Evaluation of Impression Cytology for Diagnosis of Ocular Surface Squamous Neoplasia in Two Kenyan Tertiary Hospitals.

IF 1.8 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2025-04-01 Epub Date: 2025-04-15 DOI:10.1080/07357907.2025.2492031

Chisomo Griffin Phiri, Rhoda M Munene, Stephen Gichuhi, Lucy W Muchiri

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引用次数: 0

Abstract

Introduction: Ocular surface squamous neoplasia (OSSN) is a broad term encompassing pre-cancerous and cancerous conditions affecting the ocular surface. Given the non-specific clinical presentation, there is a need for reliable diagnostic tools that can be used in resource-limited settings. This study assessed the diagnostic accuracy of Impression Cytology (IC) in diagnosing OSSN, compared to histopathology, the gold standard.

Methods: A diagnostic accuracy study was conducted involving 40 patients suspected to have OSSN at Kenyatta National Hospital and Kikuyu Hospital. Patients were scheduled for IC followed by surgical excision and Histopathological examination. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were calculated.

Results: There were 40 participants, 28 females and 12 males, with a mean age of 40.5 years (range 18-70). IC had a sensitivity of 100%, specificity of 82.1%, accuracy of 87.5%, positive predictive value of 70.6%, and negative predictive value of 100%.

Conclusion: IC is an effective, minimally invasive diagnostic tool for OSSN, demonstrating high sensitivity and negative predictive value. Its implementation in clinical settings could improve early detection and management of OSSN, particularly in regions with limited access to histopathological services.

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肯尼亚两所三级医院印象细胞学诊断眼表鳞状瘤变的评价。

眼表鳞状瘤变（OSSN）是一个广义的术语，包括影响眼表的癌前病变和癌性病变。鉴于非特异性临床表现，需要可靠的诊断工具，可以在资源有限的情况下使用。与金标准组织病理学相比，本研究评估了印象细胞学（IC）诊断OSSN的准确性。方法：对肯雅塔国立医院和基库尤医院的40例疑似OSSN患者进行诊断准确性研究。患者计划在手术切除和组织病理学检查后进行IC。计算敏感性、特异性、准确性、阳性预测值和阴性预测值。结果：40例受试者，女性28例，男性12例，平均年龄40.5岁（18-70岁）。IC的敏感性为100%，特异性为82.1%，准确率为87.5%，阳性预测值为70.6%，阴性预测值为100%。结论：IC是一种有效的微创诊断OSSN的工具，具有较高的敏感性和阴性预测值。它在临床环境中的实施可以改善OSSN的早期发现和管理，特别是在组织病理学服务有限的地区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.