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Evaluation of the Efficacy of Postoperative Adjuvant Therapy for HER2-Positive Ductal Carcinoma in Situ with Microinvasion. 对微小浸润的 HER2 阳性原位乳管癌术后辅助治疗的疗效评估
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.1080/07357907.2024.2355320
Zhihong Xu, Dan Tao, Zhibing Zhou, Qihua Jiang, Wensong Wei
{"title":"Evaluation of the Efficacy of Postoperative Adjuvant Therapy for HER2-Positive Ductal Carcinoma <i>in Situ</i> with Microinvasion.","authors":"Zhihong Xu, Dan Tao, Zhibing Zhou, Qihua Jiang, Wensong Wei","doi":"10.1080/07357907.2024.2355320","DOIUrl":"10.1080/07357907.2024.2355320","url":null,"abstract":"<p><p>A retrospective study on 90 eligible HER2+ ductal carcinoma <i>in situ</i> with microinvasion (DCIS-MI) patients was performed with a median follow-up time of 57 months. The baseline was consistent between the 4-cycle and 6-cycle chemotherapy groups. There were more patients with multiple foci of micrometastasis in the target therapy group in the two groups with or without target therapy (<i>p</i> < 0.01). Postoperative chemotherapy with a 4-cycle regimen can achieve the expected therapeutic effect in patients with HER2+ DCIS-MI, but the role of target therapy in HER2+ DCIS-MI patients has not been confirmed.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"408-415"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Analysis of N6-Methylandenosine-Related lncRNAs in Clear Cell Renal Cell Carcinoma: A Correlation With Prognosis, Tumor Progression, and Therapeutic Response 全面分析透明细胞肾细胞癌中的 N6-甲基腺苷相关 lncRNA：与预后、肿瘤进展和治疗反应的相关性
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-21 DOI: 10.1080/07357907.2024.2330103
Chang Meng, Juan Li, Xiang Wang, Yicen Ying, Zhihua Li, Aixiang Wang, Xuesong Li
{"title":"Comprehensive Analysis of N6-Methylandenosine-Related lncRNAs in Clear Cell Renal Cell Carcinoma: A Correlation With Prognosis, Tumor Progression, and Therapeutic Response","authors":"Chang Meng, Juan Li, Xiang Wang, Yicen Ying, Zhihua Li, Aixiang Wang, Xuesong Li","doi":"10.1080/07357907.2024.2330103","DOIUrl":"https://doi.org/10.1080/07357907.2024.2330103","url":null,"abstract":"This study aims to develop a prognostic signature based on m6A-related lncRNAs for clear cell renal cell carcinoma (ccRCC). Differential expression analysis and Pearson correlation analysis were us...","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"17 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140634807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma 预测胰腺导管腺癌患者预后的 15 种炎症相关基因特征
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-14 DOI: 10.1080/07357907.2024.2340577
Xiaofeng Sun, Hao Song, Xiaoran Sun, Chunhua Liao, Guoqiang Wang, Yu Xu, Leo Li, Yusheng Han, Chunwei Xu, Wenxian Wang, Shangli Cai, Hua Liang, Hao Yu
{"title":"A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma","authors":"Xiaofeng Sun, Hao Song, Xiaoran Sun, Chunhua Liao, Guoqiang Wang, Yu Xu, Leo Li, Yusheng Han, Chunwei Xu, Wenxian Wang, Shangli Cai, Hua Liang, Hao Yu","doi":"10.1080/07357907.2024.2340577","DOIUrl":"https://doi.org/10.1080/07357907.2024.2340577","url":null,"abstract":"Chronic inflammation promotes the development of pancreatic ductal adenocarcinoma (PDAC) and PDAC-related inflammatory tumor microenvironment facilitates tumor growth and metastasis. Thus, we aimed...","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"20 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity 开发新型食管鳞状细胞癌预后模型：洞察免疫细胞相互作用和药物敏感性
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-14 DOI: 10.1080/07357907.2024.2340576
Pu Wang, Yu Liu, Lingyu Wei, Jia Wang, Jinsheng Wang, Bin Du
{"title":"Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity","authors":"Pu Wang, Yu Liu, Lingyu Wei, Jia Wang, Jinsheng Wang, Bin Du","doi":"10.1080/07357907.2024.2340576","DOIUrl":"https://doi.org/10.1080/07357907.2024.2340576","url":null,"abstract":"Esophageal squamous cell carcinoma (ESCC) presents a five-year survival rate below 20%, underscoring the need for improved prognostic markers. Our study analyzed ESCC-specific datasets to identify ...","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"60 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Veliparib‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis 癌症患者中由 Veliparib 引起的毒性：系统回顾与元分析
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-08 DOI: 10.1080/07357907.2024.2338128
Peirong Wang, Ruizhen Zhao, Xiaohui Jin, Xianhua Zhou, Xiaolong Xie
