针对各种分子途径治疗宫颈癌的新型研究药物:现状与前景

IF 1.8 4区 医学 Q3 ONCOLOGY
Cancer Investigation Pub Date : 2024-08-01 Epub Date: 2024-07-05 DOI:10.1080/07357907.2024.2373841
Rakesh Kumar Kore, Ekta Shirbhate, Vaibhav Singh, Achal Mishra, Ravichandran Veerasamy, Harish Rajak
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引用次数: 0

摘要

目前,宫颈癌(CC)是全球妇女第四大常见癌症。尽管由于筛查识别和创新治疗方法,发病率和死亡率有所下降,但仍有许多转移或复发病例被发现。对于无法接受手术和放疗等根治性疗法的患者,姑息化疗仍然是标准的治疗方法。本文旨在全面总结目前治疗CC的疗法。作者在回顾临床研究结果的同时,还强调了正在进行的试验。利用生物机制靶向不同分子通路的药物,如表皮生长因子受体(EGFR)、血管内皮生长因子(VEGF)、哺乳动物雷帕霉素靶点(mTOR)、多聚 ADP-核糖聚合酶(PARP)和表观遗传生物机制等,是研究前景引人入胜的缩影。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New Investigational Drug's Targeting Various Molecular Pathways for Treatment of Cervical Cancer: Current Status and Future Prospects.

Currently, cervical cancer (CC) is the fourth recorded widespread cancer among women globally. There are still many cases of metastatic or recurring disease discovered, despite the incidence and fatality rates declining due to screening identification and innovative treatment approaches. Palliative chemotherapy continues to be the standard of care for patients who are not contenders for curative therapies like surgery and radiotherapy. This article seeks to provide a thorough and current summary of therapies that have been looked into for the management of CC. The authors emphasize the ongoing trials while reviewing the findings of clinical research. Agents that use biological mechanisms to target different molecular pathways such as epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), mammalian target of rapamycin (mTOR), poly ADP-ribosepolymerase (PARP), and epigenetic biological mechanisms epitomize and offer intriguing research prospects.

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来源期刊
Cancer Investigation
Cancer Investigation 医学-肿瘤学
CiteScore
3.80
自引率
4.20%
发文量
71
审稿时长
8.5 months
期刊介绍: Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.
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