CellPub Date : 2025-07-28DOI: 10.1016/j.cell.2025.07.002
Zhiying Zhang, Thomas C. Todeschini, Yi Wu, Roman Kogay, Ameena Naji, Joaquin Cardenas Rodriguez, Rupavidhya Mondi, Daniel Kaganovich, David W. Taylor, Jack P.K. Bravo, Marianna Teplova, Triana Amen, Eugene V. Koonin, Dinshaw J. Patel, Franklin L. Nobrega
{"title":"Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites","authors":"Zhiying Zhang, Thomas C. Todeschini, Yi Wu, Roman Kogay, Ameena Naji, Joaquin Cardenas Rodriguez, Rupavidhya Mondi, Daniel Kaganovich, David W. Taylor, Jack P.K. Bravo, Marianna Teplova, Triana Amen, Eugene V. Koonin, Dinshaw J. Patel, Franklin L. Nobrega","doi":"10.1016/j.cell.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.002","url":null,"abstract":"Bacteria and archaea deploy diverse antiviral defense systems, many of which remain mechanistically uncharacterized. Here, we characterize Kiwa, a widespread two-component system composed of the transmembrane sensor KwaA and the DNA-binding effector KwaB. Cryogenic electron microscopy (cryo-EM) analysis reveals that KwaA and KwaB assemble into a large, membrane-associated supercomplex. Upon phage binding, KwaA senses infection at the membrane, leading to KwaB binding of ejected phage DNA and inhibition of replication and late transcription, without inducing host cell death. Although KwaB can bind DNA independently, its antiviral activity requires association with KwaA, suggesting spatial or conformational regulation. We show that the phage-encoded DNA-mimic protein Gam directly binds and inhibits KwaB but that co-expression with the Gam-targeted RecBCD system restores protection by Kiwa. Our findings support a model in which Kiwa coordinates membrane-associated detection of phage infection with downstream DNA binding by its effector, forming a spatially coordinated antiviral mechanism.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"9 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy","authors":"Lanqi Gong, Jie Luo, Emily Yang, Beibei Ru, Ziyang Qi, Yuma Yang, Anshu Rani, Abhilasha Purohit, Yu Zhang, Grace Guan, Rohit Paul, Trang Vu, Zuojia Chen, Renyue Ji, Chi-Ping Day, Chuan Wu, Glenn Merlino, David Fitzgerald, Grégoire Altan-Bonnet, Kenneth Aldape, Peng Jiang","doi":"10.1016/j.cell.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.004","url":null,"abstract":"Secreted proteins are central mediators of intercellular communications and can serve as therapeutic targets in diverse diseases. The ∼1,903 human genes encoding secreted proteins are difficult to study through common genetic approaches. To address this hurdle and, more generally, to discover cancer therapeutics, we developed the Cancer Immunology Data Engine (CIDE, <span><span>https://cide.ccr.cancer.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>), which incorporates 90 omics datasets spanning 8,575 tumor profiles with immunotherapy outcomes from 17 solid tumor types. CIDE systematically identifies all genes associated with immunotherapy outcomes. Then, we focused on secreted proteins prioritized by CIDE without known cancer roles and validated regulatory effects on immune checkpoint blockade for AOAH, CR1L, COLQ, and ADAMTS7 in mouse models. The top hit, acyloxyacyl hydrolase (AOAH), potentiates immunotherapies in multiple tumor models by sensitizing T cell receptors to weak antigens and protecting dendritic cells through depleting immunosuppressive arachidonoyl phosphatidylcholines and oxidized derivatives.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"4 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-07-26DOI: 10.1016/j.cell.2025.06.048
Jeanette A.I. Johnson, Daniel R. Bergman, Heber L. Rocha, David L. Zhou, Eric Cramer, Ian C. Mclean, Yoseph W. Dance, Max Booth, Zachary Nicholas, Tamara Lopez-Vidal, Atul Deshpande, Randy Heiland, Elmar Bucher, Fatemeh Shojaeian, Matthew Dunworth, André Forjaz, Michael Getz, Inês Godet, Furkan Kurtoglu, Melissa Lyman, Paul Macklin
