Oguz Altunyuva, Nur Balcin, Gokhan Ocakoglu, Mevlut Ozgur Taskapilioglu, Selcuk Yilmazlar
{"title":"Statistical Geometric Morphometric Shape Analysis of Ventricular Shape Changes in Giant Pituitary Adenomas Invading the Third Ventricle.","authors":"Oguz Altunyuva, Nur Balcin, Gokhan Ocakoglu, Mevlut Ozgur Taskapilioglu, Selcuk Yilmazlar","doi":"10.5137/1019-5149.JTN.49331-25.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.49331-25.2","url":null,"abstract":"<p><strong>Abstract: </strong>AIM: To investigate the preoperative, early and late postoperative differences in the anterior callosal angle, lateral and third ventricle shapes of patients with pituitary macroadenoma operated via the transsphenoidal approach. MATERIAL and METHODS: Shape data of the third and lateral ventricles were collected from the two-dimensional digital images. The generalised Procteus analysis was used to obtain mean shapes in the preoperative, early and late postoperative phases. The shape deformation of the ventricles from pre-to postoperative phases was evaluated using the thin plate spline method. Anterior callosal angle (ACA) was measured pre-to postoperative images and was analyzed statistically. RESULTS: There was no significant lateral ventricle shape and ACA measurement difference in the pre and postoperative phases. The high-level deformations from the pre- to postoperative phase were seen in thin plate spline graphs. The highest deformation was observed at the third ventricle. Third ventricle deformation continued from the early to the late postoperative period, but this deformation is more limited than in preoperative comparisons. CONCLUSION: We demonstrated that shape changes in the third ventricle of patients with pituitary macroadenoma persisted during the postoperative period through statistical geometric morphometric shape analysis. This phenomenon may result from dysfunction of the ventricular surface cilia due to chronic tumor compression and surgery-related neurotrauma. Additionally, we identified the diagnostic limitations of ACA in patients without radiological signs of hydrocephalus.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 4","pages":"509-516"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Population-Based Study of Pediatric and Adult Brainstem Glioma: Prognostic Nomograms for Overall and Cancer-Specific Survival.","authors":"Cong Xu, Yongyao Zhao, Xiangyu Wang, Zhaoming Li","doi":"10.5137/1019-5149.JTN.49881-25.4","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.49881-25.4","url":null,"abstract":"<p><strong>Abstract: </strong>AIM: To establish an effective predictive model to inform clinical practice for brainstem glioma, a rare and highly aggressive tumor of the central nervous system, given the lack of prior retrospective studies using the SEER database that have included both pediatric and adult patients. MATERIAL and METHODS: Cases of brainstem tumors diagnosed between 2000 and 2022 were identified from the SEER database. X-tile software and Maxstat were used to define the optimal tumor size cutoff value and risk subgroups for brainstem glioma. Independent prognostic factors were determined using univariate and multivariate Cox proportional hazards regression. These factors were used to construct two nomograms predicting 1-, 2-, and 3-year overall survival and cancer-specific survival for brainstem glioma. RESULTS: Age, tumor size, histological type, surgery, radiation, and chemotherapy were identified as independent prognostic factors for overall and cancer-specific survival. Notably, gross total resection was significantly associated with improved survival outcomes. CONCLUSION: This work enhances our understanding of the prognosis of brainstem glioma and corroborates the importance of surgical resection as a prognostic factor in its management. The validated nomograms offer a superior and personalized tool for risk stratification and prognostic estimation, which may be helpful for clinical decision making and patient counseling.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"632-645"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cengiz Atis, Mehmet Akif Erbas, Cengiz Cokluk, Mehmet Emin Onger, Abdullah Hilmi Marangoz
