Case Reports in Medicine最新文献_第3页

A Pruritic Predicament: An Unusual Presentation of Graves' Disease Complicated by Pregnancy. 瘙痒困境：Graves病合并妊娠的不寻常表现。

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Case Reports in Medicine Pub Date : 2026-08-10 eCollection Date: 2026-01-01 DOI: 10.1155/carm/5816822

Rob Lawless, Evan Smith, Camryn Slone, Thaddeus Salmon

引用次数: 0

Ulcerative Colitis in a Patient With Auricular Chondritis and Sweet Syndrome: A Rare Case. 溃疡性结肠炎合并耳软骨炎和甜综合征：罕见病例。

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Case Reports in Medicine Pub Date : 2026-08-07 eCollection Date: 2026-01-01 DOI: 10.1155/carm/1251336

Guang-He Zhang, Hai-Yan Wang, Chun-Fang Guo, Xian-Wei Han

{"title":"Ulcerative Colitis in a Patient With Auricular Chondritis and Sweet Syndrome: A Rare Case.","authors":"Guang-He Zhang, Hai-Yan Wang, Chun-Fang Guo, Xian-Wei Han","doi":"10.1155/carm/1251336","DOIUrl":"10.1155/carm/1251336","url":null,"abstract":"Relapsing polychondritis (RP) is a rare immune-mediated inflammatory disorder primarily affecting cartilaginous tissues throughout the body that may involve other connective tissues. The initial manifestation is often auricular chondritis, and cutaneous presentations are relatively uncommon. Approximately 30% of RP cases have an association with autoimmune diseases, but it is incredibly rare for there to be any coexistence with inflammatory bowel disease (IBD). Sweet syndrome (SS), which is also known as acute febrile neutrophilic dermatosis, also has an association with autoimmune disorders and is considered to be an incredibly rare extraintestinal IBD manifestation. In this article, a case of a patient simultaneously presenting with auricular chondritis, ulcerative colitis (UC), and SS, which had an effective response to systemic corticosteroid therapy is reported. As far as we are aware, this is the first reported case of the coexistence of these three disorders, and it will provide valuable insights into the diagnosis and management of RP that is complicated by UC and other associated conditions.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"1251336"},"PeriodicalIF":1.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of Subcapsular Hepatic Hematoma in a Multiparous Pregnant Woman at 21 Weeks of Gestation: A Fatal Complication of HELLP Syndrome. 妊娠21周多胎妊娠妇女包膜下肝血肿1例：HELLP综合征的致命并发症。

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Case Reports in Medicine Pub Date : 2026-08-07 eCollection Date: 2026-01-01 DOI: 10.1155/carm/4808034

Hamideh Parsapour, Neda Shafie, Seed Rouhollah Hosseini, Samar Moghadami, Zeinab Assareh

引用次数: 0

Elbow Metastasis From Primary Lung Adenocarcinoma: A Case Report. 原发性肺腺癌肘部转移1例。

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Case Reports in Medicine Pub Date : 2026-08-06 eCollection Date: 2026-01-01 DOI: 10.1155/carm/9169413

Liliana Fernandez-Trujillo, Ciro D Ibarra-Enriquez, Carlos A García, Luz F Sua

{"title":"Elbow Metastasis From Primary Lung Adenocarcinoma: A Case Report.","authors":"Liliana Fernandez-Trujillo, Ciro D Ibarra-Enriquez, Carlos A García, Luz F Sua","doi":"10.1155/carm/9169413","DOIUrl":"10.1155/carm/9169413","url":null,"abstract":"Background: Lung cancer is a leading cause of cancer-related death worldwide, with bone metastasis frequently seen in advanced stages and often located in the axial skeleton or proximal long bones. Metastasis to the elbow is extremely rare and poses diagnostic and therapeutic challenges.Case presentation: We report the case of a 39-year-old male with a history of smoking and recent occupational exposure, presenting with an 8-month history of progressive pain, swelling, and limited mobility in the left elbow. Imaging revealed an osteolytic lesion in the distal humerus, prompting further evaluation. A biopsy confirmed metastatic adenocarcinoma from a primary lung tumor. Following diagnosis, the patient underwent a targeted treatment regimen, including chemotherapy, immunotherapy, and localized radiotherapy for elbow metastasis. After 2 years of treatment, the patient achieved complete oncological remission.Conclusion: This case underscores the potential for positive outcomes in rare presentations of metastatic lung cancer to atypical sites such as the distal humerus. Although bone metastasis in lung cancer usually signals poor prognosis and limited therapeutic options, a personalized, multimodal treatment approach can substantially improve outcomes, even in advanced-stage lung cancer with unusual metastasis.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"9169413"},"PeriodicalIF":1.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Hereditary Angioedema in a 7-Year-Old Girl: Presentation, Diagnosis, and Bridging the Management Gap. 一例罕见的遗传性血管性水肿的7岁女孩：表现，诊断和弥合管理差距。

