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Cancer and Metastasis Reviews最新文献

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Survival mechanisms of circulating tumor cells and their implications for cancer treatment. 循环肿瘤细胞的生存机制及其对癌症治疗的影响。
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-09-01 Epub Date: 2024-03-04 DOI: 10.1007/s10555-024-10178-7
Shuang Zhou, Huanji Xu, Yichun Duan, Qiulin Tang, Huixi Huang, Feng Bi
{"title":"Survival mechanisms of circulating tumor cells and their implications for cancer treatment.","authors":"Shuang Zhou, Huanji Xu, Yichun Duan, Qiulin Tang, Huixi Huang, Feng Bi","doi":"10.1007/s10555-024-10178-7","DOIUrl":"10.1007/s10555-024-10178-7","url":null,"abstract":"<p><p>Metastasis remains the principal trigger for relapse and mortality across diverse cancer types. Circulating tumor cells (CTCs), which originate from the primary tumor or its metastatic sites, traverse the vascular system, serving as precursors in cancer recurrence and metastasis. Nevertheless, before CTCs can establish themselves in the distant parenchyma, they must overcome significant challenges present within the circulatory system, including hydrodynamic shear stress (HSS), oxidative damage, anoikis, and immune surveillance. Recently, there has been a growing body of compelling evidence suggesting that a specific subset of CTCs can persist within the bloodstream, but the precise mechanisms of their survival remain largely elusive. This review aims to present an outline of the survival challenges encountered by CTCs and to summarize the recent advancements in understanding the underlying survival mechanisms, suggesting their implications for cancer treatment.</p>","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"941-957"},"PeriodicalIF":7.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140020944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation and targeting of SREBP-1 in hepatocellular carcinoma. SREBP-1在肝细胞癌中的调控和靶向作用。
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-12-01 DOI: 10.1007/s10555-023-10156-5
Fengting Su, Andreas Koeberle
{"title":"Regulation and targeting of SREBP-1 in hepatocellular carcinoma.","authors":"Fengting Su, Andreas Koeberle","doi":"10.1007/s10555-023-10156-5","DOIUrl":"10.1007/s10555-023-10156-5","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic reprogramming. De novo lipogenesis is under the control of the transcription factor sterol regulatory element-binding protein 1 (SREBP-1) and essentially contributes to HCC progression. Here, we summarize the current knowledge on the regulation of SREBP-1 isoforms in HCC based on cellular, animal, and clinical data. Specifically, we (i) address the overarching mechanisms for regulating SREBP-1 transcription, proteolytic processing, nuclear stability, and transactivation and (ii) critically discuss their impact on HCC, taking into account (iii) insights from pharmacological approaches. Emphasis is placed on cross-talk with the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mechanistic target of rapamycin (mTOR) axis, AMP-activated protein kinase (AMPK), protein kinase A (PKA), and other kinases that directly phosphorylate SREBP-1; transcription factors, such as liver X receptor (LXR), peroxisome proliferator-activated receptors (PPARs), proliferator-activated receptor γ co-activator 1 (PGC-1), signal transducers and activators of transcription (STATs), and Myc; epigenetic mechanisms; post-translational modifications of SREBP-1; and SREBP-1-regulatory metabolites such as oxysterols and polyunsaturated fatty acids. By carefully scrutinizing the role of SREBP-1 in HCC development, progression, metastasis, and therapy resistance, we shed light on the potential of SREBP-1-targeting strategies in HCC prevention and treatment.</p>","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"673-708"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic regulation of breast cancer metastasis. 癌症转移的表观遗传学调控。
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-10-19 DOI: 10.1007/s10555-023-10146-7
Chitra Thakur, Yiran Qiu, Aashna Pawar, Fei Chen
{"title":"Epigenetic regulation of breast cancer metastasis.","authors":"Chitra Thakur, Yiran Qiu, Aashna Pawar, Fei Chen","doi":"10.1007/s10555-023-10146-7","DOIUrl":"10.1007/s10555-023-10146-7","url":null,"abstract":"<p><p>Breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women worldwide. Recurrent metastasis is associated with poor patient outcomes and poses a significant challenge in breast cancer therapies. Cancer cells adapting to a new tissue microenvironment is the key event in distant metastasis development, where the disseminating tumor cells are likely to acquire genetic and epigenetic alterations during the process of metastatic colonization. Despite several decades of research in this field, the exact mechanisms governing metastasis are not fully understood. However, emerging body of evidence indicates that in addition to genetic changes, epigenetic reprogramming of cancer cells and the metastatic niche are paramount toward successful metastasis. Here, we review and discuss the latest knowledge about the salient attributes of metastasis and epigenetic regulation in breast cancer and crucial research domains that need further investigation.</p>","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"597-619"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49674599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases. PRUNE1 和 NME/NDPK 家族蛋白影响癌症转移过程中的能量代谢和信号转导。
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2024-01-05 DOI: 10.1007/s10555-023-10165-4
