发布求助
文献互助 智能选刊 最新文献

Cancer Investigation最新文献

筛选
英文 中文
Artificial Intelligence in Cancer Clinical Research: II. Development and Validation of Clinical Prediction Models. 人工智能在癌症临床研究中的应用：II.临床预测模型的开发与验证。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-07-01 Epub Date: 2024-05-22 DOI: 10.1080/07357907.2024.2354991
Gary H Lyman, Nicole M Kuderer
{"title":"Artificial Intelligence in Cancer Clinical Research: II. Development and Validation of Clinical Prediction Models.","authors":"Gary H Lyman, Nicole M Kuderer","doi":"10.1080/07357907.2024.2354991","DOIUrl":"10.1080/07357907.2024.2354991","url":null,"abstract":"","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"447-451"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review. 维生素 B12 升高、癌症风险和死亡率：系统回顾
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI: 10.1080/07357907.2024.2366907
Sandra B Amado-Garzon, Luisana Molina-Pimienta, Andrea Vejarano-Pombo, Mariana Vélez-Bonilla, Jaime Moreno-Chaparro, Adriana Buitrago-Lopez
{"title":"Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review.","authors":"Sandra B Amado-Garzon, Luisana Molina-Pimienta, Andrea Vejarano-Pombo, Mariana Vélez-Bonilla, Jaime Moreno-Chaparro, Adriana Buitrago-Lopez","doi":"10.1080/07357907.2024.2366907","DOIUrl":"10.1080/07357907.2024.2366907","url":null,"abstract":"<p><p>Vitamin B12 (B12) is a molecule involved in several biological. Abnormally high levels are frequently found, but their causes can be multiple, and consequences have not been clearly elucidated. The objective of this review was to summarize the current evidence on the associations of elevated B12 and the development of cancer, and all-cause mortality in adults. Six references looking at mortality and seven looking at cancer risk were included. The evidence suggests an association between elevated B12 with a higher risk of cancer, with risk ratios ranging 1,88 to 5,9. There was less consistent evidence linking vitamin B12 and mortality.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"515-526"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Effects of Sarcopenia on Patients with Bladder Cancer: A Systematic Review and Meta-Analysis. 肌肉疏松症对膀胱癌患者预后的影响：系统回顾与元分析》。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-07-01 Epub Date: 2024-06-18 DOI: 10.1080/07357907.2024.2363879
Yinghan Zeng, Chengna Cai, Nafen Pan
{"title":"Prognostic Effects of Sarcopenia on Patients with Bladder Cancer: A Systematic Review and Meta-Analysis.","authors":"Yinghan Zeng, Chengna Cai, Nafen Pan","doi":"10.1080/07357907.2024.2363879","DOIUrl":"10.1080/07357907.2024.2363879","url":null,"abstract":"<p><p>Sarcopenia can negatively impact the survival of cancer patients. This study intends to delve into the correlation of sarcopenia with survival and complications in patients with bladder cancer (BC) after surgery. Web of Science, Cochrane Library, Embase, and PubMed databases were retrieved up to April 7, 2023, to collect studies on the impact of sarcopenia on the prognosis of adults with BC. Primary outcomes encompassed overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS). The secondary outcome consisted of postoperative complications. A meta-analysis was conducted using Stata. Forest plots and summary effect models were employed to present the results. The quality of eligible studies was assessed using the Newcastle-Ottawa Scale (NOS). Initially, 1713 studies were identified through searches across four databases, and 26 studies were ultimately included in the analysis. Sarcopenia was significantly associated with OS (HR:1.62; 95% CI: 1.43-1.83; <i>P</i> < 0.001, <i>I</i><sup>2</sup> = 0.9%), CSS (HR: 1.81, 95% CI: 1.52-2.15, <i>P</i> < 0.001, <i>I</i><sup>2</sup> = 0.0%), and RFS (HR: 1.76, 95% CI: 1.21-2.56, <i>P</i> = 0.003, <i>I</i><sup>2</sup> = 0.0%) in BC patients. Subgroup analyses revealed that sarcopenia is strongly linked to prognosis and postoperative complications in BC patients.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"500-514"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Bioinformatic Analysis of Gut Microbiota Related with Immune Cell Infiltration in Colorectal Cancer. 结直肠癌免疫细胞浸润相关肠道微生物群的生物信息学分析