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Case Reports in Medicine Pub Date : 2026-07-31 eCollection Date: 2026-01-01 DOI: 10.1155/carm/9980409

Amir Hasan Farzaneh, Abbas Dabbaghzadeh

{"title":"A Rare Case of Hereditary Angioedema in a 7-Year-Old Girl: Presentation, Diagnosis, and Bridging the Management Gap.","authors":"Amir Hasan Farzaneh, Abbas Dabbaghzadeh","doi":"10.1155/carm/9980409","DOIUrl":"10.1155/carm/9980409","url":null,"abstract":"Hereditary angioedema (HAE) is a rare, potentially life-threatening genetic disorder characterized by recurrent episodes of localized subcutaneous or submucosal swelling resulting from C1 esterase inhibitor deficiency or dysfunction. We report the case of a 7-year-old girl who presented with acute left-sided facial and upper lip edema that initially appeared as periorbital discoloration resembling ecchymosis following an upper respiratory tract infection. Her history included recurrent self-limited swelling episodes and an initially unrecognized family history of angioedema. Physical examination demonstrated nonpitting, nonpruritic facial edema without signs of airway compromise. Routine laboratory investigations were unremarkable. Complement testing subsequently confirmed HAE Type I, demonstrating markedly reduced C1 esterase inhibitor antigen and C4 levels with normal C1q concentrations. Because specific C1-INH replacement therapy was unavailable, the patient received fresh frozen plasma (approximately 15 mL/kg), resulting in complete clinical resolution within 3 days. This case highlights the diagnostic challenges of pediatric HAE, particularly when clinical manifestations mimic more common allergic, infectious, or traumatic conditions. It also illustrates the importance of early recognition, timely complement testing, and family screening for establishing the diagnosis. Furthermore, this report demonstrates that fresh frozen plasma may serve as an effective therapeutic alternative for acute attacks in resource-limited settings where targeted therapies are inaccessible. Early diagnosis, patient education, trigger avoidance, and appropriate long-term follow-up remain essential to reduce morbidity and prevent potentially life-threatening complications.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"9980409"},"PeriodicalIF":1.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13426242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Adult-Onset Still Disease Presenting as Fever of Unknown Origin and Severe Myalgia in a Resource-Limited Tertiary Hospital in Brazil. 急性成人发病Still病表现为不明原因发热和严重肌痛在巴西一家资源有限的三级医院。

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Case Reports in Medicine Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.1155/carm/6925896

Breno Bopp Antonello, Cainã Gonçalves Rodrigues, Giovanna Giovacchini Dos Santos, Laura Grespan Dill, Paulo Victor Zattar Ribeiro

