Cancer Investigation最新文献

Topical Curcumin for Prevention of Radiation-Induced Dermatitis: A Pilot Double‑Blind, Placebo‑Controlled Trial.

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-03-27 DOI: 10.1080/07357907.2025.2479542

Behrooz Heydari, Soudabe Sheikhalishahi, Farahnaz Hoseinzade, Masood Shabani, Vahid Ramezani, Fatemeh Saghafi

{"title":"Topical Curcumin for Prevention of Radiation-Induced Dermatitis: A Pilot Double‑Blind, Placebo‑Controlled Trial.","authors":"Behrooz Heydari, Soudabe Sheikhalishahi, Farahnaz Hoseinzade, Masood Shabani, Vahid Ramezani, Fatemeh Saghafi","doi":"10.1080/07357907.2025.2479542","DOIUrl":"https://doi.org/10.1080/07357907.2025.2479542","url":null,"abstract":"Background: Radiation-induced dermatitis, a common radiotherapy (RT) complication, affects 95% of breast cancer patients, with 10% experiencing severe reactions. Despite advancements, radiation dermatitis remains a challenge, disrupting treatment schedules and compromising patients' quality of life. Exploring herbal compounds, particularly Curcumin, has shown promise in addressing radiation-induced dermatitis, with its non-toxic and anti-inflammatory properties offering the potential for clinical trials to prevent these reactions.Methods: This phase II randomized, double-blinded, placebo-controlled trial focused on adult females undergoing conventional fractionated RT. The main objective was to assess the efficacy of topical Curcumin in reducing the severity of radiation dermatitis.Results: During a five-month study, 52 breast cancer patients completed the research. Participants were divided into Curcumin and placebo groups. In the first week, a significant difference in redness (P-value = 0.001) and irritation (P-value = 0.017) was observed, with the Curcumin group showing lower percentages. This trend continued in the second, third, and fourth weeks (P-value = 0.001). No statistical difference was found in itching (P-value = 0.446), and the occurrence of dryness (P-value = 1.000) remained constant in both groups throughout the four weeks. In pain the differences were significant in the second, third, and fourth weeks (P-value = 0.001).Conclusion: The study highlights the success of a 2% Curcumin gel in reducing skin side effects during breast cancer radiation therapy, suggesting its potential to enhance patients' quality of life.Trial registration: IRCT20181208041882N3, 06/11/2020 (https://en.irct.ir/trial/49228).","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Validation of Local Versus Commercial Genomic Testing in Cancer: A Comparison of Tissue and Plasma Concordance.

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-02-01 Epub Date: 2025-02-24 DOI: 10.1080/07357907.2025.2464684

Lucy G Faulkner, Lynne Howells, Susann Lehman, Caroline Cowley, Zahirah Sidat, Jacqui Shaw, Anne L Thomas

{"title":"Clinical Validation of Local Versus Commercial Genomic Testing in Cancer: A Comparison of Tissue and Plasma Concordance.","authors":"Lucy G Faulkner, Lynne Howells, Susann Lehman, Caroline Cowley, Zahirah Sidat, Jacqui Shaw, Anne L Thomas","doi":"10.1080/07357907.2025.2464684","DOIUrl":"10.1080/07357907.2025.2464684","url":null,"abstract":"Genomic sequencing of tumours improves patient outcomes through implementation of precision oncology. At present, genomic testing is mainly confined to research settings, with samples sent to biopharmaceutical companies for analysis. The ever-expanding catalogue approved of targeted therapies has created an urgent unmet need for local genomic testing facilities, to enable upscaling of testing. Here, we compare the outcomes of local (IonTorrent™) and commercial (Foundation Medicine) genomic testing collected from 30 cancer patients in from plasma and tissue samples. Overall concordance was high in both tissue (98%) and plasma (94.2%). Variants identified by both platforms had a strong correlation in variant allele frequencies (VAF%): plasma: r = 0.99 p < 0.0001, tissue: r = 0.91 p < 0.0001. However, numerous low VAF% variants resulted in low positive percentage agreement (tissue 78.8% plasma 16.1%) and positive predictive values (tissue 56.3% plasma 71.4%). Local sequencing demonstrated higher fidelity in detecting fusions but low fidelity in detecting indels. Overall, this study supports the use of local genomic testing for routine molecular diagnostics but highlights outstanding issues before widespread implementation. Processing of variants detected at low VAF% and the limit of detection of assays needs to be addressed. Construction of gene panels requires careful consideration, including incorporation of markers of genomic instability.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"119-140"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exclusion of People Living with HIV in Aggressive B-Cell Non-Hodgkin Lymphoma Studies: A Cross-Sectional Analysis of Clinical Trials from 2014 to 2024.

