Case Reports in Ophthalmology最新文献_第8页

The Management of Two Cases with Retinal Arterial Macroaneurysm by Anti-Vascular Endothelial Growth Factor. 抗血管内皮生长因子治疗两例视网膜动脉大动脉瘤病例

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-06-12 eCollection Date: 2024-01-01 DOI: 10.1159/000538998

Michiko Takamiya

{"title":"The Management of Two Cases with Retinal Arterial Macroaneurysm by Anti-Vascular Endothelial Growth Factor.","authors":"Michiko Takamiya","doi":"10.1159/000538998","DOIUrl":"10.1159/000538998","url":null,"abstract":"Introduction: We report on one case of age-related macular degeneration and one case of diabetic macular edema with concomitant retinal arterial macroaneurysm (RAM) that were treated with anti-vascular endothelial growth factor (VEGF) intravitreal injections.Case presentation: Case 1 involved a 71-year-old woman with a 30-year history of diabetes who was undergoing dialysis. Pretreatment visual acuity in the right eye was 0.4. Fundus fluorescein angiography (FA) showed that numerous microaneurysms and RAM were located at a distance of two papillary diameters from the macular area. Diabetic macular edema was diagnosed. After 12 anti-VEGF injections, the macular edema resolved, microaneurysms decreased, and the RAM also disappeared. Visual acuity in the right eye improved to 0.7. Case 2 involved an 81-year-old woman receiving treatment for disorders including hypertension and dyslipidemia. Pretreatment visual acuity in the right eye was 0.03. And vitreous hemorrhage was present. After one ranibizumab intravitreal injection, the fundus became clearly visible. Macular subretinal hemorrhage and an RAM in the upper macula area were evident on FA and optical coherence tomography. After four intravitreal injections of ranibizumab, macular hemorrhage resolved, RAM disappeared, and visual acuity improved to 0.2. All cases were treated by intravitreal injection of anti-VEGF. After several injections, the macular hemorrhage or macular edema was resolved. RAM disappeared, and visual acuity improved.Conclusion: Intravitreal injection of anti-VEGF appears effective for age-related macular degeneration or diabetic macular edema with concomitant RAM. Although anti-VEGF intravitreal injections are not covered by health insurance for the treatment of RAM, their effectiveness means that the expansion of indications is desirable.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"490-496"},"PeriodicalIF":0.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytomegalovirus Retinitis in an Eye with Unilateral Retinoblastoma: A Case Report. 单侧视网膜母细胞瘤患者的巨细胞病毒视网膜炎：病例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-06-12 eCollection Date: 2024-01-01 DOI: 10.1159/000538738

Leo Meller, Vasan Jagadeesh, Michael Oca, Katherine Wilson, Connor Zuraski, Zachary A Koretz, Patricia Chevez-Barrios, Catherine Liu, Jesse L Berry, Nathan L Scott

{"title":"Cytomegalovirus Retinitis in an Eye with Unilateral Retinoblastoma: A Case Report.","authors":"Leo Meller, Vasan Jagadeesh, Michael Oca, Katherine Wilson, Connor Zuraski, Zachary A Koretz, Patricia Chevez-Barrios, Catherine Liu, Jesse L Berry, Nathan L Scott","doi":"10.1159/000538738","DOIUrl":"10.1159/000538738","url":null,"abstract":"Introduction: Cytomegalovirus (CMV) retinitis in the setting of pediatric retinoblastoma is exceedingly unusual. Here, we present the first reported case of CMV retinitis in an enucleated eye with retinoblastoma after chemotherapy in the western hemisphere.Case presentation: A 2-year-old Hispanic male without a family history of retinoblastoma presented with a 3-month history of right eye exotropia and squinting. Clinical examination revealed dense white vitreous opacities in the right eye. Ocular oncology evaluation unveiled an exudative retinal detachment with vitreous seeds, subretinal seeding, and a tumor emanating from the retina in the superonasal quadrant of the right eye. The patient was diagnosed with unilateral Group D retinoblastoma, and RB1 sequencing revealed a pathogenic variant with mosaicism. Treatment involved systemic chemotherapy, intravitreal chemotherapy, and cryotherapy. However, the patient developed a rhegmatogenous retinal detachment with diffuse vitreous hemorrhage and ultimately underwent right eye enucleation. Interestingly, histopathological analysis of the enucleated eye revealed concomitant CMV retinitis alongside retinoblastoma. After consultation with infectious disease, antiviral treatment was not initiated as the patient remained asymptomatic and maintained a recovered immune system. Repeat CMV PCR confirmed viral clearance. The patient received a prosthetic eye and continues to be monitored for retinoblastoma recurrence.Conclusion: Clinicians should be aware of the potential for CMV retinitis to develop in retinoblastoma patients receiving chemotherapy, which may complicate clinical decision-making and management. Timely identification of CMV retinitis in this setting may improve patient ocular outcomes and overall prognosis.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"483-489"},"PeriodicalIF":0.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Submacular and Intraretinal Fluid Associated with Arteritic Anterior Ischemic Optic Neuropathy. 与动脉炎性前缺血性视神经病变相关的视网膜下和视网膜内积液

