Cancer Investigation最新文献

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Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva as a Diagnostic Specimen for Rapid Classification of Oral Squamous Cell Carcinoma Using Chemometrics Methods. 使用化学计量学方法对作为诊断样本的唾液进行衰减全反射-傅立叶变换红外光谱分析,以快速对口腔鳞状细胞癌进行分类。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-10-01 DOI: 10.1080/07357907.2024.2403086
Mohammad Mahdi Khanmohammadi Khorrami, Nozhan Azimi, Maryam Koopaie, Mahsa Mohammadi, Soheila Manifar, Mohammadreza Khanmohammadi Khorrami
{"title":"Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva as a Diagnostic Specimen for Rapid Classification of Oral Squamous Cell Carcinoma Using Chemometrics Methods.","authors":"Mohammad Mahdi Khanmohammadi Khorrami, Nozhan Azimi, Maryam Koopaie, Mahsa Mohammadi, Soheila Manifar, Mohammadreza Khanmohammadi Khorrami","doi":"10.1080/07357907.2024.2403086","DOIUrl":"https://doi.org/10.1080/07357907.2024.2403086","url":null,"abstract":"<p><strong>Background & aim: </strong>Recent advancements in analytical techniques have highlighted the potential of Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) spectroscopy as a quick, cost-effective, non-invasive, and efficient tool for cancer diagnosis. This study aims to evaluate the effectiveness of ATR-FTIR spectroscopy in combination with supervised machine learning classification models for diagnosing OSCC using saliva samples.</p><p><strong>Methods & materials: </strong>Eighty unstimulated whole saliva samples from OSCC patients and healthy controls were collected. The ATR-FTIR spectroscopy was performed and spectral data were used to classify healthy and OSCC groups. The data were analyzed using machine learning classification methods such as Partial Least Squares-Discriminant Analysis (PLS-DA) and Support Vector Machine Classification (SVM-C). The classification performance of the models was evaluated by computing sensitivity, specificity, precision, and accuracy.</p><p><strong>Results: </strong>The samples were classified into two classes based on their spectral data. The obtained results demonstrate a high level of accuracy in the prediction sets of the PLS-DA and SVM-C models, with accuracy values of 0.960 and 0.962, respectively. The OSCC group sensitivity values for both PLS-DA and SVM-C models was 1.00, respectively.</p><p><strong>Conclusion: </strong>The study indicates that ATR-FTIR spectroscopy, combined with chemometrics, is a potential method for the non-invasive diagnosis of OSCC using saliva samples. This method achieved high accuracy and the findings of this study suggest that ATR-FTIR spectroscopy could be further developed for clinical applications in OSCC diagnosis.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Antiperspirant Products and Risk of Breast Cancer: A Meta-Analysis of Case-Control Studies. 使用止汗剂产品与乳腺癌风险:病例对照研究的元分析》(Meta-Analysis of Case-Control Studies)。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-09-26 DOI: 10.1080/07357907.2024.2405864
Thao Thi Kim Trinh, Seung-Kwon Myung, Tien Hoang Tran, Kui Son Choi
{"title":"Use of Antiperspirant Products and Risk of Breast Cancer: A Meta-Analysis of Case-Control Studies.","authors":"Thao Thi Kim Trinh, Seung-Kwon Myung, Tien Hoang Tran, Kui Son Choi","doi":"10.1080/07357907.2024.2405864","DOIUrl":"https://doi.org/10.1080/07357907.2024.2405864","url":null,"abstract":"<p><p>Although several observational studies have reported a link between the use of underarm cosmetic products and the risk of breast cancer, the findings remain inconsistent. This study aimed to investigate these associations using a meta-analysis of observational studies. In the meta-analysis of seven case-control studies, we found no association between the use of underarm antiperspirants or deodorants and the risk of breast cancer (OR = 0.96, 95%CI 0.78-1.17; <i>I</i><sup>2</sup> = 60.0%). Further prospective cohort studies that provide a higher level of evidence are warranted to confirm our findings.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucose Metabolism and Glucose Transporters in Head and Neck Squamous Cell Carcinoma. 头颈部鳞状细胞癌中的葡萄糖代谢和葡萄糖转运体
