Turkish neurosurgery最新文献

{"title":"Effect of Electrical Capacitance-Based Therapy on the Viability of U87 and T98-G Glioblastoma Cell Lines.","authors":"Eray Abat, Hatice Bekci, Mukerrem Betul Yerer, Nimetullah Alper Durmus, Ali Sahin, Serhat Albayrak, Sukru Oral, Ahmet Kucuk, Halil Ulutabanca","doi":"10.5137/1019-5149.JTN.49048-25.3","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.49048-25.3","url":null,"abstract":"<p><strong>Abstract: </strong>AIM: To examine the selective cytotoxic effects of Electro-Capacitive Cancer Therapy (ECCT) on human glioblastoma (GBM) cell lines (U87-MG and T98-G) and to evaluate its impact on normal epithelial cells. MATERIAL and METHODS: U87-MG and T98-G glioblastoma cells, along with Beas-2B normal epithelial cells, were exposed to ECCT at 100 kHz frequency and 20 V for 24 hours. Cell viability was determined using the MTT assay, while morphological changes were assessed through phase-contrast microscopy. Statistical analyses were conducted using one-way ANOVA and Student's t-test, with statistical significance defined as p < 0.05. RESULTS: ECCT exposure caused a time-dependent reduction in the viability of both GBM cell lines. U87-MG cells showed significant inhibition at all exposure durations, whereas T98-G cells exhibited a marked decrease only after 24 hours (p < 0.0001). In contrast, Beas-2B cells maintained their morphology and viability, suggesting that ECCT selectively targets malignant cells while sparing normal epithelial cells. CONCLUSION: ECCT significantly inhibits glioblastoma cell proliferation without adversely affecting normal cells, highlighting its promise as a non-invasive adjunctive treatment option for GBM. Further preclinical and clinical studies are warranted to clarify its underlying mechanisms, optimize exposure parameters, and determine its potential integration into multimodal glioblastoma therapy.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"658-663"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Technique to Improve Intraoperative Visualization for the Lower Cervical Spine in Spine Surgery.","authors":"Ajoy Prasad Shetty, Juan Esteban Muñoz Montoya, Antonio José Gómez Díaz","doi":"10.5137/1019-5149.JTN.49758-25.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.49758-25.2","url":null,"abstract":"<p><strong>Abstract: </strong>Localising the lower cervical spine intraoperatively using conventional fluoroscopy with lateral projections has limitations. The main factor limiting the adequate visualisation of the cervicothoracic spaces is the superposition of the shoulder's structures (soft tissue, muscle, and bone), which creates a significant obstacle when making intraoperative decisions. Various techniques have been described for this purpose. Some are complex and involve different X-ray projection angles or the creation of special devices. However, fluoroscopy techniques using conventional AP and lateral projections can be employed in conjunction with shoulder traction, dorsiflexion of the feet, and pushing the feet upward to accurately identify lower cervical spaces and even the cervicothoracic junction. This technique is unique in that it is cost effective, yielding favourable results without requiring investment in new or expensive devices. Both shoulders were secured to the operating table using shoulder traction, and dorsiflexion and pushing the feet upward bilaterally were performed simultaneously. Doing so enabled the capture of favourable images and the implementation of accurate surgical approaches to treat lower cervical structures. The usefulness of this new technique for visualising lower cervical spaces was demonstrated in the presented cases. Our technique facilitates the acquisition of fluoroscopic images with adequate magnification and accurate visualisation of the lower cervical spaces. The results were similar to those of other studies.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"718-721"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Perioperative Experiences of Patients Undergoing Awake Craniotomy: A Retrospective, Observational Study.","authors":"Mehmet Bolat, Ozge Ozen, Ahmet Ilkay Isikay, Sahin Hanalioglu, Basak Akca","doi":"10.5137/1019-5149.JTN.49789-26.1","DOIUrl":"10.5137/1019-5149.JTN.49789-26.1","url":null,"abstract":"<p><strong>Abstract: </strong>AIM: To evaluate the satisfaction and experiences of patients who underwent awake craniotomy, a relatively uncommon procedure. MATERIAL and METHODS: Following institutional ethics committee approval, data from 60 patients who underwent awake craniotomy between January 2019 and September 