Cell最新文献 - Book学术

IF 45.1 1区生物学

Cell Pub Date : 2026-09-03 Epub Date: 2026-08-11 DOI: 10.1016/j.cell.2026.07.047

Feng Wang, Damian C Ekiert, Insha Ahmad, Wenli Yu, Yong Zhang, Omar Bazirgan, Ali Torkamani, Terje Raudsepp, Waithaka Mwangi, Michael F Criscitiello, Ian A Wilson, Peter G Schultz, Vaughn V Smider

引用次数: 0

Genomics and social practices at Mogou and other Gansu sites during prehistoric trans-Eurasian exchange 史前跨欧亚交流期间，莫沟和甘肃其他遗址的基因组学和社会实践

IF 64.5 1区生物学

Cell Pub Date : 2026-09-03 DOI: 10.1016/j.cell.2026.07.050

Han Shi,E. Andrew Bennett,Guoke Chen,Hui Wang,Tianyi Wang,Peng Cao,Ruilin Mao,Fan Bai,Qingyan Dai,Feng Liu,Xiaotian Feng,Yongan Wang,Chong Yao,Jing Wu,Wenjun Wang,Ming Zhang,Tianxiang Liu,Jingkun Ran,Yue-Chen Liu,Yuan Liu,Dan Ju,Chuyan Li,Hongwei Hou,Xinyi Liu,Qiaomei Fu

{"title":"Genomics and social practices at Mogou and other Gansu sites during prehistoric trans-Eurasian exchange","authors":"Han Shi,E. Andrew Bennett,Guoke Chen,Hui Wang,Tianyi Wang,Peng Cao,Ruilin Mao,Fan Bai,Qingyan Dai,Feng Liu,Xiaotian Feng,Yongan Wang,Chong Yao,Jing Wu,Wenjun Wang,Ming Zhang,Tianxiang Liu,Jingkun Ran,Yue-Chen Liu,Yuan Liu,Dan Ju,Chuyan Li,Hongwei Hou,Xinyi Liu,Qiaomei Fu","doi":"10.1016/j.cell.2026.07.050","DOIUrl":"https://doi.org/10.1016/j.cell.2026.07.050","url":null,"abstract":"Beginning approximately 4,000 years ago, southwest-Asian-originating domesticated crops and livestock began appearing in Gansu, a key crossroads in northwestern China, yet the population dynamics and social practices underlying these historically transformative events in the region have not been fully explored. Despite the adoption of western domesticates, genome sequences of 149 individuals from the large Mogou cemetery and ten other sites in Gansu, dating between 4,700 and 3,000 years ago, revealed migrations within East Asian regions but no detectable evidence of genetic influence from western or central Eurasia, suggesting that early agricultural dispersals may have followed a model distinct from that documented in Europe and Central Asia. The Mogou cemetery represents a continuous community that interacted with surrounding regions but does not exhibit clear matrilocal or patrilocal residential patterns. We found no strong evidence that co-buried individuals represented biological relatives. Non-local ancestry appears to be linked to lower-status burial practices.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"4 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The regulatory logic linking inflammation and fibrosis 炎症和纤维化之间的调节逻辑

IF 64.5 1区生物学

Cell Pub Date : 2026-09-03 DOI: 10.1016/j.cell.2026.08.001

Michael Alexanian,Deepak Srivastava

引用次数: 0

Structural basis for host membrane binding and remodeling by invading malaria parasites. 入侵疟原虫结合和重塑宿主膜的结构基础。

IF 45.1 1区生物学

Cell Pub Date : 2026-09-03 Epub Date: 2026-06-30 DOI: 10.1016/j.cell.2026.06.012

Meseret T Haile, Daphne A Kaxiras, James Zhen, Carolyn L Lee, Britney Jiang, Jennifer L Small-Saunders, Chi-Min Ho

{"title":"Structural basis for host membrane binding and remodeling by invading malaria parasites.","authors":"Meseret T Haile, Daphne A Kaxiras, James Zhen, Carolyn L Lee, Britney Jiang, Jennifer L Small-Saunders, Chi-Min Ho","doi":"10.1016/j.cell.2026.06.012","DOIUrl":"10.1016/j.cell.2026.06.012","url":null,"abstract":"The Plasmodium moving junction is central to malarial host-cell invasion, and yet its function remains unclear. Here, we determine the endogenous structure of the basic repeating unit of the moving junction, purified directly from invasion-stalled Plasmodium falciparum parasites, revealing a sailboat-shaped 1:1:1:1 assembly of apical membrane antigen 1 (PfAMA1) and rhoptry neck proteins 2, 4, and 5 (PfRON2, PfRON4, and PfRON5). We observe two PfRON2 transmembrane helices that anchor the complex in the red blood cell (RBC) membrane and display an extracellular handle for PfAMA1 binding. PfAMA1 directly contacts the RBC membrane, strengthening the connection. PfRON2/4/5 form a large, basic platform inside the RBC that electrostatically engages the RBC membrane and wedges seven amphipathic helices deep into the bilayer, suggesting an active role in host-membrane remodeling. We then leverage the native membrane context revealed by our structure, along with recent advances in computational protein design, to enable the rational design of a small protein binder that inhibits invasion.","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"5625-5639.e6"},"PeriodicalIF":45.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The complete gustatory connectome of adult Drosophila reveals how taste guides feeding, foraging, and social behavior 成年果蝇完整的味觉连接体揭示了味觉如何指导进食、觅食和社会行为