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-09-26 DOI: 10.1080/07357907.2024.2407424
Yanyan Ye, Zaizai Cao
{"title":"Glucose Metabolism and Glucose Transporters in Head and Neck Squamous Cell Carcinoma.","authors":"Yanyan Ye, Zaizai Cao","doi":"10.1080/07357907.2024.2407424","DOIUrl":"https://doi.org/10.1080/07357907.2024.2407424","url":null,"abstract":"<p><p>Head and neck squamous cell carcinoma ranks seventh globally in malignancy prevalence, with persistent high mortality rates despite treatment advancements. Glucose, pivotal in cancer metabolism via the Warburg effect, enters cells via glucose transporters, notably GLUT proteins. Glycolysis, aerobic oxidation, and the pentose phosphate pathway in glucose metabolism significantly impact HNSCC progression. HNSCC exhibits elevated expression of glucose metabolism enzymes and GLUT proteins, correlating with prognosis. Heterogeneity in HNSCC yields varied metabolic profiles, influenced by factors like HPV status and disease stage. This review highlights glucose metabolism's role and potential as therapeutic targets and cancer imaging tracers in HNSCC.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Immune-Related Gene Pair Signature to Predict Prognosis of Diffuse Large B-Cell Lymphoma Based on Bioinformatics Analyses. 基于生物信息学分析鉴定用于预测弥漫大 B 细胞淋巴瘤预后的免疫相关基因对签名
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-09-23 DOI: 10.1080/07357907.2024.2405184
Zeinab Davoodi-Moghaddam, Farideh Jafari-Raddani, Davood Bashash
{"title":"Identification of Immune-Related Gene Pair Signature to Predict Prognosis of Diffuse Large B-Cell Lymphoma Based on Bioinformatics Analyses.","authors":"Zeinab Davoodi-Moghaddam, Farideh Jafari-Raddani, Davood Bashash","doi":"10.1080/07357907.2024.2405184","DOIUrl":"https://doi.org/10.1080/07357907.2024.2405184","url":null,"abstract":"<p><p>Since over one-third of DLBCL patients experience relapse or refractory after standard therapy, high-risk patients must be predicted. We developed a prognostic immune-related gene pairs (IRGPs) signature for DLBCL patients using bioinformatics analyses. This signature can predict the prognosis of these patients adequately, either alone or in combination with other clinical parameters. It hopes to improve the stratification and management of these patients for broad clinical applications.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flamingo Search Sailfish Optimizer Based SqueezeNet for Detection of Breast Cancer Using MRI Images. 基于 Flamingo Search Sailfish Optimizer 的 SqueezeNet 利用核磁共振成像检测乳腺癌。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-09-20 DOI: 10.1080/07357907.2024.2403088
P Vijaya, Satish Chander, Roshan Fernandes, Anisha P Rodrigues, Maheswari Raja
{"title":"Flamingo Search Sailfish Optimizer Based SqueezeNet for Detection of Breast Cancer Using MRI Images.","authors":"P Vijaya, Satish Chander, Roshan Fernandes, Anisha P Rodrigues, Maheswari Raja","doi":"10.1080/07357907.2024.2403088","DOIUrl":"https://doi.org/10.1080/07357907.2024.2403088","url":null,"abstract":"<p><p>Breast cancer with increased risk in women is identified with Breast Magnetic Resonance Imaging (Breast MRI) and this helps in evaluating treatment therapies. Breast MRI is time time-consuming process that involves the assessment of current imaging. This research work depends on the detection of breast cancer at the earlier stages. Among various cancers, breast cancer in women occurs in larger accounts for almost 30% of estimated cancer cases. In this research, many steps are followed for breast cancer detection like pre-processing, segmentation, augmentation, extraction of features, and cancer detection. Here, the median filter is utilized for pre-processing, as well as segmentation is followed after pre-processing, which is done by Psi-Net. Moreover, the process of augmentation like shearing, translation, and cropping are followed after segmentation. Also, the segmented image tends to process feature extraction, where features like shape features, Completed Local Binary Pattern (CLBP), Pyramid Histogram of Oriented Gradients (PHOG), and statistical features are extracted. Finally, breast cancer is detected using the DL model, SqueezeNet. Here, the newly devised Flamingo Search SailFish Optimizer (FSSFO) is used in training Psi-Net as well as SqueezeNet. Furthermore, FSSFO is the combination of both the Flamingo Search Algorithm (FSA) and SailFish Optimizer (SFO).</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of First-Line Platinum-Based Doublet Chemotherapy in Advanced Primary Pulmonary Salivary Gland Tumors (PSGTs). 晚期原发性肺唾液腺肿瘤(PSGTs)一线铂基双联化疗的有效性和安全性
