The Association Between Vulnerability and Taste Changes in Older Cancer Patients Undergoing Chemotherapy.

IF 1.8 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2025-05-05 DOI:10.1080/07357907.2025.2500495

Yajun Dong, Jiajia Lu, Danhui Wang, Min Zhu, Liping Teng

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Abstract

This study aimed to examine the association between taste changes and vulnerability in elderly cancer patients undergoing chemotherapy. A cross-sectional study was conducted among older cancer patients undergoing chemotherapy in Wuxi, China. The Chemotherapy-induced Taste Alteration Scale (CiTAS) was used to measure taste alteration. The Vulnerable Elders Survey (VES) was used to measure vulnerability status. The univariate, correlation, and hierarchical regression analyses were applied to assess the association between taste changes and vulnerability. Of 200 older cancer patients, 123 (61.5%) participants were non-vulnerable. The univariate analysis revealed significant distribution differences of vulnerability in education level, smell abnormalities, drinking history, chemotherapy cycle, and taste changes. The level of taste changes was positively correlated with vulnerability (r = 0.401, p < 0.01). Results of the regression analysis indicated that vulnerability in older cancer patients was significantly associated with higher odds of "phantogeusia and parageusia" (OR = 4.505, p < 0.001). Taste changes may be an important influencing factor of vulnerability in older cancer patients.

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接受化疗的老年癌症患者的脆弱性和味觉变化之间的关系。

本研究旨在研究接受化疗的老年癌症患者味觉变化与易感性之间的关系。在中国无锡接受化疗的老年癌症患者中进行了一项横断面研究。使用化疗诱导味觉改变量表（CiTAS）测量味觉改变。使用脆弱长者调查（VES）来衡量脆弱性状况。应用单变量、相关和层次回归分析来评估味觉变化与易感性之间的关系。在200名老年癌症患者中，123名（61.5%）参与者是非易感人群。单因素分析显示，受教育程度、嗅觉异常、饮酒史、化疗周期和味觉变化的易感性分布差异显著。味觉变化水平与易损性呈正相关（r = 0.401, p < 0.05）

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.