IF 64.5 1区生物学

Cell Pub Date : 2025-08-11 DOI: 10.1016/j.cell.2025.07.028

Yue Xie, Tinghao Zhang, Minghao Yang, Hongchang Lyu, Yupan Zou, Yangchang Sun, Jun Xiao, Wenzhao Lian, Jianhua Tao, Hua Han, Cao Xu

{"title":"Engineering crop flower morphology facilitates robotization of cross-pollination and speed breeding","authors":"Yue Xie, Tinghao Zhang, Minghao Yang, Hongchang Lyu, Yupan Zou, Yangchang Sun, Jun Xiao, Wenzhao Lian, Jianhua Tao, Hua Han, Cao Xu","doi":"10.1016/j.cell.2025.07.028","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.028","url":null,"abstract":"Artificial intelligence (AI) and robots offer vast opportunities in shifting toward precision agriculture to enhance crop yields, reduce costs, and promote sustainable practices. However, many crop traits obstruct the application of AI-based robots. One bottleneck is flower morphology with recessed stigmas, which hinders emasculation and pollination during hybrid breeding. We developed a crop-robot co-design strategy in tomatoes by combining genome editing with artificial-intelligence-based robots (GEAIR). We generated male-sterile lines bearing flowers with exserted stigmas, and then trained a mobile robot to automatically recognize and cross-pollinate those stigmas. GEAIR enables automated F1 hybrid breeding with efficiency comparable to manual pollination and facilitates the rapid breeding of stress-resilient and flavorful tomatoes when combined with de novo domestication under speed-breeding conditions. Multiplex gene editing in soybean recapitulated the male-sterile, exserted-stigma phenotype, potentially unlocking robotized hybrid breeding. We demonstrate the potential of GEAIR in boosting efficiency and lowering costs through automated, faster breeding of climate-resilient crops.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"53 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants nrt11 b作为脱落酸受体参与植物对复合环境信号的整合

IF 64.5 1区生物学

Cell Pub Date : 2025-08-11 DOI: 10.1016/j.cell.2025.07.027

Xiaojun Ma, Wei Wang, Jingyi Zhang, Zhimin Jiang, Chengyuan Xu, Wenjun Zhu, Bihai Shi, Wanling Yang, Haiwei Su, Xiaohan Wang, Da Chen, Yanfei Wang, Juntao Wang, Jingchi Wang, Xiujie Liu, Xiaotian Wang, Xiahe Huang, Wenjun Xie, Yanting Cai, Ke Xu, Bin Hu

{"title":"NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants","authors":"Xiaojun Ma, Wei Wang, Jingyi Zhang, Zhimin Jiang, Chengyuan Xu, Wenjun Zhu, Bihai Shi, Wanling Yang, Haiwei Su, Xiaohan Wang, Da Chen, Yanfei Wang, Juntao Wang, Jingchi Wang, Xiujie Liu, Xiaotian Wang, Xiahe Huang, Wenjun Xie, Yanting Cai, Ke Xu, Bin Hu","doi":"10.1016/j.cell.2025.07.027","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.027","url":null,"abstract":"Abscisic acid (ABA) is the most crucial phytohormone for plants in adapting to environmental conditions. While the ABA signaling network in plants has been extensively explored, our understanding of the diverse ABA sensing systems remains limited. Here, we found that the transcriptional response to ABA is suppressed under high-nitrate conditions but substantially increases under low-nitrate conditions, suggesting a tight integration of ABA signaling with nutrient conditions. Interestingly, NRT1.1B, traditionally recognized as a nitrate transporter and receptor, exhibits a markedly higher affinity for ABA, leading to the formation of an ABA-facilitated NRT1.1B-SPX4 complex. This complex triggers the release of SPX4-sequestered transcription factor NLP4, thereby initiating the transcriptional response to ABA. These findings establish that NRT1.1B functions as an ABA receptor. Notably, the competitive binding of nitrate and ABA to NRT1.1B unveils a mechanism that enables a flexible ABA response to fluctuating nutrient conditions, illustrating a sophisticated strategy for integrating compound environmental cues.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"15 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility 南高加索从青铜器时代到中世纪早期的遗传历史：5000年的遗传连续性，尽管高流动性

