Cancer Investigation最新文献_第8页

COVID-19 Outbreak Impact on Cancer Multidisciplinary Team Meetings. A Multicenter French Experience. COVID-19 爆发对癌症多学科团队会议的影响。法国多中心经验。

IF 2.4 4区医学

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.1080/07357907.2024.2311856

Wafa Bouleftour, Amandine Mondiere-Wichurski, Pierre Fournel, Quentin Reboul

引用次数: 0

Gain of Chromosome 5q Predicts a Favorable Prognosis in Localized Renal Cell Carcinoma. 5q 染色体增益预示局部肾细胞癌的良好预后

IF 2.4 4区医学

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.1080/07357907.2024.2308172

Cedric Lebacle, Aydin Pooli, Brian Shuch, Nagesh Rao, Karim Chamie, Nils Kroeger, Izak Faiena, Sandy Liu, Erika L Wood, Arie Belldegrun, Alexandra Drakaki, Allan J Pantuck

引用次数: 0

Microvessel Density (MVD) in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis. 骨肉瘤患者的微血管密度 (MVD)：系统回顾与元分析》。

IF 1.8 4区医学

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1080/07357907.2024.2311266

Konstantinos Perivoliotis, Panagiotis Ntellas, Katerina Dadouli, Athina A Samara, Sotirios Sotiriou, Maria Ioannou, Konstantinos Tepetes

引用次数: 0

The Nature, Origin and Evolution of Life: Part I The Fundamental Logic and Organization of Life. 生命的本质、起源与进化：第一部分生命的基本逻辑与组织。

IF 2.4 4区医学

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2023-09-28 DOI: 10.1080/07357907.2023.2262122

Gary H Lyman, Christopher H Lyman, Nicole M Kuderer

引用次数: 0

Single Nucleotide Polymorphisms Associated with Prostate Cancer Progression: A Systematic Review. 与前列腺癌进展相关的单核苷酸多态性：系统综述。

IF 1.8 4区医学

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2023-12-18 DOI: 10.1080/07357907.2023.2291776

Daniel Felipe Mendivelso González, Santiago Andrés Sánchez Villalobos, Andrea Estefanía Ramos, Wendy Johana Montero Ovalle, Martha Lucía Serrano López

{"title":"Single Nucleotide Polymorphisms Associated with Prostate Cancer Progression: A Systematic Review.","authors":"Daniel Felipe Mendivelso González, Santiago Andrés Sánchez Villalobos, Andrea Estefanía Ramos, Wendy Johana Montero Ovalle, Martha Lucía Serrano López","doi":"10.1080/07357907.2023.2291776","DOIUrl":"10.1080/07357907.2023.2291776","url":null,"abstract":"Background: New biomarkers of progression in patients with prostate cancer (PCa) are needed to improve their classification and clinical management. This systematic review investigated the relationship between single nucleotide polymorphisms (SNPs) and PCa progression.Methods: A keyword search was performed in Pubmed, EMBASE, Scopus, Web of Science, and Cochrane for publications between 2007 and 2022. We included articles with adjusted and significant associations, a median follow-up greater than or equal to 24 months, patients taken to radical prostatectomy (RP) as a first therapeutic option, and results presented based on biochemical recurrence (BCR).Results: In the 27 articles selected, 73 SNPs were identified in 39 genes, organized in seven functional groups. Of these, 50 and 23 SNPs were significantly associated with a higher and lower risk of PCa progression, respectively. Likewise, four haplotypes were found to have a significant association with PCa progression.Conclusion: This article highlights the importance of SNPs as potential markers of PCa progression and their possible functional relationship with some genes relevant to its development and progression. However, most variants were identified only in cohorts from two countries; no additional studies reproduce these findings.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"75-96"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138486725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One Heresy and One Orthodoxy: On Dialetheism, Dimathematism, and the Non-normativity of Logic. 一个异端和一个正统：论 Dialetheism、Dimathematism 和逻辑的非规范性。

IF 0.9 4区医学

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2022-03-09 DOI: 10.1007/s10670-022-00528-8

Heinrich Wansing

引用次数: 0

Comorbidity in Small Cell Lung Cancer: Prognostic Impacts of Hypertension/Coronary Artery Disease, Diabetes Mellitus, and Chronic Obstructive Pulmonary Disease. 小细胞肺癌的合并症：高血压/冠状动脉疾病、糖尿病和慢性阻塞性肺病的预后影响。

IF 2.4 4区医学

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2024-02-01 DOI: 10.1080/07357907.2024.2310574

Faruk Tas, Akin Ozturk, Kayhan Erturk

引用次数: 0

Human Mycobiota and Its Role in Cancer Progression, Diagnostics and Therapeutics: A Link Lesser-Known. 人类霉菌生物群及其在癌症进展、诊断和治疗中的作用：鲜为人知的联系

