Cancer and Metastasis Reviews最新文献_第9页

Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer. 靶向微小RNA是一种很有前途的抗癌治疗策略，用于治疗交通相关的空气污染介导的肺癌癌症。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-11-01 DOI: 10.1007/s10555-023-10142-x

Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Gilles J Guillemin, Wanxi Peng, Mortaza Aghbashlo, Meisam Tabatabaei

{"title":"Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer.","authors":"Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Gilles J Guillemin, Wanxi Peng, Mortaza Aghbashlo, Meisam Tabatabaei","doi":"10.1007/s10555-023-10142-x","DOIUrl":"10.1007/s10555-023-10142-x","url":null,"abstract":"Air pollutants are increasingly emitted into the atmosphere because of the high dependency of humans on fossil-derived fuels. Wind speed and direction assisted high dispersibility and uncontrolled nature of air pollution across geo-/demographical borders, making it one of the major global concerns. Besides climate change, air pollution has been found to be associated with various diseases, such as cancer. Lung cancer, which is the world's most common type of cancer, has been found to be associated with traffic-related air pollution. Research and political efforts have been taken to explore green/renewable energy sources. However, these efforts at the current intensity cannot cope with the increasing need for fossil fuels. More specifically, political tensions such as the Russian-Ukraine war, economic tension (e.g., China-USA economic tensions), and other issues (e.g., pandemic, higher inflation rate, and poverty) significantly hindered phasing out fossil fuels. In this context, an increasing global population will be exposed to traffic-related air pollution, which justifies the current uptrend in the number of lung cancer patients. To combat this health burden, novel treatments with higher efficiency and specificity must be designed. One of the potential \"life changer\" options is microRNA (miRNA)-based therapy to target the expression of oncogenic genes. That said, this review discusses the association of traffic-related air pollution with lung cancer, the changes in indigenous miRNAs in the body during lung cancer, and the current status of miRNA therapeutics for lung cancer treatment. We believe that the article will significantly appeal to a broad readership of oncologists, environmentalists, and those who work in the field of (bio)energy. It may also gain the policymakers' attention to establish better health policies and regulations about air pollution, for example, by promoting (bio)fuel exploration, production, and consumption.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"657-672"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression. 肿瘤微环境的影响：揭示物理线索在乳腺癌进展中的作用。

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2024-01-19 DOI: 10.1007/s10555-024-10166-x

Ayuba Akinpelu, Tosin Akinsipe, L Adriana Avila, Robert D Arnold, Panagiotis Mistriotis

引用次数: 0

Correction to: Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward? Correction to：以自旋轴突素-溶血磷脂酸受体轴为靶点的抗癌策略：有出路吗？

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-06-01 DOI: 10.1007/s10555-021-09966-2

Gábor Tigyi, Mélanie A Dacheux, Kuan-Hung Lin, Junming Yue, Derek Norman, Zoltán Benyó, Sue Chin Lee

引用次数: 0

Prospects of earthworm coelomic fluid as a potential therapeutic agent to treat cancer. 蚯蚓体腔液作为治疗癌症的潜在药物的前景。

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-11-01 DOI: 10.1007/s10555-023-10148-5

Shafiul Haque, Arif Hussain, Atiah H Almalki, Mohammed F Aldawsari, Basant Lal, Ashutosh Kumar Rai, Manish Srivastava, Marta Fiołka

{"title":"Prospects of earthworm coelomic fluid as a potential therapeutic agent to treat cancer.","authors":"Shafiul Haque, Arif Hussain, Atiah H Almalki, Mohammed F Aldawsari, Basant Lal, Ashutosh Kumar Rai, Manish Srivastava, Marta Fiołka","doi":"10.1007/s10555-023-10148-5","DOIUrl":"10.1007/s10555-023-10148-5","url":null,"abstract":"Cancer is a major public health concern because it is one of the main causes of morbidity and mortality worldwide. As a result, numerous studies have reported the development of new therapeutic compounds with the aim of selectively treating cancer while having little negative influence on healthy cells. In this context, earthworm coelomic fluid has been acknowledged as a rich source of several bioactive substances that may exhibit promising anticancer activity. Therefore, the objective of the present review is to evaluate the findings of the reported studies exploring the antitumor effects of coelomic fluid in the context of its possible utilization as a natural therapeutic agent to cure different types of cancer. The possible mechanisms underlying the coelomic fluid's anticancerous potential as well as the possibility for future development of cutting-edge therapeutic agents utilizing coelomic fluid-derived natural bioactive compounds to treat cancer disorders have been discussed along with future challenges. In addition, the feasibility of encapsulation of bioactive compounds derived from coelomic fluid with nanomaterials that could be further explored to attain more effective anticancer competence is discussed.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"621-637"},"PeriodicalIF":9.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clonal tracking in cancer and metastasis. 癌症和转移的克隆追踪。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-11-01 DOI: 10.1007/s10555-023-10149-4

