Turkish neurosurgery最新文献_第3页

Investigation of the Protective and Therapeutic Effects of Ginger (Zingiber officinale) Extracts on Neuroinflammatory, Motor and Cognitive Impairments Caused by Mild Traumatic Brain Injury Model.

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46057-23.7

Guven Akcay, Fikri Ozdemir, Sevil Ozkinali, Filiz Demirdogen, Ali Yilmaz

{"title":"Investigation of the Protective and Therapeutic Effects of Ginger (Zingiber officinale) Extracts on Neuroinflammatory, Motor and Cognitive Impairments Caused by Mild Traumatic Brain Injury Model.","authors":"Guven Akcay, Fikri Ozdemir, Sevil Ozkinali, Filiz Demirdogen, Ali Yilmaz","doi":"10.5137/1019-5149.JTN.46057-23.7","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.46057-23.7","url":null,"abstract":"Aim: To examine the effects of phenolic compound-rich ginger extract on motor and cognitive functions as well as cytokine levels in the mild traumatic brain injury (mTBI) model.Material and methods: The mTBI model was modeled employing the Marmarou method. The Ginger group rats were i.p. administered 50 mg/kg of ginger extract. The Ginger+traumatic brain injury (TBI) group rats were i.p. administered 50 mg/kg of ginger extract two days before the TBI was induced. The control and TBI+Ginger group rats were provided ginger extract (50 mg/ kg i.p.) immediately after the TBI. Motor and cognitive behavioral experiments were performed. The cytokine levels were analyzed using the ELISA method.Results: While TBI caused a decline in motor and cognitive functions, significant enhancements of these functions were observed in the Ginger+TBI and TBI+Ginger groups because of the ginger treatment. While TBI induced an increased hippocampal cytokine level, significant decreases were detected in the Ginger+TBI and TBI+Ginger groups following ginger treatment.Conclusion: The study findings revealed that phenolic compound-rich ginger extract may exert therapeutic effects on cytokine levels in the mTBI model.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 2","pages":"257-264"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reviewer's Side.

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46896-24.3

Bipin Chaurasia

引用次数: 0

Evaluation of the Effects of HDAC Activity in Hydroxychloroquine Applied Human Primary Chondrocyte and Nucleus Pulposus Cultures. 羟氯喹对人原代软骨细胞和髓核培养中HDAC活性的影响。

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46503-24.2

Yasin Emre Kaya, Numan Karaarslan, Ibrahim Yilmaz, Tamer Tamdogan, Sevim Ondul, Duygu Yasar Sirin, Hanefi Ozbek

{"title":"Evaluation of the Effects of HDAC Activity in Hydroxychloroquine Applied Human Primary Chondrocyte and Nucleus Pulposus Cultures.","authors":"Yasin Emre Kaya, Numan Karaarslan, Ibrahim Yilmaz, Tamer Tamdogan, Sevim Ondul, Duygu Yasar Sirin, Hanefi Ozbek","doi":"10.5137/1019-5149.JTN.46503-24.2","DOIUrl":"10.5137/1019-5149.JTN.46503-24.2","url":null,"abstract":"Aim: To evaluate the in vitro effects of hydroxychloroquine (HCQ) on histone deacetylase (HDAC) enzyme activity and interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-α) expressions.Material and methods: Primary cell cultures were prepared. Samples that did not receive any medication constituted the control group, while culture samples treated with HCQ served as the study group. The surface morphology of cells and the extracellular matrix (ECM) were evaluated by Giemsa staining and inverted light microscopy. Cell viability, proliferation, and cytotoxicity were determined by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium-bromide (MTT) analysis. The cultures were simultaneously stained with acridine orange (AO)/propidium iodide (PI) and viewed under fluorescence microscopy. HDAC enzyme activity and IL-6, IL-10, and TNF-α expression were evaluated using commercial enzyme-linked immunosorbent assay kits. The obtained data were analyzed using statistical methods. The alpha significance level was accepted as p < 0.05.Results: HCQ applied to cell cultures at the tested doses and durations showed cytotoxic effects on cell viability, proliferation, and cell or ECM morphology. It increased HDAC activity in chondrocytes and caused a proinflammatory response, indicated by an increase in TNF-α in the cells (p < 0.05).Conclusion: The results of this study emphasized that the cytotoxic effect of HCQ increased HDAC activity; therefore, this proinflammatory response should be taken into consideration in the clinical use of HCQ.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"129-140"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Sella Morphology in Chiari Malformation Type I. I型Chiari畸形蝶鞍形态的评价。

