Burns & Trauma最新文献

{"title":"Hydrogen-Associated CXCL2 Drives Adaptive Inflammatory-to-Proliferative State Transition during Skin Wound Healing","authors":"Jiajun Tan, Chuqing Zhou, Zeming Li, Yan Qu, Ke Li, Fuqiang Chen, Yuwen Ding, Huan Ren, Fanrun Zeng, Xun Zhou, Rixing Zhan, Mingxing Lei","doi":"10.1093/burnst/tkag072","DOIUrl":"https://doi.org/10.1093/burnst/tkag072","url":null,"abstract":"Background Wound healing is an environmentally adaptive process. It requires a tightly coordinated transition from an inflammatory to a proliferative state, which occurs in response to oxidative and inflammatory stress. Molecular hydrogen (H2) is a widely recognized medical gas, and it alleviates oxidative stress and selectively eliminates highly cytotoxic reactive oxygen species. However, it remains unclear whether redox-active gases such as H2 can actively orchestrate tissue state transitions, rather than merely mitigating oxidative damage. Methods Bulk RNA sequencing, single-cell RNA sequencing, and spatial transcriptomic analyses were integrated to investigate the cellular and molecular mechanisms underlying H2-mediated wound healing. Functional studies were performed in hydrogen-mediated mouse skin injury models and in self-assembled skin organoid models. Immunofluorescence staining, Masson’s trichrome staining, and qRT-PCR were used to validate key signaling pathways and assess tissue regeneration, angiogenesis, and wound healing outcomes. Results H2 significantly accelerated wound healing, especially during the proliferative phase, where it acted as a critical regulator of the inflammatory-to-proliferative transition. Multi-omics analyses identified a hydrogen-associated macrophage program and revealed a CXCL2-ACKR1 signaling axis mediating macrophage-endothelial communication. Functional validation confirmed that activation of this axis promoted endothelial migration, angiogenesis, and granulation tissue formation. As a result, the transition from inflammation to proliferation was facilitated, and wound closure was accelerated. Conclusions H2 spatiotemporally coordinates adaptive wound healing by regulating a macrophage-endothelial CXCL2-ACKR1 signaling axis that drives the inflammatory-to-proliferative transition. These findings provide mechanistic insight into how H2 spatiotemporally coordinates adaptive wound healing and highlight the potential of hydrogen-mediated redox modulation as a mechanism for regulating tissue repair.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"27 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ETFDH Alkylation Drives Nitrogen Mustard-Induced Keratinocyte Pyroptosis","authors":"Yin Gong, Jiayi Ying, Mo Li, Anying Wei, Zhipeng Pei, Shanshan Zhang, Xiali Suo, Xiaobao Ruan, Xiaodan Chong, Mingxue Sun, Wen-Qi Meng","doi":"10.1093/burnst/tkag069","DOIUrl":"https://doi.org/10.1093/burnst/tkag069","url":null,"abstract":"Background Nitrogen mustard (HN2) is a bifunctional alkylating vesicant that produces blistering and ulcerative skin lesions, yet the molecular events responsible for this tissue damage remain incompletely defined. This study aimed to identify the direct protein targets of HN2 in human skin and elucidate how target alkylation affects mitochondrial function and thereby causes skin injury. Methods An activity based probe, HNP-1, was designed for fluorescence imaging and chemical proteomic target mapping. Biochemical assays and site-directed mutagenesis were employed to confirm HN2 binding to electron-transferring flavoprotein dehydrogenase (ETFDH) and to identify the modified residue. Additionally, transcriptomic profiling and a murine cutaneous injury model were used to characterize downstream events and evaluate the effects of vitamin B2 (VB2). Results HNP-1 enabled direct visualization of HN2-derived labeling in skin cells and tissues and showed that the signal was predominantly extranuclear. Unbiased proteomic analysis then identified ETFDH as a high-affinity mitochondrial target. HN2 alkylated ETFDH at His112, impairing its interaction with ubiquinol–cytochrome c reductase core protein 2 (UQCRC2) and triggering mitochondrial oxidative stress, voltage-dependent anion channel 1 (VDAC1) oligomerization, and mitochondrial DNA (mtDNA) release. These events promoted cGAS-STING signaling and pyroptosis, whereas the H112A substitution blunted the response. Intraperitoneal VB2 administration restored the epidermal flavin adenine dinucleotide (FAD) level and attenuated HN2-induced skin injury in mice. Conclusions These findings link ETFDH alkylation to pyroptotic signaling in acute HN2 skin injury and show that VB2 mitigates skin damage in severely exposed mice.