Case Reports in Medicine最新文献

{"title":"A Rare Nasopharyngeal Hemangioma Presenting as Recurrent Cyanotic Apnea in a Neonate: A Case Report and Literature Review.","authors":"Pershia Davoodi Karsalari, Samin Mortaheb, Heliya Rafsanjani, Noosha Samieefar, Aslan Ahmadi, Parinaz Alizadeh","doi":"10.1155/carm/7094069","DOIUrl":"https://doi.org/10.1155/carm/7094069","url":null,"abstract":"<p><p><b>Background:</b> Infantile hemangiomas (IHs) are the most common vascular tumors of infancy, but airway involvement is rare and potentially life-threatening. While subglottic and laryngeal regions are most frequently affected, nasopharyngeal hemangiomas are exceptionally uncommon, particularly in premature infants presenting with nonspecific symptoms such as apnea and cyanosis. <b>Case Presentation:</b> We describe a female infant born prematurely at 35 weeks via cesarean section, who developed recurrent apnea and cyanotic episodes shortly after discharge. Flexible bronchoscopy revealed a nasopharyngeal mass causing upper airway obstruction, and imaging raised suspicion of a hemangioma. The patient underwent surgical excision of the lesion and was started on a tapering course of prednisolone. Postoperative recovery was favorable, and oral propranolol was initiated to prevent recurrence. At follow-up, the patient demonstrated normal development without respiratory symptoms. <b>Conclusion:</b> Nasopharyngeal hemangiomas are rare and may present subtly in premature infants. Early bronchoscopy and imaging should be considered in cases of unexplained apnea or airway compromise. A multidisciplinary approach ensures timely diagnosis and effective treatment, minimizing long-term respiratory complications.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"7094069"},"PeriodicalIF":0.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Heterozygous Variant in <i>HABP2</i> Causing Increased Risk of Arterial and Venous Thrombosis in a Young Male: Diagnostic and Therapeutic Challenges.","authors":"Salim Al-Busaidi, Nasiba Al-Maqrashi, Khalid Al-Thihli, Bader Al Rawahi, Hatem Al Farhan, Abdullah M Al Alawi","doi":"10.1155/carm/1490289","DOIUrl":"https://doi.org/10.1155/carm/1490289","url":null,"abstract":"<p><p>Thrombosis is a major clinical issue, affecting venous and arterial circulation, increasing morbidity and mortality. While thrombophilia syndromes are established, new genetic polymorphisms in the <i>hyaluronan binding protein 2 (HABP2)</i> gene are not well understood. A 31-year-old man, a smoker, presented with multiple thrombotic events: ST-elevation myocardial infarction (STEMI), ischemic stroke, and left upper limb deep venous thrombosis. On arrival, he experienced ventricular fibrillation, needing resuscitation and percutaneous coronary intervention. During his hospital stay, he developed severe thrombocytopenia, rhabdomyolysis, and acute kidney injury. Extensive thrombophilia workup, including whole exome sequencing, revealed a heterozygous <i>HABP2</i> variant linked to thrombotic risk. His condition required a multidisciplinary approach. Genetic findings informed antithrombotic treatment and emphasized family screening. More research is needed on <i>HABP2</i> in thrombosis.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"1490289"},"PeriodicalIF":0.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive Condyloma Lata Lesions in Unusual Sites: An Atypical Manifestation of Secondary Syphilis.","authors":"Retno Hesty Maharani, Nur Mala Il Ala, Rasmia Rowawi, Eva Krishna Sutedja, Inne Arline Diana, Laila Tsaqilah, Hermin Aminah Usman, Pati Aji Achdiat","doi":"10.1155/carm/8595258","DOIUrl":"https://doi.org/10.1155/carm/8595258","url":null,"abstract":"<p><p>Condyloma lata is a typical lesion of secondary syphilis, which usually occurs in the flexural and anogenital areas. Secondary syphilis can be misdiagnosed with atypical clinical manifestations that can mimic other skin diseases (the great imitator), especially in patients with human immunodeficiency virus (HIV) infection. Atypical condyloma lata lesions can occur outside the flexural and extragenital areas. Therefore, it can mimic other skin diseases. This case report aims to report a case of secondary syphilis in the form of extensive condyloma lata lesions in unusual sites in a 46-year-old man with HIV Stage II. Physical examination revealed flat papules and plaques on the face, trunk, and anogenital area; papules with excoriations on the extremities; and mucous patches. <i>Treponema pallidum</i> hemagglutination assay and Venereal Disease Research Laboratory (VDRL) titer were 1:5120 and 1:256, respectively. The <i>Chlamydia trachomatis</i> and hepatitis C examination, as well as CD4+ T cell count and HIV viral loads data, were unavailable for this patient. Histopathological findings from flat papules on the patient's face, abdomen, and inguinal region showed eroded epidermis with neutrophil infiltration, spongiotic reactions, acanthosis, parakeratosis, hypogranulosis, superficial pallor, and endarteritis with the infiltration of plasmocytes and polymorphonuclear cells, which support that the patient's lesion is condyloma lata. The patient was treated with a single dose of 2.4 million units of benzylpenicillin G intramuscularly. The result of VDRL titer examination after 3 months of therapy was 1:32, with improvement in the skin lesions seen as the lesions that became hyperpigmentation macules. This case report showed condyloma lata, a hallmark of secondary syphilis, can present as extensive lesions in extragenital sites. Awareness of the atypical manifestations is essential to ensure early diagnosis through histopathological and serological evaluation.