Cancer Investigation最新文献_第10页

Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study. 新辅助放化疗后病理完全缓解的局部晚期直肠癌患者的长期肿瘤预后：土耳其肿瘤组研究

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-05 DOI: 10.1080/07357907.2025.2595536

Mukremin Uysal, Sezer Saglam, İsmail Beypınar, Esra Kaytan Saglam, Elkhan Mammadov, Birol Ocak, Ozge Aybi, Rukiye Arıkan, Sefika Arzu Ergen, Pınar Gursoy, Abdullah Sakin, Vildan Kaya, Ercan Ozden, Tulay Eren, Atike Gokcen Demiray, Abdilkerim Oyman, Ali Murat Tatli, Haci Mehmet Turk, Ahmet Gulmez, Atakan Demir, Özkan Alan, Teoman Sakalar, Erdem Sen, Gokhan Ucar, Saadettin Kilickap, Ahmet Bilici, Didem Colpan Oksuz, Bulent Karabulut

{"title":"Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study.","authors":"Mukremin Uysal, Sezer Saglam, İsmail Beypınar, Esra Kaytan Saglam, Elkhan Mammadov, Birol Ocak, Ozge Aybi, Rukiye Arıkan, Sefika Arzu Ergen, Pınar Gursoy, Abdullah Sakin, Vildan Kaya, Ercan Ozden, Tulay Eren, Atike Gokcen Demiray, Abdilkerim Oyman, Ali Murat Tatli, Haci Mehmet Turk, Ahmet Gulmez, Atakan Demir, Özkan Alan, Teoman Sakalar, Erdem Sen, Gokhan Ucar, Saadettin Kilickap, Ahmet Bilici, Didem Colpan Oksuz, Bulent Karabulut","doi":"10.1080/07357907.2025.2595536","DOIUrl":"10.1080/07357907.2025.2595536","url":null,"abstract":"The goal of this study was to look at the long-term survival outcomes and clinical characteristics of stage II/III locally advanced rectal cancer (LARC) patients who acquired pathological complete response (pCR) following neoadjuvant chemoradiotherapy (NCRT). The clinicopathological characteristics and treatment details of 277 LARC patients with pCR, relapse-free survival (RFS), overall survival (OS), and locoregional and systemic recurrence rates, were assessed. The 5-year RFS and OS rates were 85.6% and 90.9%. The rates of local and systemic recurrence were 3.6% and 7.9%. Our study confirmed the favorable results in survival in patients with LARC who achieved pCR.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"127-135"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Chemotherapy Adherence in Cancer Management: A Quasi-Experimental Trial of a Smartphone Application. 在癌症管理中增强化疗依从性：智能手机应用程序的准实验试验。

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI: 10.1080/07357907.2025.2596851

Hari Prakash, Sunil Kumar D, Kiran Pk, Vanishri Arun, Deepika Yadav, Arun Gopi

{"title":"Enhancing Chemotherapy Adherence in Cancer Management: A Quasi-Experimental Trial of a Smartphone Application.","authors":"Hari Prakash, Sunil Kumar D, Kiran Pk, Vanishri Arun, Deepika Yadav, Arun Gopi","doi":"10.1080/07357907.2025.2596851","DOIUrl":"10.1080/07357907.2025.2596851","url":null,"abstract":"Background: Suboptimal adherence to chemotherapy regimens remains a significant challenge in cancer management, adversely impacting treatment outcomes and quality of life. This study aimed to develop and evaluate a user-centric mobile app intervention to promote adherence and enhance quality of life among cancer patients undergoing chemotherapy.Methodology: A quasi-experimental trial was conducted with 60 cancer patients undergoing chemotherapy, randomly assigned to an experimental group (n = 30) using the mobile app or a control group (n = 30) receiving standard care. Medication adherence was assessed using the Medication Adherence Measure Scale (MAMS), and quality of life was evaluated using the EORTC QLQ-C30 questionnaire at baseline and after one month of intervention.Results: At baseline, no significant differences between the groups were observed in adherence levels or quality of life measures. However, after one month, the experimental group demonstrated a significant improvement in medication adherence (mean MAMS score increase from 3.03 to 4.88, p = 0.012) and better scores in physical, role, emotional, and cognitive functioning domains compared to the control group (p < 0.05).Conclusion: The user-centric mobile app intervention showed potential efficacy in improving adherence to chemotherapy regimens and enhancing the specific quality of life domains among cancer patients.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"146-155"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of the Family in Treatment Decision-Making for Women with Breast Cancer: a Study from China. 家庭在女性乳腺癌治疗决策中的作用：来自中国的研究