{"title":"Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories","authors":"Jeanette A.I. Johnson, Daniel R. Bergman, Heber L. Rocha, David L. Zhou, Eric Cramer, Ian C. Mclean, Yoseph W. Dance, Max Booth, Zachary Nicholas, Tamara Lopez-Vidal, Atul Deshpande, Randy Heiland, Elmar Bucher, Fatemeh Shojaeian, Matthew Dunworth, André Forjaz, Michael Getz, Inês Godet, Furkan Kurtoglu, Melissa Lyman, Paul Macklin","doi":"10.1016/j.cell.2025.06.048","DOIUrl":"https://doi.org/10.1016/j.cell.2025.06.048","url":null,"abstract":"Cells interact as dynamically evolving ecosystems. While recent single-cell and spatial multi-omics technologies quantify individual cell characteristics, predicting their evolution requires mathematical modeling. We propose a conceptual framework—a cell behavior hypothesis grammar—that uses natural language statements (cell rules) to create mathematical models. This enables systematic integration of biological knowledge and multi-omics data to generate <em>in silico</em> models, enabling virtual “thought experiments” that test and expand our understanding of multicellular systems and generate new testable hypotheses. This paper motivates and describes the grammar, offers a reference implementation, and demonstrates its use in developing both <em>de novo</em> mechanistic models and those informed by multi-omics data. We show its potential through examples in cancer and its broader applicability in simulating brain development. This approach bridges biological, clinical, and systems biology research for mathematical modeling at scale, allowing the community to predict emergent multicellular behavior.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"720 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-07-25DOI: 10.1016/j.cell.2025.06.047
Yingjie Ding, Yuesheng Zuo, Bin Zhang, Yanling Fan, Gang Xu, Zhongyi Cheng, Shuai Ma, Shuaiqi Fang, Ao Tian, Dandan Gao, Xi Xu, Qiaoran Wang, Yaobin Jing, Mengmeng Jiang, Muzhao Xiong, Jiaming Li, Zichu Han, Shuhui Sun, Si Wang, Fuchu He, Guang-Hui Liu
{"title":"Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures","authors":"Yingjie Ding, Yuesheng Zuo, Bin Zhang, Yanling Fan, Gang Xu, Zhongyi Cheng, Shuai Ma, Shuaiqi Fang, Ao Tian, Dandan Gao, Xi Xu, Qiaoran Wang, Yaobin Jing, Mengmeng Jiang, Muzhao Xiong, Jiaming Li, Zichu Han, Shuhui Sun, Si Wang, Fuchu He, Guang-Hui Liu","doi":"10.1016/j.cell.2025.06.047","DOIUrl":"https://doi.org/10.1016/j.cell.2025.06.047","url":null,"abstract":"Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensive proteomic and histological analysis of 516 samples from 13 human tissues spanning five decades. This dynamic atlas reveals widespread transcriptome-proteome decoupling and proteostasis decline, characterized by amyloid accumulation. Based on aging-associated protein changes, we developed tissue-specific proteomic age clocks and characterized organ-level aging trajectories. Temporal analysis revealed an aging inflection around age 50, with blood vessels being a tissue that ages early and is markedly susceptible to aging. We further defined a plasma proteomic signature of aging that matches its tissue origins and identified candidate senoproteins, including GAS6, driving vascular and systemic aging. Together, our findings lay the groundwork for a systems-level understanding of human aging through the lens of proteins.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"25 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-07-24DOI: 10.1016/j.cell.2025.06.046
Tornike Mamuladze, Tiago H. Zaninelli, Leon C.D. Smyth, Yue Wu, Daviti Abramishvili, Ruben Silva, Brian Imbiakha, Daan Verhaege, Siling Du, Zachary Papadopoulos, Xingxing Gu, David Lee, Steffen Storck, Richard J. Perrin, Igor Smirnov, Xinzhong Dong, Song Hu, Michael S. Diamond, Felipe A. Pinho-Ribeiro, Jonathan Kipnis
{"title":"Mast cells regulate the brain-dura interface and CSF dynamics","authors":"Tornike Mamuladze, Tiago H. Zaninelli, Leon C.D. Smyth, Yue Wu, Daviti Abramishvili, Ruben Silva, Brian Imbiakha, Daan Verhaege, Siling Du, Zachary Papadopoulos, Xingxing Gu, David Lee, Steffen Storck, Richard J. Perrin, Igor Smirnov, Xinzhong Dong, Song Hu, Michael S. Diamond, Felipe A. Pinho-Ribeiro, Jonathan Kipnis","doi":"10.1016/j.cell.2025.06.046","DOIUrl":"https://doi.org/10.1016/j.cell.2025.06.046","url":null,"abstract":"Cerebrospinal fluid (CSF) flow is essential for brain homeostasis, and its disruption is implicated in neurodegenerative and neuroinflammatory