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A one-pot photocatalytic triazole-based linkerology for PROTACs 用于 PROTAC 的基于三唑的单锅光催化连接技术
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-08-02 DOI: 10.1016/j.xcrp.2024.102139
{"title":"A one-pot photocatalytic triazole-based linkerology for PROTACs","authors":"","doi":"10.1016/j.xcrp.2024.102139","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102139","url":null,"abstract":"<p>Proteolysis-targeting chimeras (PROTACs) are a powerful approach for targeted protein degradation. One of the current bottlenecks for developing PROTACs is the lack of an operationally simple linkerology to rapidly construct PROTACs with various linkers. The classic convergent synthesis strategy by coupling pre-assembled linkers with two ligands stepwise commonly needs at least four steps to give the final target PROTACs, which results in low total yields with long reaction times (several days) and tedious operations. Here, we develop an efficient photocatalytic one-pot linkerology for the rapid coupling of analogs of PROTACs containing triazole-based linkers without any linker-pre-assembled procedure. The reaction was completed within 4 h with up to 95% yields at room temperature. Easily accessible cyclic ethers are directly used as linker precursors to furnish the one-pot fashion, including alkenyl, polyethylene glycol (PEG), ketone, and cyclohexane chains. The study provides a highly efficient, step-economic, operationally simple, and environmentally friendly one-pot linkerology for PROTAC drug discovery.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"57 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141882798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hierarchically porous films for ultrahigh-throughput characterization of chemical exposome in biological fluids 用于超高通量表征生物液体中化学暴露体的分层多孔薄膜
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-08-02 DOI: 10.1016/j.xcrp.2024.102136
{"title":"Hierarchically porous films for ultrahigh-throughput characterization of chemical exposome in biological fluids","authors":"","doi":"10.1016/j.xcrp.2024.102136","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102136","url":null,"abstract":"<p>Exposome science captures the totality of environmental drivers of human health. However, the comprehensive determination of numerous exogenous and endogenous compounds remains extremely challenging, restricting the purpose of exposome science to characterize both external and internal exposure. Herein, we develop hierarchically porous polymers of intrinsic microporosity (HPPIM) films to achieve ultrahigh-throughput determination of exo/endogenous molecules in biological fluids. The film’s porous properties, including three-stage micro-submicro-nanometer architectures, large specific surface area, and appropriate pore geometry and organophilicity enable fast molecular transport and high trapping capability, therefore achieving ultrahigh-throughput determination of exo/endogenous molecules in biological fluids. Further application in a small-scale cancer study demonstrates the unique advantages of HPPIM films over existing techniques, including broad coverage of analytes, satisfactory trapping efficiency, low-volume demand on specimens, high simplicity and reusability, and drastically reduced financial cost. Our work demonstrates the great potential of HPPIM for advancing exposome science from concept to utility.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"106 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141882799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the impact of different electrode inhomogeneities on the voltage response of Li-ion batteries 不同电极不均匀性对锂离子电池电压响应影响的研究
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-08-02 DOI: 10.1016/j.xcrp.2024.102138
{"title":"Investigation of the impact of different electrode inhomogeneities on the voltage response of Li-ion batteries","authors":"","doi":"10.1016/j.xcrp.2024.102138","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102138","url":null,"abstract":"<p>As commercial batteries and battery packs become larger and larger, one topic that is gaining interest is that of cell-to-cell variations and inhomogeneities. In this theoretical study, we use a degradation mode model along with a segmented cell approach to investigate the impact of different inhomogeneity modes on the performance of two typical Li-ion batteries. This unique approach shows that out of the nine considered modes (state of charge, rate, resistance, and capacity for each electrode as well as their offset), when at a mild level and randomly distributed, only three could affect performance, with two unlikely to happen in real cells because they would disappear during rest. Model results show that some of these inhomogeneities open the possibility of a snowball effect to induce local rate variations and lithiation inhomogeneities. Our study also shows that it is necessary to assess the level at which the paralleling occurs, electrode or full cell, as the model predicts an impact on how the current, and how much of it, is flowing within or in between the electrodes.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"216 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141882796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yarn-grouping weaving soft robotics with directional inflation, bilateral bending, and self-sensing for healthcare 具有定向充气、双侧弯曲和自感应功能的纱线编织软机器人，可用于医疗保健领域
