Oral Oncology Reports最新文献_第6页

Innovations and advancements in adhesives for maxillofacial prosthesis in carcinoma rehabilitated patients 癌症康复患者颌面假体粘合剂的创新与进步

Oral Oncology Reports Pub Date : 2024-08-03 DOI: 10.1016/j.oor.2024.100625

N. Gopi Chander, Neha Venkat, A. Noorul Rizwana

{"title":"Innovations and advancements in adhesives for maxillofacial prosthesis in carcinoma rehabilitated patients","authors":"N. Gopi Chander, Neha Venkat, A. Noorul Rizwana","doi":"10.1016/j.oor.2024.100625","DOIUrl":"10.1016/j.oor.2024.100625","url":null,"abstract":"<div><p>Maxillofacial prosthetics play a crucial role in the rehabilitation of oral cancer patients, significantly enhancing their quality of life by restoring facial structure and function. The success of these prosthetics is dependent on adhesives, that ensures assured attachment and stability. Despite their significance, adhesives have received reduced attention in the literature. This review aims to meet this literature gap by exploring the innovations and advancements in adhesives for maxillofacial prosthetics.</p><p>Traditional adhesives, while widely used, often fall short in terms of durability and biocompatibility, especially under the dynamic conditions of the oral cavity. Recent developments in biocompatible materials and applied technology have introduced new adhesives that offer improved adhesion strength, durability, and patient comfort. Smart adhesives, which respond to environmental stimuli like pH and temperature, present significant advancements, enhancing the adaptive nature of prosthetic attachment.</p><p>Customized adhesive solutions, facilitated by digital printing of prosthesis, provide more accurate prosthesis and reduces the interfacial gap with the skin and prosthesis. This further improving prosthetic performance with a predictable layer of adhesives in the interface. Additionally, new application techniques and tools have enhanced the precision and ease of adhesive use, ensuring consistent and reliable attachment.</p><p>This review highlights the importance of advanced adhesives in managing oral cancer patients, presenting the crucial role they play in the effectiveness and comfort of maxillofacial prosthetics. It also emphasizes the need for these adhesives to be a key focus in future research and clinical practice.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004710/pdfft?md5=6a237bb2f9bbc6ab37bbf5f1646d3c8b&pid=1-s2.0-S2772906024004710-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the mTOR pathway: A new horizon in oral cancer treatment 靶向 mTOR 通路：口腔癌治疗的新视野

Oral Oncology Reports Pub Date : 2024-08-02 DOI: 10.1016/j.oor.2024.100619

Mahalakshmi Devaraji, Punniyakoti V. Thanikachalam

引用次数: 0

The role of liquid biopsy in early detection and monitoring of oral cancer 液体活检在口腔癌早期检测和监测中的作用

Oral Oncology Reports Pub Date : 2024-07-31 DOI: 10.1016/j.oor.2024.100618

Mahalakshmi Devaraji, Lokeshvar Ravikumar

引用次数: 0

Innovations in early detection of oral cancer: Advancing diagnostic technologies and reducing global disparities 口腔癌早期检测的创新：推动诊断技术发展，缩小全球差距

Oral Oncology Reports Pub Date : 2024-07-30 DOI: 10.1016/j.oor.2024.100620

Lokeshvar Ravikumar, Ramaiyan Velmurugan

引用次数: 0

Comparison of clinicopathological characteristics of young and old North Indian patients of oral squamous cell carcinoma 北印度年轻和老年口腔鳞状细胞癌患者临床病理特征的比较

Oral Oncology Reports Pub Date : 2024-07-30 DOI: 10.1016/j.oor.2024.100615

G. Sharma, M. Kamboj, A. Narwal, A. Devi, J. Yadav, M. Sharma

{"title":"Comparison of clinicopathological characteristics of young and old North Indian patients of oral squamous cell carcinoma","authors":"G. Sharma, M. Kamboj, A. Narwal, A. Devi, J. Yadav, M. Sharma","doi":"10.1016/j.oor.2024.100615","DOIUrl":"10.1016/j.oor.2024.100615","url":null,"abstract":"<div><h3>Introduction</h3><p>Oral squamous cell carcinoma (OSCC) ranks among the most prevalent epithelial malignancies in the head and neck region. Although it predominantly affects older individuals, there has been a concerning rise in incidence among the younger population in recent years. This study aimed to compare the clinicopathological features of OSCC at our institution distinguishing between young and older age groups.</p></div><div><h3>Methods</h3><p>In the present retrospective study, histopathologically confirmed cases of OSCC were retrieved and assigned into two groups based on their age. Demographic data along with histopathological parameters were assessed. The data collected were statistically analysed using descriptive analysis, chi-square, kappa and multinomial logistic regression tests. A p-value less than or equal to 0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>Of the 707 OSCC patients, 585 were over 40 years old, while 122 were 40 or younger. Both the groups exhibited comparable observations with a high degree of keratinization, moderate nuclear pleomorphism, type 3 pattern of invasion, low tumor budding, high stromal and low intratumoral infiltration of lymphocytes, except lymphoplasmacytic infiltrate which was marked in a higher number of young cases.</p></div><div><h3>Conclusion</h3><p>OSCC in young and older individuals exhibited similar clinical as well as histopathological findings. Although the increased incidence of OSCC in the young is a cause of concern, so future multicentric studies with a larger sample size are warranted, to shed more light on the behavior and prognosis of OSCC in the young.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004618/pdfft?md5=143d264da8320b2a571bb461b286f08f&pid=1-s2.0-S2772906024004618-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141961009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-defining pT4b buccal mucosa squamous cell carcinoma: Looking beyond palliation in select patients 重新定义 pT4b 口腔粘膜鳞状细胞癌：对特定患者的治疗不能仅限于缓解症状。