Syed Mohammed Musheer Aalam, Long Viet Nguyen, Megan L Ritting, Nagarajan Kannan

引用次数: 0

Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications. 癌症进展中的组织衍生细胞外小泡：机制、作用和潜在应用。

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-10-18 DOI: 10.1007/s10555-023-10147-6

Ziyang Ye, Wenjie Chen, Genpeng Li, Jing Huang, Jianyong Lei

{"title":"Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications.","authors":"Ziyang Ye, Wenjie Chen, Genpeng Li, Jing Huang, Jianyong Lei","doi":"10.1007/s10555-023-10147-6","DOIUrl":"10.1007/s10555-023-10147-6","url":null,"abstract":"Extracellular vesicles (EVs) are small lipid bilayer-enclosed vesicles that mediate vital cellular communication by transferring cargo between cells. Among these, tissue-derived extracellular vesicles (Ti-EVs) stand out due to their origin from the tissue microenvironment, providing a more accurate reflection of changes in this setting. This unique advantage makes Ti-EVs valuable in investigating the intricate relationship between extracellular vesicles and cancer progression. Despite considerable research efforts exploring the association between Ti-EVs and cancers, a comprehensive clustering or grouping of these studies remains lacking. In this review, we aim to fill this gap by presenting a comprehensive synthesis of the mechanisms underlying Ti-EV generation, release, and transport within cancer tissues. Moreover, we delve into the pivotal roles that Ti-EVs play in cancer progression, shedding light on their potential as diagnostic and therapeutic tools. The review culminates in the construction of a comprehensive functional spectrum of Ti-EVs, providing a valuable reference for future research endeavors. By summarizing the current state of knowledge on Ti-EVs and their significance in tumor biology, this work contributes to a deeper understanding of cancer microenvironment dynamics and opens up avenues for harnessing Ti-EVs in diagnostic and therapeutic applications.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"575-595"},"PeriodicalIF":9.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41232560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging roles of histone demethylases in cancers. 组蛋白去甲基化酶在癌症中的新作用。

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2024-01-16 DOI: 10.1007/s10555-023-10160-9

Dali Tong, Ying Tang, Peng Zhong

引用次数: 0

Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy 癌症相关成纤维细胞：肿瘤进展、转移和靶向治疗中的多功能介质

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-04-11 DOI: 10.1007/s10555-024-10186-7

Tianchen Guo, Junfen Xu

引用次数: 0

In vivo manufacture and manipulation of CAR-T cells for better druggability 在体内制造和操纵 CAR-T 细胞，提高可药性

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-04-09 DOI: 10.1007/s10555-024-10185-8

Rui Hou, Xiaoxue Zhang, Xu Wang, Xuan Zhao, Sijin Li, Zhangchun Guan, Jiang Cao, Dan Liu, Junnian Zheng, Ming Shi

{"title":"In vivo manufacture and manipulation of CAR-T cells for better druggability","authors":"Rui Hou, Xiaoxue Zhang, Xu Wang, Xuan Zhao, Sijin Li, Zhangchun Guan, Jiang Cao, Dan Liu, Junnian Zheng, Ming Shi","doi":"10.1007/s10555-024-10185-8","DOIUrl":"https://doi.org/10.1007/s10555-024-10185-8","url":null,"abstract":"The current CAR-T cell therapy products have been hampered in their druggability due to the personalized preparation required, unclear pharmacokinetic characteristics, and unpredictable adverse reactions. Enabling standardized manufacturing and having clear efficacy and pharmacokinetic characteristics are prerequisites for ensuring the effective practicality of CAR-T cell therapy drugs. This review provides a broad overview of the different approaches for controlling behaviors of CAR-T cells in vivo. The utilization of genetically modified vectors enables in vivo production of CAR-T cells, thereby abbreviating or skipping the lengthy in vitro expansion process. By equipping CAR-T cells with intricately designed control elements, using molecule switches or small-molecule inhibitors, the control of CAR-T cell activity can be achieved. Moreover, the on–off control of CAR-T cell activity would yield potential gains in phenotypic remodeling. These methods provide beneficial references for the future development of safe, controllable, convenient, and suitable for standardized production of CAR-T cell therapy products.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"2015 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140580665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas 侵袭性癌中的纤维脂肪生成祖细胞 APOD+DCN+LUM+ 细胞群

IF 9.2 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-03-11 DOI: 10.1007/s10555-024-10181-y

Lingyi Cai, Mikhail G. Kolonin, Dimitris Anastassiou

引用次数: 0