CellPub Date : 2025-10-17DOI: 10.1016/j.cell.2025.09.021
Aya Ludin, Georgia L. Stirtz, Asaf Tal, Ajit J. Nirmal, Kathleen L. Pfaff, Michael Manos, Naomi Besson, Nebiyat Eskndir, Billie Porter, Stephanie M. Jones, Hannah M. Faulkner, Qiyu Gong, Sophia Liu, Irving Barrera, Lijian Wu, Cecilia Pessoa Rodrigues, Aditi Sahu, Elizabeth Jerison, Joao V. Alessi, Biagio Ricciuti, Leonard I. Zon
{"title":"CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success","authors":"Aya Ludin, Georgia L. Stirtz, Asaf Tal, Ajit J. Nirmal, Kathleen L. Pfaff, Michael Manos, Naomi Besson, Nebiyat Eskndir, Billie Porter, Stephanie M. Jones, Hannah M. Faulkner, Qiyu Gong, Sophia Liu, Irving Barrera, Lijian Wu, Cecilia Pessoa Rodrigues, Aditi Sahu, Elizabeth Jerison, Joao V. Alessi, Biagio Ricciuti, Leonard I. Zon","doi":"10.1016/j.cell.2025.09.021","DOIUrl":"https://doi.org/10.1016/j.cell.2025.09.021","url":null,"abstract":"T cell-mediated tumor killing underlies immunotherapy success. Here, we used long-term <em>in vivo</em> imaging and high-resolution spatial transcriptomics of zebrafish endogenous melanoma, as well as multiplex imaging of human melanoma, to identify domains facilitating the immune response during immunotherapy. We identified cancer regions of antigen presentation and T cell engagement and retention (CRATERs) as pockets at the stroma-melanocyte boundaries of zebrafish and human melanoma. CRATERs are rich in antigen-recognition molecules, harboring the highest density of CD8<sup>+</sup> T cells in tumors. In zebrafish, CD8<sup>+</sup> T cells formed prolonged interactions with melanoma cells within CRATERs, characteristic of antigen recognition. Following immunostimulatory treatment, CRATERs expanded, becoming the major sites of activated CD8<sup>+</sup> T cell accumulation and tumor killing. In humans, elevation in CRATER density in biopsies following immune checkpoint blockade (ICB) therapy correlated with a clinical response to therapy. CRATERs are structures that show active tumor killing and may be useful as a diagnostic indicator for immunotherapy success.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"27 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-10-16DOI: 10.1016/j.cell.2025.09.011
Fabienne Gehrke, Holger Puchta
{"title":"CRISPR meets AI-based robotics: Advancing sustainable agriculture","authors":"Fabienne Gehrke, Holger Puchta","doi":"10.1016/j.cell.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.cell.2025.09.011","url":null,"abstract":"In this issue of <em>Cell</em>, Xu and colleagues develop an approach integrating genome editing, artificial intelligence, and robotics to enhance crop improvement. By reconfiguring reproductive traits for automated pollination in crops such as tomatoes and soybeans, their approach accelerates hybrid seed production and yields crops with better stress tolerance, flavor, and resilience, supporting sustainable agriculture and crop diversity.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"27 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-10-16DOI: 10.1016/j.cell.2025.09.023
Chen Zhou, Huican Li, Jiaxing Wang, Cheng Qian, Hui Xiong, Zhilin Chu, Qiming Shao, Xuan Li, Shijin Sun, Ke Sun, Aiqin Zhu, Jiawei Wang, Xueqin Jin, Fan Yang, Tamer M. Gamal El-Din, Bo Li, Jing Huang, Kun Wu, Peilong Lu
{"title":"De novo designed voltage-gated anion channels suppress neuron firing","authors":"Chen Zhou, Huican Li, Jiaxing Wang, Cheng Qian, Hui Xiong, Zhilin Chu, Qiming Shao, Xuan Li, Shijin Sun, Ke Sun, Aiqin Zhu, Jiawei Wang, Xueqin Jin, Fan Yang, Tamer M. Gamal El-Din, Bo Li, Jing Huang, Kun Wu, Peilong Lu","doi":"10.1016/j.cell.2025.09.023","DOIUrl":"https://doi.org/10.1016/j.cell.2025.09.023","url":null,"abstract":"Design of ion channels responsive to environmental cues has significant implications in modulating cellular activities and sensor development, but it remains a significant challenge due to the complexities involved in designing stimuli-induced conformational changes in proteins. Here, we report the accurate <em>de novo</em> design of voltage-gated anion channels, namely dVGACs. dVGACs adopt a 15-helix pentameric architecture featuring arginine constrictions within the transmembrane span and show voltage-dependent anions