Turkish neurosurgery最新文献_第4页

Evaluating the Predictive Value of a Coagulation-Related Gene Model in Glioma. 评估凝血相关基因模型在胶质瘤中的预测价值。

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.45238-23.2

Ming Cao, Jie Chen, Rong-Zeng Guo

{"title":"Evaluating the Predictive Value of a Coagulation-Related Gene Model in Glioma.","authors":"Ming Cao, Jie Chen, Rong-Zeng Guo","doi":"10.5137/1019-5149.JTN.45238-23.2","DOIUrl":"10.5137/1019-5149.JTN.45238-23.2","url":null,"abstract":"Aim: To evaluate coagulation related gene model as a biomarker for predicting prognosis of gliomas.Material and methods: The mRNA expression and clinical data of glioma were downloaded from the TCGA and CGGA databases. Coagulation-related genes were downloaded from the KEGG database. The expression model was constructed using LASSO regression. The GBM data were divided into high and low-risk expression groups based on the median risk score, and the differences in overall survival and progression-free survival between them were calculated. The prognostic model was further validated using the TCGA-LGG and CGGA glioma databases, respectively. The accuracy of the risk score was calculated by ROC analysis for 1 year and 3 years.Results: Four model genes, namely the SERPINA5, PLAUR, BDKRB1, and PTGIR, were identified, and the risk score was calculated as follows: risk score= SERPINA5*0.126264111304559 + PLAUR*0.288587629696211 + BDKRB1*0.349215422945011 + PTGIR*0.17334527969703, respectively. Based on glioma data from three groups, patients were divided into high and low-risk groups according to the median risk score. The overall survival, progression-free survival, and risk scores of the high-risk score group were worse than the low-risk group. The ROC curve analysis showed that the AUC values of the coagulation-related gene model at 1 year, 3 years, and 5 years were more than 0.65, validating the reliability of the prognostic model.Conclusion: This study established the correlation between the coagulation-related gene model and glioma prognosis, providing deeper insight into the mechanism and treatment of glioma.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Perspective to Gamma-Knife Radiosurgery for Solitary Meningiomas: Adaptability of Fast Imaging Employing Steady-State Acquisition/Constructive Interference in Steady-State Magnetic Resonance Imaging. 伽马刀放射外科治疗单发脑膜瘤的新视角：利用稳态采集/稳态磁共振成像中的结构性干扰进行快速成像的适应性。

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.44895-23.2

Umit Akin Dere, Emrah Egemen, Fatih Yakar, Rasim Asar, Baris Albuz, Serkan Civlan, Batuhan Bakirarar, Ergin Sagtas, Feridun Acar, Mehmet Erdal Coskun

{"title":"A Novel Perspective to Gamma-Knife Radiosurgery for Solitary Meningiomas: Adaptability of Fast Imaging Employing Steady-State Acquisition/Constructive Interference in Steady-State Magnetic Resonance Imaging.","authors":"Umit Akin Dere, Emrah Egemen, Fatih Yakar, Rasim Asar, Baris Albuz, Serkan Civlan, Batuhan Bakirarar, Ergin Sagtas, Feridun Acar, Mehmet Erdal Coskun","doi":"10.5137/1019-5149.JTN.44895-23.2","DOIUrl":"10.5137/1019-5149.JTN.44895-23.2","url":null,"abstract":"Aim: To compare T1-weighted contrast-enhanced (T1+C) with fast imaging employing steady-state acquisition (FIESTA) magnetic resonance imaging (MRI) sequences to protect healthy brain tissue during meningioma treatment with Gamma-Knife radiosurgery (GKRS).Material and methods: After reviewing the data of 54 patients with solitary meningioma who underwent GKRS between January 2020 and June 2022, demographic characteristics were noted, tumor volumes on T1+C and FIESTA MRI sequences were measured, and sequences were compared. The patients were then divided into two groups according to the presence of invasion to intracranial venous sinuses (groups 1 and 2, respectively). SPSS 11.5 software was used for data analysis, with the level of significance set at 0.05.Results: While no significant age and tumor size differences were observed between groups 1 and 2, sinus invasion was significantly higher among males. Tumor volumes measured in both groups were significantly smaller on FIESTA sequences than on T1+C sequences.Conclusion: The T1+C sequence has been the primary imaging method because of meningiomas' high contrast enhancement feature. However, the T1+C sequence during GKRS planning is an effective imaging method in treating meningiomas; FIESTA sequences can more precisely delineate the tumor border. In this study, we consider that using the FIESTA/CISS sequence MRI for planning meningioma therapy with Gamma-Knife can reduce target volume and prevent irradiation of healthy brain tissue.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141862014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-Mediated Brain Tumor Diagnostics from Peripheral Fluids: A Review of Clinical Data. 从外周体液中获得外泌体介导的脑肿瘤诊断方法：临床数据回顾。

