Cancer and Metastasis Reviews最新文献_第8页

Tissue-engineered patient-derived osteosarcoma models dissecting tumour-bone interactions. 组织工程患者衍生骨肉瘤模型剖析肿瘤与骨骼之间的相互作用。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-27 DOI: 10.1007/s10555-024-10218-2

Tina Frankenbach-Désor, Isabella Niesner, Parveen Ahmed, Hans Roland Dürr, Alexander Klein, Thomas Knösel, Jonathan Gospos, Jacqui A McGovern, Dietmar W Hutmacher, Boris M Holzapfel, Susanne Mayer-Wagner

{"title":"Tissue-engineered patient-derived osteosarcoma models dissecting tumour-bone interactions.","authors":"Tina Frankenbach-Désor, Isabella Niesner, Parveen Ahmed, Hans Roland Dürr, Alexander Klein, Thomas Knösel, Jonathan Gospos, Jacqui A McGovern, Dietmar W Hutmacher, Boris M Holzapfel, Susanne Mayer-Wagner","doi":"10.1007/s10555-024-10218-2","DOIUrl":"10.1007/s10555-024-10218-2","url":null,"abstract":"Osteosarcoma is the most common malignant bone tumor, primarily affecting children and young adults. For these young patients, the current treatment options for osteosarcoma impose considerable constraints on daily life with significant morbidity and a low survival rate. Despite ongoing research efforts, the 5-year survival rate of first-diagnosed patients without metastases has not changed in the past four decades. The demand for novel treatments is currently still unmet, in particular for effective second-line therapy. Therefore, there is an urgent need for advanced preclinical models and drug-testing platforms that take into account the complex disease characteristics, the high heterogeneity of the tumour and the interactions with the bone microenvironment. In this review, we provide a comprehensive overview about state-of-the-art tissue-engineered and patient-specific models for osteosarcoma. These sophisticated platforms for advanced therapy trials aim to improve treatment outcomes for future patients by modelling the patient's disease state in a more accurate and complex way, thus improving the quality of preclinical research studies.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"8"},"PeriodicalIF":7.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: EET signaling in cancer. 撤稿说明：癌症中的 EET 信号转导。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-26 DOI: 10.1007/s10555-024-10229-z

Dipak Panigrahy, Emily R Greene, Ambra Pozzi, Dao Wen Wang, Darryl C Zeldin

引用次数: 0

Cell-cell interactions mediating primary and metastatic breast cancer dormancy. 介导原发性和转移性乳腺癌休眠的细胞间相互作用

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-25 DOI: 10.1007/s10555-024-10223-5

Nicholas A Lenart, Shreyas S Rao

{"title":"Cell-cell interactions mediating primary and metastatic breast cancer dormancy.","authors":"Nicholas A Lenart, Shreyas S Rao","doi":"10.1007/s10555-024-10223-5","DOIUrl":"10.1007/s10555-024-10223-5","url":null,"abstract":"Breast cancer remains one of the leading causes of death in women around the world. A majority of deaths from breast cancer occur due to cancer cells colonizing distant organ sites. When colonizing these distant organ sites, breast cancer cells have been known to enter into a state of dormancy for extended periods of time. However, the mechanisms that promote dormancy as well as dormant-to-proliferative switch are not fully understood. The tumor microenvironment plays a key role in mediating cancer cell phenotype including regulation of the dormant state. In this review, we highlight cell-cell interactions in the tumor microenvironment mediating breast cancer dormancy at the primary and metastatic sites. Specifically, we describe how immune cells from the lymphoid lineage, tumor-associated myeloid lineage cells, and stromal cells of non-hematopoietic origin as well as tissue resident stromal cells impact dormancy vs. proliferation in breast cancer cells as well as the associated mechanisms. In addition, we highlight the importance of developing model systems and the associated considerations that will be critical in unraveling the mechanisms that promote primary and metastatic breast cancer dormancy mediated via cell-cell interactions.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"6"},"PeriodicalIF":7.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small cell lung cancer with liver metastases: from underlying mechanisms to treatment strategies. 肝转移的小细胞肺癌：从基本机制到治疗策略。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-25 DOI: 10.1007/s10555-024-10220-8