currents in patch-clamp experiments. Cryo-electron microscopy (cryo-EM) structures of dVGACs closely align with the design models. Cryo-EM structures and molecular dynamics simulations suggest that the arginine constrictions undergo voltage-induced conformational changes, serving as both a voltage sensor and a selectivity filter as designed. Notably, the anion selectivity and voltage sensitivity of dVGACs can be tuned through targeted mutations for suppressing neuronal firing <em>in situ</em>. The ability to create ion channels with custom-designed conformational changes refreshes our insights into membrane biophysics and unveils diverse potential applications.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"93 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-10-16DOI: 10.1016/j.cell.2025.09.002
Balázs Gyuris, Leonid Vyazov, Attila Türk, Pavel Flegontov, Bea Szeifert, Péter Langó, Balázs Gusztáv Mende, Veronika Csáky, Andrey A. Chizhevskiy, Ilgizar R. Gazimzyanov, Aleksandr A. Khokhlov, Aleksandr G. Kolonskikh, Natalia P. Matveeva, Rida R. Ruslanova, Marina P. Rykun, Ayrat Sitdikov, Elizaveta V. Volkova, Sergei G. Botalov, Dmitriy G. Bugrov, Ivan V. Grudochko, Anna Szécsényi-Nagy
{"title":"Long shared haplotypes identify the southern Urals as a primary source for the 10th-century Hungarians","authors":"Balázs Gyuris, Leonid Vyazov, Attila Türk, Pavel Flegontov, Bea Szeifert, Péter Langó, Balázs Gusztáv Mende, Veronika Csáky, Andrey A. Chizhevskiy, Ilgizar R. Gazimzyanov, Aleksandr A. Khokhlov, Aleksandr G. Kolonskikh, Natalia P. Matveeva, Rida R. Ruslanova, Marina P. Rykun, Ayrat Sitdikov, Elizaveta V. Volkova, Sergei G. Botalov, Dmitriy G. Bugrov, Ivan V. Grudochko, Anna Szécsényi-Nagy","doi":"10.1016/j.cell.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.cell.2025.09.002","url":null,"abstract":"The origins of the early medieval Magyars who appeared in the Carpathian Basin by the end of the 9th century CE remain incompletely understood. Previous archaeogenetic research identified the newcomers as migrants from the Eurasian steppe. However, genome-wide ancient DNA from putative source populations has not been available to test alternative theories of their precise source. We generated genome-wide ancient DNA data for 131 individuals from archaeological sites in the Ural region in northern Eurasia, which are candidates for the source based on historical, linguistic, and archaeological evidence. Our results tightly link the Magyars to people of the early medieval Karayakupovo archaeological horizon on both the European and Asian sides of the southern Urals. The ancestors of the people of the Karayakupovo archaeological horizon were established in the broader Urals by the Late Iron Age, and their descendants persisted in the Volga-Kama region until at least the 14th century.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"2 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-10-16DOI: 10.1016/j.cell.2025.09.013
Patricia A. Possik, David J. Adams, Flavia C. Aguiar, Tamires Caixeta Alves, Fabíola S. Alves-Hanna, Carlos Mario Restrepo Arboleda, Erick Armingol, Liã Bárbara Arruda, Yesid Cuesta Astroz, Jacqueline M. Boccacino, Danielle C. Bonfim, Juan F. Calderon, Alexis Germán Murillo Carrasco, Danielle G. Carvalho, Benilton S. Carvalho, Paulo Vinícius Sanches Daltro de Carvalho, Alex Castro, Lia Chappell, Ricardo Chinchilla-Monge, Daniela Di Bella, Mariana Boroni
{"title":"Exploring Latin America one cell at a time","authors":"Patricia A. Possik, David J. Adams, Flavia C. Aguiar, Tamires Caixeta Alves, Fabíola S. Alves-Hanna, Carlos Mario Restrepo Arboleda, Erick Armingol, Liã Bárbara Arruda, Yesid Cuesta Astroz, Jacqueline M. Boccacino, Danielle C. Bonfim, Juan F. Calderon, Alexis Germán Murillo Carrasco, Danielle G. Carvalho, Benilton S. Carvalho, Paulo Vinícius Sanches Daltro de Carvalho, Alex Castro, Lia Chappell, Ricardo Chinchilla-Monge, Daniela Di Bella, Mariana Boroni","doi":"10.1016/j.cell.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.cell.2025.09.013","url":null,"abstract":"Single-cell and spatial transcriptomics are revolutionizing science. Latin America’s unique genetic diversity, environment, and endemic infectious diseases offer exceptional opportunities to deploy these technologies for societal and scientific impact. We highlight regional challenges and opportunities, offering recommendations to boost capacity, foster collaboration, and promote research equity.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"10 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-10-16DOI: 10.1016/j.cell.2025.09.008