{"title":"Time-Dependent Neurovascular Effects of Thymoquinone on Basilar Artery Morphometry in a Rat Model of Subarachnoid Haemorrhage.","authors":"Cengiz Atis, Mehmet Akif Erbas, Cengiz Cokluk, Mehmet Emin Onger, Abdullah Hilmi Marangoz","doi":"10.5137/1019-5149.JTN.51344-26.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.51344-26.2","url":null,"abstract":"<p><strong>Abstract: </strong>AIM: To investigate the effects of short- and long-term intraperitoneal thymoquinone administration on basilar artery morphometry and cerebral perfusion in a subarachnoid haemorrhage (SAH) model. MATERIAL and METHODS: Forty-two adult male Wistar rats were randomly allocated to seven experimental groups, including control, sham, untreated SAH, and SAH groups treated with vehicle or thymoquinone (10 mg/kg/day) for 3 or 8 days. SAH was induced by autologous blood injection into the cisterna magna, and animals were sacrificed on days 3 or 8. Basilar artery luminal and tunica media areas were assessed using unbiased stereological methods. Cerebral blood flow was measured by laser Doppler flowmetry, and neurological function was evaluated as a secondary outcome. RESULTS: Basilar artery luminal area differed significantly among experimental groups (p.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"671-681"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Neurosurgical Odyssey: From Apprenticeship to Stewardship.","authors":"","doi":"10.5137/1019-5149.JTN.52460-26.0","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.52460-26.0","url":null,"abstract":"","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"629-631"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to: Anti-Inflammatory, Antioxidant and Neuroprotective Effects of Niacin on Mild Traumatic Brain Injury in Rats.","authors":"","doi":"10.5137/1019-5149.JTN.49401-25.2","DOIUrl":"10.5137/1019-5149.JTN.49401-25.2","url":null,"abstract":"","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"194"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Levent Aydin, Munibe Busra Erdem, Caghan Tonge, Cagri Elbir, Emrah Keskin, Fatih Yakar, Mehmet Erhan Turkoglu
{"title":"Endovascular Treatment of Multiple Intracranial Aneurysms: A Multicenter Study from Türkiye on Morphology-Based Strategies and Clinical Outcomes.","authors":"Levent Aydin, Munibe Busra Erdem, Caghan Tonge, Cagri Elbir, Emrah Keskin, Fatih Yakar, Mehmet Erhan Turkoglu","doi":"10.5137/1019-5149.JTN.49423-25.2","DOIUrl":"10.5137/1019-5149.JTN.49423-25.2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the role of recent endovascular techniques as less invasive alternatives in the management of multiple intracranial aneurysms, particularly in the context of heterogeneous aneurysm morphology and anatomical complexity.</p><p><strong>Material and methods: </strong>This retrospective analysis included 65 patients with a total of 151 MIAs that were treated using endovascular approaches. Morphological parameters, anatomical location, and clinical features were evaluated. Treatment strategies included primary coiling, stent-assisted coiling, Y/X-stent coiling, flow diversion (with or without coiling), use of Woven EndoBridge devices, and parent artery occlusion. Patient outcomes were assessed radiologically (Raymond-Roy Occlusion Classification) and clinically (Modified Rankin Scale, Glasgow Outcome Scale).</p><p><strong>Results: </strong>Morphometric parameters significantly differed by aneurysm location. Flow diversion was preferred for wide-necked ınternal carotid artery aneurysms, while coiling was more commonly used for aneurysms at bifurcation sites. Complete occlusion (Class I) was achieved in 70.2% of the cases, while residual neck/sac (Classes II-IIIa) were observed in 29.8% of the cases. Incomplete occlusion was associated with higher aspect ratios and was more frequent in aneurysms in the anterior and posterior communicating arteries and at the middle cerebral artery bifurcation. The clinical outcomes were favorable, with median Modified Rankin Scale and Glasgow Outcome Scale scores of 0.5 and 5, respectively. The mortality rate was 12%, with a median follow-up of 8.5 months.</p><p><strong>Conclusion: </strong>Endovascular therapy provides a safe and effective approach to treat MIAs. Aneurysm morphology, especially location and aspect ratio, significantly influences angiographic outcomes, supporting the need for individualized treatment plans.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"25-33"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Suk Ahn, Hong Jun Jeon, Byung Moon Cho, Se Hyuck Park