Linjie Fan, Yiwen Lin, Yunjie Fu, Jie Wang

{"title":"Small cell lung cancer with liver metastases: from underlying mechanisms to treatment strategies.","authors":"Linjie Fan, Yiwen Lin, Yunjie Fu, Jie Wang","doi":"10.1007/s10555-024-10220-8","DOIUrl":"10.1007/s10555-024-10220-8","url":null,"abstract":"Small cell lung cancer (SCLC) represents an aggressive neuroendocrine (NE) tumor within the pulmonary region, characterized by very poor prognoses. Druggable targets for SCLC remain limited, thereby constraining treatment options available to patients. Immuno-chemotherapy has emerged as a pivotal therapeutic strategy for extensive-stage SCLC (ES-SCLC), yet it fails to confer significant efficacy in cases involving liver metastases (LMs) originating from SCLC. Therefore, our attention is directed towards the challenging subset of SCLC patients with LMs. Disease progression of LM-SCLC patients is affected by various factors in the tumor microenvironment (TME), including immune cells, blood vessels, inflammatory mediators, metabolites, and NE substances. Beyond standard immuno-chemotherapy, ongoing efforts to manage LMs in SCLC encompass anti-angiogenic therapy, radiotherapy, microwave ablation (MWA) / radiofrequency ablation (RFA), trans-arterial chemoembolization (TACE), and systemic therapies in conjunction with local interventions. Prospective experimental and clinical investigations into SCLC should prioritize precise and individualized approaches to enhance the prognosis across distinct patient cohorts.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"5"},"PeriodicalIF":7.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaping and tumor metastasis: current insights and progress. 吸烟与肿瘤转移：当前的见解与进展。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-25 DOI: 10.1007/s10555-024-10221-7

Yibo Xi, Lei Yang, Barbara Burtness, He Wang

{"title":"Vaping and tumor metastasis: current insights and progress.","authors":"Yibo Xi, Lei Yang, Barbara Burtness, He Wang","doi":"10.1007/s10555-024-10221-7","DOIUrl":"10.1007/s10555-024-10221-7","url":null,"abstract":"Tumor metastasis is the primary cause of cancer-related mortality and remains a major hurdle in cancer treatment. Traditional cigarette smoking has been extensively studied for its role in promoting metastasis. However, the impact of e-cigarette (e-cig) on cancer metastasis is not well understood despite their increasing popularity as a supposedly safer alternative. This mini review synthesizes current literature on the effects of e-cig on cancer metastasis, focusing on the processes of dissemination, dormancy, and colonization. It also incorporates recent findings from our laboratory regarding the role of e-cig in tumor progression. E-cig exposure enhances metastatic potential through various mechanisms: it induces epithelial-mesenchymal transition (EMT), increasing cell migratory and invasive capabilities; promotes lymphangiogenesis, aiding tumor cell spread; and alters the pre-metastatic niche to support dormant tumor cells, enhancing their reactivation and colonization. Furthermore, e-cig induce significant epigenetic changes, such as DNA methylation and histone modifications, which regulate genes involved in metastasis. Our data suggest that e-cig upregulate histone demethylases like KDM6B in macrophages, impacting the TME and promoting metastasis. These findings underscore the need for further research to understand the long-term health implications of e-cig use and inform public health policies to reduce e-cig use.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"4"},"PeriodicalIF":7.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KIF18A inhibition: the next big player in the search for cancer therapeutics. KIF18A 抑制：寻找癌症疗法的下一个重要角色。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-24 DOI: 10.1007/s10555-024-10225-3

Ain Syafiza Mohd Amin, Sarah Eastwood, Courtney Pilcher, Jia Q Truong, Richard Foitzik, Joanne Boag, Kylie L Gorringe, Jessica K Holien

{"title":"KIF18A inhibition: the next big player in the search for cancer therapeutics.","authors":"Ain Syafiza Mohd Amin, Sarah Eastwood, Courtney Pilcher, Jia Q Truong, Richard Foitzik, Joanne Boag, Kylie L Gorringe, Jessica K Holien","doi":"10.1007/s10555-024-10225-3","DOIUrl":"10.1007/s10555-024-10225-3","url":null,"abstract":"Kinesin-like protein 18A (KIF18A) is a member of the kinesin family of molecular motor proteins, which utilise energy from the hydrolysis of adenosine triphosphate (ATP) to regulate critical cellular processes such as chromosome movement and microtubule dynamics. KIF18A plays a vital role in controlling microtubule length, which is crucial for maintaining proper cell function and division. Notably, increased expression levels of KIF18A have been observed in various types of cancer, indicating its potential involvement in tumour progression. Although preclinical studies have demonstrated that KIF18A is not essential for normal somatic cell division, it appears to be crucial for the survival and division of cancer cells, particularly those exhibiting chromosomal instability. This dependency makes KIF18A a promising target for developing new therapeutic strategies aimed at treating chromosomally unstable cancers. This review delves into the structural and functional aspects of KIF18A, and its role in cancer development, and evaluates current and emerging approaches to targeting KIF18A with innovative cancer treatments.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"3"},"PeriodicalIF":7.7,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A possible role of plasmin-dependent activation of TGF-β in cancer-associated thrombosis: Implications for therapy. 凝血酶依赖性激活 TGF-β 在癌症相关血栓形成中的可能作用：对治疗的启示。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-22 DOI: 10.1007/s10555-024-10222-6