diseases. Arachnoid cuff exit (ACE) points, anatomical discontinuities in the arachnoid mater around bridging veins, serve as key sites of CSF-dura exchange. Here, we show that dural mast cells regulate CSF dynamics at ACE points. Upon degranulation, mast cells release histamine, inducing vasodilation of bridging veins and reducing perivascular spaces critical for CSF drainage. During bacterial meningitis, pathogens exploit ACE points to access the brain. However, mast cell activation redirects CSF flow, recruits neutrophils, and limits bacterial invasion. Mice lacking dural mast cells exhibit impaired immune responses and higher brain bacterial loads. These findings reveal dural mast cells as central players in modulating CSF flow and meningeal immunity. Targeting mast cells or their mediators may enhance CNS clearance and defense mechanisms, offering a potential therapeutic avenue for brain infections.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"115 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-07-24DOI: 10.1016/j.cell.2025.06.043
Vanessa Villalba-Mouco, Arev Pelin Sümer
{"title":"Unmasking the Denisovans","authors":"Vanessa Villalba-Mouco, Arev Pelin Sümer","doi":"10.1016/j.cell.2025.06.043","DOIUrl":"https://doi.org/10.1016/j.cell.2025.06.043","url":null,"abstract":"The Harbin cranium, linked to Denisovans via mitochondrial DNA, broadens their known range and provides the first insights into Denisovan morphology. This discovery highlights the potential of biomolecular analysis from nontraditional sources, enhancing understanding of archaic human evolution in Asia and filling gaps in the scarce Denisovan fossil record.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"703 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-07-24DOI: 10.1016/j.cell.2025.06.045
Ruchita Kothari, Mostafa W. Abdulrahim, Hyun Jong Oh, Daniel H. Capuzzi, Collin B. Kilgore, Sumil K. Nair, Yaowu Zhang, Nathachit Limjunyawong, Sarbjit S. Saini, Jennifer E. Kim, Justin M. Caplan, Fernanado L. Gonzalez, Christopher M. Jackson, Chetan Bettegowda, Judy Huang, Bhanu P. Ganesh, Chunfeng Tan, Raymond C. Koehler, Rafael J. Tamargo, Louise D. McCullough, Xinzhong Dong
{"title":"A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis","authors":"Ruchita Kothari, Mostafa W. Abdulrahim, Hyun Jong Oh, Daniel H. Capuzzi, Collin B. Kilgore, Sumil K. Nair, Yaowu Zhang, Nathachit Limjunyawong, Sarbjit S. Saini, Jennifer E. Kim, Justin M. Caplan, Fernanado L. Gonzalez, Christopher M. Jackson, Chetan Bettegowda, Judy Huang, Bhanu P. Ganesh, Chunfeng Tan, Raymond C. Koehler, Rafael J. Tamargo, Louise D. McCullough, Xinzhong Dong","doi":"10.1016/j.cell.2025.06.045","DOIUrl":"https://doi.org/10.1016/j.cell.2025.06.045","url":null,"abstract":"The immune environment surrounding the brain plays a fundamental role in monitoring signs of injury. Insults, including ischemic stroke, can disrupt this balance and incite an exaggerated inflammatory response, yet the underlying mechanism remains unclear. Here, we show that the mast-cell-specific receptor Mrgprb2 regulates post-stroke brain inflammation from the meninges. Mrgprb2 causes meningeal mast cell degranulation after stroke, releasing immune mediators. This process recruits skull bone marrow neutrophils into the dura and further promotes neutrophil migration from the dura into the brain by cleaving the chemorepellent semaphorin 3a. We demonstrate that the human ortholog, MRGPRX2, is expressed in human meningeal mast cells and is activated by upregulation of the neuropeptide substance P following stroke. Pharmacologically inhibiting Mrgprb2 reduces post-stroke inflammation and improves neurological outcomes in mice, providing a druggable target. Collectively, our study identifies Mrgprb2 as a critical meningeal gatekeeper for immune migration from skull bone marrow reservoirs into the brain.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"53 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-07-23DOI: 10.1016/j.cell.2025.07.001
N. Bishara Marzook, Ok-Ryul Song, Lotta Baumgärtel, Netanya Bernitz, Tapoka T. Mkandawire, Lucy C. Watson, Vanessa Nunes, Scott Warchal, James I. MacRae, Michael Howell, Adam Sateriale