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1080/07357907.2025.2596850

Xinyu Lin, Nan Lin, Kai Fang, Ying Wang, Wenqing Hu, Lihua Li

{"title":"Role of the Family in Treatment Decision-Making for Women with Breast Cancer: a Study from China.","authors":"Xinyu Lin, Nan Lin, Kai Fang, Ying Wang, Wenqing Hu, Lihua Li","doi":"10.1080/07357907.2025.2596850","DOIUrl":"10.1080/07357907.2025.2596850","url":null,"abstract":"Background: To describe family involvement in decision making for treatment in China.Methods: A cross-sectional study was conducted with women diagnosed with breast cancer and their nominated family members.Results: A total of 180 patients and their designated 180 family members participated. Most participants (>90%) thought that family should be involved in cancer TDM. Family members who were most engaged in TDM were more likely to be young, children of the patient, employed and first-degree relatives. The characteristics of breast cancer patients whose families made treatment decisions were as follows: the patient was older, the TNM stage was IV, and the level of education was relatively low. Most respondents stated that family involvement was helpful and did not hamper patient autonomy or complicate the cancer TDM process.Conclusions: Patients and family caregivers expect and value family involvement in cancer TDM. Several factors influence the TDM process, including age, education level and cancer stage.Practice: The TDM process heavily involves family members. This should be taken into consideration by medical staff during counseling to identify the best treatment.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"136-145"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Cancer Susceptibility: Meta-Analysis of Cytochrome P450 2C19 (CYP2C19) and Estrogen Receptor-1 (ESR1) Genetic Variants. 乳腺癌易感性：细胞色素P450 2C19 （CYP2C19）和雌激素受体-1 （ESR1）遗传变异的荟萃分析

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1080/07357907.2025.2596854

Anu Shibi Anilkumar, Sheena Mariam Thomas, Ramakrishnan Veerabathiran

引用次数: 0

Research Progress of Nutrition and Coagulation-Based Markers as Predictors for Digestive System Cancers. 营养和凝血标志物作为消化系统癌症预测指标的研究进展。

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1080/07357907.2025.2596305

Jiayi Huang, Tingting Zeng

引用次数: 0

Construction and Validation of a Prognostic Survival Prediction Model for NMIBC Patients Undergoing Radical Cystectomy. NMIBC根治性膀胱切除术患者预后生存预测模型的构建与验证。

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI: 10.1080/07357907.2025.2596860

Jie Wang, Xi Zhao, Xiao Lei Jiang, Guixi Liu, Lin Cao, Lihao Zhang, Jiabing Li

{"title":"Construction and Validation of a Prognostic Survival Prediction Model for NMIBC Patients Undergoing Radical Cystectomy.","authors":"Jie Wang, Xi Zhao, Xiao Lei Jiang, Guixi Liu, Lin Cao, Lihao Zhang, Jiabing Li","doi":"10.1080/07357907.2025.2596860","DOIUrl":"10.1080/07357907.2025.2596860","url":null,"abstract":"To screen predictors of prognosis in NMIBC patients treated with RC and construct a predictive model that accurately assesses their overall survival (OS). 1129 patients screened from the SEER database were randomized in a 7:3 ratio into a training group (790) and a validation group (339). Univariate and multivariate Cox regression analyses screened for prognostic factors, the best predictive model was determined by AIC minimum, and variables were examined for multicollinearity. Based on the total score obtained from the column line graph and the X-Tile procedure to find the best cutoff point and create a risk classification system. Finally, the model was evaluated and validated by C-index, AUC, drawing calibration curves (1000 bootstrap resamples), and Decision curve analysis (DCA). In the training group, the C-index was 0.67, and the ROC curves showed AUCs of 0.655, 0.704, and 0.722 for 1-, 5-, and 10-year OS, respectively; in the validation group, the AUCs were 0.738, 0.694, and 0.705, respectively. Meanwhile, the predictive performance of the present model was superior to that of the TNM staging, pLNR, and N staging, which can be used as a basis for patient counseling, follow-up scheduling, and treatment choice The model can provide a basis for patient counseling, follow-up scheduling and treatment selection.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"156-173"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Significance of CIAPIN1 Expression and Its Association to Clinicopathological Factors in Swedish Patients with Colorectal Cancer. 瑞典结直肠癌患者CIAPIN1表达的预后意义及其与临床病理因素的关系

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-26 DOI: 10.1080/07357907.2025.2598037

Son Dinh An Truong, Levar Shamoun, Jan Dimberg, Lina Hellman, Kalle Landerholm, Dick Wågsäter