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"8595258"},"PeriodicalIF":0.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyke-Davidoff-Masson Syndrome in Pediatrics: Case Report of Atypical Status Epilepticus and Therapeutic Challenges in the Caribbean.","authors":"María Belén Martín-Sanz, Delvis Lucas-Muñoz, Manuel Colomé-Hidalgo, Gabriela Vásquez-Gómez","doi":"10.1155/carm/8388244","DOIUrl":"10.1155/carm/8388244","url":null,"abstract":"<p><p>Dyke-Davidoff-Masson syndrome (DDMS), also known as cerebral hemiatrophy, is characterized by brain damage resulting in hypoplasia of one cerebral hemisphere. It is described as a rare disorder, primarily characterized by epileptic seizures and convulsions, as well as hemiparesis and cognitive impairments. We present the evolution of a child with DDMS and the neurodevelopmental milestones achieved from the onset of symptoms at 10 days of age to 3 years. Clinical features included persistent seizures and hemiparesis. Neuroimaging revealed right cerebral hemiatrophy with associated structural changes. The aim of this study is to present a case report of a pediatric patient with DDMS, detailing the clinical evaluation, therapeutic approaches, and disease progression, while describing the healthcare process and challenges associated with managing this rare condition in the Dominican Republic. Through this, we aim to improve the therapeutic strategies implemented in the region for the management of this infrequent condition and enhance the understanding of DDMS in the Caribbean.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"8388244"},"PeriodicalIF":0.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misdiagnosis of a Ruptured Ovarian Ectopic Pregnancy as Ovarian Malignancy: Case Report and Literature Review.","authors":"Rebecca Shin, Bridget Neal, Alireza Abidi","doi":"10.1155/carm/2904664","DOIUrl":"10.1155/carm/2904664","url":null,"abstract":"<p><p>Ruptured ovarian ectopic pregnancy (ROEP) is a rare and life-threatening condition that can increase maternal morbidity and mortality. This case report describes a patient with an atypical presentation that illustrates the diagnostic difficulty of ROEP. Due to overlapping clinical features, it was initially misdiagnosed as an ovarian malignancy. We review relevant clinical symptoms, βHCG trends, and imaging findings that should be evaluated together when considering differential diagnoses. Although most ROEPs are ultimately diagnosed intraoperatively and by histopathology, this case report highlights key diagnostic decision points in the setting of ambiguous clinical and radiologic findings.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"2904664"},"PeriodicalIF":0.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Adenomyoma: A Rare Entity Mimicking Pyloric Neoplasia-A Case Report.","authors":"Valentina Velasco-Muñoz, J Santiago Pabón-Castro, María Camila Escudero-Bohórquez, Andres G Aponte-Vargas, Gabriel Alberto Roa-Rossi, Jose Manuel Sánchez Jaramillo, Pablo García-Echeverri, William H Salamanca-Chaparro","doi":"10.1155/carm/9964542","DOIUrl":"10.1155/carm/9964542","url":null,"abstract":"<p><p><b>Introduction:</b> Gastric adenomyoma is a rare benign lesion that may present with nonspecific gastrointestinal symptoms or be incidentally discovered. Due to its rarity and imaging resemblance to malignant tumors, it often leads to diagnostic and therapeutic dilemmas. <b>Methods:</b> A retrospective study was conducted, and a literature review was made to describe the background of the case found. <b>Case Report:</b> We report a case of a 50-year-old female who developed a gastric adenomyoma mimicking a pyloric lesion initially suspected to be malignant. Histopathological examination confirmed the diagnosis of gastric adenomyoma. The patient's postoperative course was uneventful, and she remains asymptomatic on follow-up. <b>Conclusions:</b> Gastric adenomyoma should be considered in the differential diagnosis of pyloric masses. Awareness of its imaging and histopathological characteristics can prevent unnecessary radical surgery.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"9964542"},"PeriodicalIF":0.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Complicated Microbiology Diagnosis and Treatment of Tonsillopharyngitis in Pregnancy: A Case Report.","authors":"Vasil Boyanov, Ivo Sirakov, Bilyana Sirakova, Liliya Boyanova, Raina Gergova","doi":"10.1155/carm/5675549","DOIUrl":"10.1155/carm/5675549","url":null,"abstract":"<p><p>Pregnancy is a special period characterized by changes in the immune system as well as alteration of the microbiota predisposing to opportunistic infections, including tonsillopharyngitis. <i>Streptococcus anginosus</i> has numerous virulence factors, and it is associated with a variety of diseases. Being a part of the normal oral microbiota, it can be overlooked as a causative agent of infections in the oral cavity. A clinical case of a 29-year-old pregnant female who was allergic to penicillins and presented with recurrent tonsillopharyngitis has been described. Previous microbiological examinations have not shown any etiologic cause of patient's symptoms. Two species were isolated. <i>S. anginosus</i> and <i>S. oralis</i> were identified using various methods, including nucleotide sequencing. <i>S. anginosus</i> was defined as the causative agent. Both were susceptible to all tested antibiotics. <i>S. anginosus</i> was positive for the duplicated <i>sagA</i> gene, encoding streptolysin S, an important factor of virulence. Based on clinical symptoms, paraclinical tests, immune competence, and characteristics of the strain, a multifactorial evaluation is required to determine whether an opportunist is a causative agent. Moreover, treatment of pregnant patients, particularly with antibiotics, is limited, which leads to therapeutic difficulties.