Cancer and Metastasis Reviews最新文献_第7页

Electrical excitability of cancer cells-CELEX model updated. 癌细胞的电兴奋性--CELEX 模型更新。

IF 4.4 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-07-08 DOI: 10.1007/s10555-024-10195-6

Mustafa B A Djamgoz

{"title":"Electrical excitability of cancer cells-CELEX model updated.","authors":"Mustafa B A Djamgoz","doi":"10.1007/s10555-024-10195-6","DOIUrl":"10.1007/s10555-024-10195-6","url":null,"abstract":"The normal functioning of every cell in the body depends on its bioelectric properties and many diseases are caused by genetic and/or epigenetic dysregulation of the underlying ion channels. Metastasis, the main cause of death from cancer, is a complex multi-stage process in which cells break away from a primary tumour, invade the surrounding tissues, enter the circulation by encountering a blood vessel and spread around the body, ultimately lodging in distant organs and reproliferating to form secondary tumours leading to devastating organ failure. Such cellular behaviours are well known to involve ion channels. The CELEX model offers a novel insight to metastasis where it is the electrical excitation of the cancer cells that is responsible for their aggressive and invasive behaviour. In turn, the hyperexcitability is underpinned by concomitant upregulation of functional voltage-gated sodium channels and downregulation of voltage-gated potassium channels. Here, we update the in vitro and in vivo evidence in favour of the CELEX model for carcinomas. The results are unequivocal for the sodium channel. The potassium channel arm is also broadly supported by existing evidence although these data are complicated by the impact of the channels on the membrane potential and consequent secondary effects. Finally, consistent with the CELEX model, we show (i) that carcinomas are indeed electrically excitable and capable of generating action potentials and (ii) that combination of a sodium channel inhibitor and a potassium channel opener can produce a strong, additive anti-invasive effect. We discuss the possible clinical implications of the CELEX model in managing cancer.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"1579-1591"},"PeriodicalIF":4.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies. 肽治疗微生物诱发的癌症：最新治疗策略及其先进技术。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-07-15 DOI: 10.1007/s10555-024-10197-4

Ziqi Lin, Yehuda G Assaraf, Hang Fai Kwok

{"title":"Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies.","authors":"Ziqi Lin, Yehuda G Assaraf, Hang Fai Kwok","doi":"10.1007/s10555-024-10197-4","DOIUrl":"10.1007/s10555-024-10197-4","url":null,"abstract":"Cancer is a significant global health concern associated with multiple distinct factors, including microbial and viral infections. Numerous studies have elucidated the role of microorganisms, such as Helicobacter pylori (H. pylori), as well as viruses for example human papillomavirus (HPV), hepatitis B virus (HBV), and hepatitis C virus (HCV), in the development of human malignancies. Substantial attention has been focused on the treatment of these microorganism- and virus-associated cancers, with promising outcomes observed in studies employing peptide-based therapies. The current paper provides an overview of microbe- and virus-induced cancers and their underlying molecular mechanisms. We discuss an assortment of peptide-based therapies which are currently being developed, including tumor-targeting peptides and microbial/viral peptide-based vaccines. We describe the major technological advancements that have been made in the design, screening, and delivery of peptides as anticancer agents. The primary focus of the current review is to provide insight into the latest research and development in this field and to provide a realistic glimpse into the future of peptide-based therapies for microbe- and virus-induced neoplasms.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"1315-1336"},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiomics approach towards characterization of tumor cell plasticity and its significance in precision and personalized medicine. 多组学方法表征肿瘤细胞的可塑性及其在精准和个性化医疗中的意义。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-05-18 DOI: 10.1007/s10555-024-10190-x