2023 were retrospectively analyzed in this observational study. Demographic data, perioperative experiences, overall satisfaction levels, and patient recommendations were collected using surveys and retrospective evaluations. The data were analyzed using statistical methods. RESULTS: The study revealed that most patients (93.3%) were satisfied with their communication with the surgical team, with 98.3% indicating that they received adequate information regarding anesthetic and surgical procedures. However, 21.7% perceived the written informational materials as insufficient. CONCLUSION: These findings emphasize the necessity of a patient-centered approach throughout the surgical pathway, suggesting that comprehensive information and support systems can enhance patient experience. Furthermore, awake craniotomy can be successfully performed through close collaboration within a multidisciplinary team that prioritizes patient comfort and reassurance. However, improvements are needed in the quality of written informational materials and in reducing the discomfort associated with local anesthetic injections. This study expands the existing evidence base by presenting patient-centered data on awake craniotomy practices in Turkey, highlighting the need for standardization and quality improvement initiatives aimed at optimizing patient experience.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"755-760"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accessory Nerve Meningioma of the Foramen Magnum: A Rare Neurosurgical Entity.","authors":"Mohammed Aladdam, Mehmet Sabri Gurbuz, Mehmet Ali Kahraman, Simge Sezgin, Gulsen Ishakoglu, Burak Bayraktar, Tuce Soylemez Akkurt","doi":"10.5137/1019-5149.JTN.49346-25.2","DOIUrl":"10.5137/1019-5149.JTN.49346-25.2","url":null,"abstract":"<p><p>Meningiomas, which are the most common primary intracranial tumors, frequently arise from the dura of the convexities, parasagittal regions, and skull base. The accessory nerve (cranial nerve XI) at the level of the foramen magnum is an exceptionally uncommon site of origin. To date, only a few cases have been clearly documented in the literature. We report the case of a 66-year-old woman who presented with dizziness, headaches, and left-sided shoulder weakness. The lesion was initially presumed to be a regular foramen magnum meningioma. Intraoperatively, the spinal accessory nerve was centrally engulfed by the tumor, with gross invasion of the nerve sheath and no identifiable dissection plane. The final histopathology confirmed the diagnosis of a World Health Organization Grade I meningioma. Accessory nerve meningiomas are exceedingly rare and can closely mimic the more common dural-based foramen magnum tumors.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 3","pages":"483-488"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Anterior Temporal Lobectomy in Adults with Temporal Lobe Epilepsy: A Comprehensive Analysis of a 20-Year, 168-Patient Cohort.","authors":"Ozan Hasimoglu, Tuba Ozge Karacoban, Taha Hanoglu, Nur Bahar Geylan, Demet Kinay, Gunay Gul, Ayten Ceyhan Dirican, Murat Mert Atmaca, Ozan Barut, Omer Batu Hergunsel, Bekir Tugcu","doi":"10.5137/1019-5149.JTN.48548-25.4","DOIUrl":"10.5137/1019-5149.JTN.48548-25.4","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the long-term clinical outcomes and histopathological classifications of anterior temporal lobectomy in adult patients with mesial temporal lobe epilepsy (TLE) associated with hippocampal sclerosis.</p><p><strong>Material and methods: </strong>This was a retrospective study of 168 adult patients diagnosed with drug-resistant mesial temporal lobe epilepsy who underwent resection surgery and were histopathologically confirmed to have hippocampal sclerosis between 2006 and 2025. Preoperative evaluations included video-EEG, high-resolution brain Magnetic Resonance Imaging, neuropsychological tests, and PET-CT. Postoperative outcomes were assessed using the Engel classification. The impact of demographic characteristics, age at epilepsy onset, epilepsy duration, initial precipitating injury, family history, histopathological findings, and diagnostic evaluations on long-term seizure outcomes was evaluated using Kaplan-Meier and multivariate analyses.</p><p><strong>Results: </strong>Among the 168 patients included in the study, 95.2% achieved Engel Class I seizure freedom in the first year, with a long-term seizure freedom rate of 85.1%. The mean follow-up duration was 117.74 months. Histopathological evaluations revealed that HS-ILAE Type 1 was the most common histopathological classification, (73.8%). Longer preoperative epilepsy duration (p=0.009) and positive family history were risk factors for seizure recurrence (p=0.021). There was no significant association between histopathological classification and seizure control (p>0.05).