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-07-01 Epub Date: 2024-06-21 DOI: 10.1080/07357907.2024.2368233
Dan Liu, Jiang Zhou, Qiong Fu, Yuanzhu Zhao, Panpan Wang, Yang Zheng, Meihong Cui, Heng Zhang
{"title":"A Bioinformatic Analysis of Gut Microbiota Related with Immune Cell Infiltration in Colorectal Cancer.","authors":"Dan Liu, Jiang Zhou, Qiong Fu, Yuanzhu Zhao, Panpan Wang, Yang Zheng, Meihong Cui, Heng Zhang","doi":"10.1080/07357907.2024.2368233","DOIUrl":"10.1080/07357907.2024.2368233","url":null,"abstract":"<p><strong>Objective: </strong>The composition of microbiota which correlates with infiltrating immune cells and clinical signatures is not clarified in CRC.</p><p><strong>Methods: </strong>We applied 4 kinds of bioinformatic tools GSVA (version: 1.42.0), ESTIMATE (version: 1.0.13), CIBERSORT (version: 2.0), and immune-related genes.</p><p><strong>Results: </strong>We found that a total of 8 types of microbiotas appeared in the three immune correlation analyses. Among these microbiotas, significant enrichments in relative abundances associated with immune cell infiltration can be found for the dominant phyla Proteobacteria, Firmicutes, and Actinobacteria. Moreover, there existed correlations between some of the 8 microbiotas and clinical-related indicators.</p><p><strong>Conclusion: </strong>We identified some novel microbiotas involved in immune regulation in CRC.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"491-499"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gustative Roussy Immune Score is a Predictor for Major Pathological Response in Rectal Cancer: A Result from the Preoperative Intraarterial Chemoembolization Combined with Radiotherapy (PCAR) Study. Gustative Roussy 免疫评分是直肠癌主要病理反应的预测指标：术前动脉内化疗栓塞联合放疗（PCAR）研究结果。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-07-01 Epub Date: 2024-07-05 DOI: 10.1080/07357907.2024.2366912
Wei-Na Yang, Xue-Mei Li, Chao-Fan Li, Chuan Chen, Yan Feng, Nan Dai, Yu-Xin Yang, Meng-Xia Li, Chun-Xue Li, Cheng-Yuan Qian, Dong Wang, He Xiao, Jia-Min Luo
{"title":"Gustative Roussy Immune Score is a Predictor for Major Pathological Response in Rectal Cancer: A Result from the Preoperative Intraarterial Chemoembolization Combined with Radiotherapy (PCAR) Study.","authors":"Wei-Na Yang, Xue-Mei Li, Chao-Fan Li, Chuan Chen, Yan Feng, Nan Dai, Yu-Xin Yang, Meng-Xia Li, Chun-Xue Li, Cheng-Yuan Qian, Dong Wang, He Xiao, Jia-Min Luo","doi":"10.1080/07357907.2024.2366912","DOIUrl":"10.1080/07357907.2024.2366912","url":null,"abstract":"<p><p>Despite the emergence of various treatment strategies for rectal cancer based on neoadjuvant chemoradiotherapy, there is currently a lack of reliable biomarkers to determine which patients will respond well to neoadjuvant chemoradiotherapy. Through collecting hematological and biochemical parameters data of patients prior to receiving neoadjuvant chemoradiotherapy, we evaluated the predictive value of systemic inflammatory indices for pathological response and prognosis in rectal cancer patients. We found that baseline GRIm-Score was an independent predictor for MPR in rectal cancer patients. However, no association was observed between several commonly systemic inflammation indices and long-term outcome.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"527-537"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of Epigenetic Modifier Drug Combination for Synergistic Effect against Glioblastoma Multiform Cancer Cell Lines 优化表观遗传修饰剂药物组合，实现对多形性胶质母细胞瘤癌症细胞株的协同作用
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-05-02 DOI: 10.1080/07357907.2024.2345183
Morvarid Soleiman, Mehrnoosh Fathi-Roudsari, Khosro Khajeh, Amir Maghsoudi
{"title":"Optimization of Epigenetic Modifier Drug Combination for Synergistic Effect against Glioblastoma Multiform Cancer Cell Lines","authors":"Morvarid Soleiman, Mehrnoosh Fathi-Roudsari, Khosro Khajeh, Amir Maghsoudi","doi":"10.1080/07357907.2024.2345183","DOIUrl":"https://doi.org/10.1080/07357907.2024.2345183","url":null,"abstract":"Glioblastoma multiforme (GBM), is a frequent class of malignant brain tumors. Epigenetic therapy, especially with synergistic combinations is highly paid attention for aggressive solid tumors like ...","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"30 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140829478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence in Cancer Clinical Research: I. Introduction 人工智能在癌症临床研究中的应用：I. 导言