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-02-01 Epub Date: 2025-02-08 DOI: 10.1080/07357907.2025.2462568

Daniel J Olivieri, Ajay K Gopal, Thomas S Uldrick, Manoj P Menon

{"title":"Exclusion of People Living with HIV in Aggressive B-Cell Non-Hodgkin Lymphoma Studies: A Cross-Sectional Analysis of Clinical Trials from 2014 to 2024.","authors":"Daniel J Olivieri, Ajay K Gopal, Thomas S Uldrick, Manoj P Menon","doi":"10.1080/07357907.2025.2462568","DOIUrl":"10.1080/07357907.2025.2462568","url":null,"abstract":"Background: Human immunodeficiency virus is associated with the development of various aggressive non-Hodgkin B-cell lymphomas (NHL). Despite this, people living with HIV (PLWH) are often excluded from clinical trials. Here we analyze the change in clinical trial exclusion among PLWH resulting from multilateral advocacy efforts since 2017.Methods: We identified all US-based clinical trials with the keyword \"lymphoma\" with start dates between January 01, 2014 and January 04, 2025 using the publicly available NIH Clinical Trial Database (https://www.clinicaltrials.gov/). All studies with aggressive B-cell NHL subtypes were included. Regression models were performed to analyze descriptive factors.Results: 1,973 US-based clinical trials were captured, of which 945 met criteria for further analysis. PLWH were excluded from 59% pre-2018 versus 48% post-2018. After multivariate adjustment, NIH-funded trials (24% exclusion rate, p < 0.001), other funders (64% exclusion rate), and studies initiated post-2018 (48% exclusion rate, p < 0.001) were associated with inclusion, while CAR-T-related studies (62% exclusion rate, p < 0.05) were associated with exclusion.Conclusions: Likely partly due to advocacy from ASCO, NCI, and NCCN, there was a significant decrease in exclusion among PLWH in US-based NHL clinical trials. Future research should analyze the safety and efficacy of immunotherapy in PLWH to foster inclusion and reduce stigma among physicians and researchers.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"141-148"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Search for Healthcare and Breast/Gynecological Cancer Prevention Among Brazilian Lesbian Cisgender Women.

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI: 10.1080/07357907.2025.2457614

Carolina de Souza, Manoel Antônio Dos Santos

{"title":"Search for Healthcare and Breast/Gynecological Cancer Prevention Among Brazilian Lesbian Cisgender Women.","authors":"Carolina de Souza, Manoel Antônio Dos Santos","doi":"10.1080/07357907.2025.2457614","DOIUrl":"10.1080/07357907.2025.2457614","url":null,"abstract":"Although breast, cervical, endometrial, and ovarian cancers account for more than 43% of new cases in 2023 in Brazilian women, no national studies were found on the incidence, risk factors, and prevention of breast and gynecological neoplasms in lesbian women, causing the health needs of non-heterosexual women to go unnoticed by professionals. This study aims to identify and analyze the search for healthcare related to the prevention of breast/gynecological cancer among Brazilian lesbian cisgender women who have not had the disease. Seven lesbian women participated in this qualitative study. Semi-structured interviews were conducted and subsequently transcribed and analyzed following the reflexive thematic analysis approach and the theoretical framework of gender studies. Two thematic axes were constructed: gynecological appointments, which includes the subthemes follow-ups, types of exams, and struggles with the healthcare system, and meeting health professionals, which includes relationships with professionals, searching for professionals, discussing sexual orientation, and (un)preparedness. The participants in this study reported visiting a gynecologist at least once and doing preventive exams, although the frequency of these appointments varied for each woman. However, they highlighted that healthcare providers are not adequately prepared to address the needs of lesbian women and to talk about sexual orientation.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"149-160"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Diagnostic Tools & Outcomes Evaluation for t (9;22)-Positive Leukemias in Pediatric Low Middle-Income Country (LMIC) Patients.

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-02-01 Epub Date: 2025-01-24 DOI: 10.1080/07357907.2025.2457144

Syed Ibrahim Bukhari, Sadaf Altaf, Hira Saleem, Zehra Fadoo, Asim Fakhruddin Belgaumi, Tariq Moatter, Zeeshan Ansar

{"title":"Optimizing Diagnostic Tools & Outcomes Evaluation for t (9;22)-Positive Leukemias in Pediatric Low Middle-Income Country (LMIC) Patients.","authors":"Syed Ibrahim Bukhari, Sadaf Altaf, Hira Saleem, Zehra Fadoo, Asim Fakhruddin Belgaumi, Tariq Moatter, Zeeshan Ansar","doi":"10.1080/07357907.2025.2457144","DOIUrl":"10.1080/07357907.2025.2457144","url":null,"abstract":"Accurate and timely diagnosis of t(9;22)-positive leukemias is vital to improving survival in pediatric patients. In low-resource settings, where healthcare disparities are exacerbated by limited resources, cost-effective and efficient diagnostic methods are essential for bridging these gaps and ensuring better outcomes. Among the diagnostic tools evaluated among 23 patients sample, RT-PCR demonstrated superior sensitivity (100%) and the shortest turnaround time (7 days), significantly outperforming FISH and karyotyping in both accuracy and timeliness. This capability of RT-PCR to provide reliable and rapid results enables earlier treatment initiation, which is critical in managing these aggressive leukemias. Simplified statistical reporting underscores RT-PCR's unmatched sensitivity, while FISH and karyotyping, though useful, showed moderate performance with longer delays. By adopting RT-PCR as the primary diagnostic tool in LMICs, healthcare systems can make faster and more accurate treatment decisions, reduce overall treatment costs by avoiding diagnostic delays, and ultimately improve survival rates in pediatric leukemia patients.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"161-171"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence in Cancer Clinical Research: V. What We Have Learned About Human Intelligence from Artificial Intelligence.

