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Development and Validation of a Nomogram for Prognosis Prediction in Patients with Synchronous Primary Thyroid and Breast Cancer Based on SEER Database. 基于 SEER 数据库的同步原发性甲状腺癌和乳腺癌患者预后预测提名图的开发与验证
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-03-01 Epub Date: 2024-03-25 DOI: 10.1080/07357907.2024.2329963
Miao Huo, Jianfei Zhang, Minna Hou, Jianhui Li, Ning Bai, Ruifen Xu, Jiao Guo
{"title":"Development and Validation of a Nomogram for Prognosis Prediction in Patients with Synchronous Primary Thyroid and Breast Cancer Based on SEER Database.","authors":"Miao Huo, Jianfei Zhang, Minna Hou, Jianhui Li, Ning Bai, Ruifen Xu, Jiao Guo","doi":"10.1080/07357907.2024.2329963","DOIUrl":"10.1080/07357907.2024.2329963","url":null,"abstract":"<p><p>This study aimed to develop prognostic prediction models for patients diagnosed with synchronous thyroid and breast cancer (TBC). Utilizing the SEER database, key predictive factors were identified, including T stage of thyroid cancer, T stage of breast cancer, M stage of breast cancer, patient age, thyroid cancer surgery type, and isotope therapy. A nomogram predicting 5-year and 10-year survival rates was constructed and validated, exhibiting strong performance (C-statistic: 0.79 in the development cohort (95% CI: 0.74-0.84), and 0.82 in the validation cohort (95% CI: 0.77-0.89)). The area under the Receiver Operator Characteristic (ROC) curve ranged from 0.798 to 0.883 for both cohorts. Calibration and decision curve analyses further affirmed the model's clinical utility. Stratifying patients into high-risk and low-risk groups using the nomogram revealed significant differences in survival rates (<i>P</i> < 0.0001). The successful development and validation of this nomogram for predicting 5-year and 10-year survival rates in patients with synchronous TBC hold promise for similar patient populations, contributing significantly to cancer research.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"212-225"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Nature, Origin, and Evolution of Life: Part III the Emergence of Complex Life. 生命的本质、起源和进化：第三部分复杂生命的出现。
IF 1.8 4区 医学
Cancer Investigation Pub Date : 2024-03-01 Epub Date: 2023-11-17 DOI: 10.1080/07357907.2023.2281715
Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
{"title":"The Nature, Origin, and Evolution of Life: Part III the Emergence of Complex Life.","authors":"Gary H Lyman, Christopher H Lyman, Nicole M Kuderer","doi":"10.1080/07357907.2023.2281715","DOIUrl":"10.1080/07357907.2023.2281715","url":null,"abstract":"","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"199-201"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71478355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma. 食管鳞状细胞癌化疗期间同时使用克罗霉素的随机、双盲、安慰剂对照临床试验
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2024-02-22 DOI: 10.1080/07357907.2024.2319754
Nima Ebrahimi, Seyed Alireza Javadinia, Roham Salek, Azar Fanipakdel, Samaneh Sepahi, Mansoureh Dehghani, Niloufar Valizadeh, Seyed Ahmad Mohajeri
{"title":"Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma.","authors":"Nima Ebrahimi, Seyed Alireza Javadinia, Roham Salek, Azar Fanipakdel, Samaneh Sepahi, Mansoureh Dehghani, Niloufar Valizadeh, Seyed Ahmad Mohajeri","doi":"10.1080/07357907.2024.2319754","DOIUrl":"10.1080/07357907.2024.2319754","url":null,"abstract":"<p><p><i>Crocin</i> is the major active carotenoid of saffron (Crocus sativus L.). Its pluripotent effects have led to a growing body of literature investigating its antitumor properties as well as its diverse potentials for mood stabilization, normal tissue protection, and inflammation reduction; However, there is a gap in clinical trials testing this substance in cancer patients. In this randomized, double-blind, placebo-controlled clinical trial, patients with newly diagnosed esophageal squamous cell carcinoma were randomly assigned to either 30 mg/day of crocin or placebo, prescribed during the neoadjuvant chemo-radiotherapy. The primary endpoints were pathological response and toxicity, and secondary endpoints were depression and anxiety levels and survival analysis.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"155-164"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Nature, Origin and Evolution of Life: Part II The Origin of Life. 生命的本质、起源、发展和进化：第二部分生命的起源。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2023-10-18 DOI: 10.1080/07357907.2023.2270277
Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
{"title":"The Nature, Origin and Evolution of Life: Part II The Origin of Life.","authors":"Gary H Lyman, Christopher H Lyman, Nicole M Kuderer","doi":"10.1080/07357907.2023.2270277","DOIUrl":"10.1080/07357907.2023.2270277","url":null,"abstract":"","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"115-118"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41192055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NGS-based Tissue-Blood TMB Comparison and Blood-TMB Monitoring in Stage-III Non-Small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy. 基于 NGS 的组织-血液 TMB 比较和血液-TMB 监测在同时接受化疗放疗的 III 期非小细胞肺癌中的应用。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.1080/07357907.2024.2316297