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.45939-23.3

Hakan Ozalp, Onur Ozgural, Baran Can Alpergin, Aysenur Inceoglu, Sibel Ozalp, Ercan Armagan, Hadice Ucar, Orhan Beger

{"title":"Evaluation of the Sella Morphology in Chiari Malformation Type I.","authors":"Hakan Ozalp, Onur Ozgural, Baran Can Alpergin, Aysenur Inceoglu, Sibel Ozalp, Ercan Armagan, Hadice Ucar, Orhan Beger","doi":"10.5137/1019-5149.JTN.45939-23.3","DOIUrl":"10.5137/1019-5149.JTN.45939-23.3","url":null,"abstract":"Aim: To investigate the morphology of sella turcica (ST) in Chiari malformation type I (CM-I) using computed tomography.Material and methods: The size and shape of ST were examined using the radiological images of 32 CM-I patients (21 female/11 male, mean age: 26.09 ± 15.39 years), and 32 normal participants (19 female/13 male, mean age: 28.56 ± 19.37 years).Results: The height, diameter, width, and length of ST were similar in CM-I and control groups (p > 0.05). According to the Axelsson classification, the ST shape in CM-I was identified as normal in 16 patients (50%), oblique anterior wall in 2 patients (6.25%), irregularity in 6 patients (18.75%), and pyramidal shape of the dorsum sellae in 8 patients (25%). In controls, the ST shape was identified as normal in 18 patients (56.25%), oblique anterior wall in 4 patients (12.50%), irregularity in 2 patients (6.25%), and pyramidal shape of the dorsum sellae in 8 patients (25%). According to the Camp classification, the ST shape in CM-I was identified as oval in 6 patients (18.80%), round in 21 patients (65.60%), and flattened in 5 patients (15.60%). In controls, the ST shape was identified as oval in 19 subjects (59.40%), round in 10 patients (31.30%), and flattened in 3 patients (9.40%).Conclusion: The size of ST in patients with CM-I was similar to that in healthy partcipants. The only difference in ST morphology was that patients with CM-I had more round-shaped sella, whereas normal subjects had more oval-shaped sella.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"171-181"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Intracranial Compliance Through Noninvasive Intracranial Pressure Waveforms in Hydrocephalus Patients. A Pilot Study. 利用无创颅内压波形分析脑积水患者颅内顺应性。一项初步研究。

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.45668-23.2

Raphael Bertani, Stefan Koester, Caio Perret, Paulo Santa Maria, Sérgio Brasil, Gustavo Frigieri, Sávio Batista, Nicolas Nunes Rabello, Ruy Monteiro

{"title":"Analysis of Intracranial Compliance Through Noninvasive Intracranial Pressure Waveforms in Hydrocephalus Patients. A Pilot Study.","authors":"Raphael Bertani, Stefan Koester, Caio Perret, Paulo Santa Maria, Sérgio Brasil, Gustavo Frigieri, Sávio Batista, Nicolas Nunes Rabello, Ruy Monteiro","doi":"10.5137/1019-5149.JTN.45668-23.2","DOIUrl":"10.5137/1019-5149.JTN.45668-23.2","url":null,"abstract":"Aim: To assess the changes of intracranial pressure waveforms (ICPW) acquired noninvasively in a set of acute hydrocephalus patients prior to and posterior to interventions.Material and methods: Patients with clinical and radiological diagnosis of hydrocephalus were evaluated for alterations in ICPW by means of a system that detects cranial micro expansions just before and immediately after interventions. The system quantified the difference between ICPW peaks (P1 and P2), providing the P2/P1 ratio.Results: Fourteen patients aged from 26 to 73 years old met the inclusion criteria. Hydrocephalus etiologies were normal pressure hydrocephalus, post-traumatic and all patients had an abnormal intracranial compliance waveform, with P2 > P1 before the procedure (5 external ventricular drains (EVD) and 9 ventriculoperitoneal shunts (VPS). Immediately after, 75% of the patients changed to a standard pattern with P1 > P2.Conclusion: In this exploratory study using a novel noninvasive technique, rapid cerebrospinal fluid drainage by means of EVD and VPS was effectively assessed and had a positive impact on intracranial compliance.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"157-163"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Potential of Transorbital and Supraorbital Approaches for Stereotactic Surgery: An Anatomical Feasibility Study. 评估经眶和眶上入路在立体定向手术中的潜力：一项解剖学可行性研究。