{"title":"Veliparib‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis","authors":"Peirong Wang, Ruizhen Zhao, Xiaohui Jin, Xianhua Zhou, Xiaolong Xie","doi":"10.1080/07357907.2024.2338128","DOIUrl":"https://doi.org/10.1080/07357907.2024.2338128","url":null,"abstract":"In this study, we investigate the veliparib‑induced toxicity in cancer patients. Databases were searched for RCTs treated with veliparib. We found veliparib could increase the risk of hematologic a...","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"5 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AQP8 Modulates Mitochondrial H2O2 Transport to Influence Glioma Proliferation. AQP8 调节线粒体 H2O2 转运以影响胶质瘤增殖
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-01 Epub Date: 2024-05-14 DOI: 10.1080/07357907.2024.2352467
ZiHao Shen, HuaJun Sheng, Jing Zhao, Jin Xu, ZiLing Cai, Hao Zhang, Zhen Guo, JunNan Liu, Hang Liang, LiHao Tan, ShengWei Gan, Juan Huang, ShuJuan Zhu
{"title":"AQP8 Modulates Mitochondrial H<sub>2</sub>O<sub>2</sub> Transport to Influence Glioma Proliferation.","authors":"ZiHao Shen, HuaJun Sheng, Jing Zhao, Jin Xu, ZiLing Cai, Hao Zhang, Zhen Guo, JunNan Liu, Hang Liang, LiHao Tan, ShengWei Gan, Juan Huang, ShuJuan Zhu","doi":"10.1080/07357907.2024.2352467","DOIUrl":"10.1080/07357907.2024.2352467","url":null,"abstract":"<p><strong>Background: </strong>Aquaporin-8 (AQP8) is involved in impacting glioma proliferation and can effect tumour growth by regulating Intracellular reactive oxygen species (ROS) signalling levels. In addition to transporting H<sub>2</sub>O<sub>2</sub>, AQP8 has been shown to affect ROS signaling, but evidence is lacking in gliomas. In this study, we aimed to investigate how AQP8 affects ROS signaling in gliomas.</p><p><strong>Materials and methods: </strong>We constructed A172 and U251 cell lines with AQP8 knockdown and AQP8 rescue by CRISPR/Cas9 technology and overexpression of lentiviral vectors. We used CCK-8 and flow cytometry to test cell proliferation and cycle, immunofluorescence and Mito-Tracker CMXRos to observe the distribution of AQP8 expression in glioma cells, Amplex and DHE to study mitochondria release of H<sub>2</sub>O<sub>2</sub>, mitochondrial membrane potential (MMP) and NAD+/NADH ratio to assess mitochondrial function and protein blotting to detect p53 and p21 expression.</p><p><strong>Result: </strong>We found that AQP8 co-localised with mitochondria and that knockdown of AQP8 inhibited the release of H<sub>2</sub>O<sub>2</sub> from mitochondria and led to increased levels of ROS in mitochondria, thereby impairing mitochondrial function. We also discovered that AQP8 knockdown resulted in suppression of cell proliferation and was blocked at the G0/G1 phase with increased expression of mitochondrial ROS signalling-related p53/p21.</p><p><strong>Conclusions: </strong>This finding provides further evidence for mechanistic studies of AQP8 as a prospective target for the treatment of gliomas.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"345-356"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying Optimal Candidates for Primary Tumor Resection Among Metastatic Pancreatic Cancer Patients: A Population-Based Predictive Model. 在转移性胰腺癌患者中识别原发肿瘤切除术的最佳候选者：基于人群的预测模型。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-01 Epub Date: 2024-05-07 DOI: 10.1080/07357907.2024.2349585
Kaifeng Su, Ruifeng Duan, Yang Wu
{"title":"Identifying Optimal Candidates for Primary Tumor Resection Among Metastatic Pancreatic Cancer Patients: A Population-Based Predictive Model.","authors":"Kaifeng Su, Ruifeng Duan, Yang Wu","doi":"10.1080/07357907.2024.2349585","DOIUrl":"10.1080/07357907.2024.2349585","url":null,"abstract":"<p><strong>Background: </strong>There is a controversy about whether surgery should proceed among metastatic pancreatic cancer (mPC) patients. A survival benefit was observed in mPC patients who underwent primary tumor resection; however, determining which patients would benefit from surgery is complex. For this purpose, we created a model to identify mPC patients who may benefit from primary tumor excision.</p><p><strong>Methods: </strong>Patients with mPC were extracted from the Surveillance, Epidemiology, and End Results database, and separated into surgery and nonsurgery groups based on whether the primary tumor was resected. Propensity score matching (PSM) was applied to balance confounding factors between the two groups. A nomogram was developed using multivariable logistic regression to estimate surgical benefit. Our model is evaluated using multiple methods.