Mohammad Azhar Aziz

{"title":"Multiomics approach towards characterization of tumor cell plasticity and its significance in precision and personalized medicine.","authors":"Mohammad Azhar Aziz","doi":"10.1007/s10555-024-10190-x","DOIUrl":"10.1007/s10555-024-10190-x","url":null,"abstract":"Cellular plasticity refers to the ability of cells to change their identity or behavior, which can be advantageous in some cases (e.g., tissue regeneration) but detrimental in others (e.g., cancer metastasis). With a better understanding of cellular plasticity, the complexity of cancer cells, their heterogeneity, and their role in metastasis is being unraveled. The plasticity of the cells could also prove as a nemesis to their characterization. In this review, we have attempted to highlight the possibilities and benefits of using multiomics approach in characterizing the plastic nature of cancer cells. There is a need to integrate fragmented evidence at different levels of cellular organization (DNA, RNA, protein, metabolite, epigenetics, etc.) to facilitate the characterization of different forms of plasticity and cell types. We have discussed the role of cellular plasticity in generating intra-tumor heterogeneity. Different omics level evidence is being provided to highlight the variety of molecular determinants discovered using different techniques. Attempts have been made to integrate some of this information to provide a quantitative assessment and scoring of the plastic nature of the cells. However, there is a huge gap in our understanding of mechanisms that lead to the observed heterogeneity. Understanding of these mechanism(s) is necessary for finding targets for early detection and effective therapeutic interventions in metastasis. Targeting cellular plasticity is akin to neutralizing a moving target. Along with the advancements in precision and personalized medicine, these efforts may translate into better clinical outcomes for cancer patients, especially in metastatic stages.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"1549-1559"},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlates of health-related quality of life in African Americans diagnosed with cancer: a review of survivorship studies and the Detroit research on cancer survivors cohort. 被诊断患有癌症的非裔美国人健康相关生活质量的相关因素：幸存者研究和底特律癌症幸存者队列研究综述。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-07-20 DOI: 10.1007/s10555-024-10200-y

Matthew R Trendowski, Julie J Ruterbusch, Tara E Baird, Angela S Wenzlaff, Stephanie S Pandolfi, Theresa A Hastert, Ann G Schwartz, Jennifer L Beebe-Dimmer

{"title":"Correlates of health-related quality of life in African Americans diagnosed with cancer: a review of survivorship studies and the Detroit research on cancer survivors cohort.","authors":"Matthew R Trendowski, Julie J Ruterbusch, Tara E Baird, Angela S Wenzlaff, Stephanie S Pandolfi, Theresa A Hastert, Ann G Schwartz, Jennifer L Beebe-Dimmer","doi":"10.1007/s10555-024-10200-y","DOIUrl":"10.1007/s10555-024-10200-y","url":null,"abstract":"Advances in cancer screening and treatment have improved survival after a diagnosis of cancer. As the number of cancer survivors as well as their overall life-expectancy increases, investigations of health-related quality of life (HRQOL) are critical in understanding the factors that promote the optimal experience over the course of survivorship. However, there is a dearth of information on determinants of HRQOL for African American cancer survivors as the vast majority of cohorts have been conducted predominantly among non-Hispanic Whites. In this review, we provide a review of the literature related to HRQOL in cancer survivors including those in African Americans. We then present a summary of published work from the Detroit Research on Cancer Survivors (ROCS) cohort, a population-based cohort of more than 5000 African American cancer survivors. Overall, Detroit ROCS has markedly advanced our understanding of the unique factors contributing to poorer HRQOL among African Americans with cancer. This work and future studies will help inform potential interventions to improve the long-term health of this patient population.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"1373-1384"},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer treatments as paradoxical catalysts of tumor awakening in the lung. 癌症治疗是肺部肿瘤苏醒的矛盾催化剂。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1007/s10555-024-10196-5

Emmanuelle Nicolas, Beata Kosmider, Edna Cukierman, Hossein Borghaei, Erica A Golemis, Lucia Borriello