{"title":"The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment","authors":"N. Bishara Marzook, Ok-Ryul Song, Lotta Baumgärtel, Netanya Bernitz, Tapoka T. Mkandawire, Lucy C. Watson, Vanessa Nunes, Scott Warchal, James I. MacRae, Michael Howell, Adam Sateriale","doi":"10.1016/j.cell.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.001","url":null,"abstract":"<em>Cryptosporidium</em> is a leading cause of diarrheal disease, yet little is known regarding the infection cell biology of this intracellular intestinal parasite. To this end, we implemented an arrayed genome-wide CRISPR-Cas9 knockout screen to microscopically analyze multiple phenotypic features of a <em>Cryptosporidium</em> infection following individual host gene ablation. We discovered parasite survival within the host epithelial cell hinges on squalene, an intermediate metabolite in the host cholesterol biosynthesis pathway. A buildup of squalene within intestinal epithelial cells creates a reducing environment, making more reduced glutathione available for parasite uptake. Remarkably, the <em>Cryptosporidium</em> parasite has lost the ability to synthesize glutathione and has become dependent on this host import. This dependency can be leveraged for treatment with the abandoned drug lapaquistat, an inhibitor of host squalene synthase that shifts the redox environment, blocking <em>Cryptosporidium</em> growth <em>in vitro</em> and <em>in vivo</em>.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"76 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-07-22DOI: 10.1016/j.cell.2025.07.019
Ryan A. Flynn, Kayvon Pedram, Stacy A. Malaker, Pedro J. Batista, Benjamin A.H. Smith, Alex G. Johnson, Benson M. George, Karim Majzoub, Peter W. Villalta, Jan E. Carette, Carolyn R. Bertozzi
{"title":"Small RNAs are modified with N-glycans and displayed on the surface of living cells","authors":"Ryan A. Flynn, Kayvon Pedram, Stacy A. Malaker, Pedro J. Batista, Benjamin A.H. Smith, Alex G. Johnson, Benson M. George, Karim Majzoub, Peter W. Villalta, Jan E. Carette, Carolyn R. Bertozzi","doi":"10.1016/j.cell.2025.07.019","DOIUrl":"https://doi.org/10.1016/j.cell.2025.07.019","url":null,"abstract":"(Cell <em>184</em>, 3109–3124.e1–e11; June 10, 2021)","PeriodicalId":9656,"journal":{"name":"Cell","volume":"51 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-07-22DOI: 10.1016/j.cell.2025.05.016
Hyoung-Soo Cho, Ji-Sun Yoo, Xinyang Song, Byoungsook Goh, Alos Diallo, Jesang Lee, Sumin Son, Yoon Soo Hwang, Seung Bum Park, Sungwhan F. Oh, Dennis L. Kasper
{"title":"Structure of gut microbial glycolipid modulates host inflammatory response","authors":"Hyoung-Soo Cho, Ji-Sun Yoo, Xinyang Song, Byoungsook Goh, Alos Diallo, Jesang Lee, Sumin Son, Yoon Soo Hwang, Seung Bum Park, Sungwhan F. Oh, Dennis L. Kasper","doi":"10.1016/j.cell.2025.05.016","DOIUrl":"https://doi.org/10.1016/j.cell.2025.05.016","url":null,"abstract":"Commensals are constantly shaping the host’s immunological landscape. Lipopolysaccharides found in gram-negative microbes have a terminal lipid A in their outer membrane. Here, we report that structural variations in symbiotic lipid A lead to divergent immune responses with each lipid A structure, eliciting effects distinct from those induced by classical lipid A. Certain lipid A structures can induce a sustained interferon (IFN)-β response orchestrated by Cdc42-facilitated Toll-like receptor 4 (TLR4) endocytosis and lipid droplet (LD) formation. This lipid A-directed IFN-β response is paramount for colon RORγt<sup>+</sup> regulatory T cell (Treg) induction while simultaneously suppressing colonic T<sub>H</sub>17 cells and controlling gut inflammation. Intriguingly, the quantitatively dominant penta-acylated lipid A species in Bacteroidetes fails to elicit an IFN-β response. Instead, a less abundant tetra-acylated lipid A species sustainably induces IFN-β, thereby contributing to RORγt<sup>+</sup> Treg homeostasis. Nuances in symbiont lipid A structure contribute to maintaining potent regulation of Tregs to maintain a healthy endobiotic balance.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"52 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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