Oral Oncology Reports最新文献_第6页

Preliminary analysis of incidence, risk factors, and management of medication-related osteonecrosis of the jaw in cancer patients 癌症患者药物相关性颌骨骨坏死的发生率、危险因素及处理的初步分析

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2024.100686

P.J. Nagarathna , Santosh R. Patil

{"title":"Preliminary analysis of incidence, risk factors, and management of medication-related osteonecrosis of the jaw in cancer patients","authors":"P.J. Nagarathna , Santosh R. Patil","doi":"10.1016/j.oor.2024.100686","DOIUrl":"10.1016/j.oor.2024.100686","url":null,"abstract":"<div><h3>Background</h3><div>Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication associated with antiresorptive and antiangiogenic therapies commonly used to manage bone metastasis and improve bone density in cancer patients. This study aimed to investigate MRONJ's incidence, risk factors, and outcomes of MRONJ in patients receiving these therapies.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted involving 98 patients who had received antiresorptive or antiangiogenic medications for at least one year. Data were collected from the electronic health records, focusing on demographics, medication details, comorbidities, dental history, and MRONJ status. Logistic regression analysis was used to identify predictors of MRONJ, and Kaplan-Meier survival analysis was used to assess treatment outcomes, comparing surgical and conservative management approaches.</div></div><div><h3>Results</h3><div>The incidence of MRONJ was 21.4 % among the study cohort. Logistic regression identified prolonged medication duration (odds ratio [OR] = 2.5; p = 0.01), comorbidities (OR = 3.2; p = 0.003), and prior dental procedures (OR = 2.1; p = 0.02) as significant predictors of MRONJ. Kaplan-Meier analysis showed that surgical intervention resulted in longer survival (median 24.5 Â months) than conservative management (median 12.8 months; p < 0.01). Despite the high rates of healing (71.4 %) and pain management success (85.7 %), a recurrence rate of 23.8 % indicated MRONJ's chronic nature of MRONJ.</div></div><div><h3>Conclusion</h3><div>This study underscores the importance of early identification and interdisciplinary management of MRONJ risk factors, particularly in patients with prolonged antiresorptive or antiangiogenic therapy. Surgical intervention appears beneficial; however, high recurrence rates emphasize the need for vigilant monitoring and patient-specific treatment strategies.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100686"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Customized immunotherapy in OSCC: Leveraging neoantigens for precision medicine OSCC的定制免疫治疗：利用新抗原进行精准医疗

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2024.100687

Dr. Nitya Krishnasamy, Dr. Vikram S. Amberkar, Dr. Kochli Channapa Niranjan

引用次数: 0

Erratum regarding previously published article 关于以前发表的文章的勘误

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2023.100138

引用次数: 0

Erratum regarding previously published article 关于以前发表的文章的勘误

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2023.100137

引用次数: 0

Optimizing PD-L1/PD-1 therapies: Immune checkpoint inhibitors in nasopharyngeal carcinoma 优化PD-L1/PD-1疗法：鼻咽癌免疫检查点抑制剂

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2024.100675

Madhan Krishnan, Gayathri Sekar

引用次数: 0

Computational biology approach to predict molecular mechanism in cancer 计算生物学方法预测癌症分子机制

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2024.100651

Ansari Vikhar Danish Ahmad, Subur W. Khan, Qazi Yasar, Mohd Sayeed Shaikh, Mohd Mukhtar Khan

{"title":"Computational biology approach to predict molecular mechanism in cancer","authors":"Ansari Vikhar Danish Ahmad, Subur W. Khan, Qazi Yasar, Mohd Sayeed Shaikh, Mohd Mukhtar Khan","doi":"10.1016/j.oor.2024.100651","DOIUrl":"10.1016/j.oor.2024.100651","url":null,"abstract":"<div><div>The field of biology offers a complete structure for studying intricate molecular interactions and the strength of bonding between molecules but with an emphasis on developing treatments and discovering markers in medicine research that hold promise for targeting specific diseases like cancer subtypes effectively by pinpointing crucial signals and pathways crucial for tumor development growth, alongside network analysis as a potent tool to foresee how small molecules interact with proteins linked to cancer and determine promising new treatments. This methodical strategy enables the evaluation of potential medications by assessing their capacity to bind effectively to cancer causing targets for enhanced treatment accuracy.\" Additionally integrating machine learning methods with multi dataset analyses greatly enhances the thorough examination of cancer associated molecular connections ultimately streamlining drug development and biomarker discovery. This underscores the importance of molecular docking in forecasting interactions, between drugs and their targets within the realm of cancer bioinformatics.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100651"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum regarding previously published article 关于以前发表的文章的勘误

