Purely electrical detection of electrolyte concentration through microfluidic impedance spectroscopy

IF 7.9 2区综合性期刊 Q1 CHEMISTRY, MULTIDISCIPLINARY

Cell Reports Physical Science Pub Date : 2024-07-30 DOI:10.1016/j.xcrp.2024.102133

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Abstract

Impedance spectroscopy enables the electrical properties of samples to be probed and is commonly used to characterize solids. Extending this technique to analyze fluids within microfluidic channels could enable the rapid characterization of bodily fluids such as sweat. Here, we present a low-cost microfluidic platform with integrated aerosol-jet printed electrodes for the electrical characterization of fluids via impedance spectroscopy. A novel analysis method is presented to accurately determine the concentration of several aqueous ionic chloride solutions, namely NaCl, KCl, CaCl₂, and MgCl₂. Importantly, we identify a key parameter, the turning point frequency of the capacitance-frequency graph, which is found to have a highly linear correlation with the solution concentration for each species spanning at least three orders of magnitude. This linear dependence is highly reproducible across different cationic species, making it useful for accurate fluid characterization. Applying this technique to analyze bodily fluids in real time has implications for remote health monitoring.

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通过微流控阻抗能谱对电解质浓度进行纯电检测

阻抗光谱法可探测样品的电特性，常用于表征固体。将这一技术扩展到分析微流体通道内的流体，可实现对汗液等体液的快速表征。在这里，我们介绍了一种集成气溶胶喷射印刷电极的低成本微流控平台，用于通过阻抗光谱法对流体进行电学表征。我们提出了一种新颖的分析方法，可准确测定几种离子氯化物水溶液（即 NaCl、KCl、CaCl2 和 MgCl2）的浓度。重要的是，我们确定了一个关键参数，即电容-频率图的转折点频率，发现该频率与每种物质的溶液浓度高度线性相关，至少跨越三个数量级。这种线性关系在不同的阳离子物种之间具有很高的重现性，因此可用于准确的流体表征。应用这种技术实时分析体液对远程健康监测具有重要意义。

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来源期刊

Cell Reports Physical Science Energy-Energy (all)

CiteScore

11.40

自引率

2.20%

发文量

388

审稿时长

62 days

期刊介绍： Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.

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