最近的 "fusicoccanes "总合成

IF 7.9 2区 综合性期刊 Q1 CHEMISTRY, MULTIDISCIPLINARY
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引用次数: 0

摘要

来源于真菌、植物和细菌的木犀草烷二萜是一个多样化的天然产品家族,具有 5-8-5 三环框架。过去,它们仅限于植物生理学领域。然而,鱼腥烷类化合物目前正处于生物医学的前沿,是探究 14-3-3 蛋白质-蛋白质相互作用(PPIs)不可或缺的物质。材料供应和支架多样化的需求促进了合成界对它们的研究。这篇综述重点介绍了过去 5 年中发表的有关番荔枝烷二萜的全部合成工作。包括闭环偏合成、金属催化交叉偶联和碳环化在内的关键转化过程显著提高了合成效率和多样性。最近发现的生物合成转化激发了创新的化学酶战略。未来的研究方向应该是研究fusicoccanes的功能方面,以实现其作为通用14-3-3 PPI调节剂的治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent total syntheses of fusicoccanes

Recent total syntheses of fusicoccanes

Fusicoccane diterpenoids, originating from fungi, plants, and bacteria, constitute a diverse natural product family featuring a 5-8-5 tricyclic framework. They were restricted to plant physiology in the past. However, fusicoccanes are presently at the forefront of biomedicine and are indispensable for probing 14-3-3 protein-protein interactions (PPIs). The need for material supply and scaffold diversification encouraged their study by the synthetic community. This review highlights the total synthetic works on fusicoccane diterpenoids published in the last 5 years. Key transformations including ring-closing metathesis, metal-catalyzed cross-coupling, and carbocyclization markedly enhanced synthetic efficiency and versatility. Recently identified biosynthetic transformations inspired innovative chemoenzymatic strategies. Investigation into the functional aspects of fusicoccanes should be the future direction to realize their therapeutic potential as general 14-3-3 PPI modulators.

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来源期刊
Cell Reports Physical Science
Cell Reports Physical Science Energy-Energy (all)
CiteScore
11.40
自引率
2.20%
发文量
388
审稿时长
62 days
期刊介绍: Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.
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