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.45375-23.2

Meghna Bhattacharyya, Justin Gold, Ryan Moncman, Clint Badger, Amber Valeri, Joseph Georges, Steven Yocom

引用次数: 0

The Role of NLRP1 Inflammasome and Interleukin 1β in Experimental Neuropathic Pain Model in Rat and the Effect of Tramadol Treatment. NLRP1炎症体和白细胞介素1β在大鼠实验性神经病理性疼痛模型中的作用及曲马多治疗的效果

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.43768-23.3

Tuba Tanyel Saracoglu, Cigdem Cengelli Unel, Nusin Harmanci, Engin Yildirim, Ayten Bilir, Sacit Gulec

{"title":"The Role of NLRP1 Inflammasome and Interleukin 1β in Experimental Neuropathic Pain Model in Rat and the Effect of Tramadol Treatment.","authors":"Tuba Tanyel Saracoglu, Cigdem Cengelli Unel, Nusin Harmanci, Engin Yildirim, Ayten Bilir, Sacit Gulec","doi":"10.5137/1019-5149.JTN.43768-23.3","DOIUrl":"10.5137/1019-5149.JTN.43768-23.3","url":null,"abstract":"Aim: To evaluate the effects of tramadol on inflammation by measuring NLRP1 and IL-1 beta (IL-1β) levels in an experimental neuropathic pain model.Material and methods: Sprague-Dawley rats were divided into three groups: control, chronic constriction injury (CCI), and CCI + tramadol. Neuropathic pain was assessed using mechanical allodynia, thermal hyperalgesia, and cold allodynia. IL-1β and NLRP1 levels were evaluated using ELISA on sciatic nerve (SN), dorsal root ganglion (DRG), and serum either on day 3 or days 8 postsurgery.Results: On day 3, paw withdrawal latency (PWL) was lower in the CCI and CCI + tramadol groups than the control group in both mechanical and cold allodynia tests. On day 8, the PWL in the CCI group was also lower than in the control group. In contrast, tramadol increased the PWL on day 8 compared to day 3 in the CCI group. During cold allodynia, PWL decreased in the CCI group, however, tramadol reversed this effect on days 3 and 8. Tramadol, therefore, ameliorated pain hypersensitivity in mechanical/cold allodynia tests. Serum IL-1β levels were higher in the CCI + tramadol and CCI groups than the control group, although serum IL-1β levels in the CCI and CCI + tramadol groups were comparable. Tramadol decreased the IL-1β and NLRP1 in DRG compared with the CCI group. A similar trend was observed in the SN samples.Conclusion: Our experiments revealed an increase in IL-1β and NLRP-1 levels in a neuropathic pain model and found that tramadol had an anti-inflammatory effect on the IL-1β and NLRP1 inflammasomes.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141862020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Subgrouping Based on Immunohistochemistry in Medulloblastoma: A Single-Center Experience. 基于免疫组化的髓母细胞瘤分子分组：单中心经验

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.45863-23.2

Berrin Babaoglu, Sahin Hanalioglu, Ali Varan, Kader Karli Oguz, Burcak Bilginer, Anil Dolgun, Figen Soylemezoglu