Heather D. Hickman, Niki M. Moutsopoulos
{"title":"Don’t forget to floss! An innovative approach for vaccine delivery","authors":"Heather D. Hickman, Niki M. Moutsopoulos","doi":"10.1016/j.cell.2025.09.008","DOIUrl":"https://doi.org/10.1016/j.cell.2025.09.008","url":null,"abstract":"In a recent issue of <em>Nature Biomedical Engineering</em>, Ingrole et al. explore a new approach for needle-free vaccine delivery through the mouth. They devise and test a dental-floss-based flu vaccine as an alternative mode of mucosal vaccination.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"54 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-10-16Epub Date: 2025-08-18DOI: 10.1016/j.cell.2025.07.025
Jenny Sachweh, Mandy Börmel, Sven Klumpe, Anja Becker, Reiya Taniguchi, Marta Anna Kubańska, Verena Pintschovius, Eva Kaindl, Jürgen M Plitzko, Florian Wilfling, Martin Beck, Bernhard Hampoelz
{"title":"The small GTPase Ran defines nuclear pore complex asymmetry.","authors":"Jenny Sachweh, Mandy Börmel, Sven Klumpe, Anja Becker, Reiya Taniguchi, Marta Anna Kubańska, Verena Pintschovius, Eva Kaindl, Jürgen M Plitzko, Florian Wilfling, Martin Beck, Bernhard Hampoelz","doi":"10.1016/j.cell.2025.07.025","DOIUrl":"10.1016/j.cell.2025.07.025","url":null,"abstract":"<p><p>Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin building blocks and exemplify the structural complexity of macromolecular assemblies. To ensure transport directionality, different nucleoporin complexes are attached to the cytoplasmic and nuclear face of the NPC. How those asymmetric structures are faithfully assembled onto the symmetric scaffold architecture that exposes the same interaction surfaces to either side remained enigmatic. Here, we combine cryo-electron tomography, subtomogram averaging, and template matching with live imaging to address this question in budding yeast and Drosophila. We genetically induce ectopic nuclear pores and show that pores outside the nuclear envelope are symmetric. We furthermore demonstrate that the peripheral NPC configuration is affected by the nucleotide state of the small GTPase Ran. Our findings indicate that the nuclear transport system is self-regulatory, namely that the same molecular mechanism controls both transport and transport channel composition.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"5931-5946.e16"},"PeriodicalIF":42.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Conversion of IscB and Cas9 into RNA-guided RNA editors.","authors":"Chengtao Xu, Xiaolin Niu, Haifeng Sun, Hao Yan, Weixin Tang, Ailong Ke","doi":"10.1016/j.cell.2025.07.032","DOIUrl":"10.1016/j.cell.2025.07.032","url":null,"abstract":"<p><p>RNA-guided RNA editing represents an attractive alternative to DNA editing. However, the prevailing tool, CRISPR-Cas13, has collateral RNA cleavage activity that causes undesirable cytotoxicity in human cells. Here, we report an ultracompact RNA-editing platform engineered from IscB, which has comparable or higher activity than Cas13 but without cytotoxicity concerns. We show that IscB, the evolutionary ancestor of Cas9, has an intrinsic affinity for complementary single-stranded (ss)DNA and RNA. This activity becomes dominant when its double-stranded DNA binding activity is switched off through the deletion of its target-adjacent motif domain. The resulting R-IscB is comparable to or better than Cas13, can efficiently alter splicing outcomes in human cells, and can further mediate trans-splicing to correct any mutation at the mRNA level. R-IscB also drives efficient A-to-I editing on mRNA when fused to adenosine deaminase acting on RNA 2 (ADAR2) and mediates cleavage-based mRNA knockdown upon HNH engineering. Finally, we show that the same approach converts some Cas9s to RNA-targeting tools.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"5847-5861.e11"},"PeriodicalIF":42.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-10-15DOI: 10.1016/j.cell.2025.09.020