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"160 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Photothermal and Cuproptosis-like Death Dual-Therapeutic Copper-Phenolic Hydrogel for Infected Wound Healing","authors":"Desheng Cai, Kairu Che, Qing Zhang, Haoyang Xia, Ruyue Zhang, Xiaoxia Yang, Siyu Zhang, Dejiu Tan, Maria Mar Pérez-Madrigal, Yuqin Yang, Yunlong Yu, Jiayu Zhang","doi":"10.1093/burnst/tkag067","DOIUrl":"https://doi.org/10.1093/burnst/tkag067","url":null,"abstract":"Background Chronic wound healing remains challenging due to persistent inflammation, especially caused by methicillin-resistant Staphylococcus aureus (MRSA) and hindered tissue regeneration. Methods To resolve this issue, we developed a multifunctional hydrogel (CMCS/PA@Cu) via Schiff base and metal coordination bonds crosslinking between carboxymethyl chitosan (CMCS) and protocatechualdehyde-copper complexes (PA@Cu). The hydrogel can combine the delivery of copper ions (Cu2+) with photothermal therapy. Meanwhile, it endows the material with remarkable self-repairing properties, injectability, and sufficient tissue adhesion, thereby overcoming the limitations of CMCS hydrogels. Results More importantly, when exposed to 808 nm NIR irradiation (0.77 W/cm2), the instantaneous local temperature (47°C) synergistically interacts with Cu2+-triggered cuproptosis-like death. Transcriptomic data show that the excessive Cu2+ accumulation damages the tricarboxylic acid (TCA) cycle as well as respiratory chain of the bacteria, leading to metabolic breakdown and energy exhaustion, thereby effectively avoiding antibiotic resistance. In addition to direct antibacterial effect, the CMCS/PA@Cu hydrogel also actively reshapes the immune microenvironment of host wound. At the mechanism level, the hydrogel causes macrophages to transform into the pro-repair M2 phenotype. The phenotypic change is accompanied by the simultaneous upregulation of transcriptional programs that regulate glycolysis and oxidative metabolism. Moreover, the hydrogel can stimulate angiogenesis and enhance collagen synthesis. In vivo, this hydrogel markedly accelerates the closure of MRSA-infected wounds, reduces inflammation, and promotes orderly tissue regeneration. Conclusions Overall, this interlinked system offers a remarkable non-antibiotic strategy that enables spatially and temporally controllable treatment for complex wound care.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"42 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149150261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prussian blue nanozyme-reinforced dynamic hydrogel reprograms the oxidative microenvironment for functional skeletal muscle regeneration","authors":"Jia Sha, Shanbang Zhu, Wenshuang Sun, Hui Jiang, Zhao Tang, Tao Yuan, Shiwen Shen, Hong Qian, Nirong Bao, Zhiwen Luo, Jia Meng, Xiaojiang Yang","doi":"10.1093/burnst/tkag068","DOIUrl":"https://doi.org/10.1093/burnst/tkag068","url":null,"abstract":"Background Volumetric muscle loss (VML) leads to irreversible disability driven by extensive tissue loss and a hostile microenvironment with excessive reactive oxygen species (ROS), persistent pro-inflammatory macrophages, and fibrosis. This study aimed to develop a Prussian blue nanozyme-reinforced dynamic GelMA hydrogel capable of modulating the pathological microenvironment and promoting muscle regeneration and functional recovery after VML. Methods We engineered a photocurable, dynamic nanozyme