Cell Reports Physical Science最新文献_第8页

Self-assembled conformal SnO2 electron transport layer via targeted chelating enables efficient, scalable, and stable perovskite solar cells 通过靶向螯合自组装的共形SnO2电子传输层实现了高效、可扩展和稳定的钙钛矿太阳能电池

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-03-26 DOI: 10.1016/j.xcrp.2025.102506

Hongzhen Su, Xuesong Lin, Li He, Chao Gao, Dezhao Zhang, Haotian Zhang, Daxue Du, Hong Liu, Wenzhong Shen

引用次数: 2

Chemiosmotic ATP synthesis by minimal protocells. 最小原始细胞的化学渗透ATP合成。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-03-19 DOI: 10.1016/j.xcrp.2025.102461

Fanchen Yu, Jinbo Fei, Yi Jia, Tonghui Wang, William F Martin, Junbai Li

{"title":"Chemiosmotic ATP synthesis by minimal protocells.","authors":"Fanchen Yu, Jinbo Fei, Yi Jia, Tonghui Wang, William F Martin, Junbai Li","doi":"10.1016/j.xcrp.2025.102461","DOIUrl":"10.1016/j.xcrp.2025.102461","url":null,"abstract":"Energy conservation is crucial to life's origin and evolution. The common ancestor of all cells used ATP synthase to convert proton gradients into ATP. However, pumps generating proton gradients and lipids maintaining proton gradients are not universally conserved across all lineages. A solution to this paradox is that ancestral ATP synthase could harness naturally formed geochemical ion gradients with simpler environmentally provided precursors preceding both proton pumps and biogenic membranes. This runs counter to traditional views that phospholipid bilayers are required to maintain proton gradients. Here, we show that fatty acid membranes can maintain sufficient proton gradients to synthesize ATP by ATP synthase under the steep pH and temperature gradients observed in hydrothermal vent systems. These findings shed substantial light on early membrane bioenergetics, uncovering a functional intermediate in the evolution of chemiosmotic ATP synthesis during protocellular stages postdating the ATP synthase's origin but preceding the advent of enzymatically synthesized cell membranes.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 3","pages":"102461"},"PeriodicalIF":6.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible peptide tagging system to regulate enzyme activity 调节酶活性的可逆肽标记系统

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-03-01 DOI: 10.1016/j.xcrp.2025.102462

Yao Chen, Yi Shi, Dengming Ming, He Huang, Ling Jiang

引用次数: 20

Site-specific mutated albumin for covalently targeting NIR-II dye enables noninvasive imaging of blood-testis barrier integrity 共价靶向NIR-II染料的位点特异性突变白蛋白能够实现血睾丸屏障完整性的无创成像

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-03-01 DOI: 10.1016/j.xcrp.2025.102499

Junrong Lin, Zetao Dang, Yijing Du, Yanli Gao, Jia Li, Yuewei Zhang, Shoujun Zhu

引用次数: 0

Piezoelectric behavior of a two-dimensional violet phosphorus for controllable neurophysical regeneration 二维紫磷可控神经物理再生的压电特性

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-03-01 DOI: 10.1016/j.xcrp.2025.102498

Yuyan Wang, Zaijun Lin, Wei Liu, Xinkui Huang, Xingzhou Chen, Shifei Kang, Yuanyi Zheng, Di Sun

引用次数: 0

An enzymatic and metal-organic framework system to prevent biofilm infections 一个酶和金属有机框架系统，以防止生物膜感染

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-03-01 DOI: 10.1016/j.xcrp.2025.102468

Peng Zhang, Xianli Hu, Quan Liu, Wenzhi Wang, Jiaxuan Sun, Ruixiang Ma, Jiawei Mei, Xianzuo Zhang, Wanbo Zhu, Zheng Su, Chen Zhu

引用次数: 4

Engineering strong and tough collagen hydrogels and tissue constructs via twisting and crosslinking 工程强而坚韧的胶原蛋白水凝胶和组织结构，通过扭转和交联

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-02-25 DOI: 10.1016/j.xcrp.2025.102454