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-09-16 DOI: 10.1080/07357907.2024.2399046
Zheng Shi, Xiaohong Zeng, Wei Sun, Manyi Xu, Keda Shao, Jingwen Wei, Chunwei Xu, Zhengbo Song
{"title":"Efficacy and Safety of First-Line Platinum-Based Doublet Chemotherapy in Advanced Primary Pulmonary Salivary Gland Tumors (PSGTs).","authors":"Zheng Shi, Xiaohong Zeng, Wei Sun, Manyi Xu, Keda Shao, Jingwen Wei, Chunwei Xu, Zhengbo Song","doi":"10.1080/07357907.2024.2399046","DOIUrl":"https://doi.org/10.1080/07357907.2024.2399046","url":null,"abstract":"<p><p>Primary pulmonary salivary gland tumors (PSGT) constitute a rare subtype of non-small cell lung cancer (NSCLC). Currently, no established treatment guidelines exist for advanced PSGT. The efficacy of platinum-based chemotherapy for PSGT within the context of NSCLC remains uncertain. Therefore, we retrospectively collected 37 PSGT patients who underwent first-line platinum-based chemotherapy from 2010 to 2023. Survival analysis, employing the Kaplan-Meier method, and group comparisons via the log rank test were conducted. Our results show that first-line platinum-based chemotherapy demonstrates favorable efficacy and manageable safety in advanced PSGT, with the combination of Paclitaxel + Platinum emerging as a preferred option.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Between Body Image and Meaning of Life Among Women with Breast Cancer in Kerman, Iran. 伊朗克尔曼患乳腺癌妇女的身体形象与生活意义之间的关系。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1080/07357907.2024.2371369
Mina Mahmoodabadi, Zohreh Khoshnood, Behjat Kalantari Khandani
{"title":"The Relationship Between Body Image and Meaning of Life Among Women with Breast Cancer in Kerman, Iran.","authors":"Mina Mahmoodabadi, Zohreh Khoshnood, Behjat Kalantari Khandani","doi":"10.1080/07357907.2024.2371369","DOIUrl":"10.1080/07357907.2024.2371369","url":null,"abstract":"<p><p>We aimed to examine the relationship between body image and the meaning of life among women with breast cancer. The analytic sample included 142 women with breast cancer, and data were collected using a standardized questionnaire through face-to-face interviews. We used Kolmogorov-Smirnov test, Pearson test, Spearman and Mann-Whitney U test to determine the relationship between the research variables. We found an association between the mean score of body image and the mean score of the meaning of life. As the average score of body image increases, the score of the meaning of life increases (<i>p</i> < 0.05). Findings indicated that the body image score increases by increasing the score of the meaning of life and its dimensions, especially existential vacuum and acceptance of death. Future research and targeted treatments should consider the role of body image in shaping the meaning of life among women with breast cancer.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/β-Catenin Signaling Pathway. TTYH3通过激活Wnt/β-Catenin信号通路促进宫颈癌进展
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-09-01 Epub Date: 2024-08-27 DOI: 10.1080/07357907.2024.2395014
Xiuyan Huang, Qing Li, Xiaoxia Zheng, Chen Jiang