hydrogel (GelMA-PPB; GelMA/PBA-MA/PVA/Prussian Blue) by integrating GelMA photopolymerization with a reversible boronate ester network (PBA-MA/PVA) and Prussian Blue nanozymes. Hydrogel properties were characterized. C2C12 assays evaluated cytocompatibility, migration, intracellular ROS (DCFH-DA), and myogenic differentiation (MyHC). RAW264.7 assays assessed macrophage polarization (M1/M2 markers) and cytokines (IL-6/IL-10). Efficacy was tested in a murine tibialis anterior VML model using histology, immunofluorescence, CatWalk gait analysis, and major-organ biosafety. Results GelMA-PPB formed a porous 3D scaffold with favorable swelling/degradation and good cytocompatibility. It reduced intracellular ROS, enhanced myoblast migration and differentiation, and shifted macrophages toward a pro-regenerative M2 phenotype with decreased IL-6 and increased IL-10. In vivo, GelMA-PPB attenuated inflammation and fibrosis, promoted endogenous myogenesis and fiber maturation, improved gait-related functional parameters, and showed no obvious systemic toxicity. Conclusions GelMA-PPB reprograms the oxidative–inflammatory niche to enable structural and functional recovery after VML. The Translational Potential of this Article GelMA-PPB is an injectable, in situ photocurable hydrogel designed for defect-conformal VML filling while actively suppressing ROS-driven inflammation and fibrosis to enhance functional recovery. This off-the-shelf platform may complement or reduce reliance on muscle flap transfer and is amenable to future scale-up and integration with pro-regenerative cues.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"9 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149150262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of PL-5 Topical Spray for Burn Wound Infections: A Multicenter, Randomized, Double-Blind, Placebo-controlled, Phase IIIb Clinical Trial","authors":"Yating Wei,Guangtao Huang,Yaohua Zhao,Junci Xu,Guozhong Lv,Xiaojian Li,Haitao Wang,Wenjun Liu,Chengde Xia,Zhaohua Wang,Youfen Fan,Xiaodong Chen,Yi Li,Tianyu Li,Shijie Tang,Chang Liu,Jiajin Tu,Junlin Xiong,Luo Gaoxing,Yi Zhang,Jian Wu,Xingang Wang,Hongliang Yu,Ronghua Yang,Meishu Zhu,Hu Dong,Yuxin Chen,Jun Wu","doi":"10.1093/burnst/tkag064","DOIUrl":"https://doi.org/10.1093/burnst/tkag064","url":null,"abstract":"Abstract Background Burn wound infections pose a significant global health burden. Antimicrobial peptides PL-5 spray is a novel topical antimicrobial agent for wound infections with superior clinical efficacy compared to positive drug in previous phase II and phase IIIa clinical studies. This phase IIIb clinical trial was conducted to further evaluate the efficacy and safety of PL-5 topical spray in treating burn wound infections. Methods A multicenter, randomized, double-blind, placebo-controlled trial was conducted across 23 centers in China. Eligible patients aged 18–65 with infected burn wounds were randomized in a 2:1 ratio to receive either PL-5 spray or placebo once daily for 14 days. The primary outcome was the complete healing rate on day 15 (D15). Secondary outcomes included clinical, microbiological, comprehensive efficacy evaluations and safety assessments. Results A total of 348 patients were randomized, with 232 receiving PL-5 and 116 receiving placebo. The complete wound healing rate on D15 was higher in the PL-5 group (64.3%) compared to the placebo group (43.1%) (P = 0.0002). The PL-5 group also showed superior microbiological efficacy on D15 (72.3% vs. 50.5%, P = 0.0001) and comprehensive efficacy (63.1% vs. 41.9%, P = 0.0003). No differences were observed in adverse events between groups, and no systemic absorption of PL-5 was detected. Conclusions PL-5 topical spray is effective in promoting wound healing and reducing bacterial load in burn wound infections, with a favourable safety profile. These findings support the potential of PL-5 as an effective alternative to traditional antibiotics in managing burn wound infections. Trial Registration ChiCTR2300071255.