Cancer and Metastasis Reviews

Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.

Cancer & Metastasis Reviews 发表了关于恶性疾病生物学和治疗的最新进展的优秀评论，并强调了有希望的新方向。其目标是突出最近在基础、转化和临床研究方面的重大进展，强调对控制癌症有重大影响或在这方面具有突出潜力的研究。该刊的主题包括： 癌基因和抑癌基因的功能 癌症细胞死亡的调节 控制癌症中的细胞周期和DNA修复 与致癌作用相关的炎症和免疫系统缺陷 微生物组对致癌作用和治疗反应的影响 与转化相关的细胞代谢变化 肿瘤形成、进展、转移和对治疗反应过程中的遗传和表观遗传变化 肿瘤微环境、转移前和转移生态位以及肿瘤休眠 衰老与癌症 开发分子靶向癌症疗法，包括细胞疗法和免疫疗法，以及此类药物的临床试验 与癌症风险、癌症预防和癌症拦截相关的生物学和分子因素 用于癌症靶点鉴定和表征的系统生物学和计算生物学技术 早期发现新发或复发性肿瘤以及监测治疗反应的技术 癌症治疗的预测和预后生物标志物 癌症差异。