IF 64.5 1区生物学

Cell Pub Date : 2026-09-03 DOI: 10.1016/j.cell.2026.08.016

Ibrahim Tastekin,Inês de Haan Vicente,Rory J. Beresford,Billy J. Morris,Isabella Beckett,Philipp Schlegel,Marina Gkantia,FlyEM Project Team,Cambridge Connectomics Group,Elizabeth C. Marin,Marta Costa,Gregory S.X.E. Jefferis,Carlos Ribeiro

{"title":"The complete gustatory connectome of adult Drosophila reveals how taste guides feeding, foraging, and social behavior","authors":"Ibrahim Tastekin,Inês de Haan Vicente,Rory J. Beresford,Billy J. Morris,Isabella Beckett,Philipp Schlegel,Marina Gkantia,FlyEM Project Team,Cambridge Connectomics Group,Elizabeth C. Marin,Marta Costa,Gregory S.X.E. Jefferis,Carlos Ribeiro","doi":"10.1016/j.cell.2026.08.016","DOIUrl":"https://doi.org/10.1016/j.cell.2026.08.016","url":null,"abstract":"Gustatory systems drive critical survival behaviors such as feeding, foraging, and social interactions. However, gustation remains one of the least mapped sensory modalities at the connectome level. Here, we present the first complete wiring diagram of the male Drosophila adult gustatory system, comprehensively reconstructing gustatory receptor neurons (GRNs) from peripheral organs in a contiguous electron microscopy volume spanning brain, cervical connective, and ventral nerve cord. Integrating this with existing datasets, we generated a pan-central nervous system (CNS), cross-sex connectome that reveals GRN diversity through connectivity-based clustering, molecular identity mapping, and sexual dimorphism analysis. We mapped all feeding motor neurons and traced complete sensory-to-motor pathways to feeding, foraging, endocrine, and social behavior circuits. The emerging circuit architectures reveal distinct circuits for nutrient assessment, motor control, neuroendocrine regulation, and courtship. This work defines the gustatory system’s organization at synaptic resolution and provides a framework for understanding how internal states modulate sensory-driven decisions across behavioral contexts.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"51 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enteric glial serotonin signaling drives anti-tumor immunity in colorectal cancer 肠胶质血清素信号驱动结直肠癌的抗肿瘤免疫

IF 64.5 1区生物学

Cell Pub Date : 2026-09-03 DOI: 10.1016/j.cell.2026.08.008

Liu Yang,Michael A. Wheeler

引用次数: 0

A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death. 一种连接赖氨酸乙酰转移酶与癌基因诱导的细胞死亡的二价分子胶。

IF 45.1 1区生物学

Cell Pub Date : 2026-09-03 Epub Date: 2026-07-20 DOI: 10.1016/j.cell.2026.06.037

Meredith N Nix, Sai Gourisankar, Kevin J Bowman, Sabin A Nettles, Haopeng Yang, Brendan G Dwyer, Roman C Sarott, Hind Abuzaid, Michael M Martinez, Nick Phillips, Vincent Cabaud, Artur Hakobyan, Vahram Arakelov, Garik Petrosyan, Aram Davtyan, Yanlan Wang, Juste M Simanauskaite, Bryan A Romero, Hannah M Jones, Andrey Krokhotin, Tara N Lowensohn, Lei Chen, Cara Low, Hannes Vogel, Mark M Davis, Daniel Fernandez, Tinghu Zhang, Michael R Green, Stephen M Hinshaw, Nathanael S Gray, Gerald R Crabtree

