Oral Oncology Reports最新文献_第5页

Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification? 复发性膜性基底细胞腺瘤中 Ki67 表达的改变是否表明需要重新分类？

Oral Oncology Reports Pub Date : 2024-08-16 DOI: 10.1016/j.oor.2024.100631

Dhinakaran Paranchodi, Ashok Vikey, Jaya Joshi, Ramya Selvam, Neha Choudhary

引用次数: 0

Analysis of single nucleotide polymorphism of p16 gene in cytological samples of patients with oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) 口腔潜在恶性疾病（OPMD）和口腔鳞状细胞癌（OSCC）患者细胞学样本中 p16 基因的单核苷酸多态性分析

Oral Oncology Reports Pub Date : 2024-08-15 DOI: 10.1016/j.oor.2024.100632

Neetu Oommen , Vasanthi V , Ramya Ramadoss , Rajkumar Krishnan

{"title":"Analysis of single nucleotide polymorphism of p16 gene in cytological samples of patients with oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC)","authors":"Neetu Oommen , Vasanthi V , Ramya Ramadoss , Rajkumar Krishnan","doi":"10.1016/j.oor.2024.100632","DOIUrl":"10.1016/j.oor.2024.100632","url":null,"abstract":"<div><h3>Background</h3><p>pl6 (CDKN2a) play a role in tumorigenesis in some head and neck squamous cell carcinomas. Frequent homozygous deletions of the pl6 gene have been reported in many tumor cell lines including the brain, breast, osteosarcomas, melanomas, kidney, bladder, and ovary.</p></div><div><h3>Materials and methods</h3><p>5 patients without any tobacco using habit were included in group I as controls. 10 clinically and histopathologically confirmed cases of oral potentially malignant disorders (OPMDs) [oral submucous fibrosis (OSMF) −7 & leukoplakia (moderate dysplasia) −3] were included in group II. 10 clinically and histopathologically confirmed cases of OSCC were categorized as group III. Buccal scrapings were taken and analyzed for exon 1, 2, 3 of p16 and homozygous deletion in exon 2 of p16 was also detected by PCR and gel electrophoresis.</p></div><div><h3>Results</h3><p>PCR amplification products of exon 1, 2, 3 of p16 were found in all 25 samples which include 10 cases of OSCC, 10 cases of OPMDs and 5 controls. Homozygous deletion in exon 2 was found only in 30 % of OSCC and 20 % of OPMD.</p></div><div><h3>Conclusion</h3><p>Our study showed that cytological samples yield sufficient amount of DNA, which showed 100 % positivity with exon 1, 2, 3 of p16 gene, but the percentage of genetic alteration of p16 gene seems to be less when compared with other related studies.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004783/pdfft?md5=1abb5db1bf3ed21f7f5470bfc79d0195&pid=1-s2.0-S2772906024004783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nivolumab (Opdivo) in PD-1 pathway inhibition: Enhancing immune response in recurrent oral squamous cell carcinoma 抑制 PD-1 通路的 Nivolumab (Opdivo)：增强复发性口腔鳞状细胞癌的免疫反应

Oral Oncology Reports Pub Date : 2024-08-14 DOI: 10.1016/j.oor.2024.100630

Nandhini J., Karthikeyan E.

引用次数: 0

Preserving academic integrity in the age of AI: Ethical guidelines for medical manuscript preparation 在人工智能时代维护学术诚信：医学稿件撰写伦理指南

Oral Oncology Reports Pub Date : 2024-08-14 DOI: 10.1016/j.oor.2024.100627

Amit Medhekar, Amarnath Gupta, Smita Sonawane, Meenakshi Singh

引用次数: 0

Perspective on enhancing quality of life in oral cancer patients: Integrative approaches and comprehensive care 提高口腔癌患者生活质量的视角：综合方法和全面护理

Oral Oncology Reports Pub Date : 2024-08-12 DOI: 10.1016/j.oor.2024.100633

Sohaib Arshad , Shazia Fathima Jaffer Hussain , Selvaraj Jayaram , Vishnu Priya Veeraraghavan , Mohmed Isaqali Karobari