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"20 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced engineering strategies in human organoids for tissue repair and regeneration","authors":"Hao Zhang,Nengjie Yang,Yuqi Wu,Siyu Chen,Ya Wen,Yujuan Zhu,Xiaodong Chen","doi":"10.1093/burnst/tkag065","DOIUrl":"https://doi.org/10.1093/burnst/tkag065","url":null,"abstract":"Abstract Tissue damage and functional disorders due to diseases or trauma can lead to irreversible organ failure. Conventional treatment strategies such as organ transplantation or stem cell therapy are often limited by immune rejection, donor shortages and poor regenerative effects. Organoids, 3D miniature tissues derived from stem cells, can provide a promising approach for tissue repair and regeneration by recapitulating the complex structure and functional properties of native organs with high plasticity, scalability and physiological relevance. In this review, we present novel engineering approaches to human organoids such as generation, optimization and translational applications for tissue repair. We then introduce core technologies including organoid-on-chip, hydrogels and 3D bioprinting, which collectively address the challenges such as tissue immaturity, inadequate vascularization and poor host integration. We also discuss applications of engineered organoids to repair multiple tissues (e.g. heart, lung, brain, bone and skin) and summarize recent advances in preclinical models and their potential clinical translational applications. Finally, we discuss key challenges for organoid-based therapy including functional maturation, integration with vascular, neural, and immune systems, complexity of reproducing native biomechanical environments, ethical concerns, as well as possible solutions and directions for their application in regenerative medicine.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"27 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassembling Adipose Tissue Complexity for Next-Generation Tissue Regeneration","authors":"Rui Zhao, Lingling Sheng, Xingran Liu, Yan Zeng, Qingfeng Li, Ru-Lin Huang","doi":"10.1093/burnst/tkag066","DOIUrl":"https://doi.org/10.1093/burnst/tkag066","url":null,"abstract":"Repair of complex soft-tissue injury often requires more than volume replacement; it depends on coordinated restoration of vascular supply, matrix organization, immune balance, and tissue structure. Adipose tissue contains living cells, extracellular matrix, and local signals that may contribute to these processes. This review uses a deconstruction–reassembly framework that traces the evolution of adipose-based therapy from a vascularization-dependent living graft to fragmented derivatives, cellular products, acellular signals, and biofabrication substrates. Deconstruction separates selected components and can make delivery more flexible, but it also breaks native tissue organization. Reassembly is achieved through the preservation of existing relationships within tissue units or the reconstruction of relationships lost during processing. Neither greater complexity nor a position on this continuum establishes therapeutic superiority, standardization, or clinical maturity. Established grafts, investigational derivatives, and preclinical constructs differ in the strength and clinical relevance of the supporting evidence. We propose that product choice should start with the function that is missing at the recipient site and the main barrier to repair, such as ischemia, fibrosis, or structural loss. This complexity-matched perspective provides a translational framework for product selection and development in burns, trauma, and soft-tissue reconstruction.