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-08-01 DOI: 10.1016/j.xcrp.2024.102137
{"title":"Yarn-grouping weaving soft robotics with directional inflation, bilateral bending, and self-sensing for healthcare","authors":"","doi":"10.1016/j.xcrp.2024.102137","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102137","url":null,"abstract":"<p>Pneumatic soft robotics are highly desirable for interacting with humans and navigating uncertain environments. However, it remains a great challenge to simultaneously achieve high actuation efficiency, programmable deformations, real-time feedback, and robustness. Herein, a textile engineering approach is harnessed to integrate multifunctionality into woven actuators by tailoring yarn groupings using all-in-one industrial weaving technologies. The unique nearly zero Poisson’s ratio inflatable deformation of the actuators contributes to a large bending strain (2,250° m<sup>−1</sup>), a high output force (30 N MPa<sup>−1</sup>), and robust mechanical performance. Bilateral bending actuators with negative, zero, and positive curvatures are realized by hierarchical shape transformations of the woven layers. The embedded sensing yarns provide facile and effective methods to proprioceptively sense actuation deformation without compromising actuation performance. Moreover, this manufacturing method is cost efficient and highly scalable, which expands practical applications of soft actuators in healthcare and offers a new perspective on the structure design of customized soft actuators.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"98 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141882800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-pot transition-metal-free synthesis of alkynes and enynes 炔烃和炔烃的单锅无过渡金属合成
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-08-01 DOI: 10.1016/j.xcrp.2024.102132
{"title":"One-pot transition-metal-free synthesis of alkynes and enynes","authors":"","doi":"10.1016/j.xcrp.2024.102132","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102132","url":null,"abstract":"Alkynes are key motifs in chemistry, serving as precursors in many organic reactions toward the synthesis of bioactive compounds, polymers, and new ma…","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"46 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Online multi-scenario impedance spectra generation for batteries based on small-sample learning 基于小样本学习的电池多场景阻抗谱在线生成
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-31 DOI: 10.1016/j.xcrp.2024.102134
{"title":"Online multi-scenario impedance spectra generation for batteries based on small-sample learning","authors":"","doi":"10.1016/j.xcrp.2024.102134","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102134","url":null,"abstract":"<p>The onboard acquisition of data from electrochemical impedance spectroscopy (EIS) is critically important to the state assessment and fault diagnosis of mobile batteries, but it is technically challenging due to the stringent test requirements, limited modeling data, and varying mechanisms among batteries with different chemistries. This paper, without requiring any additional sensors, extends the traditional EIS measurement to online generation and covers most battery-using scenarios, including different battery chemistries, aging degrees, remaining capacities, and temperatures. Virtual simulation and transfer techniques are employed to train a deep neural network with a significantly reduced dataset. Specifically, we train the network with no more than 24 groups of data and achieve an average relative error lower than 5%, outperforming most “big data”-involved algorithms of its kind. Our method lowers the threshold of using EIS onboard and unlocks new opportunities to monitor the battery’s performance in both time and frequency domain comprehensively in real time.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"86 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purely electrical detection of electrolyte concentration through microfluidic impedance spectroscopy 通过微流控阻抗能谱对电解质浓度进行纯电检测
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-30 DOI: 10.1016/j.xcrp.2024.102133
{"title":"Purely electrical detection of electrolyte concentration through microfluidic impedance spectroscopy","authors":"","doi":"10.1016/j.xcrp.2024.102133","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102133","url":null,"abstract":"<p>Impedance spectroscopy enables the electrical properties of samples to be probed and is commonly used to characterize solids. Extending this technique to analyze fluids within microfluidic channels could enable the rapid characterization of bodily fluids such as sweat. Here, we present a low-cost microfluidic platform with integrated aerosol-jet printed electrodes for the electrical characterization of fluids via impedance spectroscopy. A novel analysis method is presented to accurately determine the concentration of several aqueous ionic chloride solutions, namely NaCl, KCl, CaCl<sub>2</sub>, and MgCl<sub>2</sub>. Importantly, we identify a key parameter, the turning point frequency of the capacitance-frequency graph, which is found to have a highly linear correlation with the solution concentration for each species spanning at least three orders of magnitude. This linear dependence is highly reproducible across different cationic species, making it useful for accurate fluid characterization. Applying this technique to analyze bodily fluids in real time has implications for remote health monitoring.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"66 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large-scale synthesis of transition metal dichalcogenides at atmospheric pressure in air 在常压空气中大规模合成过渡金属二钙化物