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-06-11 eCollection Date: 2024-01-01 DOI: 10.1159/000539147

Danielle Solish, Jonathan Micieli

{"title":"Submacular and Intraretinal Fluid Associated with Arteritic Anterior Ischemic Optic Neuropathy.","authors":"Danielle Solish, Jonathan Micieli","doi":"10.1159/000539147","DOIUrl":"10.1159/000539147","url":null,"abstract":"Introduction: Anterior ischemic optic neuropathy (AION) is an ischemic disorder of the optic nerve and a common cause of acute, painless, permanent vision loss. It is divided into two types: arteritic AION (AAION) and non-arteritic anterior ischemic optic neuropathy (NAION). Although subretinal fluid associated with optic disc edema has been reported in cases of NAION, it is rarely described in AAION.Case presentation: An 86-year-old female with a history of polymyalgia rheumatica presented with sudden vision loss in the left eye. Initial examination revealed left pallid optic disc edema with peripapillary hemorrhages. Optical coherence tomography (OCT) of the left macula showed intraretinal and submacular fluid. The patient was started on 50 mg of oral prednisone daily. The diagnosis of giant cell arteritis (GCA) was later confirmed with a positive temporal artery biopsy. Three weeks after presentation, an OCT was completed which demonstrated complete resolution of the intraretinal and submacular fluid. Although the presence of both intraretinal and subretinal fluid has been previously documented in cases of NAION, it is rarely reported in a patient with GCA.Conclusion: This is a newly described case of subretinal and intraretinal fluid in a patient with AAION. We postulate that the pathophysiology behind this is mediated by associated choroidal ischemia leading to altered permeability. OCT is an important imaging modality allowing for signs of GCA to be better characterized.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"478-482"},"PeriodicalIF":0.5,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Incidental and Uncomplicated Subretinal Triamcinolone Acetonide. 一例偶然发生的非并发性视网膜下曲安奈德。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-06-07 eCollection Date: 2024-01-01 DOI: 10.1159/000539190

You Zhou, Rodney Guiseppi, Touka Banaee

{"title":"A Case of Incidental and Uncomplicated Subretinal Triamcinolone Acetonide.","authors":"You Zhou, Rodney Guiseppi, Touka Banaee","doi":"10.1159/000539190","DOIUrl":"10.1159/000539190","url":null,"abstract":"Introduction: Posterior subtenon injection of triamcinolone acetonide (PSTA) is commonly done to treat refractory cases of macular edema. Complications may arise from the procedure as well as from the use of the periocular steroid medications. Side effects include subconjunctival hemorrhage, progression of cataract, scleral perforation (resulting in subretinal, subhyaloid, or intravitreal injection of the drug), retinal detachment, ptosis, orbital fat prolapse, orbital abscess, infectious scleritis, ocular hypertension, and scleral abscess. Here we describe a case of inadvertent subretinal triamcinolone acetonide (TA) deposition from a PSTA procedure without any adverse vision-threatening outcomes.Case presentation: We report a patient who presented with a history of superior temporal left eye macula-off rhegmatogenous retinal detachment, which was successfully repaired with a scleral buckle (SB), pars plana vitrectomy, and gas placement. Due to persistent diplopia, the SB was removed after 1 year post-operatively. Due to the development of cystoid macular edema, a PSTA was performed after the patient failed topical steroids and NSAIDs. The procedure was halted early due to unexpected resistance during the injection. A dilated fundus exam showed the presence of subretinal triamcinolone acetonide. The patient was observed and found to have no complications with almost complete resolution of the triamcinolone acetonide after 3 months.Conclusion: In previous SB patients, it is important to highlight the risk of globe penetration, subretinal deposition of TA, formation of retinal breaks, or reopening of prior retinal breaks with posterior subtenon injection, which could have adverse effects on the local retina as well as the risk of retinal detachment.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"472-477"},"PeriodicalIF":0.5,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silicone Granulomas in the Orbit following Breast Implant Rupture: Case Report. 乳房假体破裂后眼眶内的硅酮肉芽肿：病例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.1159/000539184