IF 64.5 1区生物学

Cell Pub Date : 2025-08-07 DOI: 10.1016/j.cell.2025.07.013

Eirini Skourtanioti, Xiaowen Jia, Nino Tavartkiladze, Liana Bitadze, Ramaz Shengelia, Nikoloz Tushabramishvili, Vladimer Aslanishvili, Boris Gasparyan, Andrew W. Kandel, David Naumann, Gunnar U. Neumann, Raffaela Angelina Bianco, Angela Mötsch, Kay Prüfer, Thiseas C. Lamnidis, Luca Traverso, Ayshin Ghalichi, Sturla Ellingvåg, Philipp W. Stockhammer, Johannes Krause, Harald Ringbauer

{"title":"The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility","authors":"Eirini Skourtanioti, Xiaowen Jia, Nino Tavartkiladze, Liana Bitadze, Ramaz Shengelia, Nikoloz Tushabramishvili, Vladimer Aslanishvili, Boris Gasparyan, Andrew W. Kandel, David Naumann, Gunnar U. Neumann, Raffaela Angelina Bianco, Angela Mötsch, Kay Prüfer, Thiseas C. Lamnidis, Luca Traverso, Ayshin Ghalichi, Sturla Ellingvåg, Philipp W. Stockhammer, Johannes Krause, Harald Ringbauer","doi":"10.1016/j.cell.2025.07.013","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.013","url":null,"abstract":"The Caucasus was a hub for cultural and technological innovation in prehistory, yet the population history between the Greater and Lesser Caucasus remains insufficiently understood. We present genome-wide data of 205 individuals from modern Georgia and 25 from Armenia, spanning the period from the Bronze Age (BA) to the “Migration Period” (c. 3500 BCE–700 CE). Our results reveal a persisting local gene pool that, during the Middle-Late BA, absorbed additional ancestry from Anatolia and the neighboring Eurasian Steppe. In subsequent periods, we document population growth and increasing genetic diversity, supported by a high rate of individual ancestry outliers, particularly in urban centers of eastern Georgia. Among 20 Medieval individuals with artificially deformed skulls, 15 were part of local mating networks and five derived ancestry from the Eurasian Steppe, suggesting that cranial modification arrived with nomadic groups but became a locally adopted cultural practice.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"11 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vagal blockade of the brain-liver axis deters cancer-associated cachexia 迷走神经阻断脑-肝轴阻止癌症相关恶病质

IF 64.5 1区生物学

Cell Pub Date : 2025-08-07 DOI: 10.1016/j.cell.2025.07.016

Aliesha Garrett, Naama Darzi, Ashlesha Deshmukh, Nataly Rosenfeld, Omer Goldman, Lital Adler, Elizabeta Bab-Dinitz, Oded Singer, Alireza Hassani Najafabadi, Chi Wut Wong, Shree Bose, Peggy M. Randon, Francisco Bustamante, Rene Larios, Alexander Brandis, Tevie Mehlman, Brandon Smaglo, Ping Chang, Jacqueline Oliva, Cara Haymaker, Xiling Shen

{"title":"Vagal blockade of the brain-liver axis deters cancer-associated cachexia","authors":"Aliesha Garrett, Naama Darzi, Ashlesha Deshmukh, Nataly Rosenfeld, Omer Goldman, Lital Adler, Elizabeta Bab-Dinitz, Oded Singer, Alireza Hassani Najafabadi, Chi Wut Wong, Shree Bose, Peggy M. Randon, Francisco Bustamante, Rene Larios, Alexander Brandis, Tevie Mehlman, Brandon Smaglo, Ping Chang, Jacqueline Oliva, Cara Haymaker, Xiling Shen","doi":"10.1016/j.cell.2025.07.016","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.016","url":null,"abstract":"Cancer-associated cachexia (CAC) is a multifactorial and currently incurable syndrome responsible for nearly one-third of cancer-related deaths. It contributes to therapy resistance and increases mortality among affected patients. In this study, we show that cancer-induced systemic inflammation alters vagal tone in CAC mouse models. This vagal dysregulation disrupts the brain-liver vagal axis, leading to a reprogramming of hepatic protein metabolism through the depletion of HNF4α, a key transcriptional regulator of liver function. The loss of HNF4α disrupts hepatic metabolism and promotes systemic inflammation, resulting in cachectic phenotypes. Interventions targeting the right cervical vagus nerve surgically, chemically, electrically, or through a non-invasive transcutaneous device attenuate CAC progression, alleviate its clinical manifestations, and synergize with chemotherapy to improve overall health and survival in mice.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"102 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