Tingting Li, Zixing Zhou, Yang Xie, Wei Cai, Xiaobin Zhu, Yuanbo Jia, Zuoqi Zhang, Feng Xu, Guoyou Huang

引用次数: 6

Transporter excess and clustering facilitate adaptor protein shuttling for bacterial efflux. 转运蛋白过剩和聚集有利于细菌外排的衔接蛋白穿梭。

IF 7.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-02-19 Epub Date: 2025-02-12 DOI: 10.1016/j.xcrp.2025.102441

Wenyao Zhang, Christine E Harper, Junsung Lee, Bing Fu, Malissa Ramsukh, Christopher J Hernandez, Peng Chen

{"title":"Transporter excess and clustering facilitate adaptor protein shuttling for bacterial efflux.","authors":"Wenyao Zhang, Christine E Harper, Junsung Lee, Bing Fu, Malissa Ramsukh, Christopher J Hernandez, Peng Chen","doi":"10.1016/j.xcrp.2025.102441","DOIUrl":"10.1016/j.xcrp.2025.102441","url":null,"abstract":"Multidrug efflux pumps confer not only antibiotic resistance to bacteria but also cell proliferation. In gram-negative bacteria, the ATP-binding cassette (ABC)-family transporter MacB, the adaptor protein MacA, and the outer membrane protein TolC form the MacA6:MacB2:TolC3 assembly to extrude antibiotics and virulence factors. Here, using quantitative single-molecule single-cell imaging, we uncover that, in E. coli cells, there is a large excess of MacB (and TolC) driving the limiting adaptor protein MacA mostly into the MacAB-TolC assembly. Moreover, the excess MacB transporters can dynamically cluster around the assembly, and MacA can dynamically disassemble from the MacAB-TolC assembly, leading to an adaptor protein shuttling mechanism for efficient substrate sequestration from the periplasm toward efflux. We further show that both MacB clustering and MacAB-TolC assembly can be perturbed chemically or physically via microfluidics-based extrusion loading for compromised antibiotic tolerance. These insights may provide opportunities for countering the activities of multidrug efflux systems for antimicrobial treatments.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 2","pages":""},"PeriodicalIF":7.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Membrane-assisted Aβ40 aggregation pathways. 膜辅助Aβ40聚集途径。

IF 7.3 2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-02-19 Epub Date: 2025-02-11 DOI: 10.1016/j.xcrp.2025.102436

Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou

{"title":"Membrane-assisted Aβ40 aggregation pathways.","authors":"Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou","doi":"10.1016/j.xcrp.2025.102436","DOIUrl":"10.1016/j.xcrp.2025.102436","url":null,"abstract":"Alzheimer's disease (AD) is caused by the assembly of amyloid-beta (Aβ) peptides into oligomers and fibrils. Endogenous Aβ aggregation may be assisted by cell membranes, which can accelerate the nucleation step enormously, but knowledge of membrane-assisted aggregation is still very limited. Here, we used extensive molecular dynamics (MD) simulations to structurally and energetically characterize key intermediates along the membrane-assisted aggregation pathways of Aβ40. Reinforcing experimental observations, the simulations reveal unique roles of GM1 ganglioside and cholesterol in stabilizing membrane-embedded β sheets and of Y10 and K28 in the ordered release of a small oligomeric seed into solution. The same seed leads to either an open-shaped or R-shaped fibril, with significant stabilization provided by inter- or intra-subunit interfaces between a straight β sheet (residues Q15-D23) and a bent β sheet (residues A30-V36). This work presents a comprehensive picture of membrane-assisted aggregation of Aβ40, with broad implications for developing AD therapies and rationalizing disease-specific polymorphisms of amyloidogenic proteins.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 2","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-temperature-sinterable, highly conductive ink for 3D printing enabled by volume change effect 低温烧结，高导电性的3D打印墨水，通过体积变化效应实现

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-02-01 DOI: 10.1016/j.xcrp.2025.102432

Jialiang Li, Huiying Yan, Zewen Lin, Youpeng Ding, Yanan Zhao, Xinping Lin, Shumin Lin, Xiaolan Hu, Hua Bai

引用次数: 2