium storage in densely packed mesoporous titanium dioxide-carbon composite","authors":"","doi":"10.1016/j.xcrp.2024.102123","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102123","url":null,"abstract":"<p>Transition metal oxides with small grain sizes are promising candidates for capacitive charge storage. However, the overall performance of such oxide materials is still limited by low tap density and finite conductivity. Here, we present a type of densely packed titanium dioxide (TiO<sub>2</sub>) composite that comprises three-dimensional aligned mesoporous TiO<sub>2</sub> microspheres and coated ultrathin mesoporous carbon shells. The fabricated mesoporous meso-TiO<sub>2</sub>@meso-C complex possesses a highly accessible surface area (134 m<sup>2</sup> g<sup>−1</sup>), dual mesopore channels (11.8 and 21.6 nm), and a much higher tap density (1.52 g cm<sup>−3</sup>). As expected, this designed mesoporous composite achieves superior electrochemical performance, including both a maximized specific capacity of 255 mAh g<sup>−1</sup> and a volumetric capacity of 390 mAh cm<sup>−3</sup> at 0.025 A g<sup>−1</sup>. Our mesoscopic composite electrode that enables fast redox reaction reveals the importance of incorporating conductive and dense mesostructures as an alternative pathway for high-volumetric pseudocapacitive materials.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"79 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applying the intrinsic principle of cell collectives to program robot swarms 将细胞集体的内在原理应用于机器人群编程
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-26 DOI: 10.1016/j.xcrp.2024.102122
{"title":"Applying the intrinsic principle of cell collectives to program robot swarms","authors":"","doi":"10.1016/j.xcrp.2024.102122","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102122","url":null,"abstract":"<p>Many control algorithms for formation of robot swarms are often inspired by animal swarms. However, these algorithms require robots having sensing and computational capabilities and are not applicable to robot swarms working in extreme environments, such as at micro/nanoscale and in space. Here, we directly apply the differential adhesion hypothesis (DAH) of cell biology to the formation of robot swarms. Like cell collectives, swarms of sensor-less robots aggregate and sort in a self-organized manner. We quantitatively investigate the DAH principle in both swarms of cells and robots. We find that the sorting time is nonlinearly related to the levels of adhesion differences. This sheds light on the mechanisms of timing control in morphogenesis. Based on these findings, we program robot swarms to form functional morphologies by tuning their adhesion. This work advances swarm robotics in forming functional morphologies in a self-organized manner and enables us to investigate morphogenesis in cell collectives using robot swarms.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"5 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-treating fields increase cytotoxic degranulation of natural killer cells against cancer cells 肿瘤治疗场可增加自然杀伤细胞对癌细胞的细胞毒性脱颗粒作用
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-25 DOI: 10.1016/j.xcrp.2024.102119
{"title":"Tumor-treating fields increase cytotoxic degranulation of natural killer cells against cancer cells","authors":"","doi":"10.1016/j.xcrp.2024.102119","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102119","url":null,"abstract":"<p>Tumor-treating fields (TTFs) are a non-invasive treatment for glioblastoma (GBM) that applies low-intensity, intermediate-frequency, alternating electric fields. Given a 5-year survival of less than 7% for GBM patients, multi-modal treatments are required to improve survival. Natural killer (NK) cells are innate lymphocytes that kill cancer cells and are thus a major target for new immunotherapy approaches. There is potential to combine TTFs with an NK cell-based therapy for GBM treatment. Here, we investigate the impact of TTFs on NK cell viability and functions. Exposure to TTFs does not affect NK cell viability or interferon (IFN)-γ production, a key NK cell function. Of significance, exposure to TTFs increases NK cell degranulation, a proxy of cell killing. These data suggest that the combination of TTFs and NK cell-based therapy may boost tumor cell killing. This provides a basis to further explore this combination, with the end goal of enhancing NK cell immunotherapy potential for patients with GBM.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"62 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced recovery of activation metals for accelerated hydrogen generation from aluminum and seawater 加强活化金属回收,加速铝和海水制氢
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-25 DOI: 10.1016/j.xcrp.2024.102121