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI: 10.1080/07357907.2025.2467565

Gary Lyman, Nicole Kuderer

引用次数: 0

Correction.

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-02-01 Epub Date: 2025-01-30 DOI: 10.1080/07357907.2025.2456336

引用次数: 0

A Comprehensive Insight into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics. 细胞凋亡：分子机制、信号通路和调节疗法。

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-01-01 Epub Date: 2025-01-06 DOI: 10.1080/07357907.2024.2445528

Mehrdad Mosadegh, Narjes Noori Goodarzi, Yousef Erfani

{"title":"A Comprehensive Insight into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics.","authors":"Mehrdad Mosadegh, Narjes Noori Goodarzi, Yousef Erfani","doi":"10.1080/07357907.2024.2445528","DOIUrl":"10.1080/07357907.2024.2445528","url":null,"abstract":"Apoptosis, or programmed cell death, is a fundamental biological process essential for maintaining tissue homeostasis. Dysregulation of apoptosis is implicated in a variety of diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. This review provides an in-depth insight into the molecular mechanisms and signaling pathways that regulate apoptosis, highlighting both intrinsic and extrinsic pathways. Additionally, the review explains the tumor microenvironment's influence on apoptosis and its implications for cancer therapy resistance. Understanding the complex interplay between apoptotic signaling and cellular responses is crucial for developing targeted therapies that can effectively manage diseases associated with apoptosis dysregulation. The effects of conventional therapeutics and alternative substances with natural sources such as herbal compounds, alongside vitamins, minerals, and trace elements on cellular homeostasis and disease pathogenesis have been thoroughly investigated. Moreover, recent advances in therapeutic strategies aimed at modulating apoptosis are discussed, with a focus on novel interventions such as nutrition bio shield dietary supplement. These emerging approaches offer potential benefits beyond conventional treatments by selectively targeting apoptotic pathways to inhibit cancer progression and metastasis. By integrating insights from recent studies, this review aims to enhance our understanding of apoptosis and guide future research in developing innovative therapeutic approaches.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"33-58"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Brain Cancer Occurrence and Risk Assessment of Brain Hemorrhage Using Hybrid Deep Learning Technique. 基于混合深度学习技术的脑癌发生预测及脑出血风险评估。

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-01-01 Epub Date: 2024-12-04 DOI: 10.1080/07357907.2024.2431829

Rajeshwar Prasad, Amit Kumar Saxena, Suman Laha

{"title":"Prediction of Brain Cancer Occurrence and Risk Assessment of Brain Hemorrhage Using Hybrid Deep Learning Technique.","authors":"Rajeshwar Prasad, Amit Kumar Saxena, Suman Laha","doi":"10.1080/07357907.2024.2431829","DOIUrl":"10.1080/07357907.2024.2431829","url":null,"abstract":"The prediction of brain cancer occurrence and risk assessment of brain hemorrhage using a hybrid deep learning (DL) technique is a critical area of research in medical imaging analysis. One prominent challenge in this field is the accurate identification and classification of brain tumors and hemorrhages, which can significantly impact patient prognosis and treatment planning. The objectives of the study address the prediction of brain cancer occurrence and the assessment of risk levels associated with both brain cancers due to brain hemorrhage. A diverse dataset of brain MRI and CT scan images. Utilize Unsymmetrical Trimmed Median Filter with Optics Clustering for noise removal while preserving edges and details. The Chan-Vese segmentation process for refined segmentation. Brain cancer detection using Multi-Head Self-Attention Dilated Convolution Neural Network (MH-SA-DCNN) with Efficient Net Model. Brain cancer detection using MH-SA-DCNN with Efficient Net Model. This trains the algorithm to predict cancerous regions in brain images. Further, implement a Graph-Based Deep Neural Network Model (G-DNN) to capture spatial relationships and risk factors from brain images. Cox regression model to estimate cancer risk over time and fine-tune and optimize the model's parameters and features using the Osprey optimization algorithm (OPA).","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"80-102"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Inflammation and Cancer: Key Pathways and Targeted Therapies. 慢性炎症和癌症：关键途径和靶向治疗。

IF 1.8 4区医学

Cancer Investigation Pub Date : 2025-01-01 Epub Date: 2024-12-08 DOI: 10.1080/07357907.2024.2437614

Gauri Kapoor, Swati Prakash, Vishakha Jaiswal, Ashok K Singh

引用次数: 0