</p><p><strong>Conclusion: </strong>Anterior temporal lobectomy are effective surgical options for achieving high rates of seizure freedom in patients with mesial TLE associated with hippocampal sclerosis. Longer preoperative epilepsy duration and a positive family history were identified as negative prognostic factors for seizure recurrence. This study makes a significant contribution to the literature, with long-term outcomes of these procedures in a large cohort of adult patients with TLE.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 3","pages":"440-449"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Assessment of Clinical, Radiological, and Histopathological Parameters in Lumbar Disc Herniation Using Correlation Matrices Analysis.","authors":"Cezmi Cagri Turk, Elif Sevde Topalli, Umut Ogun Mutlucan, Oktay Elter, Gulsum Akar, Kerem Yilmaz, Onur Elmas, Dinc Suren","doi":"10.5137/1019-5149.JTN.49270-25.2","DOIUrl":"10.5137/1019-5149.JTN.49270-25.2","url":null,"abstract":"<p><strong>Aim: </strong>To provide deeper insights into the biological mechanisms underlying disc degeneration and recurrence by studying histopathological features of excised disc tissue. Moreover, due to limited predictive role of radiological grading systems like Pfirrmann and Modic classifications in understanding postoperative outcomes and recurrence mechanisms, to perform holistic analysis on clinical, patient specific factors, radiological and histological findings on matrix correlation statistics.</p><p><strong>Material and methods: </strong>We conducted a retrospective study including 87 patients who underwent lumbar discectomy between 2019 and 2024. Detailed preoperative magnetic resonance imaging (MRI) evaluations using Pfirrmann grading, along with semi-quantitative histopathological analysis, were performed. Statistical analyses included Spearman correlation and ANOVA to explore relationships between clinical, radiological, and histopathological parameters.</p><p><strong>Results: </strong>Higher Pfirrmann grades were significantly associated with radiological instability (p.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 3","pages":"394-405"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148146018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Specific Lattice Cage Design for Cervical Spinal Fusion.","authors":"Bulent Bozyigit, Mehmet Akif Oymak, Erkan Bahce, Gurminder Singh","doi":"10.5137/1019-5149.JTN.49659-25.3","DOIUrl":"10.5137/1019-5149.JTN.49659-25.3","url":null,"abstract":"<p><strong>Aim: </strong>To propose a patient-specific interbody cage with graded stiffness distributions analogous to the Young's modulus of the cervical spinal bone interface in order to improve mechanical compatibility, promote physiological load sharing, and enhance osseointegration.</p><p><strong>Material and methods: </strong>A synthetic database of spinal bone Young modulus values was used, incorporating anatomical regions (cervical, thoracic, lumbar) and patient-specific factors (age, bone density, health status). A parametric generative design approach allowed dynamic modification of lattice unit cell geometry to achieve target stiffness values (200-3000 MPa) while preserving structural integrity.</p><p><strong>Results: </strong>Finite element endplate analysis demonstrated a 30%-50% reduction in stress shielding compared with conventional solid or homogeneous mesh lattices. Additively manufactured prototypes showed tunable stiffness-porosity trade-offs, achieving yield strength ≥150 MPa while supporting osseointegration.</p><p><strong>Conclusion: </strong>This study demonstrates improved load distribution and reduced risk of cage collapse compared with cadaveric spine data. Integrating computational design, biomechanical compatibility, and additive manufacturing may facilitate the development of patient-specific spinal implants with superior mechanical and biological performance.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"74-81"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Articular vs Medial Branch Pulsed Radiofrequency in the Management of Lumbar Facet Joint-Related Low Back Pain: A Prospective Randomized Trial.","authors":"Burak Erken, Suat Demir, Ipek Saadet Edipoglu","doi":"10.5137/1019-5149.JTN.49271-25.2","DOIUrl":"10.5137/1019-5149.JTN.49271-25.2","url":null,"abstract":"<p><strong>Aim: </strong>To compare the efficacy of intra-articular PRF (IA-PRF) and medial branch PRF (MB-PRF) in the treatment of facet joint-related low back pain.