</p><p><strong>Results: </strong>About 662 of 14,183 mPC patients had primary tumor surgery. Kaplan-Meier analyses showed that the surgery group had a better prognosis. After PSM, a survival benefit was still observed in the surgery group. Among the surgery cohort, 202 patients survived longer than 4 months (surgery-beneficial group). The nomogram discriminated better in training and validation sets under the receiver operating characteristic (ROC) curve (AUC), and calibration curves were consistent. Decision curve analysis (DCA) revealed that it was clinically valuable. This model is better at identifying candidates for primary tumor excision.</p><p><strong>Conclusion: </strong>A helpful prediction model was developed and validated to identify ideal candidates who may benefit from primary tumor resection in mPC.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"333-344"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on Pediatric Thyroid Cancer Incidence and Mortality Trends in the United States, 2000-2018. 2000-2018年美国小儿甲状腺癌发病率和死亡率趋势的最新情况。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-01 Epub Date: 2024-05-14 DOI: 10.1080/07357907.2024.2353313
Guan Li, Jesse W Tai, Peter K Moon, Uchechukwu C Megwalu
{"title":"Update on Pediatric Thyroid Cancer Incidence and Mortality Trends in the United States, 2000-2018.","authors":"Guan Li, Jesse W Tai, Peter K Moon, Uchechukwu C Megwalu","doi":"10.1080/07357907.2024.2353313","DOIUrl":"10.1080/07357907.2024.2353313","url":null,"abstract":"<p><p>Thyroid cancer is the most common endocrine malignancy in the pediatric population. A recent study has revealed a recent decline in overall US thyroid cancer incidence rates. The aim of this study is to assess whether there has been a corresponding decline in incidence rates in the pediatric population. We used the Surveillance, Epidemiology, and End Results (SEER) database to analyze the pediatric thyroid cancer incidence rate. The results demonstrate that the incidence rate of pediatric thyroid cancer continued to increase from 2000 to 2018. Future studies are needed to understand how recent changes in guidelines are affecting incidence rates.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"357-360"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Nature, Origin, and Evolution of Life: Part IV Cellular Differentiation and the Emergence of Multicellular Life. 生命的本质、起源和进化：第四部分 细胞分化和多细胞生命的出现》。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-04-01 Epub Date: 2024-01-18 DOI: 10.1080/07357907.2024.2302201
Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
{"title":"The Nature, Origin, and Evolution of Life: Part IV Cellular Differentiation and the Emergence of Multicellular Life.","authors":"Gary H Lyman, Christopher H Lyman, Nicole M Kuderer","doi":"10.1080/07357907.2024.2302201","DOIUrl":"10.1080/07357907.2024.2302201","url":null,"abstract":"","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"275-277"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacts of Perioperative Comprehensive Nursing Intervention on Postoperative Urinary Incontinence and Quality of Life of Patients Undergoing Laparoscopic Radical Prostatectomy. 围手术期综合护理干预对腹腔镜根治性前列腺切除术患者术后尿失禁和生活质量的影响
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-03-01 Epub Date: 2024-03-19 DOI: 10.1080/07357907.2024.2308173
Lulu Xin, Jinjin Guo
{"title":"Impacts of Perioperative Comprehensive Nursing Intervention on Postoperative Urinary Incontinence and Quality of Life of Patients Undergoing Laparoscopic Radical Prostatectomy.","authors":"Lulu Xin, Jinjin Guo","doi":"10.1080/07357907.2024.2308173","DOIUrl":"10.1080/07357907.2024.2308173","url":null,"abstract":"<p><p>To evaluate the impact of perioperative comprehensive nursing intervention on postoperative urinary incontinence, various aspects of patient well-being were assessed. The comprehensive group, that received the nursing intervention, demonstrated significant improvements in self-care skills, health knowledge level, self-care responsibility, and self-concept compared to the standard group. The findings indicate that perioperative comprehensive nursing intervention has a remarkable effect on patients undergoing laparoscopic radical prostatectomy. This nursing intervention not only effectively improves postoperative urinary incontinence and alleviates negative emotions, such as anxiety and depression. Therefore, the implementation of this nursing intervention model is highly recommended for clinical practice and wider application.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"202-211"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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