{"title":"Enhanced recovery of activation metals for accelerated hydrogen generation from aluminum and seawater","authors":"","doi":"10.1016/j.xcrp.2024.102121","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102121","url":null,"abstract":"<p>When activated, aluminum reacts with water to generate hydrogen gas, heat, and aluminum oxyhydroxide, a non-toxic and valuable commodity. This process serves as an efficient and cost-effective means of producing and transporting both hydrogen and thermal energy. The study presented here focuses on recovering a gallium-indium eutectic utilized as a surface coating to induce aluminum’s reactivity in water. The findings indicate that the addition of very low concentrations (0.02 M) of imidazole to seawater leads to rapid reactions being completed in under 10 min, enabling the retrieval and reuse of over 90% of the relatively costly gallium-indium eutectic and producing 99% of the anticipated hydrogen output based on the aluminum’s mass. Additionally, conducting the reaction at elevated temperatures ensures the swift and complete reaction of aluminum in saltwater.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"45 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements and prospects of deep learning in biomaterials evolution 深度学习在生物材料进化方面的进展和前景
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-25 DOI: 10.1016/j.xcrp.2024.102116
{"title":"Advancements and prospects of deep learning in biomaterials evolution","authors":"","doi":"10.1016/j.xcrp.2024.102116","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102116","url":null,"abstract":"<p>In recent decades, significant strides have been made in advancing biomaterials for biomedical applications. Ideal biomaterials necessitate suitable mechanical properties, excellent biocompatibility, and specific bioactivities. However, the design and preparation of materials with these essential characteristics pose formidable challenges, persisting as significant issues in the field. The development and optimization of high-performance biomaterials, along with the construction of composites and hybrids with diverse biofunctions, present promising strategies for enhancing therapeutic and diagnostic procedures. However, reliance on traditional “trial and error” methods for acquiring a substantial volume of experimental data proves to be laborious, time consuming, and unreliable. An emerging and promising approach involves the successful application of artificial intelligence (AI), specifically deep learning (DL), to investigate and optimize the preparation and manufacturing techniques for various biomaterials. DL, as an automated and intelligent tool within the AI domain, finds widespread application in devising, analyzing, and optimizing different biomaterials. Through the “experiment-AI” technique, DL predicts the potential feature information and performance of biomaterials, showcasing remarkable potential in biomaterial research and development. This review comprehensively explores the application of DL-based technologies in the biomedical field, emphasizing cutting-edge advantages and providing insights and recommendations to enhance the efficacy of such approaches in biomaterials.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"69 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoimaging of SARS-CoV-2 viral invasion toward the nucleus and genome SARS-CoV-2 病毒入侵细胞核和基因组的纳米成像技术
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-24 DOI: 10.1016/j.xcrp.2024.102111
{"title":"Nanoimaging of SARS-CoV-2 viral invasion toward the nucleus and genome","authors":"","doi":"10.1016/j.xcrp.2024.102111","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102111","url":null,"abstract":"<p>The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, has been linked to significant worldwide illness and death. Examining the ultrastructure and nanomechanical characteristics of SARS-CoV-2 viruses, from a physical standpoint, aids in categorizing their mechanical attributes, providing valuable information for novel treatment approaches and pinpointing susceptible regions that can guide precise medical interventions. This review presents the structural and mechanical characteristics of SARS-CoV-2 virus particles, focusing on their interaction with cells and their effects on nuclear pore transit and epigenetic modifications. We present the latest progress in utilizing a high-speed atomic force microscope for nanoscale observation of the SARS-CoV-2 virus and its constituents. SARS-CoV-2 viruses utilize several components to interact with the host’s nuclear transport receptors and the nucleoporins of the nuclear pore complex to influence the host’s nuclear transport and genome modality. In this review, we also provide an updated summary of how the parts of SARS-CoV-2 interact with the host’s nuclear transport system and how these interactions change the host’s chromatin.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"133 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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