{"title":"Molecular Subgrouping Based on Immunohistochemistry in Medulloblastoma: A Single-Center Experience.","authors":"Berrin Babaoglu, Sahin Hanalioglu, Ali Varan, Kader Karli Oguz, Burcak Bilginer, Anil Dolgun, Figen Soylemezoglu","doi":"10.5137/1019-5149.JTN.45863-23.2","DOIUrl":"10.5137/1019-5149.JTN.45863-23.2","url":null,"abstract":"Aim: To investigate the efficacy of immunohistochemical methods to determine molecular subgroups and prognostic predictions of medulloblastomas (MBs).Material and methods: β-catenin, GAB1, YAP1, filamin A and p53 were immunohistochemically stained, and MYC and MYCN fluorescent in situ hybridization (FISH) procedures were applied to 218 cases in our series.Results: Based on the histomorphological characteristics of the cases, 67.9% were deemed classic MB; 15.6% as desmoplastic/ nodular medulloblastoma (DNMB); 12.8% as large cell/anaplastic (LC/A) MB; 3.7% as medulloblastoma with extensive nodularity (MBEN). Molecular characteristics revealed that 50.5% had non-WNT/non-SHH; 33.9% had SHH-activated and TP53-wildtype; 8.7% had WNT-activated; 6.9% had SHH-activated and TP53-mutant. According to the survival curves, LC/A MBs or non-WNT/ non-SHH tumors showed the worst prognosis, whereas DNMBs and WNT-activated tumors showed the best prognosis. Classic MBs or SHH-activated tumors showed a moderate course. MYCN amplification was found to act as an independent poor prognostic factor in the study.Conclusion: The distribution of histological subtypes and molecular subgroups, amplification rates, and prognostic data obtained through immunohistochemical methods in our study were consistent with those reported in the literature. It was therefore hypothesized that the determination of molecular subgroups by immunohistochemical methods can be useful in daily diagnostic practice, especially in centers with limited access to molecular techniques.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediation of Epigenetic Mechanisms in the Regenerative Effect of Uridine in a Rat Model of Sciatic Nerve Injury. 尿苷在坐骨神经损伤大鼠模型中的再生效应中的表观遗传学机制的中介作用

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.45425-23.2

Ali Imran Ozmarasali, Cansu Koc, Huseyin Uzabaci, Mehmet Cansev, Ilker Mustafa Kafa, Ahmet Bekar

{"title":"Mediation of Epigenetic Mechanisms in the Regenerative Effect of Uridine in a Rat Model of Sciatic Nerve Injury.","authors":"Ali Imran Ozmarasali, Cansu Koc, Huseyin Uzabaci, Mehmet Cansev, Ilker Mustafa Kafa, Ahmet Bekar","doi":"10.5137/1019-5149.JTN.45425-23.2","DOIUrl":"10.5137/1019-5149.JTN.45425-23.2","url":null,"abstract":"Aim: To investigate the possible mediation of epigenetic mechanisms underlying the regenerative effect of uridine in a sciatic nerve transection rat model.Material and methods: Fifty adult male rats were randomized to sham, control, and uridine groups. After unilateral transection and primary anastomosis of the right sciatic nerve, a single daily dose of saline (1 ml/kg; sham and control groups) or uridine (500 mg/kg; uridine group) was injected intraperitoneally for a week. The sciatic nerves were removed en bloc on the eighth day and levels of histone deacetylase 1 (HDAC1), acetylated histone-H3, and acetylated histone-H4 were analyzed in nerve homogenates. The number of myelinated axons in the sciatic nerve specimens was analyzed histomorphologically.Results: The HDAC1 levels were significantly greater in the control group than in the sham (p < 0.001) and uridine (p < 0.01) groups. Compared to the sham group, the acetylated histone-H3 and histone-H4 levels decreased in the control group (by 81.49% and 79.98%, respectively for both; p < 0.001) and increased significantly in the uridine group (by 62.54% and 51.68% respectively; p < 0.01, p < 0.05). The number of myelinated axons decreased significantly (p < 0.001) in the control group, which was enhanced significantly by uridine administration.Conclusion: Epigenetic mechanisms may partly mediate the regenerative effect of uridine treatment in a rat model of sciatic nerve injury. Our data provides novel insights in the management of peripheral nerve damage and suggests potential benefit of uridine for degenerative diseases in which epigenetic impairments are involved.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonacute Subdural Hematoma Evacuation Using a Rigid Endoscopy System: A Clinical Study. 通过硬质内窥镜系统清除非急性硬膜下血肿：临床研究。

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.46194-23.2

Emrah Egemen, Umit Akin Dere, Emrah Celtikci, Ali Nehir, Yucel Dogruel, Defne Sahinoglu, Rasim Asar, Batuhan Bakirarar, Baris Albuz, Mehmet Erdal Coskun, Fatih Yakar

