Burns & Trauma最新文献

{"title":"Mitochondrion-targeted therapies for diabetic wound healing: from mechanism to therapeutic opportunity","authors":"Qipeng Wu, Fei Xiao, Han Wang, Yuan Xiong, Bobin Mi","doi":"10.1093/burnst/tkag018","DOIUrl":"https://doi.org/10.1093/burnst/tkag018","url":null,"abstract":"Diabetic wounds are a major clinical challenge. They are driven by persistent hyperglycemia and chronic inflammation that synergistically disrupt mitochondrial homeostasis, manifesting as impaired bioenergetics, excessive reactive oxygen species (ROS) accumulation, and dysregulated mitochondrial quality control. Mitochondrial dysfunction critically undermines cellular proliferation, angiogenesis, and immunomodulation, which are essential for effective tissue repair. Intercellular mitochondrial transfer, mediated through tunneling nanotubes (TNTs), extracellular vesicles (EVs), gap junctions (GJs) and cell fusion, has recently emerged as a biologically compelling endogenous rescue mechanism capable of restoring bioenergetic capacity and redox homeostasis in metabolically compromised recipient cells. In this review, we systematically examine the mechanistic basis of mitochondrial dysfunction in the diabetic wound microenvironment, critically evaluate the therapeutic potential of intercellular mitochondrial transfer, and propose an integrated mechanism-to-translational framework coupling transfer-based strategies with bioresponsive and mitochondrion-targeted biomaterials tailored to the pathological wound milieu. Furthermore, we identify key translational barriers—including insufficient protocol standardization, the absence of robust characterization criteria, and a lack of quantitative benchmarks for transfer efficacy—that must be addressed to advance these strategies toward clinical application, thereby offering a conceptual foundation and translational roadmap for mitochondrion-centered regenerative approaches in diabetic wound care.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"32 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147329674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Research on Predicting Skin Flaps Necrosis through Quantification of the USP4/TNFAIP2 Regulated “M1 Macrophages-Tregs Axis” via Skin Barrier Monitoring Technology","authors":"Xuanlong Zhang, Xiaoqiong Jiang, Shenjie Song, Kaiyi Du, Hongxin Wang, Zihan Zhang, Yu Wang, Xiangwei Ling, Qingfeng Li","doi":"10.1093/burnst/tkag016","DOIUrl":"https://doi.org/10.1093/burnst/tkag016","url":null,"abstract":"Background Current methods used for assessing random-pattern skin flaps (RPSFs) viability are invasive and subjective. Therefore, developing an more accurate and non-invasive strategy for predicting RPSFs prognosis is important. This study discovered that skin barrier monitoring technology could predict RPSFs necrosis. In addition, the underlying mechanism was also clarified in this study. Methods Gene ontology (GO) analysis was employed to identify the potential pathways associated with RPSFs necrosis. Skin barrier monitoring technology, immunohistochemistry (IHC), immunofluorescence (IF) and western blotting (WB) were employed to assess skin barrier integrity, quantify ferroptosis level, and evaluate the recruitment of M1 macrophages and regulatory T cells (Tregs). Clinical samples were also included to validate the accuracy and efficacy of skin barrier monitoring technology in predicting RPSFs necrosis. Results The necrotic process in RPSFs was characterized by increased infiltration of M1 macrophages and Tregs, accompanied by activated ferroptosis and dysfunction of skin barrier. Notably, Tregs infiltration significantly reduced the necrotic area and restored skin barrier integrity of RPSFs by inhibiting ferroptosis and polarization of M1 macrophages. Mechanistically, USP4 regulated the interaction of M1 macrophages and Tregs (M1 macrophages-Tregs axis) via stabilization of TNFAIP2. Analysis of clinical samples revealed that skin barrier monitoring technology could serve as predictive strategy for RPSFs necrosis. Conclusion This study demonstrated that the USP4/TNFAIP2 pathway would regulate skin barrier function and ferroptosis via “M1 macrophages-Tregs axis” in RPSFs. And the skin barrier monitoring technology could serve as reliable method for RPSFs necrosis prediction.