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Identifying Optimal Candidates for Primary Tumor Resection Among Metastatic Pancreatic Cancer Patients: A Population-Based Predictive Model. 在转移性胰腺癌患者中识别原发肿瘤切除术的最佳候选者：基于人群的预测模型。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-01 Epub Date: 2024-05-07 DOI: 10.1080/07357907.2024.2349585
Kaifeng Su, Ruifeng Duan, Yang Wu
{"title":"Identifying Optimal Candidates for Primary Tumor Resection Among Metastatic Pancreatic Cancer Patients: A Population-Based Predictive Model.","authors":"Kaifeng Su, Ruifeng Duan, Yang Wu","doi":"10.1080/07357907.2024.2349585","DOIUrl":"10.1080/07357907.2024.2349585","url":null,"abstract":"<p><strong>Background: </strong>There is a controversy about whether surgery should proceed among metastatic pancreatic cancer (mPC) patients. A survival benefit was observed in mPC patients who underwent primary tumor resection; however, determining which patients would benefit from surgery is complex. For this purpose, we created a model to identify mPC patients who may benefit from primary tumor excision.</p><p><strong>Methods: </strong>Patients with mPC were extracted from the Surveillance, Epidemiology, and End Results database, and separated into surgery and nonsurgery groups based on whether the primary tumor was resected. Propensity score matching (PSM) was applied to balance confounding factors between the two groups. A nomogram was developed using multivariable logistic regression to estimate surgical benefit. Our model is evaluated using multiple methods.</p><p><strong>Results: </strong>About 662 of 14,183 mPC patients had primary tumor surgery. Kaplan-Meier analyses showed that the surgery group had a better prognosis. After PSM, a survival benefit was still observed in the surgery group. Among the surgery cohort, 202 patients survived longer than 4 months (surgery-beneficial group). The nomogram discriminated better in training and validation sets under the receiver operating characteristic (ROC) curve (AUC), and calibration curves were consistent. Decision curve analysis (DCA) revealed that it was clinically valuable. This model is better at identifying candidates for primary tumor excision.</p><p><strong>Conclusion: </strong>A helpful prediction model was developed and validated to identify ideal candidates who may benefit from primary tumor resection in mPC.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"333-344"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on Pediatric Thyroid Cancer Incidence and Mortality Trends in the United States, 2000-2018. 2000-2018年美国小儿甲状腺癌发病率和死亡率趋势的最新情况。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-01 Epub Date: 2024-05-14 DOI: 10.1080/07357907.2024.2353313
Guan Li, Jesse W Tai, Peter K Moon, Uchechukwu C Megwalu
{"title":"Update on Pediatric Thyroid Cancer Incidence and Mortality Trends in the United States, 2000-2018.","authors":"Guan Li, Jesse W Tai, Peter K Moon, Uchechukwu C Megwalu","doi":"10.1080/07357907.2024.2353313","DOIUrl":"10.1080/07357907.2024.2353313","url":null,"abstract":"<p><p>Thyroid cancer is the most common endocrine malignancy in the pediatric population. A recent study has revealed a recent decline in overall US thyroid cancer incidence rates. The aim of this study is to assess whether there has been a corresponding decline in incidence rates in the pediatric population. We used the Surveillance, Epidemiology, and End Results (SEER) database to analyze the pediatric thyroid cancer incidence rate. The results demonstrate that the incidence rate of pediatric thyroid cancer continued to increase from 2000 to 2018. Future studies are needed to understand how recent changes in guidelines are affecting incidence rates.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"357-360"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Nature, Origin, and Evolution of Life: Part IV Cellular Differentiation and the Emergence of Multicellular Life. 生命的本质、起源和进化：第四部分 细胞分化和多细胞生命的出现》。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-04-01 Epub Date: 2024-01-18 DOI: 10.1080/07357907.2024.2302201
Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
{"title":"The Nature, Origin, and Evolution of Life: Part IV Cellular Differentiation and the Emergence of Multicellular Life.","authors":"Gary H Lyman, Christopher H Lyman, Nicole M Kuderer","doi":"10.1080/07357907.2024.2302201","DOIUrl":"10.1080/07357907.2024.2302201","url":null,"abstract":"","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"275-277"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacts of Perioperative Comprehensive Nursing Intervention on Postoperative Urinary Incontinence and Quality of Life of Patients Undergoing Laparoscopic Radical Prostatectomy. 围手术期综合护理干预对腹腔镜根治性前列腺切除术患者术后尿失禁和生活质量的影响