iPSC-derived CAR-NK cells: Off-the-shelf cellular therapy for systemic sclerosis ipsc衍生的CAR-NK细胞：系统性硬化症的现成细胞疗法

IF 64.5 1区生物学

Cell Pub Date : 2025-08-07 DOI: 10.1016/j.cell.2025.07.007

May Daher, Katayoun Rezvani

引用次数: 0

A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells 通过化学诱导胚胎建立细胞实现器官发生的小鼠胚胎发生的完整模型

IF 64.5 1区生物学

Cell Pub Date : 2025-08-07 DOI: 10.1016/j.cell.2025.07.018

Huanhuan Li, Wei Guan, Jiahui Huang, Penglei Shen, Jinyi Wu, Haiping Luo, Yun Yang, Shaoqiang Ning, Litao Chang, Haiyong Zhao, Chuanxin Chen, Yake Gao, Yaoyu Chen, Xianfa Yang, Yael Costa, Chen-Leng Cai, Duanqing Pei, Guangdun Peng, Guangming Wu, Jiekai Chen, José C.R. Silva

{"title":"A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells","authors":"Huanhuan Li, Wei Guan, Jiahui Huang, Penglei Shen, Jinyi Wu, Haiping Luo, Yun Yang, Shaoqiang Ning, Litao Chang, Haiyong Zhao, Chuanxin Chen, Yake Gao, Yaoyu Chen, Xianfa Yang, Yael Costa, Chen-Leng Cai, Duanqing Pei, Guangdun Peng, Guangming Wu, Jiekai Chen, José C.R. Silva","doi":"10.1016/j.cell.2025.07.018","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.018","url":null,"abstract":"Embryo models offer opportunities for understanding development and advancing medicine but rely on intricate procedures with limitations in efficiency and developmental fidelity. Here, we employ a small-molecule-only approach to induce mouse embryonic stem cells into 8- to 16-cell-like embryo founder cells, enabling the generation of a complete embryo model. These founder cells specify all blastocyst lineages, both embryonic and extraembryonic, in vivo and in vitro. The embryo model made only from embryo founder cells faithfully recapitulates development through organogenesis. During gastrulation, it forms a primitive streak via epithelial-to-mesenchymal transition, generates the three germ layers, and develops an ectoplacental cone. The model proceeds to form 6–14 somite pairs, fore-/mid-/hindbrain, a looping heart tube, optic buds, allantois, tail bud, migrating primordial germ cells, and well-defined gut. Altogether, our system using embryo founder cells enables a direct, rapid, efficient, and accurate in vitro model of embryogenesis.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"20 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy 大脑对能量稳态的控制：对抗肥胖药物治疗的启示

IF 64.5 1区生物学

Cell Pub Date : 2025-08-07 DOI: 10.1016/j.cell.2025.06.010

Valdemar Brimnes Ingemann Johansen, Jonas Petersen, Jens Lund, Cecilie Vad Mathiesen, Henning Fenselau, Christoffer Clemmensen

引用次数: 0

Arrestins and opioid-independent analgesia 停搏药物和阿片类药物非依赖性镇痛

IF 64.5 1区生物学

Cell Pub Date : 2025-08-07 DOI: 10.1016/j.cell.2025.07.008

Olena Didenko, John N. Wood

引用次数: 0

Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline 通过人工智能辅助管道鉴定肠道微生物胆汁酸代谢酶

