{"title":"To be an Intellectual of the Brain.","authors":"Ugur Ture","doi":"10.5137/1019-5149.JTN.52037-26.0","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.52037-26.0","url":null,"abstract":"","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 Special Issue in Memoriam Prof. M. Gazi Yaşargil","pages":"41-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"M. Gazi Yaşargil (1925-2025): A Life of Devotion and a Living Lineage.","authors":"Oğuz Baran, H Hayri Kertmen","doi":"10.5137/1019-5149.JTN.52034-26.0","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.52034-26.0","url":null,"abstract":"","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 Special Issue in Memoriam Prof. M. Gazi Yaşargil","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Madison Microneurosurgery Initiative: A Tribute to Professor M. Gazi Yaşargil's Legacy in Microvascular Surgery Training. Part II - Principles Applied and Practices Implemented.","authors":"Abdullah Keles, Mustafa Kemal Baskaya","doi":"10.5137/1019-5149.JTN.50991-26.0","DOIUrl":"10.5137/1019-5149.JTN.50991-26.0","url":null,"abstract":"<p><p>Building on the historical foundations established by Professor M. Gazi Yaşargil and early microsurgical pioneers, as summarized in Part I, this manuscript focuses on the lessons derived from their early experiences and examines how these lessons were translated into guiding principles and contemporary microsurgical training practices. It then describes how these principles informed structured microsurgical training models and were implemented on a global scale through outreach efforts within the Madison Microneurosurgery Initiative. Through basic and advanced equipment donations, offline, live-streamed, and in-person educational support strategies, and sustained mentorship, microsurgical laboratory training has been established in 86 centers across 45 low- and middle-income countries. Our experience demonstrates that effective microsurgical training can be achieved through thoughtful application of foundational principles rather than reliance on high-cost or technologically sophisticated infrastructure. Together, the integration of historical lessons with contemporary application illustrates how Yaşargil's foundational principles continue to guide sustainable microsurgical training across diverse institutional and resource settings.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 Special in Memoriam Prof. M. Gazi Yaşargil","pages":"26-37"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and External Validation of a Nomogram for Predicting the Survival Outcomes of Patients with Ki-67 Positive Grade 4 Diffuse Gliomas.","authors":"Hui Liu, Peng Lun, Jihu Zhao, Peng Sun","doi":"10.5137/1019-5149.JTN.47174-24.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.47174-24.2","url":null,"abstract":"<p><strong>Abstract: </strong>AIM: To establish a nomogram model of Ki-67-positive grade 4 diffuse gliomas that can predict the survival rate of patients and has certain guiding values that are useful in treatment. MATERIAL and METHODS: Data from 146 patients with Ki-67-positive grade 4 diffuse gliomas was retrospectively obtained and analyzed using the R software. Statistically significant indicators were identified via Cox regression analysis and used to establish the nomogram. The nomogram was corrected using the C-index, area under the curve (AUC), calibration curve, and decision curve analyses (DCA). Finally, the model was externally validated using the Chinese Glioma Genome Atlas database. RESULTS: Age, treatment, and IDH status were significant. The models had a C-index of 0.743, and the time-dependent receiver operating characteristic curve had an AUC of 0.832 at 3 months and 0.829 at 6 months, indicating good discriminatory ability. Finally, a nomogram was constructed and validated using the validation and DCA curves. CONCLUSION: Age, treatment, and IDH were independent prognostic factors in patients with Ki-67-positive grade 4 diffuse gliomas. The constructed model can accurately assess the disease-specific survival rates of these patients and help inform treatment options.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 4","pages":"500-508"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The First Reported Case of a Hemorrhagic Solitary Fibrous Tumor at the Cerebellopontine Angle Successfully Managed with Multimodal Therapy.","authors":"I-Chiao Tsai, Pei-Yu Chen, Hung-Lin Lin","doi":"10.5137/1019-5149.JTN.49979-25.