Veronica Ferrucci, Santosh Lomada, Thomas Wieland, Massimo Zollo
{"title":"PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases.","authors":"Veronica Ferrucci, Santosh Lomada, Thomas Wieland, Massimo Zollo","doi":"10.1007/s10555-023-10165-4","DOIUrl":"10.1007/s10555-023-10165-4","url":null,"abstract":"<p><p>We describe here the molecular basis of the complex formation of PRUNE1 with the tumor metastasis suppressors NME1 and NME2, two isoforms appertaining to the nucleoside diphosphate kinase (NDPK) enzyme family, and how this complex regulates signaling the immune system and energy metabolism, thereby shaping the tumor microenvironment (TME). Disrupting the interaction between NME1/2 and PRUNE1, as suggested, holds the potential to be an excellent therapeutic target for the treatment of cancer and the inhibition of metastasis dissemination. Furthermore, we postulate an interaction and regulation of the other Class I NME proteins, NME3 and NME4 proteins, with PRUNE1 and discuss potential functions. Class I NME1-4 proteins are NTP/NDP transphosphorylases required for balancing the intracellular pools of nucleotide diphosphates and triphosphates. They regulate different cellular functions by interacting with a large variety of other proteins, and in cancer and metastasis processes, they can exert pro- and anti-oncogenic properties depending on the cellular context. In this review, we therefore additionally discuss general aspects of class1 NME and PRUNE1 molecular structures as well as their posttranslational modifications and subcellular localization. The current knowledge on the contributions of PRUNE1 as well as NME proteins to signaling cascades is summarized with a special regard to cancer and metastasis.</p>","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"755-775"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect. UCP2 与胰腺癌：有意识地解除耦合以达到治疗效果。
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2024-01-09 DOI: 10.1007/s10555-023-10157-4
Emily G Caggiano, Cullen M Taniguchi
{"title":"UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect.","authors":"Emily G Caggiano, Cullen M Taniguchi","doi":"10.1007/s10555-023-10157-4","DOIUrl":"10.1007/s10555-023-10157-4","url":null,"abstract":"<p><p>Pancreatic cancer has an exaggerated dependence on mitochondrial metabolism, but methods to specifically target the mitochondria without off target effects in normal tissues that rely on these organelles is a significant challenge. The mitochondrial uncoupling protein 2 (UCP2) has potential as a cancer-specific drug target, and thus, we will review the known biology of UCP2 and discuss its potential role in the pathobiology and future therapy of pancreatic cancer.</p>","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"777-794"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer. 靶向微小RNA是一种很有前途的抗癌治疗策略，用于治疗交通相关的空气污染介导的肺癌癌症。
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-11-01 DOI: 10.1007/s10555-023-10142-x
Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Gilles J Guillemin, Wanxi Peng, Mortaza Aghbashlo, Meisam Tabatabaei
{"title":"Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer.","authors":"Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Gilles J Guillemin, Wanxi Peng, Mortaza Aghbashlo, Meisam Tabatabaei","doi":"10.1007/s10555-023-10142-x","DOIUrl":"10.1007/s10555-023-10142-x","url":null,"abstract":"<p><p>Air pollutants are increasingly emitted into the atmosphere because of the high dependency of humans on fossil-derived fuels. Wind speed and direction assisted high dispersibility and uncontrolled nature of air pollution across geo-/demographical borders, making it one of the major global concerns. Besides climate change, air pollution has been found to be associated with various diseases, such as cancer. Lung cancer, which is the world's most common type of cancer, has been found to be associated with traffic-related air pollution. Research and political efforts have been taken to explore green/renewable energy sources. However, these efforts at the current intensity cannot cope with the increasing need for fossil fuels. More specifically, political tensions such as the Russian-Ukraine war, economic tension (e.g., China-USA economic tensions), and other issues (e.g., pandemic, higher inflation rate, and poverty) significantly hindered phasing out fossil fuels. In this context, an increasing global population will be exposed to traffic-related air pollution, which justifies the current uptrend in the number of lung cancer patients. To combat this health burden, novel treatments with higher efficiency and specificity must be designed. One of the potential \"life changer\" options is microRNA (miRNA)-based therapy to target the expression of oncogenic genes. That said, this review discusses the association of traffic-related air pollution with lung cancer, the changes in indigenous miRNAs in the body during lung cancer, and the current status of miRNA therapeutics for lung cancer treatment. We believe that the article will significantly appeal to a broad readership of oncologists, environmentalists, and those who work in the field of (bio)energy. It may also gain the policymakers' attention to establish better health policies and regulations about air pollution, for example, by promoting (bio)fuel exploration, production, and consumption.</p>","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"657-672"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression. 肿瘤微环境的影响：揭示物理线索在乳腺癌进展中的作用。
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2024-01-19 DOI: 10.1007/s10555-024-10166-x
