Comparative Evaluation of Serum Irisin Levels in Cancer Patients and Healthy Individuals: A Systematic Review and Meta-Analysis of Diagnostic Evidence.
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引用次数: 0
Abstract
Background: Irisin influences key cancer-related processes such as cell proliferation, apoptosis, angiogenesis, and metastasis. This review aimed to evaluate serum irisin's potential in cancer diagnosis, prognosis, and treatment monitoring.
Methods: Databases including Scopus, PubMed, Cochrane, and others were searched. Studies comparing serum irisin in cancer patients and healthy individuals were assessed using Joanna Briggs Institute criteria.
Results: Nine studies showed significantly lower irisin levels in cancer patients (SMD: -1.16, p < 0.0001), especially in hepatocellular and bladder cancers.
Conclusion: Reduced serum irisin may serve as a diagnostic cancer biomarker, though its utility varies by cancer type and requires further research.
期刊介绍:
Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.