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46170-23.2

Berkhan Genc, Nazlı Cakici Oksuz, Naci Emre Aksehirli, Bahar Tekin, Bayram Ufuk Sakul, Mehmet Tonge

{"title":"Assessing the Potential of Transorbital and Supraorbital Approaches for Stereotactic Surgery: An Anatomical Feasibility Study.","authors":"Berkhan Genc, Nazlı Cakici Oksuz, Naci Emre Aksehirli, Bahar Tekin, Bayram Ufuk Sakul, Mehmet Tonge","doi":"10.5137/1019-5149.JTN.46170-23.2","DOIUrl":"10.5137/1019-5149.JTN.46170-23.2","url":null,"abstract":"Aim: To evaluate the supraorbital and transorbital approaches as alternative entry sites and trajectories targeting the nucleus accumbens (NAc), subcallosal cingulate gyrus (SCG), and lateral hypothalamic area (LHA), in cadavers and surgical planning station.Material and methods: The three-dimensional relationship of the identified trajectories within the anterior and middle cranial fossae as well as the stereotactically targeted NAc, SCG, and LHA, were demonstrated through dissection studies conducted in cadavers. To validate the accuracy of the measurements from the cadaver, trajectory planning was replicated using radiological imaging of patients without a space-occupying lesion who underwent gamma knife surgery. These measurements were compared with those from cadavers.Results: The transorbital and supraorbital trajectories did not pass through the lateral ventricles and they can be used for subventricular targets. Additionally, the NAc and LHA can be targeted simultaneously. These trajectories pass along a broader anatomical area within the NAc due to the anatomical orientation of the nucleus.Conclusion: These findings suggest that these entry points may offer new opportunities for stimulating different targets in the prefrontal cortex and may serve as an approach for future clinical use.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"141-156"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic Effects of Hypericum Perforatum on Glioblastoma Cells by Inducing Oxidative Stress, Autophagy and Apoptosis. 贯叶连翘通过诱导氧化应激、自噬和凋亡对胶质母细胞瘤细胞的细胞毒作用。

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.45958-23.3

Mesut Mete, Ulkun Unlu Unsal, Fatih Collu, Isil Aydemir, Erdogan Kocamaz, Mustafa Barutcuoglu, Beyhan Gurcu, Muge Karakayali, Mehmet Ibrahim Tuglu

{"title":"Cytotoxic Effects of Hypericum Perforatum on Glioblastoma Cells by Inducing Oxidative Stress, Autophagy and Apoptosis.","authors":"Mesut Mete, Ulkun Unlu Unsal, Fatih Collu, Isil Aydemir, Erdogan Kocamaz, Mustafa Barutcuoglu, Beyhan Gurcu, Muge Karakayali, Mehmet Ibrahim Tuglu","doi":"10.5137/1019-5149.JTN.45958-23.3","DOIUrl":"10.5137/1019-5149.JTN.45958-23.3","url":null,"abstract":"Aim: To identify the autophagy mechanism T98 glioma cells.Material and methods: Three groups were created with T98 human glioblastoma cells; Group 1: T98 glioma cells without treatment (Control group). Group 2: T98 glioma cells treated with 3 µl/ml JWO. Group 3: T98 glioma cells treated with 6 µl/ml JWO. The cell proliferation, oxidative stress, types of cell death were studied at IC50 dose of JWO.Results: The proliferation of glioma cells was inhibited in 5.296 µl/ml dose. JWO induced apoptosis in T98 glioma cells in comparison with the control and there was statistically significant difference (p < 0.001). Apoptosis was analyzed via TUNEL method and results were checked by flow cytometry. We also investigated the effects of JWO on autophagy in T98 glioma cells by immunostaining LC3-II and MDC fluorescent stainings. The differences between JWO treated and control group were notably significant (p < 0.001). The immunofluorescence staining resultsof LC3-II was confirmed by Western blotting analysis.Conclusion: JWO seems to be an effective treatment agent for glioblastoma. Not only does it induce apoptosis via oxidative stress but also affects the autophagy. The use of JWO in combination with other treatment options may increase the efficacy of treatment.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"46-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brachial Artery Access for Carotid Artery Stenting: A Pooled Analysis. 颈动脉支架置入的肱动脉通路：一项汇总分析。

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46534-24.2

Marcelo Porto Sousa, Sávio Batista, Guilherme Melo Silva, Márcio Yuri Ferreira, Leonardo Oliveira Brenner, José Victor Dantas dos Santos, Raphael Muszkat Besborodco, Filipi Fim Andreão, Agostinho C Pinheiro, Raphael Bertani, José Alberto Almeida Filho

