tDCS对脑缺血再灌注模型大鼠钙和谷氨酸兴奋毒性的治疗作用。

Turkish neurosurgery Pub Date : 2025-01-01 DOI:10.5137/1019-5149.JTN.46166-23.6

Guven Akcay, Filiz Demirdogen, Dilcan Kotan, Tuba Gul, Ali Yilmaz, Yusuf Muslum Ergul, Cagla Celik

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引用次数: 0

摘要

目的：脑缺血导致运动和认知功能的显著损伤。本研究旨在探讨经颅直流电刺激（tDCS）对缺血再灌注（IR）所致钙和谷氨酸兴奋毒性的治疗作用。材料与方法：采用大脑中动脉短暂性闭塞模型。分别于IR第2、24、48 h给予tDCS治疗，剂量为1 mA，每日30 min。评估运动和认知功能以及海马组织中Ca2+、谷氨酸和n -甲基- d -天冬氨酸受体（NMDAR）的浓度。结果：结果显示，与假手术组相比，IR组的运动和认知功能有所下降，而与IR组相比，IR+tDCS组的运动和认知功能有所增加。Ca2+、谷氨酸和NMDAR浓度在IR组高于假手术组，但在IR+tDCS组低于IR组。结论：tDCS治疗可改善IR后的运动和认知功能障碍，并通过调节Ca2+和谷氨酸兴奋毒性对学习和记忆产生治疗作用。

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Therapeutic Effects of tDCS on Calcium and Glutamate Excitotoxicity in a Cerebral Ischemia? Reperfusion Rat Model.

Aim: To investigate the therapeutic effects of transcranial direct current stimulation (tDCS) on calcium and glutamate excitotoxicity caused by ischemia?reperfusion (IR).

Material and methods: The IR model was generated by transient middle cerebral artery occlusion. tDCS treatment was applied at 1 mA for 30 min daily at the 2 nd , 24 th , and 48 th h of IR. The motor and cognitive functions and the concentrations of Ca 2+ , glutamate, and N-methyl-D-aspartate receptor (NMDAR) in the hippocampus tissues were evaluated.

Results: Results showed a reduction in motor and cognitive functions in the IR group compared with that in the sham group, whereas these functions increased in the IR+tDCS group compared with those in the IR group. Ca 2+ , glutamate, and NMDAR concentrations were higher in the IR group than in the sham group but lower in the IR+tDCS group than in the IR group.

Conclusion: These results suggest that tDCS treatment improves motor and cognitive dysfunctions after IR and exerts therapeutic effects on learning and memory through the regulation of Ca 2+ and glutamate excitotoxicity.

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Turkish neurosurgery

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