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引用次数: 0
摘要
糖尿病是一种炎症性疾病,通常会导致慢性伤口,目前还没有令人满意的治疗方法。在此,我们报告了一种利用冷大气等离子体(CAP)针对糖尿病伤口局部调节伤口炎症阶段的物理方法。本文结合氦等离子体射流特性的物理研究,对炎症因素进行了全面分析。同时还分析了 CAP 射流对人体的物理和生物安全性以及临床应用前景。研究结果首次证明,CAP疗法可以激发人体自身的炎症调节功能,使其达到正常状态,而不是对单一目标进行过度干预。这包括在发病子阶段抑制促炎因子,在随后的消炎子阶段促进抗炎因子。这项研究有助于开发高效安全的局部疗法,促进慢性伤口愈合。
A nature-based solution for regulating the inflammatory phase of diabetic wound healing using a cold atmospheric plasma
Diabetes is an inflammatory disease that usually causes chronic wounds for which no satisfactory therapies currently exist. Here we report a physical approach using a cold atmospheric plasma (CAP) to target diabetic wounds locally for regulating the inflammatory phase of the wounds. In this paper, a comprehensive analysis of inflammatory factors combined with physical investigations of the helium plasma jet characteristics is conducted. The physical and biological safety and clinical application prospects of the CAP jet for the human body are also analyzed. The results demonstrate for the first time that CAP therapy can stimulate the body’s own inflammatory regulation function to achieve a normal state, rather than excessively interfere in a single target. This involves the inhibition of pro-inflammatory factors in the onset subphase and the promotion of anti-inflammatory factors in the subsequent resolution subphase. This research contributes to the development of highly effective and safe topical therapies to promote chronic wound healing.
期刊介绍:
Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.