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Chemotherapy Primary Dose Reduction in Older Cancer Patients: A Retrospective Cohort. 老年癌症患者化疗初始剂量的减少：回顾性队列
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.1080/07357907.2024.2357166
Wafa Bouleftour, Fabien Tinquaut, Ludovic Lafaie
{"title":"Chemotherapy Primary Dose Reduction in Older Cancer Patients: A Retrospective Cohort.","authors":"Wafa Bouleftour, Fabien Tinquaut, Ludovic Lafaie","doi":"10.1080/07357907.2024.2357166","DOIUrl":"10.1080/07357907.2024.2357166","url":null,"abstract":"<p><p>Primary dose reduction (PDR) in the first course of chemotherapy is an empirical practice, commonly used in older population. Patients over 70 years old receiving a first course of chemotherapy for a solid tumor were enrolled. A total of 179 patients were included. Standard dose was used in 69.8% of patients, while 30.2% received PDR of chemotherapy. Only 29.6% received a standardized geriatric assessment. Patients receiving standard doses presented 83.2% of toxicities, while 68% of toxicities were reported in patients receiving PDR. The toxicity rate was significantly decreased in patients treated with reduced first-cycle dose of chemotherapy.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"416-424"},"PeriodicalIF":2.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enrollment Trends Among Patients with Melanoma Brain Metastasis in Active Clinical Trials. 活跃临床试验中黑色素瘤脑转移患者的入组趋势。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-05-01 Epub Date: 2024-05-22 DOI: 10.1080/07357907.2024.2354809
Omar Elghawy, Reema Patel, Jason Xu, Jonathan Sussman, Bethany Horton, Varinder Kaur
{"title":"Enrollment Trends Among Patients with Melanoma Brain Metastasis in Active Clinical Trials.","authors":"Omar Elghawy, Reema Patel, Jason Xu, Jonathan Sussman, Bethany Horton, Varinder Kaur","doi":"10.1080/07357907.2024.2354809","DOIUrl":"10.1080/07357907.2024.2354809","url":null,"abstract":"<p><p>The CNS is a common site for distant metastasis and treatment failure in melanoma patients. This study aimed to evaluate the inclusion rate of patients with melanoma brain metastases (MBM) in prospective clinical trials. 69.3% of trials excluded MBM patients based on their CNS disease. In univariate analysis, trials not employing immunotherapy (<i>p</i> = 0.0174), inclusion of leptomeningeal disease (<i>p</i> < 0.0001) and non-pharmaceutical sponsor trials (<i>p</i> = 0.0461) were more likely to enroll patients with MBM. Thoughtful reconsideration of clinical trial designs is needed to give patients with MBMs access to promising investigational agents and improve outcomes for patients with MBM.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"400-407"},"PeriodicalIF":2.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of High-Dimensional Data Classification for Skin Malignancy Detection Using DL-Based Techniques. 利用基于 DL 的技术评估用于皮肤恶性肿瘤检测的高维数据分类。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-05-01 Epub Date: 2024-05-20 DOI: 10.1080/07357907.2024.2345184
B Gunasundari, R Thiagarajan
{"title":"Evaluation of High-Dimensional Data Classification for Skin Malignancy Detection Using DL-Based Techniques.","authors":"B Gunasundari, R Thiagarajan","doi":"10.1080/07357907.2024.2345184","DOIUrl":"10.1080/07357907.2024.2345184","url":null,"abstract":"<p><p>Skin cancer can be detected through visual screening and skin analysis based on the biopsy and pathological state of the human body. The survival rate of cancer patients is low, and millions of people are diagnosed annually. By determining the different comparative analyses, the skin malignancy classification is evaluated. Using the Isomap with the vision transformer, we analyze the high-dimensional images with dimensionality reduction. Skin cancer can present with severe cases and life-threatening symptoms. Overall performance evaluation and classification tend to improve the accuracy of the high-dimensional skin lesion dataset when completed. In deep learning methodologies, the distinct phases of skin malignancy classification are determined by its accuracy, specificity, F1 recall, and sensitivity while implementing the classification methodology. A nonlinear dimensionality reduction technique called Isomap preserves the data's underlying nonlinear relationships intact. This is essential for the categorization of skin malignancies, as the features that separate malignant from benign skin lesions may not be linearly separable. Isomap decreases the data's complexity while maintaining its essential characteristics, making it simpler to analyze and explain the findings. High-dimensional datasets for skin lesions have been evaluated and classified more effectively when evaluated and classified using Isomap with the vision transformer.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"365-389"},"PeriodicalIF":2.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical and Clinical Validation of a Target-Enhanced Whole Genome Sequencing-Based Comprehensive Genomic Profiling Test. 基于目标增强全基因组测序的综合基因组轮廓测试的分析和临床验证。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-05-01 Epub Date: 2024-05-21 DOI: 10.1080/07357907.2024.2352438
