Review on electrical stimulation combined with electroactive biomaterials to promote peripheral nerve regeneration

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2025-05-31 DOI:10.1093/burnst/tkaf039

Jiahui Song, Zhengchao Yuan, Xiao Yu, Yihong Shen, Jinglei Wu, Binbin Sun, Cheng Xue Qin, Mohamed EL-Newehy, Xiumei Mo, Hongbing Gu

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Abstract

Peripheral nerve injury (PNI) results in sensory and motor dysfunction, which is an enormous economic burden for patients and society. Complete recovery of peripheral nerve function after injury is complicated. Utilizing the electrophysiological properties of natural nerves for neuronal regulation and axon regeneration has attracted considerable interest. Electroactive biomaterials induce an active state of electrical stimulation (ES) at the site of peripheral nerve injury when incorporated into nerve guidance channels (NGCs). Numerous studies have demonstrated that combining ES with electroactive biomaterials can enhance peripheral nerve repair. This review summarizes the regulation of signal pathways by ES and the functions of various electroactive biomaterials, including metals, carbon-based materials, conductive polymers and piezoelectric materials. Recent advances and research of ES combined with electroactive biomaterials in peripheral nerve repair are reviewed, which may help to come up with more effective strategies to restore neural function after PNI.

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电刺激联合电活性生物材料促进周围神经再生的研究进展

周围神经损伤（PNI）导致感觉和运动功能障碍，给患者和社会带来了巨大的经济负担。损伤后周围神经功能的完全恢复是复杂的。利用自然神经的电生理特性进行神经元调节和轴突再生已经引起了人们的广泛关注。电活性生物材料掺入神经引导通道（NGCs）后，可在周围神经损伤部位诱发活跃的电刺激（ES）状态。大量研究表明，ES与电活性生物材料相结合可以增强周围神经的修复。本文综述了ES对信号通路的调控以及各种电活性生物材料的功能，包括金属、碳基材料、导电聚合物和压电材料。本文综述了电活性生物材料联合ES在周围神经修复中的最新研究进展，以期为PNI术后神经功能的恢复提供更有效的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.