IF 2.4 4区医学

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2024-01-07 DOI: 10.1080/07357907.2024.2301733

Souvik Roy, Dhrisaj Ray, Ishani Laha, Lopamudra Choudhury

引用次数: 0

Efficacy of Adjuvant First-Generation TKIs versus Chemotherapy in Patients with Completely Resected EGFR-Mutant Non-Small Cell Lung Cancer: A Meta-Analysis. 完全切除的表皮生长因子受体突变非小细胞肺癌患者第一代 TKIs 辅助治疗与化疗的疗效对比：一项 Meta 分析。

IF 2.4 4区医学

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI: 10.1080/07357907.2024.2303311

Bin Shen, Dongping Wu, Jianjiang Liu, Yang Yang

{"title":"Efficacy of Adjuvant First-Generation TKIs versus Chemotherapy in Patients with Completely Resected EGFR-Mutant Non-Small Cell Lung Cancer: A Meta-Analysis.","authors":"Bin Shen, Dongping Wu, Jianjiang Liu, Yang Yang","doi":"10.1080/07357907.2024.2303311","DOIUrl":"10.1080/07357907.2024.2303311","url":null,"abstract":"Background: The use of adjuvant first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) in patients with resected EGFR-mutant non-small cell lung cancer (NSCLC) remains controversial. Therefore, we performed a systematic review with meta-analysis to investigate the overall survival (OS) in patients with resected NSCLC.Methods: Relevant studies were identified from the PubMed and EMBASE databases, and pooled hazard risks were obtained by random-effects models.Results: Three prospective phase III and one phase II randomized controlled trials were identified, including a total of 839 patients who had undergone resection of EGFR-sensitive mutation in our analysis, 429 of whom received adjuvant first-generation TKIs therapy. For all patients with complete resection, adjuvant first-generation TKIs therapy was associated with improved disease-free survival (DFS) [hazard ratio (HR): 0.50, 95% confidence interval (CI): 0.30-0. 82] but not OS (HR: 0.78, 95% CI: 0.48-1.27) compared with adjuvant chemotherapy. In addition, we reconstructed the OS curves of the ADJUVANT and IMPACT studies, and the pooled 3- and 5-year OS rates of stage II-III patients in the TKI group and chemotherapy group were 80% vs. 79% and 66% vs. 64%, respectively. We also reconstructed the DFS curves based on the ADJUVANT, IMPACT, and EVIDENCE studies, and the pooled 1-, 3- and 5-year DFS rates of stage II-III patients in the TKI group and chemotherapy group were 87% vs. 70%, 49% vs. 37% and 28% vs. 29%, respectively.Conclusions: In patients with completely resected EGFR-mutant NSCLC, adjuvant first-generation TKIs may delay disease progression but still fail to improve long-term survival compared with conventional chemotherapy.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"63-74"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer. 转移性结直肠癌miRNA和EMT标志物的比较分析。

IF 2.4 4区医学

Cancer Investigation Pub Date : 2023-12-01 Epub Date: 2024-01-02 DOI: 10.1080/07357907.2023.2283495

Veronika Hanusova, Petra Matouskova, Monika Manethova, Jiri Soukup, Stanislav John, Martin Zofka, Hana Vošmikova, Lukas Krbal, Emil Rudolf

{"title":"Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer.","authors":"Veronika Hanusova, Petra Matouskova, Monika Manethova, Jiri Soukup, Stanislav John, Martin Zofka, Hana Vošmikova, Lukas Krbal, Emil Rudolf","doi":"10.1080/07357907.2023.2283495","DOIUrl":"10.1080/07357907.2023.2283495","url":null,"abstract":"Colorectal cancer (CRC) is the fourth most commonly diagnosed malignant condition in the world. Micro RNAs (miRNAs) as well as epithelial to mesenchymal transition (EMT) play an important role in the pathogenesis of CRC. We performed a comparative analysis of the expression of selected miRNA genes and EMT markers in bioptic samples from patients (n = 45) with primary CRC or metastatic (m)CRC to the regional lymph node using reverse transcription-quantitative PCR and IHC staining. Results: Out of all miRNA analyzed, the miR-17 expression was most significantly different and associated with lower risk of CRC spread to the lymph node. In addition, significant relationships were found between the tumor side localization and several miRNAs expressions (miR-9, miR-29b, miR-19a, miR-19b, miR-21, miR-106a, miR-20a and miR-17). In addition, of the examined EMT markers, only VEGFA expression correlated with tumor progression (tumor grade G2). In the examined set of patient samples and their matched healthy tissue, several specific molecular markers (miRNAs associated with EMT and tumor progression) were identified with a promising prognostic potential. Their further examination in larger patient cohorts is planned to validate the present data.","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"837-847"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138298481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0