停搏药物和阿片类药物非依赖性镇痛

IF 42.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-08-07 DOI:10.1016/j.cell.2025.07.008

Olena Didenko, John N. Wood

引用次数: 0

摘要

在这一期的Cell杂志上，Ji和他的同事描述了SBI-810的发展，SBI-810是一种神经紧张素受体1 （NTSR1）的β-抑制蛋白偏调制剂。该化合物在啮齿类动物急性和慢性疼痛模型中提供有效的镇痛作用，且无副作用。这项研究强调了靶向抑制蛋白偏向性GPCR信号在非阿片类疼痛管理中的治疗潜力。

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Arrestins and opioid-independent analgesia

In this issue of Cell, Ji and colleagues describe the development of SBI-810, a β-arrestin-biased modulator of neurotensin receptor 1 (NTSR1). This compound provides potent analgesia in rodent models of acute and chronic pain without side effects. This study highlights the therapeutic potential of targeting arrestin-biased GPCR signaling for non-opioid pain management.

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.