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-03-01 Epub Date: 2024-03-19 DOI: 10.1080/07357907.2024.2308173
Lulu Xin, Jinjin Guo
{"title":"Impacts of Perioperative Comprehensive Nursing Intervention on Postoperative Urinary Incontinence and Quality of Life of Patients Undergoing Laparoscopic Radical Prostatectomy.","authors":"Lulu Xin, Jinjin Guo","doi":"10.1080/07357907.2024.2308173","DOIUrl":"10.1080/07357907.2024.2308173","url":null,"abstract":"<p><p>To evaluate the impact of perioperative comprehensive nursing intervention on postoperative urinary incontinence, various aspects of patient well-being were assessed. The comprehensive group, that received the nursing intervention, demonstrated significant improvements in self-care skills, health knowledge level, self-care responsibility, and self-concept compared to the standard group. The findings indicate that perioperative comprehensive nursing intervention has a remarkable effect on patients undergoing laparoscopic radical prostatectomy. This nursing intervention not only effectively improves postoperative urinary incontinence and alleviates negative emotions, such as anxiety and depression. Therefore, the implementation of this nursing intervention model is highly recommended for clinical practice and wider application.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"202-211"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of a Nomogram for Prognosis Prediction in Patients with Synchronous Primary Thyroid and Breast Cancer Based on SEER Database. 基于 SEER 数据库的同步原发性甲状腺癌和乳腺癌患者预后预测提名图的开发与验证
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-03-01 Epub Date: 2024-03-25 DOI: 10.1080/07357907.2024.2329963
Miao Huo, Jianfei Zhang, Minna Hou, Jianhui Li, Ning Bai, Ruifen Xu, Jiao Guo
{"title":"Development and Validation of a Nomogram for Prognosis Prediction in Patients with Synchronous Primary Thyroid and Breast Cancer Based on SEER Database.","authors":"Miao Huo, Jianfei Zhang, Minna Hou, Jianhui Li, Ning Bai, Ruifen Xu, Jiao Guo","doi":"10.1080/07357907.2024.2329963","DOIUrl":"10.1080/07357907.2024.2329963","url":null,"abstract":"<p><p>This study aimed to develop prognostic prediction models for patients diagnosed with synchronous thyroid and breast cancer (TBC). Utilizing the SEER database, key predictive factors were identified, including T stage of thyroid cancer, T stage of breast cancer, M stage of breast cancer, patient age, thyroid cancer surgery type, and isotope therapy. A nomogram predicting 5-year and 10-year survival rates was constructed and validated, exhibiting strong performance (C-statistic: 0.79 in the development cohort (95% CI: 0.74-0.84), and 0.82 in the validation cohort (95% CI: 0.77-0.89)). The area under the Receiver Operator Characteristic (ROC) curve ranged from 0.798 to 0.883 for both cohorts. Calibration and decision curve analyses further affirmed the model's clinical utility. Stratifying patients into high-risk and low-risk groups using the nomogram revealed significant differences in survival rates (<i>P</i> < 0.0001). The successful development and validation of this nomogram for predicting 5-year and 10-year survival rates in patients with synchronous TBC hold promise for similar patient populations, contributing significantly to cancer research.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"212-225"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Nature, Origin, and Evolution of Life: Part III the Emergence of Complex Life. 生命的本质、起源和进化：第三部分复杂生命的出现。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-03-01 Epub Date: 2023-11-17 DOI: 10.1080/07357907.2023.2281715
Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
{"title":"The Nature, Origin, and Evolution of Life: Part III the Emergence of Complex Life.","authors":"Gary H Lyman, Christopher H Lyman, Nicole M Kuderer","doi":"10.1080/07357907.2023.2281715","DOIUrl":"10.1080/07357907.2023.2281715","url":null,"abstract":"","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"199-201"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71478355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma. 食管鳞状细胞癌化疗期间同时使用克罗霉素的随机、双盲、安慰剂对照临床试验
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2024-02-22 DOI: 10.1080/07357907.2024.2319754
Nima Ebrahimi, Seyed Alireza Javadinia, Roham Salek, Azar Fanipakdel, Samaneh Sepahi, Mansoureh Dehghani, Niloufar Valizadeh, Seyed Ahmad Mohajeri
