Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges.

IF 7.7 2区医学 Q1 ONCOLOGY

Cancer and Metastasis Reviews Pub Date : 2025-05-10 DOI:10.1007/s10555-025-10267-1

Nam Anh Tran, Shehzahdi S Moonshi, Alfred K Lam, Cu Tai Lu, Cong Quang Vu, Satoshi Arai, Hang Thu Ta

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引用次数: 0

Abstract

Gaining significant attention in recent years, starvation therapy based on the blocking nutrients supply to cancer cells via blood occlusion and metabolic interventions is a promisingly novel approach in cancer treatment. However, there are many crucial obstacles to overcome to achieve effective treatment, for example, poor-targeting delivery, cellular hypoxia, adverse effects, and ineffective monotherapy. The starvation-based multitherapy based on multifunctional nanomaterials can narrow these gaps and pave a promising way for future clinical translation. This review focuses on the progression in nanomaterials-mediated muti-therapeutic modalities based on starvation therapy in recent years and therapeutic limitations that prevent their clinical applications. Moreover, unlike previous reviews that focused on a single aspect of the field, this comprehensive review presents a broader perspective on starvation therapy by summarising advancements across its various therapeutic strategies.

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纳米材料在癌症饥饿治疗中的应用：开拓性进展、治疗潜力和临床挑战。

近年来，通过血液阻塞和代谢干预来阻断癌细胞的营养供应的饥饿疗法受到了广泛关注，是一种很有前途的癌症治疗新方法。然而，为了实现有效的治疗，有许多关键的障碍需要克服，例如，靶向性差的递送，细胞缺氧，不良反应和无效的单一治疗。基于多功能纳米材料的饥饿综合治疗可以缩小这些差距，为未来的临床转化铺平了一条有希望的道路。本文综述了近年来基于饥饿治疗的纳米材料介导的多治疗方式的进展以及阻碍其临床应用的治疗局限性。此外，不像以前的评论只关注该领域的一个方面，这篇全面的综述通过总结各种治疗策略的进展，对饥饿治疗提供了更广阔的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer and Metastasis Reviews 医学-肿瘤学

CiteScore

17.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.