Magdalena Rados, Anna Landegger, Lukas Schmutzler, Kimberlie Rabidou, Sabine Taschner-Mandl, Irfete S. Fetahu
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引用次数: 0
Abstract
Natural killer (NK) cells have multifaceted roles within the complex tumor milieu. They are pivotal components of innate immunity and shape the dynamic landscape of tumor-immune cell interactions, and thus can be leveraged for use in therapeutic interventions. NK-based immunotherapies have had remarkable success in hematological malignancies, but these therapies are met with many challenges in solid tumors, including neuroblastoma (NB), a childhood tumor arising from the sympathetic nervous system. With a focus on NB, this review outlines the mechanisms employed by NK cells to recognize and eliminate malignant cells, delving into the dynamic relationship between ligand-receptor interactions, cytokines, and other molecules that facilitate the cross talk between NK and NB cells. We discuss the immunomodulatory functions of NK cells and the mechanisms that contribute to loss of this immunosurveillance in NB, with a focus on how this dynamic has been utilized in recent immunotherapy advancements for NB.
自然杀伤（NK）细胞在复杂的肿瘤环境中发挥着多方面的作用。它们是先天性免疫的关键组成部分，决定着肿瘤-免疫细胞相互作用的动态格局，因此可用于治疗干预。基于 NK 的免疫疗法在血液恶性肿瘤中取得了显著的成功，但在实体瘤中却遇到了许多挑战，其中包括神经母细胞瘤（NB），这是一种产生于交感神经系统的儿童肿瘤。本综述以 NB 为重点，概述了 NK 细胞识别和消灭恶性细胞的机制，深入探讨了配体与受体之间的相互作用、细胞因子以及促进 NK 和 NB 细胞之间交叉对话的其他分子之间的动态关系。我们讨论了 NK 细胞的免疫调节功能以及导致 NB 丧失这种免疫监视功能的机制，并重点探讨了在最近的 NB 免疫疗法进展中如何利用这种动态关系。
期刊介绍：
Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments.
A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.
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