{"title":"Cancer treatments as paradoxical catalysts of tumor awakening in the lung.","authors":"Emmanuelle Nicolas, Beata Kosmider, Edna Cukierman, Hossein Borghaei, Erica A Golemis, Lucia Borriello","doi":"10.1007/s10555-024-10196-5","DOIUrl":"10.1007/s10555-024-10196-5","url":null,"abstract":"Much of the fatality of tumors is linked to the growth of metastases, which can emerge months to years after apparently successful treatment of primary tumors. Metastases arise from disseminated tumor cells (DTCs), which disperse through the body in a dormant state to seed distant sites. While some DTCs lodge in pre-metastatic niches (PMNs) and rapidly develop into metastases, other DTCs settle in distinct microenvironments that maintain them in a dormant state. Subsequent awakening, induced by changes in the microenvironment of the DTC, causes outgrowth of metastases. Hence, there has been extensive investigation of the factors causing survival and subsequent awakening of DTCs, with the goal of disrupting these processes to decrease cancer lethality. We here provide a detailed overview of recent developments in understanding of the factors controlling dormancy and awakening in the lung, a common site of metastasis for many solid tumors. These factors include dynamic interactions between DTCs and diverse epithelial, mesenchymal, and immune cell populations resident in the lung. Paradoxically, among key triggers for metastatic outgrowth, lung tissue remodeling arising from damage induced by the treatment of primary tumors play a significant role. In addition, growing evidence emphasizes roles for inflammation and aging in opposing the factors that maintain dormancy. Finally, we discuss strategies being developed or employed to reduce the risk of metastatic recurrence.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"1165-1183"},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Striated muscle: an inadequate soil for cancers. 横纹肌：癌症的土壤不足。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-07-12 DOI: 10.1007/s10555-024-10199-2

Alastair A E Saunders, Rachel E Thomson, Craig A Goodman, Robin L Anderson, Paul Gregorevic

{"title":"Striated muscle: an inadequate soil for cancers.","authors":"Alastair A E Saunders, Rachel E Thomson, Craig A Goodman, Robin L Anderson, Paul Gregorevic","doi":"10.1007/s10555-024-10199-2","DOIUrl":"10.1007/s10555-024-10199-2","url":null,"abstract":"Many organs of the body are susceptible to cancer development. However, striated muscles-which include skeletal and cardiac muscles-are rarely the sites of primary cancers. Most deaths from cancer arise due to complications associated with the development of secondary metastatic tumours, for which there are few effective therapies. However, as with primary cancers, the establishment of metastatic tumours in striated muscle accounts for a disproportionately small fraction of secondary tumours, relative to the proportion of body composition. Examining why primary and metastatic cancers are comparatively rare in striated muscle presents an opportunity to better understand mechanisms that can influence cancer cell biology. To gain insights into the incidence and distribution of muscle metastases, this review presents a definitive summary of the 210 case studies of metastasis in muscle published since 2010. To examine why metastases rarely form in muscles, this review considers the mechanisms currently proposed to render muscle an inhospitable environment for cancers. The \"seed and soil\" hypothesis proposes that tissues' differences in susceptibility to metastatic colonization are due to differing host microenvironments that promote or suppress metastatic growth to varying degrees. As such, the \"soil\" within muscle may not be conducive to cancer growth. Gaining a greater understanding of the mechanisms that underpin the resistance of muscles to cancer may provide new insights into mechanisms of tumour growth and progression, and offer opportunities to leverage insights into the development of interventions with the potential to inhibit metastasis in susceptible tissues.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":" ","pages":"1511-1527"},"PeriodicalIF":7.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The roles of periostin derived from cancer-associated fibroblasts in tumor progression and treatment response. 来源于癌症相关成纤维细胞的骨膜蛋白在肿瘤进展和治疗反应中的作用。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-30 DOI: 10.1007/s10555-024-10233-3

Yasmin De Oliveira Macena, Maria Eduarda Nunes Cezar, Cinthya Brunelly Ferreira Lira, Laryssa Bheatriz Dantas Machado De Oliveira, Thais Noronha Almeida, Ana Dora Alecio Virtuoso Costa, Bernardo Mansur Dantas De Araujo, Durval de Almeida Junior, Henrique Macêdo Dantas, Emanuel Cézar De Mélo, Sandra Taveiros de Araújo, Raimundo Rodrigues de França Júnior, Maria Amélia Dos Santos Lemos Gurgel, Carlos Alberto de Carvalho Fraga

