Cancer Investigation最新文献_第5页

Cancer Stem Cell-Targeted Therapies in Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis. 肿瘤干细胞靶向治疗三阴性乳腺癌：系统回顾和荟萃分析。

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-19 DOI: 10.1080/07357907.2026.2717683

Olfa Rebai, Mohamed Amri, Sami Fattouch

引用次数: 0

Measurement Properties of the Brazilian-Portuguese Version of Memorial Symptom Assessment Scale in Hospitalized Patients Undergoing Chemotherapy: A Longitudinal Study. 巴西-葡萄牙版记忆症状评估量表在住院化疗患者中的测量特性：一项纵向研究。

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-19 DOI: 10.1080/07357907.2026.2720328

William de Lima Selles, Cristina Maria Nunes Cabral, Mariana Pardini Morais, Othávio Oliveira Ferreira, Gabriela Moreira Azevedo, Luciana Rocha Bataglia, Adriana Claudia Lunardi

{"title":"Measurement Properties of the Brazilian-Portuguese Version of Memorial Symptom Assessment Scale in Hospitalized Patients Undergoing Chemotherapy: A Longitudinal Study.","authors":"William de Lima Selles, Cristina Maria Nunes Cabral, Mariana Pardini Morais, Othávio Oliveira Ferreira, Gabriela Moreira Azevedo, Luciana Rocha Bataglia, Adriana Claudia Lunardi","doi":"10.1080/07357907.2026.2720328","DOIUrl":"https://doi.org/10.1080/07357907.2026.2720328","url":null,"abstract":"Objective: To evaluate the reliability, validity and responsiveness of the Memorial Symptom Assessment Scale (MSAS) in adult patients undergoing chemotherapy.Methods: Longitudinal study including 61 patients hospitalised for chemotherapy for gastrointestinal, lung or breast cancer. The MSAS (total score and subscales: psychological symptoms-PSYCH, physical symptoms-PHYS, and global distress-GDI) was administered at three time points: baseline to test convergent validity with Brief Fatigue Inventory-BFI, 24 hours later to test reliability, and 72 hours after the start of chemotherapy to assess responsiveness.Results: The MSAS showed validity with the BFI (PSYCH: r = 0.41, p = 0.001; PHYS: r = 0.44, p < 0.001; GDI: r = 0.52, p < 0.001; total: r = 0.54, p < 0.001). Reliability was substantial (ICC PSYCH = 0.87; PHYS = 0.86; GDI = 0.86; total = 0.82) and measurement error was classified as very good (SEM PSYCH = 0.12; PHYS = 0.30; GDI = 0.23; total = 0.54). The effect size for change over time ranged from small to moderate (d PSYCH = 0.27; PHYS = 0.27; GDI = 0.38; total = 0.58). External responsiveness by ROC curve analysis was absent for PSYCH (0.53), GDI (0.50), PHYS (0.37) and total score (0.62).Conclusion: The MSAS demonstrated substantial reliability, adequate validity and limited to moderate responsiveness, supporting its use for the assessment of physical and psychological. However, the MSAS is limited in its ability to detect clinical change over time.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor Lysis Syndrome in Solid Tumors: An Emerging Oncologic Emergency in the Era of Precision Oncology. 实体肿瘤肿瘤溶解综合征：精准肿瘤时代新出现的肿瘤学急症。

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-19 DOI: 10.1080/07357907.2026.2717692

Takehiro Okabayashi, Ryo Inada, Motoyasu Tabuchi, Nobuo Takata, Naoki Mimura

引用次数: 0

Incidence, Management, and Clinical Outcomes of Cardiovascular Adverse Events in Patients Receiving ALK Inhibitors for Advanced Non-Small Cell Lung Cancer: A Real-World Single-Center Analysis. 接受ALK抑制剂治疗晚期非小细胞肺癌患者心血管不良事件的发生率、管理和临床结果：一项真实世界单中心分析

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-11 DOI: 10.1080/07357907.2026.2711635