Ayuba Akinpelu, Tosin Akinsipe, L Adriana Avila, Robert D Arnold, Panagiotis Mistriotis
{"title":"The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression.","authors":"Ayuba Akinpelu, Tosin Akinsipe, L Adriana Avila, Robert D Arnold, Panagiotis Mistriotis","doi":"10.1007/s10555-024-10166-x","DOIUrl":"10.1007/s10555-024-10166-x","url":null,"abstract":"<p><p>Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the contribution of genetic and epigenetic modifications to breast cancer progression has been widely acknowledged, emerging evidence underscores the pivotal role of physical stimuli in driving breast cancer metastasis. In this review, we summarize the changes in the mechanics of the breast cancer microenvironment and describe the various forces that impact migrating and circulating tumor cells throughout the metastatic process. We also discuss the mechanosensing and mechanotransducing molecules responsible for promoting the malignant phenotype in breast cancer cells. Gaining a comprehensive understanding of the mechanobiology of breast cancer carries substantial potential to propel progress in prognosis, diagnosis, and patient treatment.</p>","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"823-844"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward? Correction to：以自旋轴突素-溶血磷脂酸受体轴为靶点的抗癌策略：有出路吗？
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-06-01 DOI: 10.1007/s10555-021-09966-2
Gábor Tigyi, Mélanie A Dacheux, Kuan-Hung Lin, Junming Yue, Derek Norman, Zoltán Benyó, Sue Chin Lee
{"title":"Correction to: Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?","authors":"Gábor Tigyi, Mélanie A Dacheux, Kuan-Hung Lin, Junming Yue, Derek Norman, Zoltán Benyó, Sue Chin Lee","doi":"10.1007/s10555-021-09966-2","DOIUrl":"10.1007/s10555-021-09966-2","url":null,"abstract":"","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"845"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9578461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospects of earthworm coelomic fluid as a potential therapeutic agent to treat cancer. 蚯蚓体腔液作为治疗癌症的潜在药物的前景。
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-11-01 DOI: 10.1007/s10555-023-10148-5
Shafiul Haque, Arif Hussain, Atiah H Almalki, Mohammed F Aldawsari, Basant Lal, Ashutosh Kumar Rai, Manish Srivastava, Marta Fiołka
{"title":"Prospects of earthworm coelomic fluid as a potential therapeutic agent to treat cancer.","authors":"Shafiul Haque, Arif Hussain, Atiah H Almalki, Mohammed F Aldawsari, Basant Lal, Ashutosh Kumar Rai, Manish Srivastava, Marta Fiołka","doi":"10.1007/s10555-023-10148-5","DOIUrl":"10.1007/s10555-023-10148-5","url":null,"abstract":"<p><p>Cancer is a major public health concern because it is one of the main causes of morbidity and mortality worldwide. As a result, numerous studies have reported the development of new therapeutic compounds with the aim of selectively treating cancer while having little negative influence on healthy cells. In this context, earthworm coelomic fluid has been acknowledged as a rich source of several bioactive substances that may exhibit promising anticancer activity. Therefore, the objective of the present review is to evaluate the findings of the reported studies exploring the antitumor effects of coelomic fluid in the context of its possible utilization as a natural therapeutic agent to cure different types of cancer. The possible mechanisms underlying the coelomic fluid's anticancerous potential as well as the possibility for future development of cutting-edge therapeutic agents utilizing coelomic fluid-derived natural bioactive compounds to treat cancer disorders have been discussed along with future challenges. In addition, the feasibility of encapsulation of bioactive compounds derived from coelomic fluid with nanomaterials that could be further explored to attain more effective anticancer competence is discussed.</p>","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"621-637"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal tracking in cancer and metastasis. 癌症和转移的克隆追踪。
IF 7.7 2区 医学
Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-11-01 DOI: 10.1007/s10555-023-10149-4
Syed Mohammed Musheer Aalam, Long Viet Nguyen, Megan L Ritting, Nagarajan Kannan
{"title":"Clonal tracking in cancer and metastasis.","authors":"Syed Mohammed Musheer Aalam, Long Viet Nguyen, Megan L Ritting, Nagarajan Kannan","doi":"10.1007/s10555-023-10149-4","DOIUrl":"10.1007/s10555-023-10149-4","url":null,"abstract":"<p><p>The eradication of many cancers has proven challenging due to the presence of functionally and genetically heterogeneous clones maintained by rare cancer stem cells (CSCs), which contribute to disease progression, treatment refractoriness, and late relapse. The characterization of functional CSC activity has necessitated the development of modern clonal tracking strategies. This review describes viral-based and CRISPR-Cas9-based cellular barcoding, lineage tracing, and imaging-based approaches. DNA-based cellular barcoding technology is emerging as a powerful and robust strategy that has been widely applied to in vitro and in vivo model systems, including patient-derived xenograft models. This review also highlights the potential of these methods for use in the clinical and drug discovery contexts and discusses the important insights gained from such approaches.</p>","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"639-656"},"PeriodicalIF":7.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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