IF 64.5 1区生物学

Cell Pub Date : 2025-08-07 DOI: 10.1016/j.cell.2025.07.017

Yong Ding, Xi Luo, Jiasheng Guo, Baiying Xing, Haoyu Lin, Haohan Ma, Yicun Wang, Meng Li, Chuan Ye, Sen Yan, Kangjie Lin, Jinxin Zhang, Yingying Zhuo, Qixing Nie, Donghui Yang, Zhipeng Zhang, Yanli Pang, Kai Wang, Ming Ma, Luhua Lai, Changtao Jiang

{"title":"Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline","authors":"Yong Ding, Xi Luo, Jiasheng Guo, Baiying Xing, Haoyu Lin, Haohan Ma, Yicun Wang, Meng Li, Chuan Ye, Sen Yan, Kangjie Lin, Jinxin Zhang, Yingying Zhuo, Qixing Nie, Donghui Yang, Zhipeng Zhang, Yanli Pang, Kai Wang, Ming Ma, Luhua Lai, Changtao Jiang","doi":"10.1016/j.cell.2025.07.017","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.017","url":null,"abstract":"The modifications of bile acids (BAs) are fundamental to their role in host physiology and pathology. Identifying their synthetases is crucial for uncovering the diversity of BAs and developing targeted interventions, yet it remains a significant challenge. To address this hurdle, we developed an artificial intelligence (AI)-assisted workflow, bile acid enzyme announcer unit tool (BEAUT), which predicted over 600,000 candidate BA metabolic enzymes that we compiled into the human generalized microbial BA metabolic enzyme (HGBME) database (https://beaut.bjmu.edu.cn<svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg>). We identified a series of uncharacterized BA enzymes, including monoacid acylated BA hydrolase (MABH) and 3-acetoDCA synthetase (ADS). Notably, ADS can produce an unreported skeleton BA, 3-acetoDCA, with a carbon-carbon bond extension. After determining its bacterial source and catalytic mechanism, we found that 3-acetoDCA is widely distributed among populations and regulates the microbial interactions in the gut. In conclusion, our work offers alternative insights into the relationship between microbial BAs and the host from an enzymatic perspective.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"1 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation 具有二价组蛋白标记的复合转座子在细胞命运调控中发挥rna依赖性增强子的作用

IF 64.5 1区生物学

Cell Pub Date : 2025-08-06 DOI: 10.1016/j.cell.2025.07.014

Ziqiang Zhou, Shicong Zhu, Yaqiang Hong, Guangpu Jin, Rui Ma, Fan Lin, Yiyang Zhang, Hsiang-Ying Lee, Nian Liu

{"title":"Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation","authors":"Ziqiang Zhou, Shicong Zhu, Yaqiang Hong, Guangpu Jin, Rui Ma, Fan Lin, Yiyang Zhang, Hsiang-Ying Lee, Nian Liu","doi":"10.1016/j.cell.2025.07.014","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.014","url":null,"abstract":"Discrete genomic units can recombine into composite transposons that transcribe and transpose as single units, but their regulation and function are not fully understood. We report that composite transposons harbor bivalent histone marks, with activating and repressive marks in distinct regions. Genome-wide CRISPR-Cas9 screening, using a reporter driven by the hominid-specific composite transposon SVA (SINE [short interspersed nuclear element]-VNTR [variable number of tandem repeats]-Alu) in human cells, identified diverse genes that modify bivalent histone marks to regulate SVA transcription. SVA transcripts are critical for SVA’s cis-regulatory function in selectively contacting and activating long-range gene expression. Remarkably, a subset of bivalent SVAs is activated during erythropoiesis to boost multiple erythroid gene expression, and knocking down these SVAs leads to deficient erythropoiesis. The RNA-dependent cis-regulatory function of SVA activates genes for myelopoiesis and can contribute to aging-associated myeloid-biased hematopoiesis. These results reveal that the cis-regulatory functions of composite transposons are bivalently regulated to control cell fate transitions in development and aging.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"21 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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