Stephanie Ferguson, Shruthi Sriram, Jonathan Kyle Wallace, Jeonghoon Lee, Jung-Ah Kim, Yoonsuh Lee, Brian Baek-Lok Oh, Won Chul Lee, Sangmoon Lee, Erin Connolly-Strong
{"title":"Analytical and Clinical Validation of a Target-Enhanced Whole Genome Sequencing-Based Comprehensive Genomic Profiling Test.","authors":"Stephanie Ferguson, Shruthi Sriram, Jonathan Kyle Wallace, Jeonghoon Lee, Jung-Ah Kim, Yoonsuh Lee, Brian Baek-Lok Oh, Won Chul Lee, Sangmoon Lee, Erin Connolly-Strong","doi":"10.1080/07357907.2024.2352438","DOIUrl":"10.1080/07357907.2024.2352438","url":null,"abstract":"<p><p>Evaluation of the test performance of the Target enhanced whole-genome sequencing (TE-WGS) assay for comprehensive oncology genomic profiling. The analytical validation of the assay included sensitivity and specificity for single nucleotide variants (SNVs), insertions/deletions (indels), and structural variants (SVs), revealing a revealed a sensitivity of 99.8% for SNVs and 99.2% for indels. The positive predictive value (PPV) was 99.3% SNVs and 98.7% indels. Clinical validation was benchmarked against established orthogonal methods and demonstrated high concordance with reference methods. TE-WGS provides insights beyond targeted panels by comprehensive analysis of key biomarkers and the entire genome encompassing both germline and somatic findings.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"390-399"},"PeriodicalIF":2.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Efficacy of Postoperative Adjuvant Therapy for HER2-Positive Ductal Carcinoma in Situ with Microinvasion. 对微小浸润的 HER2 阳性原位乳管癌术后辅助治疗的疗效评估
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.1080/07357907.2024.2355320
Zhihong Xu, Dan Tao, Zhibing Zhou, Qihua Jiang, Wensong Wei
{"title":"Evaluation of the Efficacy of Postoperative Adjuvant Therapy for HER2-Positive Ductal Carcinoma <i>in Situ</i> with Microinvasion.","authors":"Zhihong Xu, Dan Tao, Zhibing Zhou, Qihua Jiang, Wensong Wei","doi":"10.1080/07357907.2024.2355320","DOIUrl":"10.1080/07357907.2024.2355320","url":null,"abstract":"<p><p>A retrospective study on 90 eligible HER2+ ductal carcinoma <i>in situ</i> with microinvasion (DCIS-MI) patients was performed with a median follow-up time of 57 months. The baseline was consistent between the 4-cycle and 6-cycle chemotherapy groups. There were more patients with multiple foci of micrometastasis in the target therapy group in the two groups with or without target therapy (<i>p</i> < 0.01). Postoperative chemotherapy with a 4-cycle regimen can achieve the expected therapeutic effect in patients with HER2+ DCIS-MI, but the role of target therapy in HER2+ DCIS-MI patients has not been confirmed.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"408-415"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Analysis of N6-Methylandenosine-Related lncRNAs in Clear Cell Renal Cell Carcinoma: A Correlation With Prognosis, Tumor Progression, and Therapeutic Response 全面分析透明细胞肾细胞癌中的 N6-甲基腺苷相关 lncRNA：与预后、肿瘤进展和治疗反应的相关性
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-21 DOI: 10.1080/07357907.2024.2330103
Chang Meng, Juan Li, Xiang Wang, Yicen Ying, Zhihua Li, Aixiang Wang, Xuesong Li
{"title":"Comprehensive Analysis of N6-Methylandenosine-Related lncRNAs in Clear Cell Renal Cell Carcinoma: A Correlation With Prognosis, Tumor Progression, and Therapeutic Response","authors":"Chang Meng, Juan Li, Xiang Wang, Yicen Ying, Zhihua Li, Aixiang Wang, Xuesong Li","doi":"10.1080/07357907.2024.2330103","DOIUrl":"https://doi.org/10.1080/07357907.2024.2330103","url":null,"abstract":"This study aims to develop a prognostic signature based on m6A-related lncRNAs for clear cell renal cell carcinoma (ccRCC). Differential expression analysis and Pearson correlation analysis were us...","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"17 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140634807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma 预测胰腺导管腺癌患者预后的 15 种炎症相关基因特征
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-14 DOI: 10.1080/07357907.2024.2340577
Xiaofeng Sun, Hao Song, Xiaoran Sun, Chunhua Liao, Guoqiang Wang, Yu Xu, Leo Li, Yusheng Han, Chunwei Xu, Wenxian Wang, Shangli Cai, Hua Liang, Hao Yu