{"title":"Integration of a Hybrid Operating Room for the Management of Severe Traumatic Brain Injury: A Combined Approach with Real-Time Xper-CT Imaging and Neurointervention.","authors":"Hong Suk Ahn, Hong Jun Jeon, Byung Moon Cho, Se Hyuck Park","doi":"10.5137/1019-5149.JTN.49125-25.1","DOIUrl":"10.5137/1019-5149.JTN.49125-25.1","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the safety and efficacy of the hybrid operating room (HOR) approach in the management of severe traumatic brain injury (sTBI) using Xper-computed tomography (CT)-guided imaging and neurointerventional techniques.</p><p><strong>Material and methods: </strong>A retrospective analysis was conducted on 154 patients with TBI treated surgically between February 2020 and December 2023. Among these, 26 patients with sTBI were managed in an HOR equipped with an Allura Xper FD 20® system. Intraoperative interventions included Xper-CT confirmation, real-time imaging-guided hematoma aspiration or catheter placement, and combined neurointerventional procedures. Clinical outcomes were assessed using the Glasgow Outcome Scale- Extended (GOS-E) at 6 months, and procedural morbidity and mortality rates were documented.</p><p><strong>Results: </strong>The 26 patients with sTBI had a mean age of 45.3 ± 12.0 years, with 60.4% being male. Xper-CT was used in all cases (mean: 1.7 scans/patient) for confirmation and in 11 cases (42.3%) for real-time guidance, enabling precise interventions such as parenchymal hematoma aspiration (30.8%) and external ventricular drainage (11.5%). Vascular injuries were managed with N-butyl cyanoacrylate glue or polyvinyl alcohol particle embolization (15.4%) and endovascular coiling for pseudoaneurysms (11.5%), with intraoperative angiography performed in 7.7% of cases. No HOR-related complications or reoperations were noted. Favorable outcomes (GOS-E≥4) were observed in 42.3% of patients at 6 months, whereas the 28-day mortality rate was 19.2%, primarily owing to initial trauma (n=3) and pneumonia or sepsis (n=2).</p><p><strong>Conclusion: </strong>The HOR approach represents a significant advancement in the management of sTBI and potentially improves the overall quality of emergency neurosurgical care.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"6-15"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Child with Three Legs or Conjoint Parasitic Twin?","authors":"Gulyara Cigdem, Mehmet Emin Boleken","doi":"10.5137/1019-5149.JTN.47617-24.5","DOIUrl":"10.5137/1019-5149.JTN.47617-24.5","url":null,"abstract":"<p><strong>Aim: </strong>Rachiphagus is a rare congenital anomaly in which conjoined twins are fused at the midline of the vertebral column region. When one twin is malformed, the condition is referred to as a parasitic twin. The term \"parasitic twin\" also encompasses cases involving extra limbs or limb-like structures. Despite ongoing research, the underlying causes of this condition remain unknown.</p><p><strong>Material and methods: </strong>This is a systematic review of the literature with a case report. A literature search was done in English language in PubMed and Semantic-Scholar from 1952 to 2023. All articles and cases with excess leg or mass which were attached at the back of the spine were reviewed and analysed.</p><p><strong>Results: </strong>A total of 65 cases with rachipagus anomaly were included in this study. Females 37 (56.9%) were affected more than males 28 (43.1%). The lower limbs were in 41 (63.1%) cases, followed by rudimental limbs and mass were in 15 (23.1%) cases, upper limbs were in 8 (12.3%) cases and rudimental upper and low limbs were in 1 (1.5%) case. In majority of cases, accessory limb or mass were attached at lumbosacral region, 27 (41.5%), followed by 12 (18.5%) cases at lumbar region, 7 (10.8%) were at thoracolumbar region, 5 (7.7%) were at sacral and other regions. More than half of the cases 34 (52%) were in Asian countries, followed by 24 (37%) cases in Africa.