Oral Oncology Reports最新文献_第5页

Biomarkers in head and neck squamous cell carcinoma (HNSCC)-An update 头颈部鳞状细胞癌 (HNSCC) 的生物标志物--最新进展

Oral Oncology Reports Pub Date : 2024-07-23 DOI: 10.1016/j.oor.2024.100611

引用次数: 0

Innovations in liquid biopsy for head and neck cancer: Progress in cell-free DNA detection 头颈癌液体活检的创新：无细胞 DNA 检测的进展

Oral Oncology Reports Pub Date : 2024-07-22 DOI: 10.1016/j.oor.2024.100606

引用次数: 0

Early detection and rapid diagnosis of circulating HPV-DNA detected using droplet digital PCR 使用液滴数字 PCR 检测循环型 HPV-DNA 的早期发现和快速诊断

Oral Oncology Reports Pub Date : 2024-07-22 DOI: 10.1016/j.oor.2024.100614

引用次数: 0

Letter to the editor: “MicroRNA-21 as a biomarker in terminal stage oral squamous cell carcinoma (OSCC) in the South Indian population” 致编辑的信："MicroRNA-21 作为南印度人口腔鳞状细胞癌 (OSCC) 末期的生物标记物"

Oral Oncology Reports Pub Date : 2024-07-19 DOI: 10.1016/j.oor.2024.100609

引用次数: 0

Oral manifestations of Nance Horan syndrome: A systematic review of case reports 南斯-霍兰综合征的口腔表现：病例报告的系统回顾

Oral Oncology Reports Pub Date : 2024-07-19 DOI: 10.1016/j.oor.2024.100612

{"title":"Oral manifestations of Nance Horan syndrome: A systematic review of case reports","authors":"","doi":"10.1016/j.oor.2024.100612","DOIUrl":"10.1016/j.oor.2024.100612","url":null,"abstract":"<div><p>Nance Horan Syndrome (NHS) is a rare congenital genetic condition. However, due to the sporadicity of cases and the similarity in manifestations of mild NHS with X-linked cataracts, it is difficult for clinicians and researchers to diagnose and treat NHS. Therefore, we undertake a comprehensive review of the existing literature on the oral manifestations of NHS and, its definitive diagnosis based on oral and craniofacial symptoms. An electronic search of PubMed-MEDLINE, Embase, Scopus, and Google Scholar databases was done to retrieve case reports documenting oral anomalies related to NHS at the time of presentation. Genetic studies or studies focussing on the genetic analysis of the case were excluded. Descriptive statistics were used to calculate simple frequency, percentages, and proportions to identify trends and commonalities in presenting symptoms and oral assessment findings. Out of 2086 identified studies, 12 studies that met the inclusion criteria were reviewed. Most patients' ages ranged from between 4 and 12 years of age. Out of 31 affected individuals, 11 were females and 20 were males. Screwdriver-shaped incisors (75 %) often accompanied by the presence of supernumerary teeth and diastema (66 % studies), Hutchinson incisors (50 % studies), Mulberry molar (41.6 %) malocclusion (58.3 % studies) were commonly seen. Besides that, talon cusps, agenesis/non-eruption of teeth, premolars, and Taurodontism were also observed. Facial dysmorphism was common in all the studies. An in-depth understanding of these anomalies will enable dental practitioners to provide specialised care, including focused interventions and preventive measures to address the oral health issues associated with NHS.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004588/pdfft?md5=bd0c558660a1f5408397ebeae26568e3&pid=1-s2.0-S2772906024004588-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy for oral cancer: Mechanisms, efficacy, and clinical applications 口腔癌的光动力疗法：机制、疗效和临床应用

Oral Oncology Reports Pub Date : 2024-07-18 DOI: 10.1016/j.oor.2024.100608

{"title":"Photodynamic therapy for oral cancer: Mechanisms, efficacy, and clinical applications","authors":"","doi":"10.1016/j.oor.2024.100608","DOIUrl":"10.1016/j.oor.2024.100608","url":null,"abstract":"<div><p>Photodynamic therapy (PDT) has emerged as a promising therapeutic approach for oral cancer, characterized by its ability to selectively target malignant cells while minimizing damage to surrounding healthy tissues. This review synthesizes current knowledge on PDT's clinical applications in oral cancer treatment, emphasizing its efficacy in managing early-stage cancers and precancerous lesions with favorable outcomes. PDT's non-invasive nature and potential for preserving critical anatomical functions make it particularly suitable for cases where surgical intervention may pose higher risks or affect quality of life adversely. Ongoing research efforts focus on refining PDT through advancements in photosensitizer formulations and optimizing light delivery systems. These developments aim to enhance treatment efficacy, extend PDT's applicability to deeper tumors, and address challenges such as treatment resistance. Furthermore, researchers are investigating personalized treatment strategies designed to enhance therapeutic results and reduce potential side effects for each patient's specific profile. Future directions include exploring synergistic combinations of PDT with chemotherapy and immunotherapy, aiming to potentiate therapeutic responses and improve long-term survival rates. By integrating technological innovations with personalized medicine strategies, PDT holds promise as a cornerstone in the multidisciplinary management of oral cancer, offering new avenues for enhancing patient care and treatment outcomes in clinical practice.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004540/pdfft?md5=43ea2ba347a6fc79935295f77ed98652&pid=1-s2.0-S2772906024004540-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel technique for managing infected mandibular reconstruction plates with 3D printed guide flange prostheses 利用 3D 打印导缘假体管理受感染下颌骨重建板的新技术