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.49979-25.2","url":null,"abstract":"<p><strong>Abstract: </strong>Intracranial solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms, and cases of tumor bleeding are rarely seen. While radiographically similar to meningioma, SFTs exhibit a more aggressive clinical course. The mainstay of treatment is surgical resection followed by adjuvant radiotherapy. We present the first case of a hemorrhagic SFT located at the cerebellopontine (CP) angle, which was successfully treated with multimodal therapy. A 31-year-old man presented with a headache and altered consciousness. Neuroimaging revealed a large dural-based tumor at the left CP angle with subdural hematoma (SDH). The patient underwent preoperative endovascular embolization and near-total surgical resection. Further histopathological analysis confirmed the diagnosis of intracranial SFT. The patient recovered favorably and underwent adjuvant gamma-knife stereotactic radiosurgery (SRS) for the residual tumor. To the best of our knowledge, this is the first reported case of a hemorrhagic SFT treated with a combination of preoperative endovascular embolization and adjuvant SRS. This case illustrates that tailored multimodal treatment is both effective and safe for managing hemorrhagic intracranial SFTs.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"775-779"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet Ali Tepebasili, Dogu Cihan Yildirim, Ali Haluk Duzkalir, Mehmet Orbay Askeroglu, Elena Vetlova, Valery Kostjuchenko, Andrey Golanov, Selcuk Peker
{"title":"Gamma Knife Radiosurgery for Brain Metastasis from Primary Thyroid Cancer.","authors":"Mehmet Ali Tepebasili, Dogu Cihan Yildirim, Ali Haluk Duzkalir, Mehmet Orbay Askeroglu, Elena Vetlova, Valery Kostjuchenko, Andrey Golanov, Selcuk Peker","doi":"10.5137/1019-5149.JTN.49225-25.1","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.49225-25.1","url":null,"abstract":"<p><strong>Abstract: </strong>AIM: To analyze the efficacy and safety of Gamma Knife radiosurgery (GKRS) in the management of thyroid cancer brain metastases (TCBM). MATERIAL and METHODS: This retrospective study analyzed patients who underwent GKRS for TCBM at two centers between September 2005 and February 2025. Patients' clinical and radiological outcomes, including local tumor control and overall follow-up, were investigated. RESULTS: Among the 3,834 patients who underwent GKRS for brain metastases at two centers, only 0.26% had primary thyroid cancer. A total of 10 patients with 40 TCBM were treated by GKRS, with a median of two metastases per patient. The most common metastasis site was the frontal lobe (47.5%), and 60% of patients had multiple metastases. Papillary carcinoma was the most frequent histological subtype (57.1%). The median latency from thyroid cancer diagnosis to the development of brain metastases was 22 months. The median GKRS dose was 23 Gy, and local failure occurred in 5% of treated metastases. Radiation-induced necrosis was observed in one case and resolved without clinical impact. Intracranial distant metastases developed in two patients. The median follow-up was 8 months, and 80% of patients died during follow-up, with one death attributed to brain metastasis. CONCLUSION: The limited number of patients and the short follow-up period, partly reflecting the aggressive nature of TCBM, may have influenced the study results. Nevertheless, despite the short follow-up, GKRS provided favorable local control without significant adverse effects, suggesting that it may be an effective treatment option for TCBM.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 4","pages":"524-530"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nomogram-Based Independent Risk Factor Analysis and Recurrence Prediction for Chronic Subdural Hematoma After Single Burr Hole Drainage.","authors":"Xu Zeng, Fengkun Ji, Yue Sun, Xiaoyu Xia, Peng Zhang, Hongtian Zhang","doi":"10.5137/1019-5149.JTN.48881-25.3","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.48881-25.3","url":null,"abstract":"<p><strong>Abstract: </strong>AIM: To identify independent risk factors and propose a predictor scoring system in chronic subdural hematoma (CSDH). MATERIAL and METHODS: Through retrospective analysis, we analyzed the data from 279 patients with CSDH from 2010 to 2020. Independent risk factors for recurrence were identified through univariate and logistic regression analyses. A risk-scoring model was developed using a nomogram, which was applied to all patients considering postoperative recurrence as a target. ROC curve analysis was done to assess the accuracy of the estimated scoring system. RESULTS: The results revealed significant differences in Glasgow outcome scale (GOS), brain re-expansion after drainage, postoperative use of atorvastatin, side and density of hematoma, the history of trauma, hematoma separated, History of diabetes, and midline shift between patients with recurrent CSDH and non-recurrent. A scoring parameter was developed through a nomogram based on a combination of scored risk factors that were significantly higher in patients with recurrent CSDH (P-value <0.001). The sensitivity and specificity of the predictor score confirmed its efficacy in predicting the recurrence risk of CSDH (sensitivity: 70.5%, specificity: 45.9 %; cutoff: 0.74 and 95% confidence interval: 6.57-0.74). CONCLUSION: A scoring system was finally obtained for the prediction of postoperative recurrence risk. The establishment of a predictor scoring system will help clinicians better monitor and adopt efficient management strategies for high-risk patients.