</p><p><strong>Conclusion: </strong>Rachipagus parasitic twin is congenital abnormalities that develops during embryogenesis and exists at birth with structural deformities of the spine and additional limb or limb like mass. This article presents a novel rachipagus case and systematically reviews the relevant literature.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 3","pages":"349-359"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148146021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Terzano, Francisco Zarra, Andrea L Castillo, Adnan Hussain Shahid, Ismail Bozkurt, Bipin Chaurasia, Alejandro Mercado Santori
{"title":"Honoring the Mentors from 2024: A Tribute to Their Legacy.","authors":"Francisco Terzano, Francisco Zarra, Andrea L Castillo, Adnan Hussain Shahid, Ismail Bozkurt, Bipin Chaurasia, Alejandro Mercado Santori","doi":"10.5137/1019-5149.JTN.49641-25.2","DOIUrl":"10.5137/1019-5149.JTN.49641-25.2","url":null,"abstract":"<p><p>The concept of a mentor represents one of the most important pillars of medical training. It constitutes one of the oldest and noblest arts that has contributed to the growth of this specialty for generations. Mentorship is the essential way to transmit knowledge and values to future generations, ensuring the continuation of legacy in the field. Therefore, the experience and knowledge of current neurosurgeons reflect the influence of previous neurosurgeons. This article aims to show respect to the educators and mentors who passed away in 2024 around the world, with deep gratitude, as learning from those who preceded us helps build a lasting legacy in neurosurgery. A literature review was conducted to examine the deaths of neurosurgeons in 2024 worldwide, without limitation to the English language. A total of 35 neurosurgeons were identified worldwide: one from Africa (Egypt), ten from Asia (Bangladesh, Japan, South Korea, India, and Pakistan); eleven from Europe (Greece, Poland, Spain and Türkiye), seven from North America (Canada and the United States), and six from South America (Argentina, Brazil, Chile, Colombia, and Mexico). In 2024 there was a great loss to the global neurosurgical community. The deceased neurosurgeons left an indelible mark and a legacy that will endure through their disciples and students. The main lesson is to remain proud and grateful for sharing this discipline across generations, preserving the true values of human knowledge.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"151-157"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Shape Analysis of the Corpus Callosum in Pediatric Hydrocephalus: A Comparison Between Cases with and without Shunt Revision Surgery.","authors":"Elif Basaran Gundogdu, Deniz Sigirli","doi":"10.5137/1019-5149.JTN.49954-25.3","DOIUrl":"10.5137/1019-5149.JTN.49954-25.3","url":null,"abstract":"<p><strong>Aim: </strong>To investigate corpus callosum shape differences in pediatric hydrocephalus patients with and without shunt revisions.</p><p><strong>Material and methods: </strong>Midsagittal magnetic resonance imaging studies from 45 cases (25 with and 20 without shunt revision surgeries) that underwent ventriculoperitoneal shunt surgery between 2016 and 2025 were retrospectively analyzed. Corpus callosum shape deformations were evaluated using thin plate spline (TPS) analysis. Landmark-based geometric morphometric methods were applied, and growth curve modeling was used to assess the relationship between centroid size and the number of shunt revisions.</p><p><strong>Results: </strong>TPS analysis revealed that patients with multiple shunt revisions exhibited the most prominent corpus callosum deformations in the posterior region. Atrophy was detected mainly in the splenium region.</p><p><strong>Conclusion: </strong>This study identified changes in the corpus callosum of pediatric hydrocephalus patients with multiple shunt revisions compared to those without shunt revisions. These findings may help characterize the clinical features of cases with multiple shunt revisions.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"310-315"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}