{"title":"Nonacute Subdural Hematoma Evacuation Using a Rigid Endoscopy System: A Clinical Study.","authors":"Emrah Egemen, Umit Akin Dere, Emrah Celtikci, Ali Nehir, Yucel Dogruel, Defne Sahinoglu, Rasim Asar, Batuhan Bakirarar, Baris Albuz, Mehmet Erdal Coskun, Fatih Yakar","doi":"10.5137/1019-5149.JTN.46194-23.2","DOIUrl":"10.5137/1019-5149.JTN.46194-23.2","url":null,"abstract":"Aim: To determine the clinical relevance of a rigid endoscopy surgical method for subdural hematomas, as previously described in a cadaver study.Material and methods: Between May 2021 and September 2023, 21 patients underwent subdural hematoma drainage using a 0-degree rigid endoscope. Traumatic acute subdural hematomas were excluded. The demographic data of the patients, antiplatelet/ antiaggregant use, perioperative findings, and pre- and post-surgery modified Rankin Scale (mRS) scores were recorded and analyzed.Results: The mean age of our cohort was 65.63 (±20.52), and the male/ female ratio was 3.2: 1. The hematoma was unilateral in 90.5% of the patients, and the rate of trauma history was 42.9%. The most common radiological diagnosis was chronic subdural hematoma with septa (61.9%). The percentage of patients with a history of antiplatelet/ antiaggregant therapy was 23.8%. No mortality related to the surgery was observed in the early postoperative period; however, two patients underwent reoperation for further bleeding. The neurological grade was the only preoperative factor that had a statistically significant effect on the mRS score at discharge, with significantly better discharge mRS scores in grade 1 and 2 patients (p=0.014).Conclusion: The procedure was found to be safe and feasible, with surgery-related morbidity and mortality within acceptable limits.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of Serum Microsomal Prostaglandin E2 Levels with Residual Tumor Volume in Patients with Astrocytoma. 星形细胞瘤患者血清微粒体前列腺素 E2 水平与残余肿瘤体积的关系

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.45184-23.3

Cafer Ak, Murat Aydin, Alper Tabanli, Engin Kayikci, Onur Bologur, Alaattin Yurt

{"title":"Relationship of Serum Microsomal Prostaglandin E2 Levels with Residual Tumor Volume in Patients with Astrocytoma.","authors":"Cafer Ak, Murat Aydin, Alper Tabanli, Engin Kayikci, Onur Bologur, Alaattin Yurt","doi":"10.5137/1019-5149.JTN.45184-23.3","DOIUrl":"10.5137/1019-5149.JTN.45184-23.3","url":null,"abstract":"Aim: To investigate the relationship between tumor volume and serum microsomal prostaglandin E2 (mPGE2) levels in patients with astrocytic tumors.Material and methods: The study included patients with astrocytic tumors who were treated at our clinic between August 2015 and December 2016. Preoperative and postoperative contrast-enhanced cranial magnetic resonance imaging (MRI) scans were performed (within the first 24 h), and preoperative and postoperative residual tumor volumes were calculated. Microsomal prostaglandin E2 (mPGE2) levels were measured and compared in the serum samples of the patients before surgery, on the first day after surgery, and at 1 week after the surgery.Results: The study included 20 patients, 13 of whom were males and 7 were females, with a mean age of 57.20 ± 14.66 yr. The mean postoperative tumor volume was 9,180.69 mm3 (range, 0.00-41,961.60), which was significantly lower than the preoperative mean tumor volume of 37,323.84 mm3 (range, 4,457.40-108,247.20; z = -3.920, p < 0.001). On the first postoperative day, the mean mPGE2 level was 1,776.50 pg/ml (range, 771-5,010), which was similar to the preoperative mean mPGE2 level of 1,769.20 pg/ml (range, 681-3,480). On the seventh postoperative day, the mean mPGE2 level was 955.50 pg/ml (range, 31-2,130), which was significantly lower than the preoperative and postoperative first-day mean mPGE2 levels (p < 0.001). No correlation was found between preoperative and postoperative tumor volumes and mPGE2 levels.Conclusion: Compared with preoperative mPGE2 levels, mPGE2 levels decreased significantly on the seventh postoperative day. However, no correlation was observed between the tumor volume removed and decrease in mPGE2 levels.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of 3- Dimensional Modeling and Virtual Reality in the Education of Posterior Spinal Instrumentation. 三维建模和虚拟现实技术在脊柱后路器械教学中的应用。