{"title":"Brachial Artery Access for Carotid Artery Stenting: A Pooled Analysis.","authors":"Marcelo Porto Sousa, Sávio Batista, Guilherme Melo Silva, Márcio Yuri Ferreira, Leonardo Oliveira Brenner, José Victor Dantas dos Santos, Raphael Muszkat Besborodco, Filipi Fim Andreão, Agostinho C Pinheiro, Raphael Bertani, José Alberto Almeida Filho","doi":"10.5137/1019-5149.JTN.46534-24.2","DOIUrl":"10.5137/1019-5149.JTN.46534-24.2","url":null,"abstract":"Aim: To examine the potential of transbrachial access (TBA) in carotid artery stenting (CAS).Material and methods: This systematic review and meta-analysis aimed to comprehensively evaluate the safety and efficacy of TBA for CAS by conducting a thorough search on Medline, Cochrane Library, Embase, and Web of Science databases. Studies reporting TBA for CAS and evaluating primary outcomes such as good neurological results, procedural success, and complications were included. Studies with fewer than 4 patients were excluded.Results: After a meticulous selection of 1837 literature articles, 11 studies were meticulously chosen for the comprehensive examination, involving a total of 273 patients. The analysis of nine studies revealed a consistent 100% procedural success rate with minimal variability (95% CI: 98% to 100%). In the final assessment of neurological status across eight studies, good neurological outcomes were observed in 99% (95% CI: 98% to 100%). Additionally, nineteen complications were identified, leading to a 1% rate (95% CI: 0% to 9%). Among the 223 patients in eight studies, resulting in a pooled estimate of 0% mortality (95% CI: 0% to 1%), indicating a favorable safety profile.Conclusion: The results of TBA for CAS demonstrate a highly effective and safe procedure. Despite the limitations, TBA can be an option in patients with no other access available, and further comparative studies are required to establish definitive conclusions.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Analysis of Stent during Stent Assisted Coil Embolization for Cerebral Aneurysms: A 17-Year Institutional Study.

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46784-24.0

Kihun Kim, Jong-Hyun Park, Gi Yong Yun, Jae-Min Ahn, Hyuk-Jin Oh, Jai-Joon Shim, Seok Mann Yoon

{"title":"A Comprehensive Analysis of Stent during Stent Assisted Coil Embolization for Cerebral Aneurysms: A 17-Year Institutional Study.","authors":"Kihun Kim, Jong-Hyun Park, Gi Yong Yun, Jae-Min Ahn, Hyuk-Jin Oh, Jai-Joon Shim, Seok Mann Yoon","doi":"10.5137/1019-5149.JTN.46784-24.0","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.46784-24.0","url":null,"abstract":"Aim: To compare the outcomes and complications of stent-assisted coil (SAC) embolization for the treatment of cerebral aneurysms according to stent type.Material and methods: Since January 2006, a total of 1293 patients have been added to our institutional aneurysm database. We excluded cases with subarachnoid hemorrhage, those not classified as Raymond Roy Class 1, and those in which flow diverters were used. Cases involving the use of overlapping stents, Y-stenting, or multiple stents were also excluded. We recorded demographic information, aneurysm characteristics, and procedural details for all patients. Patients who did not undergo diffusionweighted magnetic resonance imaging (MRI) within 1 day postoperatively or follow-up angiography within 6 months postoperatively were excluded.Results: In total, 188 patients were included in the analysis (129 females; mean age, 58 years) who were treated for aneurysms of different sizes. Regrowth occurred in 21 patients, with the rate varying according to the stent type. In particular, the lower profile stent group had a lower regrowth rate compared to the nitinol laser stent group. The rate of postoperative infarction on diffusionweighted MRI within 1 day postoperatively varied among stent types.Conclusion: None of the stent types demonstrated clear superiority for SAC embolization, indicating that stent selection should be based on surgeon preference. Despite the low regrowth rate, careful stent selection is essential, particularly for patients at high risk of ischemic stroke or regrowth. These findings provide valuable insights for optimizing the treatment of cerebral aneurysms using SAC embolization.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 2","pages":"337-344"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Transformation of a Corticotroph Pituitary Neuroendocrine Tumor 128 Months Following Primary Excision ? A Case Report.

Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.44912-23.2

Abhijit Goyal-Honavar, Ananth P Abraham, H S Asha, Geeta Chacko, Ari G Chacko

引用次数: 0