Case Reports in Medicine最新文献_第3页

The Role of Benralizumab in Eosinophilic Immune Dysfunctions: A Case Report-Based Literature Review. Benralizumab在嗜酸性免疫功能障碍中的作用:基于病例报告的文献综述。

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Case Reports in Medicine Pub Date : 2023-04-24 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8832242

Margarida Gomes, Ana Mendes, Filipa Ferreira, Joana Branco, Fernanda S Tonin, M Elisa Pedro

{"title":"The Role of Benralizumab in Eosinophilic Immune Dysfunctions: A Case Report-Based Literature Review.","authors":"Margarida Gomes, Ana Mendes, Filipa Ferreira, Joana Branco, Fernanda S Tonin, M Elisa Pedro","doi":"10.1155/2023/8832242","DOIUrl":"10.1155/2023/8832242","url":null,"abstract":"In the past years, the knowledge of eosinophils playing a primary pathophysiologic role in several associated conditions has led to the development of biologics targeting therapies aiming at normalizing the immune response, reducing chronic inflammation, and preventing tissue damage. To better illustrate the potential relationship between different eosinophilic immune dysfunctions and the effects of biological therapies in this scenario, here, we present a case of a 63-year-old male first referred to our department in 2018 with a diagnosis of asthma, polyposis, and rhinosinusitis and presenting a suspicion of nonsteroidal anti-inflammatory drugs' allergy. He also had a past medical history of eosinophilic gastroenteritis/duodenitis (eosinophilia counts >50 cells/high-power field HPF). The use of multiple courses of corticosteroid therapy failed to completely control these conditions. In October 2019, after starting benralizumab (an antibody directed against the alpha chain of the IL-5 cytokine receptor) as add-on treatment for severe eosinophilic asthma, important clinical improvements were reported both on the respiratory (no asthma exacerbations) and gastrointestinal systems (eosinophilia count 0 cells/HPF). Patients' quality of life also increased. Since June 2020, systemic corticosteroid therapy was reduced without worsening of gastrointestinal symptoms or eosinophilic inflammation. This case warns of the importance of early recognition and appropriate individualized treatment of eosinophilic immune dysfunctions and suggests the conduction of further larger studies on the use of benralizumab in gastrointestinal syndromes aiming at better understanding its relying mechanisms of action in the intestinal mucosa.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2023 ","pages":"8832242"},"PeriodicalIF":0.8,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9465783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Report of a Complicated Case of Couvelaire Uterus. 复杂子宫库夫莱尔症1例报告。

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Case Reports in Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/6668328

Hamideh Parsapour, Neda Shafie, Amir Mohammad Salehi, Zeinab Assareh

引用次数: 1

Successful Treatment of Respiratory Failure in a Patient with Prader-Willi Syndrome with Noninvasive Ventilation with AVAPS. AVAPS无创通气成功治疗Prader-Willi综合征患者呼吸衰竭。

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Case Reports in Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/9925144

Nauras Hwig, Montserrat Diaz-Abad, Victor T Peng, Jennifer Y So, Anayansi Lasso-Pirot

引用次数: 1

Epidural Blood Patch in a Patient with a Hematological Malignancy. 恶性血液病患者的硬膜外补血。

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Case Reports in Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/9955772

Ross Barman, Jack McHugh, Thomas O'Mara, Thomas Pittelkow, Ryan S D'Souza

{"title":"Epidural Blood Patch in a Patient with a Hematological Malignancy.","authors":"Ross Barman, Jack McHugh, Thomas O'Mara, Thomas Pittelkow, Ryan S D'Souza","doi":"10.1155/2023/9955772","DOIUrl":"https://doi.org/10.1155/2023/9955772","url":null,"abstract":"Postdural puncture headache is a frequently encountered complication following procedures such as lumbar puncture, neuraxial anesthesia, or intrathecal drug delivery device implantation. It classically presents as a painful orthostatic headache that is exacerbated when a patient is upright. For treatment, patients are often started on conservative options such as hydration, caffeine, bedrest, and NSAID analgesics; however, certain patients who fail these therapies may require intervention with an epidural blood patch. The epidural blood patch remains the gold standard for treating refractory postdural puncture headache. Contraindications to epidural blood patch include severe coagulopathy, patient refusal, or infection at the intended site of entry. There are no clear consensus recommendations regarding patients with a hematological malignancy and potential risk that autologous blood may seed malignant cells into the neuraxis. In this case report, we present a patient with acute myeloid leukemia who developed a postdural puncture headache after receiving subarachnoid administration of antineoplastics. The patient was refractory to conservative therapy, prompting multidisciplinary consultation and discussion with the patient about the risks and benefits of proceeding with an epidural blood patch. Ultimately, the patient elected to proceed with the offered epidural blood patch which led to complete resolution of his painful headaches and did not cause any spread of malignant cells into his neuraxis or cerebral spinal fluid.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2023 ","pages":"9955772"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Atypical Presentation of Amyloidosis in a Female Patient with Muscle Weakness. 女性肌无力患者淀粉样变性的不典型表现。

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Case Reports in Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/1553163

Raziyeh Lashkari, Maryam Loghman, Leila Aghaghazvini, Hiva Saffar, Bentolhoda Ziaadini, Reza Shahriarirad, Mohammad Nekooeian, Mohammad Nejadhosseinian, Majid Alikhani