{"title":"Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma.","authors":"Nima Ebrahimi, Seyed Alireza Javadinia, Roham Salek, Azar Fanipakdel, Samaneh Sepahi, Mansoureh Dehghani, Niloufar Valizadeh, Seyed Ahmad Mohajeri","doi":"10.1080/07357907.2024.2319754","DOIUrl":"10.1080/07357907.2024.2319754","url":null,"abstract":"<p><p><i>Crocin</i> is the major active carotenoid of saffron (Crocus sativus L.). Its pluripotent effects have led to a growing body of literature investigating its antitumor properties as well as its diverse potentials for mood stabilization, normal tissue protection, and inflammation reduction; However, there is a gap in clinical trials testing this substance in cancer patients. In this randomized, double-blind, placebo-controlled clinical trial, patients with newly diagnosed esophageal squamous cell carcinoma were randomly assigned to either 30 mg/day of crocin or placebo, prescribed during the neoadjuvant chemo-radiotherapy. The primary endpoints were pathological response and toxicity, and secondary endpoints were depression and anxiety levels and survival analysis.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"155-164"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Nature, Origin and Evolution of Life: Part II The Origin of Life. 生命的本质、起源、发展和进化：第二部分生命的起源。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2023-10-18 DOI: 10.1080/07357907.2023.2270277
Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
{"title":"The Nature, Origin and Evolution of Life: Part II The Origin of Life.","authors":"Gary H Lyman, Christopher H Lyman, Nicole M Kuderer","doi":"10.1080/07357907.2023.2270277","DOIUrl":"10.1080/07357907.2023.2270277","url":null,"abstract":"","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"115-118"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41192055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NGS-based Tissue-Blood TMB Comparison and Blood-TMB Monitoring in Stage-III Non-Small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy. 基于 NGS 的组织-血液 TMB 比较和血液-TMB 监测在同时接受化疗放疗的 III 期非小细胞肺癌中的应用。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.1080/07357907.2024.2316297
Luxi Ye, Xiao Chu, Jianjiao Ni, Li Chu, Xi Yang, Zhengfei Zhu
{"title":"NGS-based Tissue-Blood TMB Comparison and Blood-TMB Monitoring in Stage-III Non-Small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy.","authors":"Luxi Ye, Xiao Chu, Jianjiao Ni, Li Chu, Xi Yang, Zhengfei Zhu","doi":"10.1080/07357907.2024.2316297","DOIUrl":"10.1080/07357907.2024.2316297","url":null,"abstract":"<p><p>In this study, we analyzed the blood-based TMB (b-TMB) and its dynamic changes in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who received concurrent chemoradiotherapy. Baseline tissue and blood TMB from 15 patients showed a strong positive correlation (Pearson correlation = 0.937), and nearly all mutations were markedly reduced in the later course of treatment, indicating a treatment-related response. This study suggests that in patients with LA-NSCLC, b-TMB is a reliable biomarker, and its dynamic monitoring can help distinguish patients who might benefit most from the consolidated immunotherapy.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"165-175"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting EGFR and VEGFR-2 Kinases With Nanoparticles: A Computational Approach for Cancer Therapy Advancement. 用纳米粒子靶向表皮生长因子受体和血管内皮生长因子受体-2激酶：促进癌症治疗的计算方法》。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2024-03-14 DOI: 10.1080/07357907.2024.2328529
Ibrahim Khater, Aaya Nassar
{"title":"Targeting EGFR and VEGFR-2 Kinases With Nanoparticles: A Computational Approach for Cancer Therapy Advancement.","authors":"Ibrahim Khater, Aaya Nassar","doi":"10.1080/07357907.2024.2328529","DOIUrl":"10.1080/07357907.2024.2328529","url":null,"abstract":"<p><p>The study investigates titanium and zinc nanoparticles as inhibitors for the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor-2 (VEGFR-2), pivotal regulators of cell processes. VEGFR-2 activation fuels tumor angiogenesis in cancer cells, sustaining malignant tissue expansion. Molecular docking analysis illustrates the nanoparticles' binding to the active sites, inhibiting the phosphorylation of key proteins in downstream signaling. This inhibition offers a promising therapeutic approach to impede cancer-related signaling, potentially slowing down aberrant protein cascades controlled by EGFR and VEGFR-2. The findings propose a novel avenue for cancer treatment, targeting abnormal growth pathways using titanium and zinc nanoparticles.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"176-185"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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