Luxi Ye, Xiao Chu, Jianjiao Ni, Li Chu, Xi Yang, Zhengfei Zhu
{"title":"NGS-based Tissue-Blood TMB Comparison and Blood-TMB Monitoring in Stage-III Non-Small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy.","authors":"Luxi Ye, Xiao Chu, Jianjiao Ni, Li Chu, Xi Yang, Zhengfei Zhu","doi":"10.1080/07357907.2024.2316297","DOIUrl":"10.1080/07357907.2024.2316297","url":null,"abstract":"<p><p>In this study, we analyzed the blood-based TMB (b-TMB) and its dynamic changes in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who received concurrent chemoradiotherapy. Baseline tissue and blood TMB from 15 patients showed a strong positive correlation (Pearson correlation = 0.937), and nearly all mutations were markedly reduced in the later course of treatment, indicating a treatment-related response. This study suggests that in patients with LA-NSCLC, b-TMB is a reliable biomarker, and its dynamic monitoring can help distinguish patients who might benefit most from the consolidated immunotherapy.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"165-175"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting EGFR and VEGFR-2 Kinases With Nanoparticles: A Computational Approach for Cancer Therapy Advancement. 用纳米粒子靶向表皮生长因子受体和血管内皮生长因子受体-2激酶：促进癌症治疗的计算方法》。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2024-03-14 DOI: 10.1080/07357907.2024.2328529
Ibrahim Khater, Aaya Nassar
{"title":"Targeting EGFR and VEGFR-2 Kinases With Nanoparticles: A Computational Approach for Cancer Therapy Advancement.","authors":"Ibrahim Khater, Aaya Nassar","doi":"10.1080/07357907.2024.2328529","DOIUrl":"10.1080/07357907.2024.2328529","url":null,"abstract":"<p><p>The study investigates titanium and zinc nanoparticles as inhibitors for the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor-2 (VEGFR-2), pivotal regulators of cell processes. VEGFR-2 activation fuels tumor angiogenesis in cancer cells, sustaining malignant tissue expansion. Molecular docking analysis illustrates the nanoparticles' binding to the active sites, inhibiting the phosphorylation of key proteins in downstream signaling. This inhibition offers a promising therapeutic approach to impede cancer-related signaling, potentially slowing down aberrant protein cascades controlled by EGFR and VEGFR-2. The findings propose a novel avenue for cancer treatment, targeting abnormal growth pathways using titanium and zinc nanoparticles.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"176-185"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Analyses of PD-L1, LAG-3, TIM-3, OX40L Expressions and MSI Status in Gastroenteropancreatic Neuroendocrine Neoplasms. 胃肠胰神经内分泌肿瘤中 PD-L1、LAG-3、TIM-3、OX40L 表达和 MSI 状态的回顾性分析
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2024-03-14 DOI: 10.1080/07357907.2024.2330102
Fatih Gürler, Selin Aktürk Esen, Bediz Kurt İnci, Osman Sütçüoğlu, Gökhan Uçar, Orhun Akdoğan, Doğan Uncu, Nesrin Turhan, Nalan Akyürek, Nuriye Özdemir, Ahmet Özet, Ozan Yazıcı
{"title":"Retrospective Analyses of PD-L1, LAG-3, TIM-3, OX40L Expressions and MSI Status in Gastroenteropancreatic Neuroendocrine Neoplasms.","authors":"Fatih Gürler, Selin Aktürk Esen, Bediz Kurt İnci, Osman Sütçüoğlu, Gökhan Uçar, Orhun Akdoğan, Doğan Uncu, Nesrin Turhan, Nalan Akyürek, Nuriye Özdemir, Ahmet Özet, Ozan Yazıcı","doi":"10.1080/07357907.2024.2330102","DOIUrl":"10.1080/07357907.2024.2330102","url":null,"abstract":"<p><p>We investigated expressions of PD-L1, LAG-3, TIM-3, and OX40L as immune checkpoint proteins, and MSI (repetitive short-DNA-sequences due to defective DNA-repair system) status were analyzed with immunohistochemistry from tissue blocks. Of 83 patients, PD-L1 expression was observed in 18.1% (n = 15) of the patients. None of the patients exhibited LAG-3 expression. TIM-3 expression was 4.9% (n = 4), OX40L was 22.9% (n = 19), and 8.4% (n = 7) of the patients had MSI tumor. A low-to-intermediate positive correlation was observed between PD-L1 and TIM-3 expressions (rho: 0.333, <i>p</i> < 0.01). Although PD-L1 expression was higher in grade 3 NET/NEC, MSI status was prominent in grade 1/2 NET.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"141-154"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on Emerging Techniques for Diagnosis of Colorectal Cancer. 大肠癌诊断新技术综述。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2024-02-26 DOI: 10.1080/07357907.2024.2315443
Shruthi Nagainallur Ravichandran, Diptimayee Das, Erica Katriel Dayananda, Amit Dey, Antara Banerjee, Alexander Sun-Zhang, Hong Zhang, Xiao-Feng Sun, Surajit Pathak