引用次数: 0

"Extreme Nephroptosis": A Kidney in the Inguinal Hernia. “极度肾下垂”:腹股沟疝中的一个肾。

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Case Reports in Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/1439919

Dmytro Shchukin, Vladyslav Demchenko, Andrii Arkatov, Roman Stetsyshyn, Gennadii Khareba, Vladyslav Bielov

引用次数: 0

Acute Abdominal Pain as a Result of an Isolated Left Ovarian Vein Thrombosis. 孤立性左卵巢静脉血栓形成引起急性腹痛。

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Case Reports in Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/9528088

Abhay Setia, Farzin Adili, Karl Ludwig, Joerg Herold

引用次数: 0

Managing Follicular Lymphoma in the Elderly Population. 老年人群滤泡性淋巴瘤的管理。

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Case Reports in Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/1038934

Jiao Jie Cherie Tan, Yuen Lei Sze, Clarice Choong Shi Hui

{"title":"Managing Follicular Lymphoma in the Elderly Population.","authors":"Jiao Jie Cherie Tan, Yuen Lei Sze, Clarice Choong Shi Hui","doi":"10.1155/2023/1038934","DOIUrl":"https://doi.org/10.1155/2023/1038934","url":null,"abstract":"Follicular lymphoma (FL) is one of the most commonly diagnosed types of indolent non-Hodgkin lymphoma (NHL). The median age of diagnosis for FL is 65 years old. Although the median life expectancy after diagnosis is approximately 10 years, the incurable disease has a high risk of transformation. This case report focuses on an 80-year-old patient diagnosed with low-grade follicular lymphoma which subsequently transformed leading to the patient's eventual demise as the patient took on the palliative intent. This case report aims to highlight the importance of clinical markers or prognostic factors to identify patients, specifically the elderly population who are at risk of transformation to aggressive forms when their FL remains at stage I-II phases. Currently, elderly patients with FL tend to be quickly dismissed with curative intent with chemotherapy, given their age and comorbidities, despite forming the majority of the population with follicular lymphoma. Age more than 60 years old has been shown to be one of the most powerful yet poor prognostic features in follicular lymphoma international prognostic index (FLIPI)-the main scoring system used for FL. Hence, further studies are required to look into the tailoring treatment for elderly patients with follicular lymphoma after risk stratifying them with appropriate clinical and prognostic markers.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2023 ","pages":"1038934"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9099345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological Correlation of a Cardiac Mass with Multimodality Imaging. 心脏肿块与多模态影像的病理相关性。

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Case Reports in Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/7352934

Sumit Sohal, Farida A Tanko, Esad Vucic, Sergio Waxman, Suresh Gupta, Billie Fyfe-Kirschner

引用次数: 0

DNAH11 and a Novel Genetic Variant Associated with Situs Inversus: A Case Report and Review of the Literature. DNAH11和一种与位置反向相关的新遗传变异:一个病例报告和文献综述。

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Case Reports in Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/8436715

Fatemeh Sodeifian, Noosha Samieefar, Sepideh Shahkarami, Elham Rayzan, Simin Seyedpour, Meino Rohlfs, Christoph Klein, Delara Babaie, Nima Rezaei

{"title":"DNAH11 and a Novel Genetic Variant Associated with Situs Inversus: A Case Report and Review of the Literature.","authors":"Fatemeh Sodeifian, Noosha Samieefar, Sepideh Shahkarami, Elham Rayzan, Simin Seyedpour, Meino Rohlfs, Christoph Klein, Delara Babaie, Nima Rezaei","doi":"10.1155/2023/8436715","DOIUrl":"https://doi.org/10.1155/2023/8436715","url":null,"abstract":"Background: Primary ciliary dyskinesia (PCD), also known as the immotile-cilia syndrome, is a clinically and genetically heterogeneous syndrome. Improper function of the cilia causes impaired mucociliary clearance. Neonatal respiratory distress, rhinosinusitis, recurrent chest infections, wet cough, and otitis media are respiratory presentations of this disease. It could also manifest as infertility in males as well as laterality defects in both sexes, such as situs abnormalities (Kartagener syndrome). During the past decade, numerous pathogenic variants in 40 genes have been identified as the causatives of primary ciliary dyskinesia. DNAH11 (dynein axonemal heavy chain 11) is a gene that is responsible for the production of cilia's protein and encodes the outer dynein arm. Dynein heavy chains are motor proteins of the outer dynein arms and play an essential role in ciliary motility. Case Presentation. A 3-year-old boy, the offspring of consanguineous parents, was referred to the pediatric clinical immunology outpatient department with a history of recurrent respiratory tract infections and periodic fever. Furthermore, on medical examination, situs inversus was recognized. His lab results revealed elevated levels of erythrocyte sedimentation rate (ESR) and C reactive protein (CRP). Serum IgG, IgM, and IgA levels were normal, while IgE levels were elevated. Whole exome sequencing (WES) was performed for the patient. WES demonstrated a novel homozygous nonsense variant in DNAH11 (c.5247G > A; p. Trp1749Ter).Conclusion: We reported a novel homozygous nonsense variant in DNAH11 in a 3-year-old boy with primary ciliary dyskinesia. Biallelic pathogenic variants in one of the many coding genes involved in the process of ciliogenesis lead to PCD.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2023 ","pages":"8436715"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9486195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0