{"title":"Acute Adult-Onset Still Disease Presenting as Fever of Unknown Origin and Severe Myalgia in a Resource-Limited Tertiary Hospital in Brazil.","authors":"Breno Bopp Antonello, Cainã Gonçalves Rodrigues, Giovanna Giovacchini Dos Santos, Laura Grespan Dill, Paulo Victor Zattar Ribeiro","doi":"10.1155/carm/6925896","DOIUrl":"10.1155/carm/6925896","url":null,"abstract":"This case highlights the diagnostic challenges of managing a patient who initially presented with a fever of unknown source and subsequently met the criteria for fever of unknown origin (FUO) after more than 3 weeks of persistent fever despite an extensive diagnostic workup in a resource-limited tertiary hospital within Brazil's public health system. A man in his sixth decade presented with prolonged high-grade fever and severe lower-limb myalgia, initially raising suspicion for leptospirosis due to rural exposure and occupational history. Extensive evaluation-including blood cultures, serologies, and imaging screening-revealed no infectious or malignant cause. Persistent neutrophilic leukocytosis, marked hyperferritinemia, and elevated inflammatory markers suggested a systemic autoinflammatory disorder. A trial of low-dose prednisone produced partial improvement, and rheumatology consultation supported the diagnosis of adult-onset Still disease (AOSD) based on Yamaguchi criteria. Corticosteroid escalation resulted in the rapid resolution of fever and myalgia. This case underscores the importance of structured reasoning, systematic exclusion of common causes, and careful attention to laboratory patterns for timely diagnosis in resource-limited settings.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"6925896"},"PeriodicalIF":1.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13417720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Sequential Development of Multiple Sclerosis, Thymoma, Myasthenia, and Lymphoma in the Same Patient. 多发性硬化症、胸腺瘤、肌无力和淋巴瘤在同一患者中不同寻常的顺序发展。

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Case Reports in Medicine Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.1155/carm/4552045

Josef Finsterer

{"title":"Unusual Sequential Development of Multiple Sclerosis, Thymoma, Myasthenia, and Lymphoma in the Same Patient.","authors":"Josef Finsterer","doi":"10.1155/carm/4552045","DOIUrl":"10.1155/carm/4552045","url":null,"abstract":"No case has yet been described in which a patient developed multiple sclerosis (MS) followed by thymoma, myasthenia gravis (MG), and T-cell lymphoma. The patient is a 47-year-old woman who developed relapsing-remitting MS at the age of 31 and was treated with interferon-beta (IFN-β) for over seven years. She was then diagnosed with thymoma, which was treated with chemotherapy and surgery. One year later, she was diagnosed with MG, which was treated with steroids, pyridostigmine, and intravenous immunoglobulins. Due to an MS relapse at the age of 40, ocrelizumab was administered for 2.5 years, after which she developed T-cell lymphoma. As the lymphoma had responded only partially to chemotherapy, an autologous stem cell transplantation was performed. It remains unclear whether there was a causal link between the immunosuppressive MS treatment and the thymoma or lymphoma, whether these developed due to underlying immune dysregulation, individual predisposition, or the cumulative effect of prior oncological therapies, or whether this was merely a chance co-occurrence of rare diseases. The case shows that a single patient may sequentially develop MS, MG, thymoma, and T-cell lymphoma. Fundamental and comprehensive clinical studies are required to elucidate the underlying pathophysiology and to confirm or refute a possible causal link.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"4552045"},"PeriodicalIF":1.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Rare Double Primary Malignancies: A Pancreatic Gastrointestinal Stromal Tumor Mimicking as a Metastatic Lesion of Myoepithelial Carcinoma of Parotid Gland". 更正“罕见的双重原发恶性肿瘤：胰腺胃肠道间质肿瘤模拟腮腺肌上皮癌的转移灶”。

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Case Reports in Medicine Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.1155/carm/9785303

引用次数: 0

Remarkable Response to Immunotherapy and VEGFR Inhibitor in Xp11 Translocation Renal Cell Carcinoma in a 17-Year-Old Adolescent. 免疫治疗和VEGFR抑制剂在17岁青少年Xp11易位性肾细胞癌中的显著反应

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Case Reports in Medicine Pub Date : 2026-07-21 eCollection Date: 2026-01-01 DOI: 10.1155/carm/7267084