Oral Oncology Reports Pub Date : 2024-07-18 DOI: 10.1016/j.oor.2024.100610

{"title":"A novel technique for managing infected mandibular reconstruction plates with 3D printed guide flange prostheses","authors":"","doi":"10.1016/j.oor.2024.100610","DOIUrl":"10.1016/j.oor.2024.100610","url":null,"abstract":"<div><p>The technique explores an innovative application of 3D printing technology in the creation of a guide flange prosthesis for a patient who had undergone hemi-mandibulectomy and was experiencing complications due to an infected mandibular reconstruction plate. These complications not only affected the patient's functionality but also had a negative impact on their aesthetics. The issue was addressed with a 3D printed guide flange prosthesis that was custom-designed and fabricated using biocompatible resin, following the surgical removal of the infected reconstruction plate. The printed prosthesis resulted in substantial improvements in both functional and aesthetic aspects of the patient's condition. Subsequent postoperative follow-up examinations revealed no signs of infection or complications. This technique demonstrates the successful expansion of 3D printing technology into the realm of guide flange prostheses and underscores the potential for further research to evaluate the long-term efficacy of this innovative approach.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004564/pdfft?md5=4870a3dcad6ec6a977ff02e7c71fdc98&pid=1-s2.0-S2772906024004564-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor regarding, “Exploring diagnostic frontiers in oral squamous cell carcinoma: A comprehensive review from immunohistochemistry to genomic profiling” 致编辑的信，内容涉及 "探索口腔鳞状细胞癌的诊断前沿：从免疫组化到基因组分析的全面回顾"。

Oral Oncology Reports Pub Date : 2024-07-17 DOI: 10.1016/j.oor.2024.100607

引用次数: 0

Letter to Editor: Comment on “CD24 is expressed in HNSCC and is correlated with a dampened immune response” 致编辑的信：关于 "CD24在HNSCC中表达并与免疫反应减弱相关 "的评论

Oral Oncology Reports Pub Date : 2024-07-17 DOI: 10.1016/j.oor.2024.100605

引用次数: 0

Prognostic significance of neutrophil to lymphocyte ratio (NLR) in oral squamous cell carcinoma 口腔鳞状细胞癌中中性粒细胞与淋巴细胞比值（NLR）的预后意义

Oral Oncology Reports Pub Date : 2024-07-14 DOI: 10.1016/j.oor.2024.100604

{"title":"Prognostic significance of neutrophil to lymphocyte ratio (NLR) in oral squamous cell carcinoma","authors":"","doi":"10.1016/j.oor.2024.100604","DOIUrl":"10.1016/j.oor.2024.100604","url":null,"abstract":"<div><h3>Background</h3><p>Tumor microenvironment is one of the evading research in the progression of cancers. Circulating neutrophils reflect the system's inflammatory response and study the growth of tumor cells thereby inducing cancer progression.</p></div><div><h3>Aim and objectives</h3><p>The current study aims to evaluate the NLR ratio in oral squamous cell carcinoma group and to compare it with that of normal control and Premalignant group.</p></div><div><h3>Material and methods</h3><p>This study is retrospective, the medical records of 48 OSCC patients, 48 Leukoplakia patients, and 48 normal healthy controls were taken. Association between NLR and clinicopathological variables were assessed. Tukey's post-hoc test was done to compare the variables. Kaplan Meier analysis was done for the analysis of overall survival.</p></div><div><h3>Results</h3><p>The NLR ratio was assessed and compared between the three groups. The mean NLR ratio was found to be 3.79 in Oral squamous cell carcinoma patients, 2.62 in leukoplakia patients, and 2.07 in the normal control group.</p></div><div><h3>Conclusion</h3><p>An increase in NLR levels was seen in OSCC patients. Increased NLR was also seen associated with advanced tumor staging and grading.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004503/pdfft?md5=8332a5a948c8d7c503b802dd26f36f20&pid=1-s2.0-S2772906024004503-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141630143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0