Marta Smeda, Ebrahim H Maleki, Agnieszka Jasztal

{"title":"A possible role of plasmin-dependent activation of TGF-β in cancer-associated thrombosis: Implications for therapy.","authors":"Marta Smeda, Ebrahim H Maleki, Agnieszka Jasztal","doi":"10.1007/s10555-024-10222-6","DOIUrl":"10.1007/s10555-024-10222-6","url":null,"abstract":"While the prevalence of cancer-associated thrombosis (CAT) is high in cancer patients, its molecular mechanisms have not been fully elucidated. Moreover, the risks of recurrent CAT events and mortality remain high in cancer patients despite the introduction of anticoagulant/antiplatelet therapy. Here, we discuss the possibility that increased plasmin activity driven by anticoagulant/antiplatelet treatment might be the major mechanism responsible for the activation of an excess of cancer-derived transforming growth factor-beta (TGF-β) originating from cancer cells and the tumour microenvironment. Hence, high coagulation and fibrinolysis rates in cancer patients may be linked to high rates of TGF-β activation, especially the excess of TGF-β derived from cancer cells. In turn, high TGF-β activation could contribute directly to maintaining high thrombotic risk and CAT recurrence in cancer patients since TGF-β signalling increases gene expression and secretion of the fibrinolysis inhibitor plasminogen activator inhibitor 1 (PAI1). Thus, TGF-β could directly contribute to the high number of deaths among patients with cancer experiencing CAT, despite anticoagulant/antiplatelet treatment. In a longer-term perspective, increased TGF-β activation, by supporting a pro-coagulant cancer microenvironment, might also accelerate cancer progression. This review aims to discuss the published evidence that might support the scenario described above, and to put forward the hypothesis that cancer patients experiencing CAT events would largely benefit from anti-TGF-β therapy.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"2"},"PeriodicalIF":7.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bystanders or active players: the role of extra centrosomes as signaling hubs. 旁观者还是积极参与者：额外中心体作为信号枢纽的作用

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-20 DOI: 10.1007/s10555-024-10224-4

Madison M Purkerson, Sarah R Amend, Kenneth J Pienta

{"title":"Bystanders or active players: the role of extra centrosomes as signaling hubs.","authors":"Madison M Purkerson, Sarah R Amend, Kenneth J Pienta","doi":"10.1007/s10555-024-10224-4","DOIUrl":"10.1007/s10555-024-10224-4","url":null,"abstract":"Centrosomes serve as microtubule-organizing organelles that function in spindle pole organization, cell cycle progression, and cilia formation. A non-canonical role of centrosomes that has gained traction in recent years is the ability to act as signal transduction centers. Centrosome amplification, which includes numerical and structural aberrations of centrosomes, is a candidate hallmark of cancer. The function of centrosomes as signaling centers in cancer cells with centrosome amplification is poorly understood. Establishing a model of how cancer cells utilize centrosomes as signaling platforms will help elucidate the role of extra centrosomes in cancer cell survival and tumorigenesis. Centrosomes act in a diverse array of cellular processes, including cell migration, cell cycle progression, and proteasomal degradation. Given that cancer cells with amplified centrosomes exhibit an increased number and larger area of these signaling platforms, extra centrosomes may be acting to promote tumor development by enhancing signaling kinetics in pathways that are essential for the formation and growth of cancer. In this review, we identify the processes centrosomes are involved in as signal transduction platforms and highlight ways in which cancer cells with centrosome amplification may be taking advantage of these mechanisms.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"1"},"PeriodicalIF":7.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives 神经母细胞瘤中的自然杀伤细胞：免疫学见解和治疗前景

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-09-18 DOI: 10.1007/s10555-024-10212-8

Magdalena Rados, Anna Landegger, Lukas Schmutzler, Kimberlie Rabidou, Sabine Taschner-Mandl, Irfete S. Fetahu

引用次数: 0

CAR T cell therapy for pediatric central nervous system tumors: a review of the literature and current North American trials 治疗小儿中枢神经系统肿瘤的 CAR T 细胞疗法：文献综述和当前的北美试验

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-09-09 DOI: 10.1007/s10555-024-10208-4

Rebecca Ronsley, Kelsey C. Bertrand, Edward Z. Song, Andrea Timpanaro, Michelle Choe, Dana Tlais, Nicholas A. Vitanza, Julie R. Park

引用次数: 0