Piyarat Limpawittayakul, Narongchai Teerayathanakul

{"title":"Remarkable Response to Immunotherapy and VEGFR Inhibitor in Xp11 Translocation Renal Cell Carcinoma in a 17-Year-Old Adolescent.","authors":"Piyarat Limpawittayakul, Narongchai Teerayathanakul","doi":"10.1155/carm/7267084","DOIUrl":"10.1155/carm/7267084","url":null,"abstract":"Background: Xp11 translocation renal cell carcinoma (tRCC) is a rare and aggressive renal cancer characterized by gene fusion involving TFE3. It accounts for < 5% of renal cancers and shows variable responses to conventional antivascular endothelial growth factor therapies. Optimal treatment strategies for metastatic cases have not been determined.Objective: To report the clinical presentation, molecular diagnosis, and therapeutic response of an adolescent patient with metastatic Xp11 tRCC treated with pembrolizumab and lenvatinib.Methods: A 17-year-old female presented with a large left renal mass, gross hematuria, extensive metastases to the supraclavicular, mediastinal, and intra-abdominal lymph nodes, and pleural nodules. Immunohistochemistry confirmed transcription factor E3 (TFE3) positivity, and next-generation sequencing identified an ASPSCR1-TFE3 fusion. Following renal embolization for local control, the patient received systemic therapy (pembrolizumab at 200 mg/dose given every 3 weeks and lenvatinib at 10 mg-20 mg/day).Results: The patient showed rapid clinical improvement, with her Eastern Cooperative Oncology Group Performance Status Scale grade improving from 3 to 1 after the initial cycles. CT imaging after the sixth cycle demonstrated a marked reduction in the size of the primary tumor and in the sizes and numbers of metastatic lesions, involved lymph nodes, and pleural nodules. The patient recovered to normal well-being.Conclusion: Pembrolizumab combined with lenvatinib showed significant antitumor activity in an adolescent with advanced ASPSCR1-TFE3 fusion Xp11 tRCC. These findings support the utility of molecular profiling of renal tumors in young adults and suggest that this combination is an effective treatment option for this subtype of renal cancer.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"7267084"},"PeriodicalIF":1.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal Klippel-Trénaunay Syndrome Mimicking Ulcerative Colitis: A Case Report. 模拟溃疡性结肠炎的胃肠道klippel - tracimnaunay综合征1例报告。

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Case Reports in Medicine Pub Date : 2026-07-21 eCollection Date: 2026-01-01 DOI: 10.1155/carm/6780306

Modar AlAli, Tarek Khazem, Hatem Yousef Almohamad, Hassan Habeeb Hasan, Ahmad Wassouf

{"title":"Gastrointestinal Klippel-Trénaunay Syndrome Mimicking Ulcerative Colitis: A Case Report.","authors":"Modar AlAli, Tarek Khazem, Hatem Yousef Almohamad, Hassan Habeeb Hasan, Ahmad Wassouf","doi":"10.1155/carm/6780306","DOIUrl":"10.1155/carm/6780306","url":null,"abstract":"Introduction: Klippel-Trénaunay syndrome (KTS) is a rare congenital syndrome characterized by the triad of capillary malformation, varicosities, and limb hypertrophy, with an incidence of 2-5 per 100,000. Gastrointestinal (GI) involvement in KTS may be present in over 30% of patients, typically presenting with pain and bleeding. While bleeding is a well-described symptom of GI involvement in KTS in the medical literature, diarrhea remains an uncommon and underreported manifestation. This report highlights this unique finding and the diagnostic complexity it presents.Case presentation: A 64-year-old male presented to the hospital with recurrent foul-smelling bloody diarrhea over the past two months. He had been previously diagnosed and treated for ulcerative colitis. Physical examination revealed pallor, macrodactyly, and segmental hypertrophy of the lower left limb. Investigations demonstrated severe iron-deficiency anemia, splenomegaly, fundal varices, and a continuous 15-cm colonic involvement from the anal verge with varicosities and bleeding. This led to the establishment of a diagnosis of KTS.Conclusion: This case highlights the diagnostic challenge that may arise from the complexity and variability of KTS presentations, which can mimic inflammatory bowel disease (IBD) due to findings like bloody diarrhea and extensive colonic involvement. Although diarrhea is rarely reported as a manifestation of KTS, it might result from existing GI vascular and lymphatic malformation, potentially leading to protein-losing enteropathy. Awareness of this atypical presentation and early multidisciplinary evaluation are crucial for symptom control, preventing complications, and improving quality of life.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"6780306"},"PeriodicalIF":1.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0