氧化应激在烧伤创面愈合中的作用

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2025-06-11 DOI:10.1093/burnst/tkaf040

Ruiqi Chen, Hongbiao Xu, Xueshi Li, Jie Dong, Shengli Wang, Jianlei Hao, Guangping Liang

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引用次数: 0

摘要

氧化应激是烧伤创面愈合过程中固有的病理生理特征。严重烧伤会引起患者病情的快速变化，导致早期液体复苏引起的缺血再灌注损伤、神经内分泌应激和体液失衡，从而加剧氧化损伤和器官功能障碍。本文综述了氧化应激在烧伤后创面愈合中的关键作用，其引起细胞和组织损伤的潜力，以及氧化应激的机制。抗氧化治疗被推荐为一种具有成本效益的方法来调节炎症和烧伤的结果。研究成功的抗氧化治疗的预备措施，以促进烧伤患者的创面愈合。

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Role of oxidative stress in post-burn wound healing

Oxidative stress is an inherent pathophysiological feature in burn wound healing. Severe burns trigger rapid changes in patients' conditions, leading to ischemia–reperfusion injury from early fluid resuscitation, neuroendocrine stress and fluid imbalances, which exacerbate oxidative damage and organ dysfunction. This review highlights the critical role of oxidative stress in post-burn wound healing, its potential to cause cellular and tissue damage, and oxidative stress mechanisms. Antioxidant therapy is recommended as a cost-effective method of modulating inflammation and burn outcome. Preparative measures of successful antioxidant therapy should be developed in improving burn patients' wound healing.

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来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.