Xianglong Zhou, Chunli Song, Xinyuan Meng

{"title":"Incidence, Management, and Clinical Outcomes of Cardiovascular Adverse Events in Patients Receiving ALK Inhibitors for Advanced Non-Small Cell Lung Cancer: A Real-World Single-Center Analysis.","authors":"Xianglong Zhou, Chunli Song, Xinyuan Meng","doi":"10.1080/07357907.2026.2711635","DOIUrl":"https://doi.org/10.1080/07357907.2026.2711635","url":null,"abstract":"Cardiovascular adverse event (CVAE) profiles across ALK-TKI generations remain incompletely characterized in real-world practice. A retrospective study of 235 ALK-rearranged NSCLC patients receiving first-, second-, or third-generation ALK-TKIs assessed CVAE incidence, severity, timing, management, and impact on progression-free survival (PFS). Sixty patients (25.5%; 95% CI, 20.4-31.5) experienced 72 CVAEs. Bradycardia (12.8%) was most common. Overall CVAE incidence did not differ between first- (26.9%) and second-/third-generation (25.0%) agents. Hypertension was numerically more frequent with later-generation agents (9.5% vs. 1.5%; uncorrected P = 0.047), but this difference did not remain significant after correction for multiple comparisons and should be regarded as exploratory; in agent-level analysis hypertension was most frequent with lorlatinib (35.0%). Median time to onset was 44 days. Thromboembolic events were the most severe category (71.4% grade ≥3) with the lowest resolution rate (57.1%), whereas 87.5% of all CVAEs resolved or improved. CVAE occurrence was not significantly associated with PFS (time-dependent adjusted HR 1.05; 95% CI, 0.74-1.48), a finding robust across fully adjusted and switch-excluded sensitivity models. ALK-TKIs carry a meaningful CVAE burden with generation- and agent-specific profiles. Risk-adapted monitoring aligned with temporal and pharmacological characteristics may improve management without compromising oncologic outcomes.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of XPD Gene Polymorphisms with Cutaneous Melanoma Risk: A Meta-Analysis and Trial Sequence Evaluation. XPD基因多态性与皮肤黑色素瘤风险的关联：荟萃分析和试验序列评估。

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-01 Epub Date: 2026-05-21 DOI: 10.1080/07357907.2026.2675648

Nazila Farnoush, Amirhossein Rahmani, Mehdi Khosravi-Mashizi, Amirmasoud Shiri, Seyed Alireza Dastgheib, Maedeh Barahman, Ahmad Shirinzadeh-Dastgiri, Mohammad Vakili-Ojarood, Amirhosein Naseri, Fatemeh Asadian, Maryam Aghasipour, Kazem Aghili, Hossein Neamatzadeh

{"title":"Association of XPD Gene Polymorphisms with Cutaneous Melanoma Risk: A Meta-Analysis and Trial Sequence Evaluation.","authors":"Nazila Farnoush, Amirhossein Rahmani, Mehdi Khosravi-Mashizi, Amirmasoud Shiri, Seyed Alireza Dastgheib, Maedeh Barahman, Ahmad Shirinzadeh-Dastgiri, Mohammad Vakili-Ojarood, Amirhosein Naseri, Fatemeh Asadian, Maryam Aghasipour, Kazem Aghili, Hossein Neamatzadeh","doi":"10.1080/07357907.2026.2675648","DOIUrl":"10.1080/07357907.2026.2675648","url":null,"abstract":"Background: Conflicting results have emerged regarding the relationship between XPD polymorphisms and cutaneous melanoma (CM) susceptibility. This meta-analysis aims to clarify this association.Methods: A thorough literature search was performed in PubMed, Scopus, Web of Science, and CNKI databases up to September 1, 2023.Results: The analysis included 27 case-control studies comprising 11,293 cases and 14,437 controls. Thirteen studies focused on the Lys751Gln polymorphism (3,319 cases and 6,845 controls), ten on the Asp312Asn polymorphism (4,150 cases and 5,527 controls), and four on the Arg156Arg polymorphism (1,824 cases and 2,065 controls). The pooled analyses revealed no significant association between the XPD Lys751Gln and Asp312Asn polymorphisms and CM. However, the XPD Arg156Arg polymorphism showed a significant association with the AA genotype (OR = 1.191, p = 0.034), indicating an increased risk, particularly among Caucasians (AA vs. AC+CC OR = 1.203, p = 0.033).Conclusions: The XPD Arg156Arg polymorphism may increase CM risk, especially in Caucasians, while the Lys751Gln and Asp312Asn polymorphisms do not show a consistent association with CM risk. Further research in larger and more diverse ethnic populations is needed to confirm these findings.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"727-745"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Neoadjuvant Breast Cancer Therapy on Functional Performance. 乳腺癌新辅助治疗对功能表现的影响。

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-01 Epub Date: 2026-05-18 DOI: 10.1080/07357907.2026.2672758

Andrezza Moraes Flórido, Catarina Clapis Zordão, Tamires Coelho de Almeida, Hélio Humberto Angotti Carrara, Rinaldo Roberto de Jesus Guirro, Elaine Caldeira de Oliveira Guirro