Chuan Qin, Ming-Hao Dong, Luo-Qi Zhou, Yun-Hui Chu, Xiao-Wei Pang, Jia-Yi He, Ke Shang, Jun Xiao, Li Zhu, Huan Ye, Song-Bai Cai, Di Wang, Bi-Tao Bu, Gerd Meyer zu Hörste, Chun-Rui Li, Dai-Shi Tian, Wei Wang
{"title":"Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis","authors":"Chuan Qin, Ming-Hao Dong, Luo-Qi Zhou, Yun-Hui Chu, Xiao-Wei Pang, Jia-Yi He, Ke Shang, Jun Xiao, Li Zhu, Huan Ye, Song-Bai Cai, Di Wang, Bi-Tao Bu, Gerd Meyer zu Hörste, Chun-Rui Li, Dai-Shi Tian, Wei Wang","doi":"10.1016/j.cell.2025.09.020","DOIUrl":"https://doi.org/10.1016/j.cell.2025.09.020","url":null,"abstract":"Progressive multiple sclerosis (PMS), which is characterized by relentless disease progression, lacks effective treatment. While recent studies have highlighted the importance of B cells in driving compartmentalized central nervous system (CNS) inflammation in PMS pathogenesis, current B cell depletion therapies, such as CD20 monoclonal antibodies, face challenges in targeting plasma cells within the CNS. Here, we treated five patients with PMS (one primary PMS and four secondary PMS) with anti-B cell maturation antigen (BCMA) chimeric antigen receptor T (CAR-T) cell therapy in an ongoing phase 1 clinical trial (<span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>: NCT04561557). Only grade 1 cytokine release syndrome was observed, and all grade ≥3 cytopenias occurred within 40 days post-infusion in all five patients. Meanwhile, we detected plasma cell depletion in CNS compartments, prolonged expansion and relieved exhaustion of CAR-T cells in the cerebrospinal fluid, and attenuation of microglial activation. These findings provided insights into the potential application of anti-BCMA CAR-T therapy for advancing clinical management of PMS.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"53 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145289289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-10-14DOI: 10.1016/j.cell.2025.09.017
Olivier Garsmeur, Simon Rio, Nicolas Pompidor, Anna Lipzen, Catherine Hervouet, Théo Durand, Chris Daum, Yuko Yoshinaga, Mike Butterfield, Alexander Sanchez, George Piperidis, Noa Lincoln, Anna Hale, Jean Yves Hoarau, Yoshifumi Terajima, Prakash Lakshmanan, Erik Sacks, Shailendra Sharma, Marotea Vitrac, Kerrie Barry, Angélique D’Hont
{"title":"The genomic footprints of wild Saccharum species trace domestication, diversification, and modern breeding of sugarcane","authors":"Olivier Garsmeur, Simon Rio, Nicolas Pompidor, Anna Lipzen, Catherine Hervouet, Théo Durand, Chris Daum, Yuko Yoshinaga, Mike Butterfield, Alexander Sanchez, George Piperidis, Noa Lincoln, Anna Hale, Jean Yves Hoarau, Yoshifumi Terajima, Prakash Lakshmanan, Erik Sacks, Shailendra Sharma, Marotea Vitrac, Kerrie Barry, Angélique D’Hont","doi":"10.1016/j.cell.2025.09.017","DOIUrl":"https://doi.org/10.1016/j.cell.2025.09.017","url":null,"abstract":"Sugarcane is a major crop of unclear origins due to its complex polyploid interspecific genome. We analyzed genome ancestries using whole-genome sequence data from 390 representative accessions based on repeated k-mers and chloroplast phylogeny. The results provided evidence that <em>Saccharum officinarum</em> was domesticated in the New Guinea region from the <em>S. robustum</em> wild species and revealed that its genome is a mosaic involving different <em>S. robustum</em> subgroups. We discovered a wild <em>Saccharum</em> contributor to most modern cultivars, likely originating from East Melanesia. We highlighted two early centers of sugarcane diversification associated with human transport, one in continental Asia through hybridization with different <em>S. spontaneum</em> subgroups and one in the Melanesian and Polynesian islands via hybridization with the discovered ancestor and <em>Miscanthus</em>. Finally, we revealed the genome ancestry of modern cultivars, highlighting untapped wild <em>Saccharum</em> diversity as a source of alleles for breeding programs.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"21 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145283473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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