Cell Reports Physical Science最新文献_第7页

Manipulating trapped air bubbles in ice for message storage in cold regions 在寒冷地区利用冰中被困住的气泡来储存信息

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-06-01 DOI: 10.1016/j.xcrp.2025.102622

Keke Shao, Xuan Zhang, Mengjie Song, Jun Shen, Lizhen Huang, Tianzhuo Zhan, Haidong Wang, Bo You, Libor Pekař, Dong Rip Kim, Christopher Y.H. Chao, Long Zhang

{"title":"Manipulating trapped air bubbles in ice for message storage in cold regions","authors":"Keke Shao, Xuan Zhang, Mengjie Song, Jun Shen, Lizhen Huang, Tianzhuo Zhan, Haidong Wang, Bo You, Libor Pekař, Dong Rip Kim, Christopher Y.H. Chao, Long Zhang","doi":"10.1016/j.xcrp.2025.102622","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102622","url":null,"abstract":"<h2>Summary</h2> Message storage using documents and telecommunications encounters high energy consumption and a short life cycle in cold regions. Easily available low temperature and water have created the history-recording glaciers. Inspired by the naturally occurring bubbles in glaciers, we elucidate the underlying physics governing them and develop an ice-based message storage method. The formation process of trapped air bubbles is controlled by the heat and mass transfer during freezing. We identify four ice regions based on the bubbles' distribution and determine the critical freezing rate between the bubble and clear ice regions at 2.87 μm/s. Manipulating the bubble layer by varying the freezing rate successfully utilizes Morse, binary, and ternary codes to store messages. These findings reveal the underlying physics of the trapped air bubble formations, and the intermittent growth of bubble layers also provides the potential for incorporating artificial intelligence into material solidification, glacier analysis, and gas exploration.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 6","pages":"102622-102622"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.cell.com/action/showPdf?pii=S2666386425002218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Robustness in biomolecular simulations: Addressing challenges in data generation, analysis, and curation. 生物分子模拟中的稳健性：解决数据生成、分析和管理方面的挑战。

IF 7.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-05-21 Epub Date: 2025-04-30 DOI: 10.1016/j.xcrp.2025.102566

Anne M Brown, Justin A Lemkul

引用次数: 0

G-quadruplex and i-motif DNA structures form in the promoter of the key innate immune adaptor MYD88. g -四重体和i基序DNA结构在关键先天免疫适配器MYD88的启动子中形成。

IF 7.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-05-21 Epub Date: 2025-04-28 DOI: 10.1016/j.xcrp.2025.102560

Susie Brown, Kennith Swafford, Mason McCrury, Farhana Nasrin, Carlon Q Gragg, Arundhati Chavan, Samrat Roy Choudhury, Jonathan Dickerhoff, Danzhou Yang, Samantha Kendrick

{"title":"G-quadruplex and i-motif DNA structures form in the promoter of the key innate immune adaptor <i>MYD88</i>.","authors":"Susie Brown, Kennith Swafford, Mason McCrury, Farhana Nasrin, Carlon Q Gragg, Arundhati Chavan, Samrat Roy Choudhury, Jonathan Dickerhoff, Danzhou Yang, Samantha Kendrick","doi":"10.1016/j.xcrp.2025.102560","DOIUrl":"10.1016/j.xcrp.2025.102560","url":null,"abstract":"<p><p>Innate immune responses rely on a critical adaptor protein, MYD88, to bridge extracellular inflammatory signals and transcription factor networks inside the cell. Dysregulation of MYD88 is associated with immunodeficiencies, autoimmunity, and cancer. Here, we identify a stretch of guanine/cytosine-rich DNA in the <i>MYD88</i> promoter capable of adopting stable G-quadruplex and i-Motif structures. Molecular characterization of the i-motif reveals a unique folding pattern with asymmetric lateral loop sizes, a transition pH in line with previously documented i-motifs, and <i>in vitro</i> recognition by the chromatin insulator/transcription factor (CTCF). In exploring the transcriptional role and therapeutic potential of the MYD88 structures, we show the known G-quadruplex ligand, TMPyP4, destabilizes the i-motif, stabilizes the G-quadruplex, and promotes <i>MYD88</i> expression. A ligand, 33353, from the National Cancer Institute (NCI) Diversity Set, also differentially interacts with the two structures yet represses <i>MYD88</i>. This work discovers DNA structures in <i>MYD88</i> that can be pharmacologically leveraged for their ability to control gene expression.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 5","pages":""},"PeriodicalIF":7.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant piezodielectric effect near the polymorphic phase boundary of perovskites near resonant frequencies 共振频率附近钙钛矿多晶相边界附近的巨压电效应