{"title":"The roles of periostin derived from cancer-associated fibroblasts in tumor progression and treatment response.","authors":"Yasmin De Oliveira Macena, Maria Eduarda Nunes Cezar, Cinthya Brunelly Ferreira Lira, Laryssa Bheatriz Dantas Machado De Oliveira, Thais Noronha Almeida, Ana Dora Alecio Virtuoso Costa, Bernardo Mansur Dantas De Araujo, Durval de Almeida Junior, Henrique Macêdo Dantas, Emanuel Cézar De Mélo, Sandra Taveiros de Araújo, Raimundo Rodrigues de França Júnior, Maria Amélia Dos Santos Lemos Gurgel, Carlos Alberto de Carvalho Fraga","doi":"10.1007/s10555-024-10233-3","DOIUrl":"10.1007/s10555-024-10233-3","url":null,"abstract":"Periostin (POSTN), a matricellular protein predominantly secreted by cancer-associated fibroblasts (CAFs), has emerged as a key regulator of cancer progression and therapy response. This review provides an overview of recent findings regarding the diverse roles of periostin in cancer therapy and its potential as a therapeutic target. Studies have elucidated periostin's involvement in tumorigenesis, including tumor growth, metastasis, chemotherapy resistance, and modulation of the tumor microenvironment (TME). CAFs periostin + play a central role in shaping the TME by remodeling the extracellular matrix (ECM) and promoting immune evasion, thus promoting tumor cell survival and dissemination. Elevated periostin expression has been correlated with poor prognosis across multiple cancer types, suggesting its utility as a prognostic biomarker. Periostin has been implicated in mediating resistance to chemotherapy, with CAFs periostin + establishing a pro-tumorigenic niche that confers protection to cancer cells against cytotoxic therapies. Targeting periostin or its downstream effectors presents a promising strategy to overcome therapy resistance and enhance treatment efficacy. While significant progress has been made in understanding the biological functions of periostin in cancer, gaps persist in elucidating its precise mechanisms of action and clinical relevance. Future research should focus on deciphering the signaling pathways and molecular interactions underlying periostin-mediated effects in the TME. Prospective clinical studies are warranted to evaluate periostin as a predictive biomarker and therapeutic target in cancer patients.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"11"},"PeriodicalIF":7.7,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapy for leptomeningeal disease from solid tumors: current clinical outcomes and future opportunities. 实体瘤引起的脑膜轻脑病的免疫治疗：目前的临床结果和未来的机会。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-29 DOI: 10.1007/s10555-024-10235-1

Eleanor C Smith, Bryan T Mott, Emily Douglas, Stephen B Tatter, Kounosuke Watabe

{"title":"Immunotherapy for leptomeningeal disease from solid tumors: current clinical outcomes and future opportunities.","authors":"Eleanor C Smith, Bryan T Mott, Emily Douglas, Stephen B Tatter, Kounosuke Watabe","doi":"10.1007/s10555-024-10235-1","DOIUrl":"10.1007/s10555-024-10235-1","url":null,"abstract":"Leptomeningeal disease is a debilitating, late-stage form of metastatic cancer disseminated within the cerebrospinal fluid, subarachnoid space, and leptomeninges, leading to significant neurological morbidity and mortality. As systemic cancer treatments improve, rates of leptomeningeal disease have increased, yet prognosis remains exceedingly poor. A wide range of treatment modalities have been trialed; however, no standard of care has been established. Additionally, many clinical trials exclude patients with leptomeningeal disease, limiting available prospective data. In this review, we discuss the efficacy of immunotherapy for leptomeningeal disease from solid tumors including systemic and intrathecal therapies, as well as combined therapy regimens. Our review indicates a continued deficiency in the current prospective literature and highlights ongoing research regarding the leptomeningeal immune microenvironment, which will be critical in directing future study of leptomeningeal disease treatment. Currently, the efficacy of immunotherapies on leptomeningeal disease appears limited, and further prospective research is needed to draw significant conclusions. However, recent advancement in understanding the leptomeningeal microenvironment points to potential efficacy of novel immunotherapies targeting the innate immune system, and further study is warranted to evaluate the efficacy of these treatments in this subpopulation of patients.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"10"},"PeriodicalIF":7.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanoma in people living with HIV: Immune landscape dynamics and the role of immuno- and antiviral therapies. 艾滋病毒感染者的黑色素瘤：免疫景观动态和免疫和抗病毒治疗的作用。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-29 DOI: 10.1007/s10555-024-10230-6