Elin Bohman, Rikard Linderoth, Sara Jonmarker Jaraj, Gustav Stålhammar, Eva Dafgård Kopp

{"title":"Silicone Granulomas in the Orbit following Breast Implant Rupture: Case Report.","authors":"Elin Bohman, Rikard Linderoth, Sara Jonmarker Jaraj, Gustav Stålhammar, Eva Dafgård Kopp","doi":"10.1159/000539184","DOIUrl":"10.1159/000539184","url":null,"abstract":"Introduction: A known but uncommon complication following breast augmentation with silicone implants is the rupture of these implants and subsequent silicone migration through the lymphatic system. Exceptionally, there are sporadic instances of silicone granulomas forming in distant, non-lymphatic sites, posing diagnostic and management challenges in clinical practice.Case presentation: A 56-year-old woman presented with slowly progressive diplopia and photosensitivity during the past 12 months. Ophthalmic examination revealed restriction of movement in all gazes in the right eye. Investigation with magnetic resonance imaging and positron emission tomography-computed tomography showed enlarged superior lateral and inferior rectus muscles in the right orbit, and a diffusely enlarged lacrimal gland in the left orbit, as well as a ruptured silicone breast implant on the right side. In addition, multiple enlarged lymph nodes were found throughout the body, as well as a mass in the internal oblique muscle of the abdominal wall. Fine-needle aspiration biopsy of the axillary lymph node and surgical biopsy of extraocular muscles confirmed a diagnosis of silicone granulomas. The patient received anti-inflammatory treatment with intravenous steroids but with no effect on symptoms.Conclusions: This case illustrates a rare instance of silicone dissemination from a ruptured breast implant leading to granuloma formation in multiple organs, including the orbit. Notably, the spread of silicone appeared to occur through both lymphatic and hematogenous routes. This finding underscores the importance of considering silicone granulomas in the differential diagnosis of orbital lesions for patients with a history of silicone implants.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"465-471"},"PeriodicalIF":0.5,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral Venous Sinus Thrombosis with Bilateral Optic Disc Swelling and Bilateral Sixth Nerve Palsies in the Absence of Headache: A Case Report. 脑静脉窦血栓伴双侧视盘肿胀和双侧第六神经麻痹而无头痛：病例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-05-30 eCollection Date: 2024-01-01 DOI: 10.1159/000539125

Daisuke Nakata, Hiroshi Okada, Koji Ueoka, Yoshiaki Shimada, Atsuhiro Tanikawa, Masayuki Horiguchi, Yasuki Ito

{"title":"Cerebral Venous Sinus Thrombosis with Bilateral Optic Disc Swelling and Bilateral Sixth Nerve Palsies in the Absence of Headache: A Case Report.","authors":"Daisuke Nakata, Hiroshi Okada, Koji Ueoka, Yoshiaki Shimada, Atsuhiro Tanikawa, Masayuki Horiguchi, Yasuki Ito","doi":"10.1159/000539125","DOIUrl":"10.1159/000539125","url":null,"abstract":"Introduction: We report a case of cerebral venous sinus thrombosis (CVST) that presented with bilateral optic disc swelling and diplopia in the absence of headaches.Case presentation: A 54-year-old woman with no relevant medical history presented with a 2-week history of diplopia and no loss of visual acuity in each eye. Eye movements revealed bilateral abduction deficits, and fundoscopic examination revealed bilateral optic disc swelling. Non-contrast computed tomography of the head showed no abnormalities. Magnetic resonance venography revealed the absence of flow in the superior sagittal and left transverse sinuses as a consequence of thrombosis. The patient was diagnosed with intracranial hypertension associated with abducens nerve palsies secondary to CVST and was initiated on anticoagulant therapy. CVST can lead to stroke even in younger individuals.Conclusion: CVST should be considered in differential diagnosis when bilateral papilledema and abducens nerve palsies are present, even in the absence of headache or other neurological findings.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"459-464"},"PeriodicalIF":0.5,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误。

IF 0.4

Case Reports in Ophthalmology Pub Date : 2024-05-28 eCollection Date: 2024-01-01 DOI: 10.1159/000539444