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.46204-24.1

Mehmet Yigit Akgun, Oguz Baran, Efe Ogretmen, Ege Anil Ucar, Tunc Oktenoglu, Goktug Akyoldas, Ali Fahir Ozer, Ozkan Ates

{"title":"Use of 3- Dimensional Modeling and Virtual Reality in the Education of Posterior Spinal Instrumentation.","authors":"Mehmet Yigit Akgun, Oguz Baran, Efe Ogretmen, Ege Anil Ucar, Tunc Oktenoglu, Goktug Akyoldas, Ali Fahir Ozer, Ozkan Ates","doi":"10.5137/1019-5149.JTN.46204-24.1","DOIUrl":"10.5137/1019-5149.JTN.46204-24.1","url":null,"abstract":"Aim: To assess the effectiveness and safety of Virtual Reality (VR) simulations for education of posterior spinal instrumentation.Material and methods: Participants were instructed to apply Cervical-Thoracic-Lumbar and Sacral posterior instrumentation techniques using the VR. Each participant underwent a qualitative assessment of the use of the VR. Patient-specific computed tomography (CT) studies were obtained to build a whole spinal model. Bone segmentation was performed upon the CT images. The participants can easily interact with the spinal model and evaluates the outcome from all the angles.Results: A total of 63 participants who used VR stimulation as a primary application during the 4-day course were included in this study. The majority of our participants agreed with the benefit of the VR spinal instrumentation module, stating that it was useful for learning the 3D anatomy of the spinal region. Overall, according to the questionnaire and evaluations, the participants stated that this application was most beneficial in the education and preoperative planning.Conclusion: VR-based surgical training is a promising solution for surgical education, particularly for junior residents, for improving the understanding of spinal instrumentation. In addition, modelling of patient-specific CT scans on VR provides a unique opportunity for improving pre-operative planning and preventing surgical complications.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Thrombolytic Agents in Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis. 脑室内出血的溶栓药物分析：系统综述与元分析》。

Turkish neurosurgery Pub Date : 2024-01-01 DOI: 10.5137/1019-5149.JTN.45919-23.1

Felipe Soares Bolentine, Elany Portela, Iara Santos Rodrigues, Laryssa Araújo, Anderson Silva, Leonardo Zumerkorn Pipek, Josué Brito, Eberval Gadelha Figueiredo, Nicollas Nunes Rabelo

{"title":"Analysis of Thrombolytic Agents in Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis.","authors":"Felipe Soares Bolentine, Elany Portela, Iara Santos Rodrigues, Laryssa Araújo, Anderson Silva, Leonardo Zumerkorn Pipek, Josué Brito, Eberval Gadelha Figueiredo, Nicollas Nunes Rabelo","doi":"10.5137/1019-5149.JTN.45919-23.1","DOIUrl":"10.5137/1019-5149.JTN.45919-23.1","url":null,"abstract":"Aim: To determine the effectiveness of extraventricular drainage (EVD) combined with fibrinolytics in reducing morbidity and mortality rates associated with intraventricular cerebral hemorrhage (IVH).Material and methods: A literature review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (PROSPERO registration number: CRD42022332152). Articles were selected from various sources, including PubMed, Trip Database, LILACS, Cochrane Library, and ScienceDirect. Clinical trials focusing on IVH treatment using EVD and/or fibrinolytics were considered. The Risk of Bias in Non-randomized Studies of Interventions (ROB 2) tool was employed for bias assessment. A fixed-effects regression model was used following heterogeneity analysis. Treatment effectiveness was evaluated based on mortality outcomes.Results: A total of 531 patients from four studies were included. The use of fibrinolytics significantly decreased IVH mortality compared with a placebo. The odds ratio (OR) for recombinant tissue plasminogen activator (rtPA) or alteplase was 0.54 [0.36; 0.82]. For urokinase (UK), the OR was 0.21 [0.03; 1.54], rendering it statistically non-significant. The overall OR was 0.52 [0.35; 0.78], and the heterogeneity I2 was 0% (indicating low heterogeneity).Conclusion: While EVD alone is a common approach for managing hydrocephalus, its effectiveness is limited by potential blockages and infections. Combining EVD with UK or rtPA demonstrated improved patient outcomes. rtPA stands out as a reliable and effective option, while limited data are available regarding UK's effectiveness in reducing IVH mortality.","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0