{"title":"Influence of Neoadjuvant Breast Cancer Therapy on Functional Performance.","authors":"Andrezza Moraes Flórido, Catarina Clapis Zordão, Tamires Coelho de Almeida, Hélio Humberto Angotti Carrara, Rinaldo Roberto de Jesus Guirro, Elaine Caldeira de Oliveira Guirro","doi":"10.1080/07357907.2026.2672758","DOIUrl":"10.1080/07357907.2026.2672758","url":null,"abstract":"Neoadjuvant chemotherapy is used as a treatment for breast cancer patients due to its potential to enable more conservative surgeries. Chemotherapeutic agents can produce side effects that result in functional impairments. The aim of this study is to evaluate the influence of neoadjuvant therapy on functional performance in breast cancer patients. Forty women were assessed. Twenty were undergoing neoadjuvant treatment for breast cancer, and twenty had not been diagnosed with breast cancer. The functional mobility was evaluated by the Timed Up and Go test, overall weakness by the hand grip strength test, and toxicity by a chemotherapy toxicity scale prior to the first cycle of chemotherapy (pre-C1), prior to the fifth cycle (pre-C5), and after the conclusion of treatment (post-C8). In the preferred upper limb, there was a significant difference between the values of hand grip strength among the groups at all assessment points. Significant differences were observed in mobility between the groups, with a longer time needed to complete the test at the pre-C5 and post-C8 moments, despite Grade 1 toxicity being identified. Therefore, functional performance was affected by neoadjuvant chemotherapy treatment in breast cancer patients.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"718-726"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Group Counselling on Body Image and Sexual Satisfaction Among Women with Breast Cancer: A Randomized Clinical Trial. 团体咨询对乳腺癌女性身体形象和性满意度的影响：一项随机临床试验。

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-01 Epub Date: 2026-05-18 DOI: 10.1080/07357907.2026.2675651

Fatemeh Vakili, Talat Khadivzadeh, Mohsen Asgharinekah, Fatemeh Homaei Shandiz, Mohammad Taghi Shakeri

{"title":"The Effect of Group Counselling on Body Image and Sexual Satisfaction Among Women with Breast Cancer: A Randomized Clinical Trial.","authors":"Fatemeh Vakili, Talat Khadivzadeh, Mohsen Asgharinekah, Fatemeh Homaei Shandiz, Mohammad Taghi Shakeri","doi":"10.1080/07357907.2026.2675651","DOIUrl":"10.1080/07357907.2026.2675651","url":null,"abstract":"Objective: Group counselling (GC) can help people to cope with cancer-induced bodily changes. However, group counselling effects on sexual health of breast cancer patients is largely unknown. The present study aimed at investigating the effectiveness of group counselling on body image and sexual satisfaction among patients with breast cancer in Mashhad, Iran.Methods: This study was a randomised controlled trial with pre-and post-tests. Respondent-driven sampling was used to sample from women, who visited oncology hospitals in Mashhad. The primary sample consisted of 60 married breast cancer women that after providing informed consent, were randomly allocated into two intervention and control groups. GC was provided to the intervention group for four 90-130 minute sessions were administered twice a week, and the control group only received routine care. Data was gathered using index sexual satisfaction (ISS) and Body Image after Breast Cancer Questionnaire (BIBCQ) questionnaires and were analysed in two stages of pre-and post-test, using the Chi-square test and two-way covariance analysis through SPSS-16 software.Results: The mean of body image scores before and after GC was 14.7 ± 6.0 and 9.2 ± 4.4 respectively which showed -5.5 ± 3.2 decrease (p < 0.05) also, sexual satisfaction mean before and after GC was 93.5 ± 23.4 and 104.4 ± 22.0 respectively which showed 10.8 ± 10.9 scores increase (p < 0/05).Conclusion: The GC was effective in sexual satisfaction and improvement of body image among breast cancer survivors. GC has clinical significance as it provided an opportunity for women to improve their sexual health.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"746-754"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid Biopsy Biomarkers as Predictors of TNBC Recurrence: A Systematic Review. 液体活检生物标志物作为TNBC复发的预测指标：一项系统综述。

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-01 Epub Date: 2026-06-08 DOI: 10.1080/07357907.2026.2675659

Nur Rahadiani, Dyah Laksmi Dewi, Mohammad Ghozali

引用次数: 0

The Needs of Patients with Cancer Interested in Complementary and Alternative Medicine with Respect to the Physician's Attitude and Behaviour. 对补充和替代医学感兴趣的癌症患者的需求与医生的态度和行为。

