作为治疗纽带的 TFCP2:揭示癌症的分子特征。

IF 7.7 2区 医学 Q1 ONCOLOGY
Cancer and Metastasis Reviews Pub Date : 2024-09-01 Epub Date: 2024-03-07 DOI:10.1007/s10555-024-10175-w
Neha Kaushik, Apurva Jaiswal, Pradeep Bhartiya, Eun Ha Choi, Nagendra Kumar Kaushik
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引用次数: 0

摘要

抑癌基因和原癌基因构成了与癌症相关的复杂基因组图谱的大部分,只有极少数基因具有双重依赖性功能。转录因子细胞启动子 2(TFCP2)是由α球蛋白转录因子 CP2 基因编码的一种关键转录因子,是转录因子 TFCP2/grainyhead 家族的成员之一。尽管谷粒头成员在发育过程、胚胎发生和多种癌症中的关键作用已被广泛研究,但对 TFCP2 亚家族的研究相对较少。尽管 TFCP2 是癌症治疗的理想靶点和治疗标志物,但其参与癌变的分子机制仍不清楚。这篇全面的文献综述总结了 TFCP2 的分子功能,强调了它在癌症病理生理学中的参与,尤其是在上皮-间质转化和转移中的参与。该研究强调了 TFCP2 作为调控靶点的关键功能,并探讨了其作为癌症生存和炎症预后标志物的潜力。TFCP2与癌症的关系模糊不清,因此迫切需要对其进行深入了解,以促进开发更有效的靶向治疗模式和诊断工具。本研究旨在通过全面整合现有的癌症治疗知识,阐明 TFCP2 调控的多方面影响。此外,本综述还讨论了在研究其在癌症发病机制中的复杂作用时所遇到的临床相关性和固有挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer.

TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer.

Tumor suppressor genes and proto-oncogenes comprise most of the complex genomic landscape associated with cancer, with a minimal number of genes exhibiting dual-context-dependent functions. The transcription factor cellular promoter 2 (TFCP2), a pivotal transcription factor encoded by the alpha globin transcription factor CP2 gene, is a constituent of the TFCP2/grainyhead family of transcription factors. While grainyhead members have been extensively studied for their crucial roles in developmental processes, embryogenesis, and multiple cancers, the TFCP2 subfamily has been relatively less explored. The molecular mechanisms underlying TFCP2's involvement in carcinogenesis are still unclear even though it is a desirable target for cancer treatment and a therapeutic marker. This comprehensive literature review summarizes the molecular functions of TFCP2, emphasizing its involvement in cancer pathophysiology, particularly in the epithelial-mesenchymal transition and metastasis. It highlights TFCP2's critical function as a regulatory target and explores its potential as a prognostic marker for survival and inflammation in carcinomas. Its ambiguous association with carcinomas underlines the urgent need for an in-depth understanding to facilitate the development of more efficacious targeted therapeutic modality and diagnostic tools. This study aims to elucidate the multifaceted effects of TFCP2 regulation, through a comprehensive integration of the existing knowledge in cancer therapeutics. Furthermore, the clinical relevance and the inherent challenges encountered in investigating its intricate role in cancer pathogenesis have been discussed in this review.

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来源期刊
CiteScore
17.00
自引率
0.00%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.
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