{"title":"Perspective on enhancing quality of life in oral cancer patients: Integrative approaches and comprehensive care","authors":"Sohaib Arshad , Shazia Fathima Jaffer Hussain , Selvaraj Jayaram , Vishnu Priya Veeraraghavan , Mohmed Isaqali Karobari","doi":"10.1016/j.oor.2024.100633","DOIUrl":"10.1016/j.oor.2024.100633","url":null,"abstract":"<div><p>Oral cancer poses a global health challenge with high morbidity and mortality rates. Treatments, including surgery, radiation, and chemotherapy, profoundly impact patients' quality of life (QoL). Enhancing QoL requires a comprehensive approach that integrates physical health management, psychological support, social support, and integrative and palliative care.</p><p>Effective pain management, nutritional support, and oral rehabilitation are crucial for maintaining physical health. Psychological support through counseling, psychotherapy, and mind-body interventions addresses emotional distress. Social support from family, caregivers, and community resources is essential for practical and emotional needs. Integrative care approaches and early palliative care provide holistic, patient-centered solutions.</p><p>This manuscript emphasizes the necessity of a holistic approach to improve the QoL for oral cancer patients, advocating for comprehensive, compassionate care plans that address physical, emotional, and social dimensions.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004795/pdfft?md5=16924daffca05fbee2ee0d909db84beb&pid=1-s2.0-S2772906024004795-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples 亚洲头颈癌的基因组状况：对 1016 个样本的综合荟萃分析

Oral Oncology Reports Pub Date : 2024-08-10 DOI: 10.1016/j.oor.2024.100628

Srikanth S. Manda , Nafisa Arfa , Neha Sharma , Aparna R. Parikh , Thomas J. Roberts , Sewanti Limaye , Venkataraman Ramachandran , Kumar Prabhash , Moni A. Kuriakose , Prashant Kumar

{"title":"Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples","authors":"Srikanth S. Manda , Nafisa Arfa , Neha Sharma , Aparna R. Parikh , Thomas J. Roberts , Sewanti Limaye , Venkataraman Ramachandran , Kumar Prabhash , Moni A. Kuriakose , Prashant Kumar","doi":"10.1016/j.oor.2024.100628","DOIUrl":"10.1016/j.oor.2024.100628","url":null,"abstract":"<div><p>Head and neck cancer (HNC) is a diverse group of malignancies arising in the mucosal linings of the oral cavity, pharynx, and larynx, influenced by factors such as tobacco use, alcohol consumption, and human papillomavirus (HPV) infection. This study conducts a comprehensive meta-analysis of the mutational landscape of HNC across Asian cohorts, encompassing India, Korea, Japan, China, Singapore, and Saudi Arabia. The analysis highlights distinct genetic profiles influenced by environmental exposures, lifestyle habits, and genetic predispositions. Notably, the RAF family proteins, enriched in both Indian and Chinese cohorts, present potential therapeutic targets for RAF inhibitors like Vemurafenib. Additionaly, specific mutations like MET in Singaporean patients can be effectively addressed with drugs like Crizotinib, leading to rapid responses in HNSCC. Smokers exhibited high frequencies of CASP8 and FAT1 mutations. Novel driver genes, including RYR2 and ANK2, emerged with significant mutational frequencies in smokers. The RAS signaling pathway was identified as a prominent driver in HNC, contrasting with the globally prevalent PIK3CA/MTOR pathway. This study also underscores the high prevalence of HRAS mutations in Indian and Saudi cohorts. The study emphasizes the necessity for region-specific data to understand the unique molecular differences and develop effective therapies. The identification of NBEA and ANK2 as potential novel driver genes in HNC highlights new avenues for research and targeted therapeutic interventions tailored to the genetic profiles of Asian HNC patients.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004746/pdfft?md5=6cbe8b6837cd60e62c63b42b459d39b0&pid=1-s2.0-S2772906024004746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reevaluating clinical staging: Recent advances in AJCC/UICC criteria for nasopharyngeal carcinoma 重新评估临床分期：AJCC/UICC鼻咽癌标准的最新进展

Oral Oncology Reports Pub Date : 2024-08-08 DOI: 10.1016/j.oor.2024.100621

Madhan Krishnan, Shyamaladevi Babu

引用次数: 0

Circulating tumor DNA as a therapeutic approach for HPV (+) oropharyngeal squamous cell carcinoma 将循环肿瘤 DNA 作为治疗 HPV（+）口咽鳞状细胞癌的一种方法

Oral Oncology Reports Pub Date : 2024-08-08 DOI: 10.1016/j.oor.2024.100626

Raghul Murugan

引用次数: 0

Machine learning-driven insights into ctDNA for oral cancer: Applications, models, and future prospects 机器学习驱动的口腔癌ctDNA洞察力：应用、模型和未来展望

Oral Oncology Reports Pub Date : 2024-08-06 DOI: 10.1016/j.oor.2024.100629

Dheeraj Kumar, Saraswati Patel