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-30 DOI: 10.1016/j.xcrp.2024.102124
{"title":"Large-scale synthesis of transition metal dichalcogenides at atmospheric pressure in air","authors":"","doi":"10.1016/j.xcrp.2024.102124","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102124","url":null,"abstract":"<p>Transition metal dichalcogenides (TMDs) have received considerable attention in recent years because of their intriguing chemical and physical properties. However, conventional synthesis methods, including chemical vapor deposition and wet-chemical synthesis, still face many challenges in mass production. Here, we develop a dynamic salt capsulation method to massively prepare TMDs (MoS<sub>2</sub>, WS<sub>2</sub>) at atmospheric pressure in air with a high yield of over 95%. With the help of binary salts (KCl, KBr), TMDs can be easily obtained for a short reaction time of 1 h at a relatively low temperature (400°C). The as-synthesized MoS<sub>2</sub> powders show flower-like nanospheres, which exhibit a desired catalytic performance in hydrogen evolution reactions and good electrochemical performance as anode materials in lithium-ion batteries. This work provides a simple method to synthesize high-quality and large quantities of TMDs with low cost and time consumption, which has a great potential to integrate into industrial production.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"45 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluidic control programming for 3D magnetic soft metamaterials with reconfigurable mechanical behaviors 具有可重构机械行为的三维磁性软超材料的流体控制编程
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-29 DOI: 10.1016/j.xcrp.2024.102125
{"title":"Fluidic control programming for 3D magnetic soft metamaterials with reconfigurable mechanical behaviors","authors":"","doi":"10.1016/j.xcrp.2024.102125","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102125","url":null,"abstract":"<p>Active mechanical metamaterials are an attractive proposition for soft robotics, electronic devices, and biomedical devices. However, the utilization of their uncommon physical and mechanical behaviors remains underexplored because existing fabrication processes limit the decoupling of structural frameworks from the responsive mechanisms. Here, we propose a multi-step fluidic control programming strategy by fabricating three-dimensional (3D) magnetic soft materials (MSMs) with reconfigurable mechanical metamaterial behaviors, enabling magnetic-field-driven alteration between three different geometry modes in a single structure. The MSM lattices exhibit fast 3D transitions between positive (ν<sub>max</sub> = 3.41) and negative (ν<sub>max</sub> = −2.64) Poisson’s ratios. We then create MSMs with reconfigurable orthotropic behaviors, which demonstrate the positive and negative Poisson’s effect in perpendicular planes. In further demonstrations, the fast and wireless response is validated by manipulating falling loads and switching the states of electrical circuits. This research provides a controllable workflow for future magnetic soft metamaterials.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"31 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing RNA inhibitory activity using clamp-G-modified nucleobases 利用钳夹-G修饰的核碱基增强 RNA 抑制活性
IF 8.9 2区 综合性期刊
Cell Reports Physical Science Pub Date : 2024-07-29 DOI: 10.1016/j.xcrp.2024.102120
{"title":"Enhancing RNA inhibitory activity using clamp-G-modified nucleobases","authors":"","doi":"10.1016/j.xcrp.2024.102120","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102120","url":null,"abstract":"<p>We explore the potential of clamp-G nucleobase-modified peptide nucleic acids (cGPNAs) as microRNA and messenger RNA inhibitors. For proof of concept, we target miR-155, which is upregulated in diffuse large B cell lymphoma. cGPNA shows significant downregulation of miR-155 and the upregulation of its downstream targets in multiple lymphoma cell lines. Also, cGPNA treatment <em>in vivo</em> reduced tumor growth and improved survival in the U2932 cell-derived xenograft mouse model. To assess the broad application of cGPNA as an antisense modality, we also target transthyretin (<em>TTR</em>) mRNA. We establish a dose-dependent effect of antisense cGPNA on <em>TTR</em> mRNA levels. For <em>in vivo</em> studies, we conjugated cGPNA-based TTR antisense with lactobionic acid-based targeting ligand for <em>in vivo</em> liver delivery. We establish that cGPNA exhibits significant TTR protein knockdown compared to unmodified peptide nucleic acid (PNA) <em>in vivo</em>. Overall, we confirm that clamp-G-modified PNA analogs are a robust antisense therapy platform.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"262 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141865381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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