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"68 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147292666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal Decoding of Skin Biology: Development, Aging, Disease, and Regeneration","authors":"Xinran Ding, Runzhi Huang, Yixu Li, Zhaofan Xia, Shizhao Ji","doi":"10.1093/burnst/tkag019","DOIUrl":"https://doi.org/10.1093/burnst/tkag019","url":null,"abstract":"Skin shows distinct temporal dynamics and spatial heterogeneity during development, aging, disease, and regeneration. Although single-cell sequencing has revealed cellular diversity, its lack of spatial context limits the ability to characterize cells within their native tissue microenvironment. Factors such as acute injury and chronic wounds spatiotemporally disrupt skin homeostasis and induce complex remodeling and functional changes. Understanding these dynamic processes with spatiotemporal resolution remains a challenge in skin biology. Recent advances in spatiotemporal omics make it possible to integrate single-cell sequencing, spatial omics, and time series analyses, allowing the preservation of in situ cellular positions and revealing gene expression dynamics and intercellular networks. These technologies have reshaped the understanding of skin development and wound healing and have promoted advances in precision medicine and regenerative therapies. In this review, the applications of, recent advances in, and clinical translation potential of spatiotemporal omics in skin research are summarized. The construction of a high-resolution, spatiotemporal cellular atlas across the human skin life cycle will help identify key biomarkers, optimize regenerative strategies, and support personalized therapies.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"113 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147314855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoid research: new concepts and new technologies","authors":"Jin Zhang, Yuezhou Wu, Tianzhuo Shen, Yingrui Mao, Hongjing Dou, Yi Lin, Zhen Geng, Zhanghua Li, Jiacan Su","doi":"10.1093/burnst/tkag015","DOIUrl":"https://doi.org/10.1093/burnst/tkag015","url":null,"abstract":"As three-dimensional biomimetic systems developed from stem cells or somatic cells, organoids have gradually evolved into important links between basic research and clinical application. Compared with traditional two-dimensional culture and animal models, organoids can better reflect the structure and function of tissues and organs in terms of physiological relevance and prediction efficiency. This review explores the integration of organoid technology with microfluidic technology, gene editing, and artificial intelligence, focusing on the prospects of these technologies for application in precision medicine, disease modelling, drug screening, and toxicology. In addition, the latest progress in organoid research, including organ-on-a-chip, organoid biobank construction, and related applications of regenerative medicine, is summarized. The development of key technologies is reviewed in detail. These technologies include improvements in culture systems, innovations in microfluidic and matrix materials, gene editing and modification, and imaging and multiomic analyses. These achievements improve the application value of organoids in disease modelling, drug screening and toxicology. Despite challenges such as standardization, batch-to-batch consistency, and clinical translation, the integration of interdisciplinary technologies has provided a new impetus for the development of organoids. In the future, the combination of organoids with artificial intelligence, personalized medicine and regenerative medicine is expected to drive research progress on disease mechanisms and precision treatment.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"35 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146205099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Luminol-conjugated cyclodextrin biological nanoparticles for the treatment of severe burn-induced intestinal barrier disruption.","authors":"","doi":"10.1093/burnst/tkag014","DOIUrl":"https://doi.org/10.1093/burnst/tkag014","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/burnst/tkad054.].