{"title":"A Review on Emerging Techniques for Diagnosis of Colorectal Cancer.","authors":"Shruthi Nagainallur Ravichandran, Diptimayee Das, Erica Katriel Dayananda, Amit Dey, Antara Banerjee, Alexander Sun-Zhang, Hong Zhang, Xiao-Feng Sun, Surajit Pathak","doi":"10.1080/07357907.2024.2315443","DOIUrl":"10.1080/07357907.2024.2315443","url":null,"abstract":"<p><p>Common detection methods in practice for diagnosing colorectal cancer (CRC) are painful and invasive leading to less participation of individuals for CRC diagnosis. Whereas, improved or enhanced imaging systems and other minimally invasive techniques with shorter detection times deliver greater detail and less discomfort in individuals. Thus, this review is a summary of the diagnostic tests, ranging from the simple potential use in developing a flexible CRC treatment to the patient's potential benefits in receiving less invasive procedures and the advanced treatments that might provide a better assessment for the diagnosis of CRC and reduce the mortality related to CRC.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"119-140"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Cell Infiltration Types as Biomarkers for the Recurrence Diagnosis and Prognosis of Bladder Cancer. 作为膀胱癌复发诊断和预后生物标志物的免疫细胞浸润类型
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.1080/07357907.2024.2308161
Hongwei Xu, Dapeng Sun, Dahong Zhou, Shiheng Sun
{"title":"Immune Cell Infiltration Types as Biomarkers for the Recurrence Diagnosis and Prognosis of Bladder Cancer.","authors":"Hongwei Xu, Dapeng Sun, Dahong Zhou, Shiheng Sun","doi":"10.1080/07357907.2024.2308161","DOIUrl":"10.1080/07357907.2024.2308161","url":null,"abstract":"<p><p>This study aimed to investigate the role of infiltrating immune cell types in diagnosing and predicting bladder cancer recurrence. This study mainly applied some algorithms, including Estimate the Proportion of Immune and Cancer Cells (EPIC), support vector machine-recursive feature elimination (SVM-RFE), random forest out-of-bag (RF-OOB) and least absolute shrinkage and selection operator (LASSO)-Cox regression analysis. We found six immune infiltrating cell types significantly associated with recurrence prognosis and two independent clinical prognostic factors. Infiltrating immune cell types (IICTs) based on the prognostic immune risk score (pIRS) models may provide significant biomarkers for the diagnosis and prognostic prediction of bladder cancer recurrence.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"186-198"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conceptualization of Breast Cancer and Attitudes toward Breast Cancer Screening: A Qualitative Study on Iranian and Australian Women. 乳腺癌的概念和对乳腺癌筛查的态度:伊朗和澳大利亚妇女的定性研究。
IF 2.4 4区 医学
Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1080/07357907.2023.2283866
Tina Parsamand, Fariba Zarani, Leili Panaghi, Cannas Kwok
{"title":"Conceptualization of Breast Cancer and Attitudes toward Breast Cancer Screening: A Qualitative Study on Iranian and Australian Women.","authors":"Tina Parsamand, Fariba Zarani, Leili Panaghi, Cannas Kwok","doi":"10.1080/07357907.2023.2283866","DOIUrl":"10.1080/07357907.2023.2283866","url":null,"abstract":"<p><strong>Objective: </strong>Regular screening can lead to early diagnosis of breast cancer. Australia is one of the countries with a high rate of participation in breast cancer screening, while in Iran, most patients are diagnosed in advanced stages. This qualitative study used a thematic analysis method to examine the attitudes and beliefs of Iranian and Australian women toward breast cancer and breast cancer screening.</p><p><strong>Method: </strong>In-depth interviews were conducted with eight Iranian and seven Australian women. Data were collected through semi-structured interviews and analyzed using thematic analysis with an inferential approach.</p><p><strong>Results: </strong>According to the results, four main themes were extracted for the perceptions of breast cancer, including \"the meaning of breast cancer\", \"causes of breast cancer\", \"prevention of breast cancer\" and \"effects of significant people in life\". Considering the perceptions of breast cancer screening, three themes were identified, including \"beliefs about breast cancer screening,\" \"sources of information about breast cancer screening,\" and \"barriers to breast cancer screening.\"</p><p><strong>Conclusion: </strong>Cultural and social factors influence women's perceptions of breast cancer and screening. Therefore, investigating the cultural meaning of breast cancer and breast cancer screening for women can be useful for screening and prevention purposes.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"34-43"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138046174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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