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-05-02 DOI: 10.1080/07357907.2024.2347784
Gary H. Lyman, Nicole M. Kuderer
{"title":"Artificial Intelligence in Cancer Clinical Research: I. Introduction","authors":"Gary H. Lyman, Nicole M. Kuderer","doi":"10.1080/07357907.2024.2347784","DOIUrl":"https://doi.org/10.1080/07357907.2024.2347784","url":null,"abstract":"Published in Cancer Investigation (Ahead of Print, 2024)","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":"20 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140829752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Nature, Origin, and Evolution of Life: Part V Bringing It Together: Concepts, Constraints, and Closure. 生命的本质、起源和进化：第五部分：汇集：概念、限制和封闭。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-05-01 Epub Date: 2024-02-01 DOI: 10.1080/07357907.2024.2309792
Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
{"title":"The Nature, Origin, and Evolution of Life: Part V Bringing It Together: Concepts, Constraints, and Closure.","authors":"Gary H Lyman, Christopher H Lyman, Nicole M Kuderer","doi":"10.1080/07357907.2024.2309792","DOIUrl":"10.1080/07357907.2024.2309792","url":null,"abstract":"","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"361-364"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement of Chemotherapy Efficacy in Cervical Cancer via MAPK Pathway Inhibition by Osimertinib. 奥希替尼通过抑制 MAPK 通路提高宫颈癌化疗疗效
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-05-01 Epub Date: 2024-05-31 DOI: 10.1080/07357907.2024.2359987
Yue Hu, Chao Hu
{"title":"Enhancement of Chemotherapy Efficacy in Cervical Cancer via MAPK Pathway Inhibition by Osimertinib.","authors":"Yue Hu, Chao Hu","doi":"10.1080/07357907.2024.2359987","DOIUrl":"10.1080/07357907.2024.2359987","url":null,"abstract":"<p><p>Addressing recurrent cervical cancer poses a substantial challenge. Osimertinib, an FDA-approved EGFR inhibitor, has emerged as a promising option. Our study examined its potential to enhance paclitaxel's efficacy against cervical cancer. Osimertinib effectively hindered cancer cell growth and induced apoptosis across multiple cell lines. Combined with paclitaxel, it exhibited synergy in suppressing cervical cancer cells. Importantly, osimertinib's inhibitory effect was EGFR-independent; it targeted Mnk phosphorylation, reducing eIF4E activity. In mice, the combined osimertinib-paclitaxel treatment surpassed individual drugs in inhibiting cancer growth. These preclinical findings suggest osimertinib's repurposing as a means to improve paclitaxel's effectiveness in cervical cancer treatment.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"425-434"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress on CARM1 and its Relationship with Colorectal Cancer. CARM1 及其与结直肠癌关系的研究进展。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-05-01 Epub Date: 2024-05-30 DOI: 10.1080/07357907.2024.2354798
Yuchen Wu, Yannan Shen
{"title":"Research Progress on CARM1 and its Relationship with Colorectal Cancer.","authors":"Yuchen Wu, Yannan Shen","doi":"10.1080/07357907.2024.2354798","DOIUrl":"10.1080/07357907.2024.2354798","url":null,"abstract":"<p><p>Coactivator-associated arginine methyltransferase 1 (CARM1) is significant as a key member of the PRMT family, crucial for regulating arginine methylation, and its association with colorectal cancer underscores its potential as a therapeutic target. Consequently, CARM1 inhibitors have emerged as potential therapeutic agents in cancer treatment and valuable chemical tools for cancer research. Despite steady progress in CARM1 inhibitor research, challenges persist in discovering effective, isoform-selective, cell-permeable, and in vivo-active CARM1 inhibitors for colorectal cancer. This review summarizes the research progress on CARM1 and its relationship with colorectal cancer, aiming to provide a theoretical basis for the radiotherapy of colorectal cancer.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"435-442"},"PeriodicalIF":2.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信