</p>","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"14 ","pages":"tkag014"},"PeriodicalIF":9.6,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12903945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin promotes skin flap survival by inhibiting ferroptosis","authors":"Mi Liu, Jiacheng Hu, Jiayi Huang, Zhefeng Cai, Peng Zou, Jing Bu, Shanshan Yu, Yuxi Zhou, Xiaoqiong Jiang, Lianfang Gan, Shuhong Tian, Lei Dong, Fenzan Wu, Huiming Deng, Jian Xiao","doi":"10.1093/burnst/tkag012","DOIUrl":"https://doi.org/10.1093/burnst/tkag012","url":null,"abstract":"Background Random skin flaps application is considerably limited by postoperative complications, particularly distal tissue ischemia and necrosis. Melatonin, a molecule with well-documented antioxidant and cytoprotective properties, has shown promise in protecting ischemic tissues. However, its specific role in regulating ferroptosis during ischemic flap injury, as well as its safety and efficacy in primate models (a key step for clinical translation), remains to be systematically validated. In this study, we aimed to promote angiogenesis within flap tissue through exogenous melatonin administration, and to inhibit ferroptosis to mitigate ischemia-reperfusion injury, presenting a novel strategy for enhancing flap survival rates. Methods A random skin flap was constructed in C57BL/6J mice. After melatonin treatment for seven days, the influence of melatonin on the levels of oxidative stress, iron accumulation, and mitochondrial morphology within the skin flap tissue were assessed. We used Transwell migration assays, tube formation assays, flow cytometry and immunofluorescence staining to determine the effects of melatonin in vitro. The ferroptosis inducer erastin was used in combination with melatonin to treat random skin flap mice and Tert-butyl hydroperoxide (TBHP) induced cellular models, And the pathway through which melatonin counteracts iron mutations was explored. Lastly, we conducted experiments using nonhuman primate (NHP) models and analyzed the protective effects of melatonin on ischemic flaps in macaques, highlighting its potential for clinical translation. Results Melatonin ameliorated the survival area of ischemic flaps in mice, enhanced angiogenesis, reduced mitochondrial damage, and also suppressed lipid peroxidation and iron ion accumulation. Melatonin attenuated TBPH-induced cell death, lipid peroxidation, and mitochondrial damage in vitro. Further mechanistic studies revealed that melatonin inhibited ferroptosis, accompanied by nuclear translocation of nuclear factor E2-related factor 2 (Nrf2), and increases the expression of downstream gene (effector) heme oxygenase-1 (HO-1). More importantly, experiments in macaques demonstrated that melatonin could enhance flap viability and angiogenesis, and exhibited good safety profile. Conclusion Melatonin enhanced flap viability in mice and macaques by inhibiting ferroptosis, boosting angiogenesis, and attenuating oxidative stress injury.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"41 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel method for targeting lymphatic vessel imaging: methylene blue nanoparticle integrated with dissolvable microneedles","authors":"Chengyao Han, Beibei Wu, Chunxiao Cui, Peiru Min, Xinxian Meng, Yuhao Sun, Ke Wen, Chuanliang Feng, Yixin Zhang, Xueqian Wang, Ke Li","doi":"10.1093/burnst/tkaf067","DOIUrl":"https://doi.org/10.1093/burnst/tkaf067","url":null,"abstract":"The lymphatic system serves many more functions than simply in maintaining tissue fluid homeostasis, and its structural and functional changes indicate the occurrence of disease. Current clinical methods for the assessment of the lymphatic system, however, are severely limited because of their nontargeting ability, invasiveness, high cost, and radiation risk. Herein, we propose a simple and painless method for visualizing and quantifying the lymphatic system. This method is based on the noninvasive administration of a novel lymphatic tracer via dissolvable microneedles (MNs), followed by the application of a portable detection device for near-infrared (NIR) imaging. The tracer is prepared by incorporating the clinically approved NIR fluorescent dye methylene blue (ME) into nanomaterials (MPEG-PCL@ME). This novel tracer displays superior fluorescence properties, stability, biocompatibility, and targeting features in comparison with ME solution alone. Lymphography with MPEG-PCL@ME in vivo clearly revealed the lymphatic vessel morphology. Notably, compared with ME and ICG, MPEG-PCL@ME can easily identify the dominant lymphatic vessels and nodes in rats with higher imaging quality. Furthermore, a series of segmental contracting sections are detected with MPEG-PCL@ME, allowing straightforward identification of the lymphatic pump, which provides direct evidence for exquisitely evaluating lymphatic functions.