{"title":"Prognostic Significance of CIAPIN1 Expression and Its Association to Clinicopathological Factors in Swedish Patients with Colorectal Cancer.","authors":"Son Dinh An Truong, Levar Shamoun, Jan Dimberg, Lina Hellman, Kalle Landerholm, Dick Wågsäter","doi":"10.1080/07357907.2025.2598037","DOIUrl":"10.1080/07357907.2025.2598037","url":null,"abstract":"The cytokine-induced apoptosis inhibitor 1 (CIAPIN1) is an anti-apoptotic protein that is ubiquitously expressed in various cell types, including cancer cells. Our purpose was to assess the association of mRNA and protein expression of CIAPIN1 with clinicopathological factors and prognosis in patients with colorectal cancer (CRC). The study utilized plasma samples from 198 patients and tumor and paired normal tissue from 165 CRC patients to determine CIAPIN1 protein concentration and mRNA expression using enzyme-linked immunosorbent assay (ELISA) and RT-qPCR, respectively. CIAPIN1 mRNA expression differed between cancer and normal tissue, with cancer tissue showing a 55% up-regulation, and CIAPIN1 protein content in plasma was 11.5% lower than in healthy controls. Low relative CIAPIN1 mRNA expression between tumor and matching normal tissue was associated with lower cancer-specific survival in females and several clinicopathological variables. Moreover, worse cancer-specific survival was seen in patients with rectal cancer with low concentrations of CIAPIN1 protein in plasma. Our data suggests that CIAPIN1 might have a potential future role as a useful indicator for clinical prognosis and in the development of CRC.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"174-182"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Ubiquitination Regulation in Nasopharyngeal Carcinoma. 泛素化调控在鼻咽癌中的作用。

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI: 10.1080/07357907.2025.2597501

Zhenyu Yan, Xiang Cao, Chengxian Ma, Yizhi Ge, Dan Zong, Xia He

引用次数: 0

Linking p53 rs1042522 Variant to Thyroid Cancer Risk: Insights from a Comprehensive Meta-Analysis of 2116 Cases. p53 rs1042522变异与甲状腺癌风险的关联：来自2116例综合meta分析的见解

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-05 DOI: 10.1080/07357907.2025.2596853

Mohammad Vakili-Ojarood, Ahmad Shirinzadeh-Dastgiri, Mojtaba Meybodian, Maedeh Barahman, Abolhasan Alijanpour, Mehdi Khosravi-Mashizi, Seyed Masoud Haghighikian, Amirhosein Naseri, Amirhossein Rahmani, Maryam Aghasipour, Kazem Aghili, Hossein Neamatzadeh

引用次数: 0

Effect of Adjuvant Chemotherapy on Survival Among Patients with Stage IIA Colorectal Cancer Following Radical Surgery: A Propensity Score-Matching Study Using the SEER Database. 辅助化疗对IIA期结直肠癌根治术后患者生存的影响：使用SEER数据库的倾向评分匹配研究

IF 1.9 4区医学

Cancer Investigation Pub Date : 2026-01-01 Epub Date: 2025-12-09 DOI: 10.1080/07357907.2025.2593470

Qilong Lan, Lanlan Xie, Dongbo Xu, Shuangming Lin, Changyu Li

{"title":"Effect of Adjuvant Chemotherapy on Survival Among Patients with Stage IIA Colorectal Cancer Following Radical Surgery: A Propensity Score-Matching Study Using the SEER Database.","authors":"Qilong Lan, Lanlan Xie, Dongbo Xu, Shuangming Lin, Changyu Li","doi":"10.1080/07357907.2025.2593470","DOIUrl":"10.1080/07357907.2025.2593470","url":null,"abstract":"To explore the effect of adjuvant chemotherapy on the overall survival (OS) and cancer cause-specific survival (CSS) in patients with AJCC stage IIA colorectal cancer. Date of patients with stage IIA colorectal cancer who underwent radical surgery without radical therapy or preoperative chemotherapy were retrieved from the Surveillance, Epidemiology, and End Results database. Propensity score matching (1:1) was performed, yielding a cohort of 14819 patients. The 3-, 5- and 7- year OS rates in the non-chemotherapy group were 80.5%, 50.0% and 16.3%, respectively, compared with 97.2%, 86.0% and 57.3% in the chemotherapy group. Regardless of the risk factors, adjuvant chemotherapy significant improved the OS (p = 0.000), but not for CSS. The Cox proportional-hazards model revealed that age ≥ 65 years, male sex, unmarried status, rectal carcinoma, positive carcinoembryonic antigen, perineural invasion positive, fewer than 12 lymph nodes and multiple cancers were risk factors for both OS and CSS. However, adjuvant chemotherapy was a risk factor only for OS. Regardless of these risk factors or the presence of multiple cancers, adjuvant chemotherapy markedly improved OS in patients with stage IIA colorectal cancer, particularly in those with grade III/IV tumors or fewer than 12 lymph nodes, but has not been proven on CSS.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"39-50"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0