Hierarchically porous films for ultrahigh-throughput characterization of chemical exposome in biological fluids

IF 7.9 2区 综合性期刊 Q1 CHEMISTRY, MULTIDISCIPLINARY
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引用次数: 0

Abstract

Exposome science captures the totality of environmental drivers of human health. However, the comprehensive determination of numerous exogenous and endogenous compounds remains extremely challenging, restricting the purpose of exposome science to characterize both external and internal exposure. Herein, we develop hierarchically porous polymers of intrinsic microporosity (HPPIM) films to achieve ultrahigh-throughput determination of exo/endogenous molecules in biological fluids. The film’s porous properties, including three-stage micro-submicro-nanometer architectures, large specific surface area, and appropriate pore geometry and organophilicity enable fast molecular transport and high trapping capability, therefore achieving ultrahigh-throughput determination of exo/endogenous molecules in biological fluids. Further application in a small-scale cancer study demonstrates the unique advantages of HPPIM films over existing techniques, including broad coverage of analytes, satisfactory trapping efficiency, low-volume demand on specimens, high simplicity and reusability, and drastically reduced financial cost. Our work demonstrates the great potential of HPPIM for advancing exposome science from concept to utility.

Abstract Image

用于超高通量表征生物液体中化学暴露体的分层多孔薄膜
暴露组科学捕捉到了影响人类健康的全部环境因素。然而,全面测定众多外源性和内源性化合物仍然极具挑战性,这限制了暴露组科学用于表征外部和内部暴露的目的。在此,我们开发了具有内在微孔的分层多孔聚合物(HPPIM)薄膜,以实现超高通量测定生物液体中的外源性/内源性分子。该薄膜的多孔特性,包括三级微亚微纳结构、大比表面积、适当的孔几何形状和亲有机性,可实现快速分子传输和高捕获能力,从而实现生物液体中外源性/内源性分子的超高通量测定。在一项小规模癌症研究中的进一步应用证明了 HPPIM 薄膜相对于现有技术的独特优势,包括对分析物的广泛覆盖、令人满意的捕获效率、对标本的低容量需求、高度简便性和可重复使用性以及大幅降低的经济成本。我们的工作证明了 HPPIM 在推动暴露组科学从概念走向实用方面的巨大潜力。
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来源期刊
Cell Reports Physical Science
Cell Reports Physical Science Energy-Energy (all)
CiteScore
11.40
自引率
2.20%
发文量
388
审稿时长
62 days
期刊介绍: Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.
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