Lindsay N Barger, Olivia S El Naggar, Binh Ha, Gabriele Romano

{"title":"Melanoma in people living with HIV: Immune landscape dynamics and the role of immuno- and antiviral therapies.","authors":"Lindsay N Barger, Olivia S El Naggar, Binh Ha, Gabriele Romano","doi":"10.1007/s10555-024-10230-6","DOIUrl":"10.1007/s10555-024-10230-6","url":null,"abstract":"The intersection of HIV and melanoma presents a complex and unique challenge, marked by distinct patterns in incidence, mortality, and treatment response. Higher mortality rates among people with HIV who develop melanoma underscore an urgent need to identify the factors influencing these outcomes. Investigating immune system dynamics, the effects of anti-retroviral drugs, and the evolving landscape of cancer immunotherapy in this population holds promise for new insights, though significant uncertainties remain. Over the past 25 years, melanoma research has demonstrated that a robust immune response is critical for effective treatment. In the context of chronic HIV infection, viral reservoirs enable the virus to persist despite anti-retroviral therapy and foster dysregulated myeloid and T cell compartments. The resulting chronic inflammation weakens the immune system and damages tissues, potentially creating \"cold\" tumor microenvironments that are less responsive to therapy. In this challenging context, animal models become invaluable for uncovering underlying biological mechanisms. While these models do not fully replicate human HIV infection, they provide essential insights into critical questions and inform the development of tailored treatments for this patient population. Clinically, increasing trial participation and creating a centralized, accessible repository for HIV and cancer samples and data are vital. Achieving these goals requires institutions to address barriers to research participation among people with HIV, focusing on patient-centered initiatives that leverage biomedical research to improve their outcomes and extend their lives.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"9"},"PeriodicalIF":7.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue-engineered patient-derived osteosarcoma models dissecting tumour-bone interactions. 组织工程患者衍生骨肉瘤模型剖析肿瘤与骨骼之间的相互作用。

IF 7.7 2区医学

Cancer and Metastasis Reviews Pub Date : 2024-11-27 DOI: 10.1007/s10555-024-10218-2

Tina Frankenbach-Désor, Isabella Niesner, Parveen Ahmed, Hans Roland Dürr, Alexander Klein, Thomas Knösel, Jonathan Gospos, Jacqui A McGovern, Dietmar W Hutmacher, Boris M Holzapfel, Susanne Mayer-Wagner

{"title":"Tissue-engineered patient-derived osteosarcoma models dissecting tumour-bone interactions.","authors":"Tina Frankenbach-Désor, Isabella Niesner, Parveen Ahmed, Hans Roland Dürr, Alexander Klein, Thomas Knösel, Jonathan Gospos, Jacqui A McGovern, Dietmar W Hutmacher, Boris M Holzapfel, Susanne Mayer-Wagner","doi":"10.1007/s10555-024-10218-2","DOIUrl":"10.1007/s10555-024-10218-2","url":null,"abstract":"Osteosarcoma is the most common malignant bone tumor, primarily affecting children and young adults. For these young patients, the current treatment options for osteosarcoma impose considerable constraints on daily life with significant morbidity and a low survival rate. Despite ongoing research efforts, the 5-year survival rate of first-diagnosed patients without metastases has not changed in the past four decades. The demand for novel treatments is currently still unmet, in particular for effective second-line therapy. Therefore, there is an urgent need for advanced preclinical models and drug-testing platforms that take into account the complex disease characteristics, the high heterogeneity of the tumour and the interactions with the bone microenvironment. In this review, we provide a comprehensive overview about state-of-the-art tissue-engineered and patient-specific models for osteosarcoma. These sophisticated platforms for advanced therapy trials aim to improve treatment outcomes for future patients by modelling the patient's disease state in a more accurate and complex way, thus improving the quality of preclinical research studies.","PeriodicalId":9489,"journal":{"name":"Cancer and Metastasis Reviews","volume":"44 1","pages":"8"},"PeriodicalIF":7.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0