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-05-20 DOI: 10.1016/j.xcrp.2025.102602

Yixin Yang, Daniel Q. Tan, Siyu Ma, Cong Xie, Yufei Zhao, Shiyi Gao, Shuo Zhang, Nan Wang, Yachin Ivry

{"title":"Giant piezodielectric effect near the polymorphic phase boundary of perovskites near resonant frequencies","authors":"Yixin Yang, Daniel Q. Tan, Siyu Ma, Cong Xie, Yufei Zhao, Shiyi Gao, Shuo Zhang, Nan Wang, Yachin Ivry","doi":"10.1016/j.xcrp.2025.102602","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102602","url":null,"abstract":"<h2>Summary</h2> Traditional enhancement of piezoelectric properties via morphotropic phase boundary (MPB) engineering or the incorporation of relaxor ferroelectric (FE) materials faces limitations, including a reduced Curie temperature (<i>T</i><sub>C</sub>) and permittivity saturation. This article introduces a piezodielectric effect that capitalizes on the resonant frequency of common piezoelectric materials with dual-phase coexistence. This approach has yielded an extraordinary permittivity increase exceeding 1,000% at FE–FE phase transition temperature on permittivity-temperature curves. This method of magnifying the FE–FE permittivity shoulder provides a foundation for the precise determination of the MPB position on the phase diagram. In addition, by decoupling permittivity enhancement from <i>T</i><sub>C</sub> reduction, we achieved a colossal relative permittivity (>40,000) and a calculated piezoelectric coefficient (>5,000 pC/N) near room temperature alongside a relatively high <i>T</i><sub>C</sub> (>300°C) in relaxor ferroelectric ceramics. This breakthrough paves the way for amplifying dielectric and piezoelectric properties, offering significant benefits for the performance of transducers and sensors.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 6","pages":"102602-102602"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.cell.com/action/showPdf?pii=S2666386425002012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147910480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sea-cucumber-inspired bio-based polyurethane with desirable stretchability, recyclability, and self-healing capabilities 海参启发的生物基聚氨酯具有理想的拉伸性，可回收性和自我修复能力

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-05-01 DOI: 10.1016/j.xcrp.2025.102598

Yun Hu, Ye Sha, Yan Fang, Meng Zhang, Yonghong Zhou, Puyou Jia, Tianyu Zhu

{"title":"Sea-cucumber-inspired bio-based polyurethane with desirable stretchability, recyclability, and self-healing capabilities","authors":"Yun Hu, Ye Sha, Yan Fang, Meng Zhang, Yonghong Zhou, Puyou Jia, Tianyu Zhu","doi":"10.1016/j.xcrp.2025.102598","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102598","url":null,"abstract":"<h2>Summary</h2> The widespread adoption of polyurethane (PU) materials in adhesives and ultraviolet (UV)-resistant applications is limited by the challenge of balancing stretchability, recyclability, and self-healing capabilities, which requires an advanced molecular structural design. Here, we synthesize a castor-oil-based PU (COPUSD) that integrates disulfide bonds and multiple hydrogen bonds, drawing inspiration from the remarkable self-healing capabilities and stretchability of sea cucumbers. This biomimetic approach facilitates the development of a multifunctional PU material with excellent self-healing properties, tunable stretchability, and recyclable processing characteristics. The resulting PUs are employed as adhesion and anti-UV radiation materials and exhibit excellent adhesion properties. The transmittance of the PU is close to 0% in the range of 200–400 nm, indicating a strong blocking ability against UV. This study presents a pioneering approach for developing versatile and scalable PU materials that combine adjustable self-healing capabilities and efficient recyclability for adhesive and UV-resistant applications.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 5","pages":"102598-102598"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.cell.com/action/showPdf?pii=S2666386425001973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Synthesis of selective BCL-XL PROTAC and potent antitumor activity in glioblastoma 选择性BCL-XL PROTAC的合成及其在胶质母细胞瘤中的抗肿瘤活性