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"37 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RUNX1 links ATF4-associated stress adaptation to microenvironmental remodeling in POSTN+ fibroblasts during skin fibrosis","authors":"Binyu Song, Yuhan Zhu, Xiang Wang, Yige Han, Junying Song, Kai Wang, Tong Wang, Yixuan Peng, Xiaozi Liu, Zhiwei Cui, Peng Guo, Yajuan Song, Yi Shi, Zhou Yu, Baoqiang Song","doi":"10.1093/burnst/tkag063","DOIUrl":"https://doi.org/10.1093/burnst/tkag063","url":null,"abstract":"Background Skin fibrosis encompasses a spectrum of disorders and includes hypertrophic scar (HTS), keloid scar (KS), and systemic sclerosis (SSc), but the pathogenic fibroblast states and shared upstream regulators contributing to these conditions remain incompletely defined. As a common form of skin fibrosis, HTS provides a useful model for elucidating fibroblast heterogeneity and mechanism-based therapeutic vulnerability across skin fibrosis diseases. This study aimed to define the role of RUNX1 in pathogenic POSTN+ fibroblasts during skin fibrosis and to investigate the underlying stress-adaptive and microenvironment-remodeling mechanisms. Methods We performed single-cell RNA sequencing, spatial transcriptomic analysis, multiomics profiling, and cell–cell communication analysis to identify pathogenic fibroblast subpopulations and their regulatory networks in HTS. RUNX1-centered mechanisms were analyzed by CUT&Tag, RNA sequencing, rescue experiments, and functional assays, followed by in vitro and in vivo validation. High-throughput virtual screening and structural analyses were used to computationally prioritize candidate compounds predicted to bind to POSTN that are relevant to the RUNX1-high POSTN+ fibroblast state. Results The integrated analyses revealed a significantly expanded RUNX1-high POSTN+ fibroblast subpopulation in HTS and KS. RUNX1 expression was consistently elevated across human skin fibrosis diseases and experimental models of skin fibrosis. Mechanistically, RUNX1 increased the pathogenic properties of POSTN+ fibroblasts by activating ATF4 and POSTN. Through ATF4, RUNX1 increased endoplasmic reticulum stress adaptation and ferroptosis resistance, thereby supporting the ability of POSTN+ fibroblasts to remain activated under stress. Through POSTN, RUNX1 further reinforced fibroblast activation and matrix remodeling. Furthermore, RUNX1 transcriptionally activated MDK, which promoted angiogenesis-associated microenvironmental remodeling through paracrine signaling. Our computational analysis prioritized berberine (BBR) as a candidate compound predicted to bind to POSTN and BBR suppressed RUNX1/POSTN-associated stress-adaptive and profibrotic features in hypertrophic scar fibroblasts (HTSFs). In vivo validation using a bleomycin-induced skin fibrosis mouse model and a mouse scar model supported the antifibrotic potential of targeting RUNX1, and BBR reduced scar formation in a rabbit ear hypertrophic scar model, demonstrating its anti-scar therapeutic efficacy. Conclusion RUNX1 serves as a universal marker and actionable upstream regulator in skin fibrosis diseases. RUNX1-high POSTN+ fibroblasts may contribute to skin fibrosis by increasing the adaptation to ATF4-associated endoplasmic reticulum stress, ferroptosis resistance, persistent fibroblast activation, and vascular microenvironmental remodeling. BBR therefore represents a potential candidate predicted to bind to POSTN for skin fibrosis treatment.","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"53 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired Microstomia After Burns and Trauma: A Pathoanatomic Classification Based on the Dominant Restrictive Layer","authors":"Huimin Fang,Xingran Liu,Kai Liu,Qingfeng Li,Ru-Lin Huang","doi":"10.1093/burnst/tkag062","DOIUrl":"https://doi.org/10.1093/burnst/tkag062","url":null,"abstract":"","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"2 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue Light Alone Does Not Reduce\u0000 Acinetobacter baumannii\u0000 Viability: Methylene Blue Photodynamic Therapy Using a Commercial Bilirubin Phototherapy System Produces Rapid Bacterial Killing","authors":"Korry T Wirth,Rachel A George,Jenna Ahn,Martin S Pavelka,Robel T Beyene,Nicole A Wilson,Timothy M Baran","doi":"10.1093/burnst/tkag061","DOIUrl":"https://doi.org/10.1093/burnst/tkag061","url":null,"abstract":"","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"32 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}