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"38 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional nanofibrous membranes enhance diabetic wound healing by inhibiting endothelial pyroptosis and regulating macrophage polarization.","authors":"Shuang Deng, Ting Ying, Xu Zhang, Farnaz Ghorbani, Wen Luo, Chengqing Yi, Dejian Li","doi":"10.1093/burnst/tkag005","DOIUrl":"10.1093/burnst/tkag005","url":null,"abstract":"<p><strong>Background: </strong>Persistent oxidative stress and aberrant inflammatory responses are major contributors to delayed wound healing in diabetic patients. Endothelial cell pyroptosis, a form of inflammatory programmed cell death, plays a critical role in vascular dysfunction and impaired tissue regeneration in diabetic wounds. Targeting endothelial pyroptosis therefore represents a promising therapeutic strategy. This study aims to develop a multifunctional nanofibrous scaffold capable of suppressing oxidative stress-induced endothelial pyroptosis while modulating the inflammatory microenvironment to promote angiogenesis and diabetic wound repair.</p><p><strong>Methods: </strong>In this study, a pH-responsive nanoplatform based on zinc-imidazolate metal-organic frameworks (ZIF-8) was constructed for the controlled delivery of luteolin (Lut), a natural flavonoid with anti-inflammatory and antioxidant properties. The physicochemical characteristics, drug-loading efficiency, and pH-responsive release behavior of Lut@ZIF-8 nanoparticles were systematically evaluated. The effects of Lut@ZIF-8 on oxidative stress, endothelial pyroptosis, and angiogenic function were investigated <i>in vitro</i>, while therapeutic efficacy was further assessed in a diabetic mouse wound model using Lut@ZIF-8-loaded fibrous scaffolds.</p><p><strong>Results: </strong>Lut@ZIF-8 nanoparticles exhibited uniform morphology, high drug-loading efficiency, and sustained drug release under mildly acidic conditions mimicking the diabetic wound microenvironment. <i>In vitro</i>, Lut@ZIF-8 effectively suppressed reactive oxygen species accumulation and inhibited endothelial cell pyroptosis by downregulating the activation of NLRP3 inflammasome components, including caspase-1 and GSDMD, thereby preserving endothelial barrier integrity and angiogenic capacity. <i>In vivo</i>, Lut@ZIF-8-loaded scaffolds significantly reduced inflammatory cytokine expression, enhanced collagen deposition, promoted neovascularization and re-epithelialization, and ultimately accelerated wound closure in diabetic mice.</p><p><strong>Conclusions: </strong>The pH-responsive Lut@ZIF-8 nanoplatform effectively modulates oxidative stress and endothelial cell pyroptosis in diabetic wounds, thereby promoting angiogenesis and tissue regeneration. This strategy provides a promising and innovative therapeutic approach for the treatment of chronic diabetic wounds.</p>","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"14 ","pages":"tkag005"},"PeriodicalIF":9.6,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Saccharomyces boulardii</i> in patients with severe acute pancreatitis: a single center, open-label randomized controlled trial.","authors":"Jia-Lin He, Lei Ran, Xu Xiao, Yu Su, Hui Lin, Cheng Lu, Bo Tang, Shiming Yang","doi":"10.1093/burnst/tkag006","DOIUrl":"https://doi.org/10.1093/burnst/tkag006","url":null,"abstract":"<p><strong>Background: </strong>Nosocomial infections in patients with severe acute pancreatitis (SAP) are frequently driven by impaired intestinal barrier function, which facilitates bacterial translocation and contributes to adverse clinical outcomes. <i>Saccharomyces boulardii</i> (<i>S. boulardii</i>) can reconstitute gut microbiota composition. We investigated whether <i>S. boulardii</i> combined with enteral nutrition (EN) affects the microbiome and nosocomial infections in SAP.