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-01 Epub Date: 2026-05-26 DOI: 10.1080/07357907.2026.2675656

Gianluca Ciarlo, Lena Josfeld, Jutta Hübner

{"title":"The Needs of Patients with Cancer Interested in Complementary and Alternative Medicine with Respect to the Physician's Attitude and Behaviour.","authors":"Gianluca Ciarlo, Lena Josfeld, Jutta Hübner","doi":"10.1080/07357907.2026.2675656","DOIUrl":"10.1080/07357907.2026.2675656","url":null,"abstract":"Many cancer patients use complementary and alternative medicine (CAM), often seeking a more holistic approach. This study explored whether patients have different communication expectations for oncologists and any professional provider of CAM. Patients attending CAM consultations at an integrative counseling unit of a German university hospital completed a standardized questionnaire. Most reported significant limitations in daily life due to cancer. Common motivations for CAM use included reducing side effects and supporting conventional treatment. Overall, patients expressed similar expectations for both oncologists and CAM providers regarding physician attitude, consultation behavior, and preferred topics. Respectful and honest behavior during medical consultations was most valued. Despite differing therapeutic goals between CAM and conventional medicine, patients did not differentiate in their communication needs. They valued honesty, trustworthiness, time for questions, and a clear treatment plan-regardless the provider's medical background. These findings suggest that cancer survivors seek concrete, evidence-based dialogue and consistent interpersonal qualities across disciplines. Communication preferences appear shaped more by interaction quality than by medical system. Patients want to feel heard, respected, and informed, whether consulting a conventional oncologist or a CAM provider. This underscores the importance of unified communication standards in oncology care and highlights shared expectations patients hold across treatment approaches.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"755-768"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Impact of TP53 and RB1 Alterations in Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel. 多西紫杉醇治疗转移性去势抵抗性前列腺癌中TP53和RB1改变对预后的影响

IF 2.2 4区医学

Cancer Investigation Pub Date : 2026-08-01 Epub Date: 2026-05-15 DOI: 10.1080/07357907.2026.2672004

Ja Yoon Heo, Chung Lee, Heesun Shin, Sungmin Cho, Seung Hoon Beom, Young-Deuk Choi, Woong Kyu Han, Won Sik Ham, Won Sik Jang, Hyunho Han, Jongsoo Lee, Ji Eun Heo, Daniel Khalaf, Urban Emmenegger, Sangwoo Kim, Chang Gon Kim, Minsun Jung, Sang Joon Shin

{"title":"Prognostic Impact of TP53 and RB1 Alterations in Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel.","authors":"Ja Yoon Heo, Chung Lee, Heesun Shin, Sungmin Cho, Seung Hoon Beom, Young-Deuk Choi, Woong Kyu Han, Won Sik Ham, Won Sik Jang, Hyunho Han, Jongsoo Lee, Ji Eun Heo, Daniel Khalaf, Urban Emmenegger, Sangwoo Kim, Chang Gon Kim, Minsun Jung, Sang Joon Shin","doi":"10.1080/07357907.2026.2672004","DOIUrl":"10.1080/07357907.2026.2672004","url":null,"abstract":"Background: Docetaxel remains a standard treatment for metastatic castration-resistant prostate cancer (mCRPC), yet reliable prognostic markers are lacking. TP53 and RB1, key tumor suppressor genes regulating cell-cycle control and genomic stability, have been linked to aggressive disease and lineage plasticity in advanced prostate cancer. We evaluated the prognostic impact of TP53 and/or RB1 alterations in mCRPC patients treated with docetaxel.Methods: We retrospectively analyzed 125 mCRPC patients treated with docetaxel. Genetic alterations were assessed using the TruSight Oncology 500 v2 panel. Progression-free survival (PFS) and overall survival (OS) were analyzed according to TP53 and RB1 alteration status.Results: TP53 alterations were present in 45 patients (36.0%) and RB1 alterations in 16 (12.8%). Patients with alterations in either TP53 or RB1 had significantly shorter OS (median OS = 18.10 vs. 32.23 months; HR = 1.83, 95% CI = 1.19-2.84; p = .006). Co-altered patients showed the poorest OS (median OS = 11.40 months; HR = 5.09, 95% CI = 1.97-13.19; p < .001). PFS was also shorter in patients with TP53 or RB1 alterations.Conclusion: TP53 and RB1 alterations, particularly TP53/RB1 co-alteration, are associated with poor prognosis in mCRPC treated with docetaxel.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"707-717"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0