{"title":"TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/<b><i>β</i></b>-Catenin Signaling Pathway.","authors":"Xiuyan Huang, Qing Li, Xiaoxia Zheng, Chen Jiang","doi":"10.1080/07357907.2024.2395014","DOIUrl":"10.1080/07357907.2024.2395014","url":null,"abstract":"<p><p>The role of tweety homolog 3 (TTYH3) has been studied in several cancers, including hepatocellular carcinoma, cholangiocarcinoma, and gastric cancer. The results showed that TTYH3 is highly expression in cervical cancer tissues and cells and high TTYH3 expression correlates with poor prognosis in patients with cervical cancer. TTYH3 markedly reduced the apoptosis rate and promoted proliferation, migration, and invasion. Silencing of TTYH3 has been shown to have an inhibitory effect on cervical cancer progression. Moreover, TTYH3 enhanced EMT and activated Wnt/β-catenin signaling. Furthermore, TTYH3 knockdown inhibited the tumor growth in vivo. In conclusion, TTYH3 promoted cervical cancer progression by activating the Wnt/β-catenin signaling.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver Cancer Diagnosis: Enhanced Deep Maxout Model with Improved Feature Set. 肝癌诊断:改进特征集的增强型深度 Maxout 模型
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-09-01 Epub Date: 2024-08-27 DOI: 10.1080/07357907.2024.2391359
Vinnakota Sai Durga Tejaswi, Venubabu Rachapudi
{"title":"Liver Cancer Diagnosis: Enhanced Deep Maxout Model with Improved Feature Set.","authors":"Vinnakota Sai Durga Tejaswi, Venubabu Rachapudi","doi":"10.1080/07357907.2024.2391359","DOIUrl":"10.1080/07357907.2024.2391359","url":null,"abstract":"<p><p>This work proposed a liver cancer classification scheme that includes Preprocessing, Feature extraction, and classification stages. The source images are pre-processed using Gaussian filtering. For segmentation, this work proposes a LUV transformation-based adaptive thresholding-based segmentation process. After the segmentation, certain features are extracted that include multi-texon based features, Improved Local Ternary Pattern (LTP-based features), and GLCM features during this phase. In the Classification phase, an improved Deep Maxout model is proposed for liver cancer detection. The adopted scheme is evaluated over other schemes based on various metrics. While the learning rate is 60%, an improved deep maxout model achieved a higher <i>F</i>-measure value (0.94) for classifying liver cancer; however, the previous method like Support Vector Machine (SVM), Random Forest (RF), Recurrent Neural Network (RNN), Long Short Term Memory (LSTM), K-Nearest Neighbor (KNN), Deep maxout, Convolutional Neural Network (CNN), and DL model holds less <i>F</i>-measure value. An improved deep maxout model achieved minimal False Positive Rate (FPR), and False Negative Rate (FNR) values with the best outcomes compared to other existing models for liver cancer classification.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Dysfunction in Non-CNS Metastatic Cancer: Comparing Brain Metastasis, Non-CNS Metastasis, and Healthy Controls. 非中枢神经系统转移性癌症的认知功能障碍:比较脑转移癌、非中枢神经系统转移癌和健康对照组
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-09-01 Epub Date: 2024-07-15 DOI: 10.1080/07357907.2024.2371368
Christopher Collette, Gabrielle Willhelm, Victor A Del Bene, Stephen L Aita, Dario Marotta, Terina Myers, Joseph Anderson, Meredith Gammon, Adam Gerstenecker, L Burt Nabors, John Fiveash, Kristen L Triebel
{"title":"Cognitive Dysfunction in Non-CNS Metastatic Cancer: Comparing Brain Metastasis, Non-CNS Metastasis, and Healthy Controls.","authors":"Christopher Collette, Gabrielle Willhelm, Victor A Del Bene, Stephen L Aita, Dario Marotta, Terina Myers, Joseph Anderson, Meredith Gammon, Adam Gerstenecker, L Burt Nabors, John Fiveash, Kristen L Triebel","doi":"10.1080/07357907.2024.2371368","DOIUrl":"10.1080/07357907.2024.2371368","url":null,"abstract":"<p><p>Limited research has compared cognition of people with non-central nervous system metastatic cancer (NCM) <i>vs.</i> metastatic brain cancer (BM). This prospective cross-sectional study was comprised 37 healthy controls (HC), 40 NCM, and 61 BM completing 10 neuropsychological tests. The NCM performed below HCs on processing speed and executive functioning tasks, while the BM group demonstrated lower performance across tests. Tasks of processing speed, verbal fluency, and verbal memory differentiated the clinical groups (BM < NCM). Nearly 20% of the NCM group was impaired on <i>at least</i> three neuropsychological tests whereas approximately 40% of the BM group demonstrated the same level of impairment.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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