</p><p><strong>Methods: </strong>This study is a single centre, open-label randomized controlled trial. We included 50 patients with SAP in a Chinese gastroenterology intensive care unit (ICU), randomized to Probiotic group (<i>S. boulardii</i> and EN) or the Control group (EN). Throat/oropharyngeal and rectal swabs were collected from patients with SAP on days 0, 1, 3, 6, 9, 12, and 15 of ICU admission. The primary endpoints were nosocomial infection and fungemia, whereas the secondary endpoints were ICU mortality, 28-day mortality, ICU stay, and length of hospital stay. All samples were subjected to full-length 16 s rRNA and internal transcribed spacer (ITS) sequencing. Multivariate analysis was performed using normalized microbial and corresponding clinical data.</p><p><strong>Results: </strong>After data processing, 213 16S rRNA and 120 ITS samples were analysed. <i>S. boulardii</i> prevented nosocomial infections (0/27 in the Probiotic group <i>vs</i> 5/23 in the Control group; <i>P</i> < 0.05). Intestinal fungi were closely associated with nosocomial infections. Bioinformatic analysis showed that <i>S. boulardii</i> prevented nosocomial infections by reducing intestinal bacterial perturbation and inhibiting the proliferation of <i>Enterococcus</i> in the intestine, and <i>Candida</i> in the respiratory tract and intestines.</p><p><strong>Conclusions: </strong><i>S. boulardii</i> in patients with SAP may positively alter the respiratory and intestinal microbiome and decrease the incidence of nosocomial infections.</p><p><strong>Trial registration: </strong>This study was approved by the Ethics Committee of Xinqiao Hospital, Army Medical University, Chongqing China (2021-yd030-01), which was retrospectively registered at the Chinese Clinical Trial Registry (ChiCTR2200056011, Date of Registration: 30/01/2022 https://www.chictr.org.cn/showproj.html?proj=151215).</p>","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"14 ","pages":"tkag006"},"PeriodicalIF":9.6,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA Modifications: Molecular Orchestrators of Wound Healing","authors":"Xiuying Guo, Lele Liu, Junqi Yang, Yuhe Dai, Qianbo Zhang, Rifang Gu, Min Tan, Ming Tang, Xuqiang Nie","doi":"10.1093/burnst/tkag010","DOIUrl":"https://doi.org/10.1093/burnst/tkag010","url":null,"abstract":"Wound healing is a highly coordinated biological process traditionally divided into three phases: Inflammatory, proliferative, and remodeling. Diabetes and acute trauma markedly disrupt these stages, resulting in delayed wound closure, persistent inflammation, and impaired tissue regeneration. This review focuses on three trauma-relevant contexts: (i) Skin wounds, including diabetic ulcers and burns; (ii) bone fracture healing; (iii) corneal epithelial and stromal injury. Robust in vivo evidence is synthesized to delineate the mechanistic roles of the four principal RNA modifications: N6-methyladenosine, 5-methylcytosine, N7-methylguanosine, and N4-acetylcytidine. Additionally, the roles of RNA modification writers, erasers, and readers in regulating macrophage polarization, stem and progenitor cell fate, angiogenesis, lymphangiogenesis, and extracellular matrix remodeling are examined. Evidence across different tissues and wound healing phases is integrated rather than presented descriptively. Methodological limitations are highlighted, and knowledge gaps are identified alongside testable hypotheses. Translational opportunities with direct relevance to burn and trauma management are emphasized. This review aims to integrate mechanistic and translational insights into a coherent framework for therapeutic intervention. By defining how RNA modifications intersect with distinct wound healing phases, concrete therapeutic entry points and delivery strategies relevant to burns and trauma are identified, including topical hydrogels, exosome-based therapies, and bone-targeted nanoparticles. Designs for pragmatic clinical trials and biomarker strategies that enable translation of preclinical findings to patients are also discussed.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"50 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145972469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}