引用次数: 0

Atypical Central Serous Chorioretinopathy Masquerading as Vogt-Koyanagi-Harada Disease: A Case Report. 伪装成 Vogt-Koyanagi-Harada 病的非典型中央浆液性脉络膜视网膜病变：病例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-05-24 eCollection Date: 2024-01-01 DOI: 10.1159/000538736

Munevver Duran, David Shieh, Preston Choi, Yu-Guang He, Rafael L Ufret-Vincenty

{"title":"Atypical Central Serous Chorioretinopathy Masquerading as Vogt-Koyanagi-Harada Disease: A Case Report.","authors":"Munevver Duran, David Shieh, Preston Choi, Yu-Guang He, Rafael L Ufret-Vincenty","doi":"10.1159/000538736","DOIUrl":"10.1159/000538736","url":null,"abstract":"Introduction: We aimed to describe a clinical presentation of central serous retinopathy that poses a diagnostic and management dilemma.Case presentation: A 30-year-old male patient presented with bilateral vision loss and multifocal serous retinal detachments involving the posterior pole of both eyes. Optical coherence tomography revealed prominent bilateral bacillary layer detachments. The patient complained of recent headaches and tinnitus. However, the clinical exam did not reveal overt inflammation and the patient admitted to being under significant stress. The clinical presentation raised concerns for both central serous retinopathy (CSR) and Vogt-Koyanagi-Harada (VKH). Additional findings, including white fundus spots and focal areas of retinal vascular leakage, were seen in our patient. We highlight these because, while they have been described in CSR, they are not commonly discussed and could add to the diagnostic dilemma. After a conservative approach that avoided steroids, our patient showed marked improvement over the following month, supporting a diagnosis of CSR.Conclusion: CSR can mimic VKH disease. A high level of suspicion is needed to avoid instituting steroid therapy that could induce a severe iatrogenic exacerbation of the disease.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"448-457"},"PeriodicalIF":0.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Inflammatory Juvenile Conjunctival Nevus with a Rare Histopathological Type. 一例罕见组织病理学类型的炎性幼年结膜痣

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-05-17 eCollection Date: 2024-01-01 DOI: 10.1159/000538593

Chihiro Iwata, Yuichi Asahina, Takashi Ono, Yukako Taketani, Mikiko Kimakura, Tetsuya Toyono, Mariko Tanaka, Makoto Aihara, Takashi Miyai

{"title":"A Case of Inflammatory Juvenile Conjunctival Nevus with a Rare Histopathological Type.","authors":"Chihiro Iwata, Yuichi Asahina, Takashi Ono, Yukako Taketani, Mikiko Kimakura, Tetsuya Toyono, Mariko Tanaka, Makoto Aihara, Takashi Miyai","doi":"10.1159/000538593","DOIUrl":"10.1159/000538593","url":null,"abstract":"Introduction: Inflammatory juvenile conjunctival nevus (IJCN) is a rare condition affecting both children and adolescents. It has misleading clinical and histopathological features; therefore, careful assessment is necessary. We present a case of IJCN with a rare pathological type and misleading histopathological features.Case presentation: A 13-year-old girl with IJCN in the right eye was treated with antiallergic and steroid eye drops but showed no response and was referred to our hospital for excisional biopsy. Slit-lamp examination revealed a nonpigmented juxtalimbal tumor in the right eye. Histopathologically, nevus cells with mild nuclear atypia proliferated within the conjunctival epithelium. Confluent growth of junctional nests, conjunctival cysts, and prominent inflammatory infiltration were also observed. Considering the young age of the patient and immunohistochemical characteristics (HMB-45, SOX10, p16 and Ki-67), the patient was finally diagnosed with IJCN. IJCN has three pathological subtypes - compound, subepithelial, and junctional - depending on the location of the nevus cells. This case was diagnosed as a rare junctional type, as most of the examined sections only showed lesions within the epithelium; no lesions were clearly identified extending beneath the epithelium.Conclusion: The pathological diagnosis of IJCN is difficult because some features of IJCN suggest malignancy. Detailed microscopic examination, immunohistochemical staining, and the patient's young age helped render a final diagnosis.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"443-447"},"PeriodicalIF":0.5,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower Eyelid Merkel Cell Carcinoma in a Non-Immunocompromised Young Female: A Case Report. 一名非免疫缺陷年轻女性的下眼睑梅克尔细胞癌：病例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-05-17 eCollection Date: 2024-01-01 DOI: 10.1159/000536098

Yoshifumi Komatsu, Yoshiyuki Kitaguchi, Masako Kurashige, Takeshi Morimoto, Kohji Nishida

引用次数: 0