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2023.100136

引用次数: 0

HPV status and staging in oropharyngeal carcinoma: A review of recent AJCC/UICC revisions 口咽癌的HPV状态和分期：近期AJCC/UICC修订的回顾

Oral Oncology Reports Pub Date : 2024-11-29 DOI: 10.1016/j.oor.2024.100694

Madhan Krishnan , Sharan Basappa , Shyamaladevi Babu , Sandhya P

{"title":"HPV status and staging in oropharyngeal carcinoma: A review of recent AJCC/UICC revisions","authors":"Madhan Krishnan , Sharan Basappa , Shyamaladevi Babu , Sandhya P","doi":"10.1016/j.oor.2024.100694","DOIUrl":"10.1016/j.oor.2024.100694","url":null,"abstract":"<div><div>The incidence of oropharyngeal carcinoma (OPC) has been rising, particularly among HPV-positive patients, prompting a reevaluation of clinical staging practices. Recent revisions to the AJCC/UICC staging systems have recognized the distinct biological behavior associated with HPV-positive tumors, highlighting the necessity for tailored staging criteria that better reflect their unique prognostic characteristics. This review discusses the implications of HPV status on the clinical staging of oropharyngeal carcinoma, focusing on how these revisions influence prognosis and treatment strategies. The differential outcomes observed between HPV-positive and HPV-negative patients necessitate a more nuanced approach to management, advocating for personalized treatment plans that consider the specific tumor biology. Additionally, we explore the ongoing research efforts aimed at further refining staging criteria, including the identification of relevant biomarkers and the integration of advanced imaging techniques. As our understanding of HPV's role in cancer biology continues to evolve, it is imperative that our approaches to staging and management adapt accordingly. Ultimately, these revisions and the accompanying research will contribute to improved patient outcomes and more effective therapeutic interventions in the increasingly prevalent landscape of oropharyngeal carcinoma.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100694"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of cancer associated fibroblasts amongst different histological variants of oral squamous cell carcinoma 口腔鳞状细胞癌不同组织学变异中癌相关成纤维细胞的评估

Oral Oncology Reports Pub Date : 2024-11-29 DOI: 10.1016/j.oor.2024.100696

Reshma Poothakulath Krishnan , Deepak Pandiar , Pratibha Ramani , Neha Kannan , Selvaraj Jayaraman

{"title":"Assessment of cancer associated fibroblasts amongst different histological variants of oral squamous cell carcinoma","authors":"Reshma Poothakulath Krishnan , Deepak Pandiar , Pratibha Ramani , Neha Kannan , Selvaraj Jayaraman","doi":"10.1016/j.oor.2024.100696","DOIUrl":"10.1016/j.oor.2024.100696","url":null,"abstract":"<div><h3>Background</h3><div>Cancer associated fibroblasts are heterogenous activated fibroblasts that form the central component of the tumor microenvironment. These cells influence the behavior of the tumor by activating various signaling pathways and initiating epithelial mesenchymal transition. CAFs have been reported in oral squamous cell carcinomas (OSCC), however, very few studies have evaluated the role of CAFs in different variants of OSCC. The aim of this study was to compare the role of CAFs in conventional OSCC and different variants of OSCCs.</div></div><div><h3>Materials and methods</h3><div>Eight each of well differentiated, moderately differentiated and poorly differentiated OSCC, 5 each of verrucous carcinoma and verrucous carcinoma turning into OSCC, three each of spindle cell carcinoma, basaloid OSCC and OSCC with clear cell differentiation and 2 cases of papillary OSCC were retrieved, and immunohistochemistry was performed with α-SMA to identify and evaluate the CAFs. Kaplan Meier analysis was carried out to evaluate the overall survival of the patients.</div></div><div><h3>Results</h3><div>Progressive increase in the CAF immunostaining was noted from papillary squamous cell carcinoma [mean - 1] to basaloid squamous cell carcinoma [1.6 ± 0.5] to spindle cell carcinoma and squamous cell carcinoma with clear cell changes [2.6 ± 0.5] (p = 0.00 - statistically significant). Patients with abundant CAF expression showed lesser survival rate when compared to patients with scanty or focal CAF immunohistochemical staining.</div></div><div><h3>Conclusion</h3><div>Increased CAF immunoexpression was noted in PDSCCs, VCs turning into SCC, OSCC with clear cell changes and spindle cell carcinoma. This highlights the aggressive nature of these tumors. Screening these tumor for the presence of CAFs will help in treatment planning and will aid in treatment planning and survival analysis.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100696"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fight against cancer with advancement of Schiff base metal complexes: Future prospects 希夫贱金属配合物与癌症的对抗：未来展望

Oral Oncology Reports Pub Date : 2024-11-26 DOI: 10.1016/j.oor.2024.100692

Monika Tyagi, Monika Dubey

引用次数: 0