Oral Oncology Reports Pub Date : 2024-07-26 DOI: 10.1016/j.oor.2024.100616

Prateek V. Jain , Kapila Manikantan , Gary M. Clark , Indranil Mallick , Sanjoy Chatterjee , Indu Arun , Paromita Roy , Lateef Zameer , Pattatheyil Arun

{"title":"Re-defining pT4b buccal mucosa squamous cell carcinoma: Looking beyond palliation in select patients","authors":"Prateek V. Jain , Kapila Manikantan , Gary M. Clark , Indranil Mallick , Sanjoy Chatterjee , Indu Arun , Paromita Roy , Lateef Zameer , Pattatheyil Arun","doi":"10.1016/j.oor.2024.100616","DOIUrl":"10.1016/j.oor.2024.100616","url":null,"abstract":"<div><h3>Objectives</h3><p>Reports in the last 2 decades suggest that selected patients with masticator space invasion can be treated surgically with reasonable survival. This study is an attempt to identify prognosticators for disease free (DFS) and overall survival (OS) in surgically treated pT4 buccal mucosa squamous cell carcinoma (BMSCC) patients.</p></div><div><h3>Material and methods</h3><p>The cohort for this retrospective study comprised 213 patients with pT4a/b BMSCC, treated with curative intent surgery from August 2011 through December 2019. Depending upon masticator space invasion (MSI) patients were divided into 3 groups viz. pT4a, involvement of masseter and/or medial pterygoid (Low MSI) and involvement of lateral pterygoid and/or temporalis (High MSI).</p></div><div><h3>Results</h3><p>The median follow-up in this study was 45 (2–123) months. The 5-year DFS was 53 %, 42 % and 21 % for pT4a, Low MSI and high MSI groups, respectively. The 5-year OS was 68 %, 43 % and 21 % for these three groups. The MSI (HR 1.5, p = 0.113 for Low MSI, HR 2.98, p < 0.001 for high MSI), perineural invasion (PNI) (HR 2.17, p = 0.001) and extranodal extension (ENE) (HR 2.74, p = 0.001) predicted poor DFS on multivariate analysis. OS was worse in patients with MSI (HR 1.86, p = 0.020 for Low MSI, HR 3.46, p < 0.001 for high MSI), PNI (HR 2.48, p < 0.001) and ENE (HR 3.02, p = 0.001) on multivariate analysis. Adjuvant treatment improved both OS and DFS.</p></div><div><h3>Conclusion</h3><p>Select patients with masticator space involvement can benefit from aggressive treatment. Radiation with or without chemotherapy in adjuvant setting can further improve prognosis in these patients.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277290602400462X/pdfft?md5=2b2634e543c75e4c4356e750abff3b1a&pid=1-s2.0-S277290602400462X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation 革新口腔鳞状细胞癌的精准医疗：利用三维体外模型促进转化

Oral Oncology Reports Pub Date : 2024-07-26 DOI: 10.1016/j.oor.2024.100622

Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

{"title":"Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation","authors":"Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony","doi":"10.1016/j.oor.2024.100622","DOIUrl":"10.1016/j.oor.2024.100622","url":null,"abstract":"<div><p>Oral squamous cell carcinoma (OSCC) is a highly aggressive neoplasm of the surface epithelium that arises from the mucosal lining of the mouth. The poor prognosis can be attributed to the complex tumor microenvironment (TME) in OSCC, which is crucial for tumor progression, angiogenesis, invasion, metastasis, and therapeutic resistance. In recent years, three-dimensional (3D) <em>in vitro</em> models have emerged as powerful tools to study OSCC biology and evaluate targeted therapies in a more physiologically relevant context. Advanced models such as tumor spheroids, patient organoids and microfluidic devices offer unique possibilities to reconstitute intricate cellular interactions, ECM dynamics as well as physiological gradients found in the OSCC TME. The 3D OSCC model provides powerful preclinical tools for drug screening and mechanistic studies of this devastating malignancy. In this review, we discuss the role of the tumor-immune microenvironment (TIME) in tumorigenesis and the 3D <em>in vitro</em> cultures in recreating the tumor microenvironment paving the way for the development of personalized medicine in OSCC.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004680/pdfft?md5=b1bb8a1d2ca82e220e3f3f4df6b3f91f&pid=1-s2.0-S2772906024004680-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on “Deep learning for the automatic detection and segmentation of parotid gland tumors on MRI” 关于 "深度学习用于自动检测和分割核磁共振成像上的腮腺肿瘤 "的评论

Oral Oncology Reports Pub Date : 2024-07-24 DOI: 10.1016/j.oor.2024.100617

Sesuraj Balasamy, Ashok K. Sundramoorthy

引用次数: 0

Letter to the editor: Comment on “the predictive role of PD-L1 in head and neck cancer: A systematic review and meta-analysis” 致编辑的信关于 "PD-L1 在头颈癌中的预测作用：系统综述和荟萃分析 "的评论

Oral Oncology Reports Pub Date : 2024-07-23 DOI: 10.1016/j.oor.2024.100613

Muthupandian Saravanan

引用次数: 0

“Comment on the “the impact of emotional distress on suicidal ideation in head and neck cancer patients: A review” "评论 "情绪困扰对头颈部癌症患者自杀意念的影响：综述"

Oral Oncology Reports Pub Date : 2024-07-23 DOI: 10.1016/j.oor.2024.100599

Gayathri Rengasamy, Vishnu Priya Veeraraghavan

引用次数: 0