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 4","pages":"561-572"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the Effects of Amantadine, Methylprednisolone and Nimodipine in Sciatic Nerve Crush Injury.","authors":"Ismail Sagir, Recai Engin, Ilke Evrim Secinti, Idris Altun","doi":"10.5137/1019-5149.JTN.48165-24.2","DOIUrl":"10.5137/1019-5149.JTN.48165-24.2","url":null,"abstract":"","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"264-274"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anterior Contralateral Cervical Microdiscectomy at C7-T1.","authors":"Okan Kahyaoglu, S Meltem Can, Halit Cavusoglu, Ismail Yuce, Yunus Aydin","doi":"10.5137/1019-5149.JTN.49227-25.2","DOIUrl":"10.5137/1019-5149.JTN.49227-25.2","url":null,"abstract":"<p><strong>Aim: </strong>To retrospectively review the patients who had disc herniation at C7-T1 level and were treated using the senior author's anterior contralateral simple microdiscectomy without fusion technique.</p><p><strong>Material and methods: </strong>From January 2000 to December 2021, 27 patients underwent surgery for C7-T1 disc herniation, all of which were performed by the same neurosurgeon. Clinical and radiological data were collected before surgery and at 3 and 24 months after surgery. The Short Form-36 and Neck disability questionnaire were used to assess the quality of life.</p><p><strong>Results: </strong>All patients presented with radiculopathy. There were 16 male and 11 female patients, with an average age of 40 years. The average follow-up period was 9.7 years. The postoperative Short Form-36 and Neck Disability Index scores were significantly different from the preoperative scores. Overall scores at the postoperative 24th month did not differ significantly from those obtained at the postoperative third month.</p><p><strong>Conclusion: </strong>We propose that patients with symptoms of disc herniation at C7-T1 level benefit from an anterior contralateral microdiscectomy without fusion.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 3","pages":"406-412"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of Age-Related Changes of the Atlas for Posterior Cervical Screw Fixation Surgery: A Morphometric Computed Tomography Study.","authors":"Serkan Oner, Zulal Oner, Rukiye Sumeyye Bakici, Halide Temelci, Seyma Toy","doi":"10.5137/1019-5149.JTN.49164-25.2","DOIUrl":"10.5137/1019-5149.JTN.49164-25.2","url":null,"abstract":"<p><strong>Aim: </strong>To describe the morphometry of the atlas vertebrae regarding sex and age in posterior cervical surgery, provide a data source for surgery, and compare with other populations. In surgical operations, the morphology and morphometry of the atlas must be known.</p><p><strong>Material and methods: </strong>Computed tomography images of 300 individuals aged 20-69 and referred to the hospital between 2020 and 2023 were used in retrospective research. The 14 parameters determined were examined in five groups formed by dividing ages into decades. The following parameters were measured: the transverse foramen area (TFA), length of the lateral mass (LLM), weight of the lateral mass (WLM), anteroposterior diameter of the left transverse foramen (ADTF), transverse diameter of the left transverse foramen (TDTF), posterior arch area (PAA), distance from the nearest point of the lateral mass on the posterior arch to the occipital condyle (OLM), posterior arch length (PAL), height of the lateral mass (HLM), and the height of the anterior tubercle of the atlas (HAT). In statistical analysis, the two-sample T-test, one-way ANOVA, and eta-squared (η²) tests were used.</p><p><strong>Results: </strong>The HLM, WLM, PAA, PAL, OLM, HAT, TFA, ADTF, and TDTF were more considerable and statistically significant in males. It was statistically significant that the HAT and OLM were lower in the 2nd decade compared to other decades in females (p.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 3","pages":"385-393"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}