iPSC-derived CAR-NK cells: Off-the-shelf cellular therapy for systemic sclerosis

IF 42.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-08-07 DOI:10.1016/j.cell.2025.07.007

May Daher, Katayoun Rezvani

引用次数: 0

Abstract

Chimeric antigen receptor (CAR) T cell therapy has opened new possibilities for patients with refractory autoimmune diseases such as systemic sclerosis, but personalized manufacturing and treatment-related toxicities limit its broader use. In this preview, we discuss the first clinical application of an off-the-shelf, iPSC-derived CAR-NK cell product in systemic sclerosis as reported by Wang et al. in this issue of Cell.

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ipsc衍生的CAR-NK细胞：系统性硬化症的现成细胞疗法

嵌合抗原受体（CAR） T细胞疗法为难治性自身免疫性疾病（如系统性硬化症）患者开辟了新的可能性，但个性化制造和治疗相关的毒性限制了其广泛应用。在这篇预览中，我们讨论了Wang等人在本期《细胞》杂志上报道的一种现成的ipsc衍生的CAR-NK细胞产品在系统性硬化症中的首次临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.