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"5675549"},"PeriodicalIF":0.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Kaposi Sarcoma Misdiagnosed for 2 years: A Case Report.","authors":"Maram T Alkhatieb, Hussain A Alkhalifah, Lama A Aljilani, Saeed A Alhudaifi, Doaa Y Alqaidy","doi":"10.1155/carm/5112520","DOIUrl":"10.1155/carm/5112520","url":null,"abstract":"<p><p><b>Background:</b> Kaposi Sarcoma (KS) is a rare low-grade vascular neoplasm that is associated with Human herpesvirus 8 (HHV-8). KS commonly affects HIV or immunocompromised patients. However, classical KS can be present even in the absence of these factors. In this case report, we describe a case of KS in an 83-year-old, HIV-negative Saudi male who was misdiagnosed for two years. <b>Case Presentation:</b> The patient presented with right foot pain and swelling with two large masses. The patient was initially diagnosed with stasis dermatitis and chronic venous ulcer due to venous insufficiency and treated with endovenous thermal ablation. However, the patient's symptoms did not resolve, and he experienced several episodes of cellulitis that required multiple hospital admissions over a 2-year period. When the patient presented to our center, a biopsy was taken from the lesion, and it confirmed the diagnosis of KS. <b>Conclusion:</b> KS or other underlying etiologies should be suspected in cases of recurrent unresolved infections, particularly in older patients. A high index of suspicion and a low threshold for biopsy are recommended to prevent missed or delayed diagnoses, which could ultimately lead to the worst prognosis.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"5112520"},"PeriodicalIF":0.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Comorbidity of Sickle Cell Disease and Wilms' Tumor: A Case Report.","authors":"Philippe Masidi, Josué Lumbu, Henoch C Kabeya, Aymar Akilimali, Mariana Kruger","doi":"10.1155/carm/2454588","DOIUrl":"10.1155/carm/2454588","url":null,"abstract":"<p><p>Wilms' tumor (nephroblastoma) is among the most common childhood cancers in the Democratic Republic of Congo and other African countries. However, its association with sickle cell disease is rarely reported in the literature. We present a case of nephroblastoma associated with sickle cell disease. The management of such a case requires a multidisciplinary team in a specialized center. The combination of surgery with pre- and postoperative chemotherapy leads to excellent curative rates. Renal histology after nephrectomy provides the diagnosis and defines the tumor type. Multiple mutations leading to cancers in humans may explain the coexistence of these two genetic diseases with affected genes found in the same chromosome. Further research to provide a molecular genetic explanation of such comorbidity is recommended.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"2454588"},"PeriodicalIF":0.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12473983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon Presentation of Lepromatous Leprosy in a Nonendemic Setting: A Case Report.","authors":"Mhdia Elhadi Osman, Tareq Nafea Alharby, Yasser Alhabeeb, Ayman Elshenawy, Hala Ghazi Alreshidi, Saja Saleem Saja Saleem Alhayeti, Areej Alhumaidi Alshammari","doi":"10.1155/carm/8232445","DOIUrl":"10.1155/carm/8232445","url":null,"abstract":"<p><p>Leprosy, caused by <i>Mycobacterium leprae</i>, remains a significant public health concern in certain endemic regions, but it is rarely encountered in nonendemic areas, posing diagnostic challenges. This case report discusses an unusual presentation of lepromatous leprosy in a patient residing in Saudi Arabia with no history of travel to endemic regions. The patient's clinical features were atypical, lacking the classic neurological involvement and sensation loss commonly associated with leprosy. Definitive diagnosis was achieved through histopathological examination revealing diffuse histiocytic infiltrates, a grenz zone, and acid-fast bacilli confirmed by modified Ziehl-Neelsen staining. The patient responded well to multidrug therapy according to WHO guidelines. This case highlights the importance of maintaining high clinical suspicion, utilizing appropriate diagnostic techniques, and understanding the epidemiological complexities of leprosy in low-prevalence settings. Strengthening awareness and surveillance is essential to prevent underdiagnosis and curb transmission in nonendemic regions.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"8232445"},"PeriodicalIF":0.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}