{"title":"A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death.","authors":"Meredith N Nix, Sai Gourisankar, Kevin J Bowman, Sabin A Nettles, Haopeng Yang, Brendan G Dwyer, Roman C Sarott, Hind Abuzaid, Michael M Martinez, Nick Phillips, Vincent Cabaud, Artur Hakobyan, Vahram Arakelov, Garik Petrosyan, Aram Davtyan, Yanlan Wang, Juste M Simanauskaite, Bryan A Romero, Hannah M Jones, Andrey Krokhotin, Tara N Lowensohn, Lei Chen, Cara Low, Hannes Vogel, Mark M Davis, Daniel Fernandez, Tinghu Zhang, Michael R Green, Stephen M Hinshaw, Nathanael S Gray, Gerald R Crabtree","doi":"10.1016/j.cell.2026.06.037","DOIUrl":"10.1016/j.cell.2026.06.037","url":null,"abstract":"Developing cancer therapies that induce specific death of malignant cells is critical for preventing relapse. Highly effective strategies, such as immunotherapy, exemplify this principle. Here, we provide the mechanistic basis for a small-molecule approach that leverages chemically induced proximity (CIP) to kill diffuse large B cell lymphoma, the most common non-Hodgkin lymphoma. We developed lysine acetyltransferase (KAT)-based TCIPs (transcriptional/epigenetic chemical inducers of proximity), or KAT-TCIPs, which redirect p300/CREB-binding protein (CBP) to activate cell-death networks repressed by the oncogenic driver BCL6. Our lead KAT-TCIP reprograms the epigenome to initiate apoptosis. The crystal structure of the chemically induced p300-BCL6 complex reveals how chance protein-protein interactions may be exploited to confer the potency and selectivity of KAT-TCIPs. Thus, oncogenic drivers can be co-opted to activate robust cell death. Consistent with their gain-of-function mechanism, TCIPs recruiting different transcriptional activators-p300, BRD4, or CDK9-produce distinct genomic responses, suggesting specialized therapeutic uses.","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"5590-5610.e18"},"PeriodicalIF":45.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolite buffering of labile iron governs ferroptosis 不稳定铁的代谢物缓冲控制铁下垂

IF 64.5 1区生物学

Cell Pub Date : 2026-09-03 DOI: 10.1016/j.cell.2026.07.037

Amalia H. Megarioti,James A. Olzmann

引用次数: 0

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders. 主要神经退行性疾病共有的top1介导的神经元基因组损伤的复发模式。

IF 45.1 1区生物学

Cell Pub Date : 2026-09-03 Epub Date: 2026-07-01 DOI: 10.1016/j.cell.2026.06.013

Zinan Zhou, Lovelace J Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, Kisong Kim, Nandini Ramesh, Mingyun Bae, Ann Caplin, Diane D Shao, Bezawit Sahile, Kow Essuman, Eitan Goodman, Michael B Miller, August Yue Huang, William J Nathan, Andre Nussenzweig, Peter J Park, Clotilde Lagier-Tourenne, Eunjung Alice Lee, Christopher A Walsh

{"title":"Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.","authors":"Zinan Zhou, Lovelace J Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, Kisong Kim, Nandini Ramesh, Mingyun Bae, Ann Caplin, Diane D Shao, Bezawit Sahile, Kow Essuman, Eitan Goodman, Michael B Miller, August Yue Huang, William J Nathan, Andre Nussenzweig, Peter J Park, Clotilde Lagier-Tourenne, Eunjung Alice Lee, Christopher A Walsh","doi":"10.1016/j.cell.2026.06.013","DOIUrl":"10.1016/j.cell.2026.06.013","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD) represent two major categories of neurodegenerative disorders-TAR DNA-binding protein 43 (TDP-43) and tau proteinopathies-for which the mechanisms driving neuronal death remain unclear. Single-cell whole-genome sequencing of 469 neurons from C9ORF72 ALS, C9ORF72 FTD, AD, and control brains revealed increased somatic single-nucleotide variants (sSNVs) and insertions/deletions (sIndels) in all three diseases. Mutational signature analysis identified a disease-associated sSNV signature consistent with oxidative damage and an sIndel process affecting 22% of ALS, 76% of FTD, and 61% of AD neurons-but only 2% of control neurons-resembling signature ID4, previously linked to topoisomerase 1 (TOP1)-mediated mutagenesis. Rapid approach to DNA adduct recovery (RADAR) assays confirmed increased TOP1-DNA covalent complexes, and duplex sequencing confirmed the increased sIndels and identified single-strand events as likely precursor lesions. TOP1-associated sIndel mutagenesis and genome instability thus represent a mechanism shared by both TDP-43 and tau neurodegeneration.","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"5766-5782.e10"},"PeriodicalIF":45.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The organization of visual pathways in the Drosophila brain 果蝇大脑中视觉通路的组织

IF 64.5 1区生物学

Cell Pub Date : 2026-09-03 DOI: 10.1016/j.cell.2026.08.014

Judith Hoeller,Arthur Zhao,Aljoscha Nern,Edward M. Rogers,Sandro Romani,Michael B. Reiser

引用次数: 0