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-05-01 DOI: 10.1016/j.xcrp.2025.102593

Meichen Liu, Biao Sun, Rui Niu, Yue Zhang, Xinyu Li, Jiefei Wang, Xin Wang, Jinlong Yin

{"title":"Synthesis of selective BCL-XL PROTAC and potent antitumor activity in glioblastoma","authors":"Meichen Liu, Biao Sun, Rui Niu, Yue Zhang, Xinyu Li, Jiefei Wang, Xin Wang, Jinlong Yin","doi":"10.1016/j.xcrp.2025.102593","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102593","url":null,"abstract":"<h2>Summary</h2> Glioblastoma (GBM), the most aggressive and treatment-resistant form of brain cancer, is significantly influenced by GBM stem cells (GSCs), which contribute to tumor initiation and recurrence. This study introduces two innovative proteolysis-targeting chimeras (PROTACs), AN-1 and AN-2, designed to degrade BCL-X<sub>L</sub>, a key anti-apoptotic protein in the BCL-2 family. Optimized from ABT-263, these PROTACs utilize MDM2 as an E3 ligase, a strategy not previously used in GBM therapy. Our approach leverages the high expression of MDM2 in GSCs and low expression in platelets, enhancing therapeutic specificity and reducing the risk of thrombocytopenia—a key side effect of BCL-X<sub>L</sub> inhibition. Both <i>in vitro</i> and <i>in vivo</i> studies show that AN-1 and AN-2 effectively inhibit GSC proliferation, promote apoptosis, and significantly improve survival rates without inducing thrombocytopenia. This study highlights the potential of targeting underexplored E3 ligases in cancer therapy and offers a selective approach to treating GBM, overcoming current treatment limitations.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 5","pages":"102593-102593"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.cell.com/action/showPdf?pii=S2666386425001924","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cyclic brush spherical nucleic acids for enhanced gene-immunotherapy of hepatocellular carcinoma via neutrophil polarization 循环刷球核酸通过中性粒细胞极化增强肝癌基因免疫治疗

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-04-29 DOI: 10.1016/j.xcrp.2025.102562

Songbin Liu, Zhenghao Tao, Hongbing Liu, Shuang Yan, Longtianyang Lei, Yao Cheng, Rongguo Fu, Haitao Zhang, Cui‐Yun Yu, Hua Wei

引用次数: 0

Metallaphotocatalytic modular synthesis of masked arylaminomethyl trifluoromethyl ketones 蒙面芳胺甲基三氟甲基酮的金属光催化模块化合成

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-04-29 DOI: 10.1016/j.xcrp.2025.102564

Yingde Jiang, Zhongwei Zhang, Chi Wai Cheung, Jun‐An Ma

引用次数: 1

Artificial pancreas with engineered β cell microspheres overexpressing PD-L1 and algae ameliorate type 1 diabetes 利用过表达PD-L1的β细胞微球和藻类构建人工胰腺可改善1型糖尿病

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-04-18 DOI: 10.1016/j.xcrp.2025.102549

Zhangyan Jing, Xiaohong Li, Wenli Fang, Yishi Tian, Yuan Li, Chi Zhang, Zhaoxin Yang, Chanjuan Li, Zixuan Fan, Fanqiang Meng, Xin Liang, Xudong Zhang

引用次数: 5

Branched intercalating cations regulate the structural evolution of two-dimensional perovskites 支化插层阳离子调控二维钙钛矿的结构演化

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-03-29 DOI: 10.1016/j.xcrp.2025.102509

Wenxuan Li, Jianjia He, Yilan Zhang, Le Ye, Guoying Yao, Zixuan Zhang, Shiang Li, Xinhui Lu, Haipeng Lu, Tao Zeng, Zhenyu Yang

引用次数: 0