{"title":"A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma","authors":"Xiaofeng Sun, Hao Song, Xiaoran Sun, Chunhua Liao, Guoqiang Wang, Yu Xu, Leo Li, Yusheng Han, Chunwei Xu, Wenxian Wang, Shangli Cai, Hua Liang, Hao Yu","doi":"10.1080/07357907.2024.2340577","DOIUrl":"https://doi.org/10.1080/07357907.2024.2340577","url":null,"abstract":"Chronic inflammation promotes the development of pancreatic ductal adenocarcinoma (PDAC) and PDAC-related inflammatory tumor microenvironment facilitates tumor growth and metastasis. Thus, we aimed...","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"20 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity 开发新型食管鳞状细胞癌预后模型：洞察免疫细胞相互作用和药物敏感性
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-14 DOI: 10.1080/07357907.2024.2340576
Pu Wang, Yu Liu, Lingyu Wei, Jia Wang, Jinsheng Wang, Bin Du
{"title":"Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity","authors":"Pu Wang, Yu Liu, Lingyu Wei, Jia Wang, Jinsheng Wang, Bin Du","doi":"10.1080/07357907.2024.2340576","DOIUrl":"https://doi.org/10.1080/07357907.2024.2340576","url":null,"abstract":"Esophageal squamous cell carcinoma (ESCC) presents a five-year survival rate below 20%, underscoring the need for improved prognostic markers. Our study analyzed ESCC-specific datasets to identify ...","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"60 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Veliparib‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis 癌症患者中由 Veliparib 引起的毒性：系统回顾与元分析
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-08 DOI: 10.1080/07357907.2024.2338128
Peirong Wang, Ruizhen Zhao, Xiaohui Jin, Xianhua Zhou, Xiaolong Xie
{"title":"Veliparib‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis","authors":"Peirong Wang, Ruizhen Zhao, Xiaohui Jin, Xianhua Zhou, Xiaolong Xie","doi":"10.1080/07357907.2024.2338128","DOIUrl":"https://doi.org/10.1080/07357907.2024.2338128","url":null,"abstract":"In this study, we investigate the veliparib‑induced toxicity in cancer patients. Databases were searched for RCTs treated with veliparib. We found veliparib could increase the risk of hematologic a...","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"5 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AQP8 Modulates Mitochondrial H2O2 Transport to Influence Glioma Proliferation. AQP8 调节线粒体 H2O2 转运以影响胶质瘤增殖
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-04-01 Epub Date: 2024-05-14 DOI: 10.1080/07357907.2024.2352467
ZiHao Shen, HuaJun Sheng, Jing Zhao, Jin Xu, ZiLing Cai, Hao Zhang, Zhen Guo, JunNan Liu, Hang Liang, LiHao Tan, ShengWei Gan, Juan Huang, ShuJuan Zhu
{"title":"AQP8 Modulates Mitochondrial H<sub>2</sub>O<sub>2</sub> Transport to Influence Glioma Proliferation.","authors":"ZiHao Shen, HuaJun Sheng, Jing Zhao, Jin Xu, ZiLing Cai, Hao Zhang, Zhen Guo, JunNan Liu, Hang Liang, LiHao Tan, ShengWei Gan, Juan Huang, ShuJuan Zhu","doi":"10.1080/07357907.2024.2352467","DOIUrl":"10.1080/07357907.2024.2352467","url":null,"abstract":"<p><strong>Background: </strong>Aquaporin-8 (AQP8) is involved in impacting glioma proliferation and can effect tumour growth by regulating Intracellular reactive oxygen species (ROS) signalling levels. In addition to transporting H<sub>2</sub>O<sub>2</sub>, AQP8 has been shown to affect ROS signaling, but evidence is lacking in gliomas. In this study, we aimed to investigate how AQP8 affects ROS signaling in gliomas.</p><p><strong>Materials and methods: </strong>We constructed A172 and U251 cell lines with AQP8 knockdown and AQP8 rescue by CRISPR/Cas9 technology and overexpression of lentiviral vectors. We used CCK-8 and flow cytometry to test cell proliferation and cycle, immunofluorescence and Mito-Tracker CMXRos to observe the distribution of AQP8 expression in glioma cells, Amplex and DHE to study mitochondria release of H<sub>2</sub>O<sub>2</sub>, mitochondrial membrane potential (MMP) and NAD+/NADH ratio to assess mitochondrial function and protein blotting to detect p53 and p21 expression.</p><p><strong>Result: </strong>We found that AQP8 co-localised with mitochondria and that knockdown of AQP8 inhibited the release of H<sub>2</sub>O<sub>2</sub> from mitochondria and led to increased levels of ROS in mitochondria, thereby impairing mitochondrial function. We also discovered that AQP8 knockdown resulted in suppression of cell proliferation and was blocked at the G0/G1 phase with increased expression of mitochondrial ROS signalling-related p53/p21.</p><p><strong>Conclusions: </strong>This finding provides further evidence for mechanistic studies of AQP8 as a prospective target for the treatment of gliomas.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"345-356"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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