</p><p><strong>Material and methods: </strong>In this prospective observational study, 116 patients with ≥50% pain relief after diagnostic intraarticular anesthetic injection were included. Patients underwent IA-PRF (n=60) or MB-PRF (n=56). Pain and disability were assessed using the Numerical Rating Scale (NRS) and Oswestry Disability Index (ODI) at baseline and 1 and 6 months post-treatment.</p><p><strong>Results: </strong>Both groups showed significant improvements in NRS and ODI scores at 1 and 6 months (p<0.001). In the IA-PRF group, NRS scores improved from 6.55 ± 0.65 to 3.23 ± 0.43 (1 month) and 3.70 ± 0.46 (6 months); ODI scores improved from 49.70 ± 3.75 to 25.13 ± 1.66 and 26.90 ± 2.13, respectively. In the MB-PRF group, NRS scores decreased from 6.43 ± 0.66 to 3.13 ± 0.33 (1 month) and 3.57 ± 0.49 (6 months); ODI scores decreased from 49.18 ± 3.49 to 24.71 ± 1.34 (1 month) and 26.68 ± 2.20 (6 months). No significant intergroup differences were observed at follow-ups (p>0.05). No complications occurred.</p><p><strong>Conclusion: </strong>IA-PRF and MB-PRF are effective and safe in treating LFJ-induced pain after 6 months of follow-up. Significant pain control and functional improvement were achieved with both methods, with no significant difference between them regarding clinical efficacy. Our findings suggest that treatment selection should be individualized according to patient characteristics. Randomized studies with large samples and long-term follow-up are needed to improve the level of evidence in this field.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"82-88"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive Effects of Melatonin Against Post-Traumatic Contusional Expansion in Rats.","authors":"Mehmet Arif Aladag, Cengiz Golcek, Ramazan Pasahan, Harika Gozukara","doi":"10.5137/1019-5149.JTN.48436-25.3","DOIUrl":"10.5137/1019-5149.JTN.48436-25.3","url":null,"abstract":"<p><strong>Aim: </strong>To provide insight into the molecular mechanism of contusional expansion (CE) by creating experimentally induced contusion cerebri (CC) in rats and investigating whether melatonin administration prevents CE or not.</p><p><strong>Material and methods: </strong>Rats were randomized into four groups: Group 1 (control, n=5), group 2 (trauma, n=25), group 3 (trauma plus placebo, n=25), and, group 4 (trauma plus melatonin, n=25). Rats in the control group were sacrificed without undergoing any invasive procedure. Groups 2, 3, and 4 were further divided into 5 subgroups (A-E), with animals in each sacrificed at 12, 24, 72, 120, and 168 h after CC induction. Samples from these subgroups were analyzed for levels of caspase 3, caspase 8, and matrix metalloproteinase-9, as well as for evidence of ischemia, blood-brain barrier (BBB) breakdown, vasogenic edema (VE), and hemorrhage. Temporal progression of CE and correlations between these variables were also investigated.</p><p><strong>Results: </strong>Our results indicated that the ischemia, BBB breakdown, and VE are early events that initiate CE, with VE and hemorrhagic transformation due to BBB breakdown identified as key factors. Melatonin treatment prevented CE injury.</p><p><strong>Conclusion: </strong>Melatonin, a safe and well-tolerated substance with minimal toxicity, may serve as a potential therapeutic agent for preventing CE injury.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"16-24"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Professor We Knew.","authors":"Ossama Al-Mefty, Abdel Raouf Kayssi, Ali Krisht","doi":"10.5137/1019-5149.JTN.50617-26.0","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.50617-26.0","url":null,"abstract":"<p><p>Microsurgery is a remarkable gift that Professor Yaşargil has bestowed upon humanity, revolutionizing the field of surgery and opening up new possibilities for potential cure. In his brilliant career, Professor Yaşargil after his retirement from the chairmanship at the University of Zurich, he was accepted the invitation to join the department of neurosurgery at the University of Arkansas for Medical Sciences. We reflect on these very special years during which we had the opportunity to witness not only his devotion to microneurosurgery, and his scholarly scientific indulgence, but also his humanistic attributes. He touched the lives of so many through the years.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 Special Issue in Memoriam Prof. M. Gazi Yaşargil","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}