Oral Oncology Reports最新文献_第4页

Erratum regarding previously published article

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2023.100137

引用次数: 0

Optimizing PD-L1/PD-1 therapies: Immune checkpoint inhibitors in nasopharyngeal carcinoma

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2024.100675

Madhan Krishnan, Gayathri Sekar

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Computational biology approach to predict molecular mechanism in cancer

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2024.100651

Ansari Vikhar Danish Ahmad, Subur W. Khan, Qazi Yasar, Mohd Sayeed Shaikh, Mohd Mukhtar Khan

{"title":"Computational biology approach to predict molecular mechanism in cancer","authors":"Ansari Vikhar Danish Ahmad, Subur W. Khan, Qazi Yasar, Mohd Sayeed Shaikh, Mohd Mukhtar Khan","doi":"10.1016/j.oor.2024.100651","DOIUrl":"10.1016/j.oor.2024.100651","url":null,"abstract":"<div><div>The field of biology offers a complete structure for studying intricate molecular interactions and the strength of bonding between molecules but with an emphasis on developing treatments and discovering markers in medicine research that hold promise for targeting specific diseases like cancer subtypes effectively by pinpointing crucial signals and pathways crucial for tumor development growth, alongside network analysis as a potent tool to foresee how small molecules interact with proteins linked to cancer and determine promising new treatments. This methodical strategy enables the evaluation of potential medications by assessing their capacity to bind effectively to cancer causing targets for enhanced treatment accuracy.\" Additionally integrating machine learning methods with multi dataset analyses greatly enhances the thorough examination of cancer associated molecular connections ultimately streamlining drug development and biomarker discovery. This underscores the importance of molecular docking in forecasting interactions, between drugs and their targets within the realm of cancer bioinformatics.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100651"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum regarding previously published article

Oral Oncology Reports Pub Date : 2024-12-01 DOI: 10.1016/j.oor.2023.100136

引用次数: 0

HPV status and staging in oropharyngeal carcinoma: A review of recent AJCC/UICC revisions

Oral Oncology Reports Pub Date : 2024-11-29 DOI: 10.1016/j.oor.2024.100694

Madhan Krishnan , Sharan Basappa , Shyamaladevi Babu , Sandhya P

{"title":"HPV status and staging in oropharyngeal carcinoma: A review of recent AJCC/UICC revisions","authors":"Madhan Krishnan , Sharan Basappa , Shyamaladevi Babu , Sandhya P","doi":"10.1016/j.oor.2024.100694","DOIUrl":"10.1016/j.oor.2024.100694","url":null,"abstract":"<div><div>The incidence of oropharyngeal carcinoma (OPC) has been rising, particularly among HPV-positive patients, prompting a reevaluation of clinical staging practices. Recent revisions to the AJCC/UICC staging systems have recognized the distinct biological behavior associated with HPV-positive tumors, highlighting the necessity for tailored staging criteria that better reflect their unique prognostic characteristics. This review discusses the implications of HPV status on the clinical staging of oropharyngeal carcinoma, focusing on how these revisions influence prognosis and treatment strategies. The differential outcomes observed between HPV-positive and HPV-negative patients necessitate a more nuanced approach to management, advocating for personalized treatment plans that consider the specific tumor biology. Additionally, we explore the ongoing research efforts aimed at further refining staging criteria, including the identification of relevant biomarkers and the integration of advanced imaging techniques. As our understanding of HPV's role in cancer biology continues to evolve, it is imperative that our approaches to staging and management adapt accordingly. Ultimately, these revisions and the accompanying research will contribute to improved patient outcomes and more effective therapeutic interventions in the increasingly prevalent landscape of oropharyngeal carcinoma.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100694"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of cancer associated fibroblasts amongst different histological variants of oral squamous cell carcinoma

Oral Oncology Reports Pub Date : 2024-11-29 DOI: 10.1016/j.oor.2024.100696

Reshma Poothakulath Krishnan , Deepak Pandiar , Pratibha Ramani , Neha Kannan , Selvaraj Jayaraman

{"title":"Assessment of cancer associated fibroblasts amongst different histological variants of oral squamous cell carcinoma","authors":"Reshma Poothakulath Krishnan , Deepak Pandiar , Pratibha Ramani , Neha Kannan , Selvaraj Jayaraman","doi":"10.1016/j.oor.2024.100696","DOIUrl":"10.1016/j.oor.2024.100696","url":null,"abstract":"<div><h3>Background</h3><div>Cancer associated fibroblasts are heterogenous activated fibroblasts that form the central component of the tumor microenvironment. These cells influence the behavior of the tumor by activating various signaling pathways and initiating epithelial mesenchymal transition. CAFs have been reported in oral squamous cell carcinomas (OSCC), however, very few studies have evaluated the role of CAFs in different variants of OSCC. The aim of this study was to compare the role of CAFs in conventional OSCC and different variants of OSCCs.</div></div><div><h3>Materials and methods</h3><div>Eight each of well differentiated, moderately differentiated and poorly differentiated OSCC, 5 each of verrucous carcinoma and verrucous carcinoma turning into OSCC, three each of spindle cell carcinoma, basaloid OSCC and OSCC with clear cell differentiation and 2 cases of papillary OSCC were retrieved, and immunohistochemistry was performed with α-SMA to identify and evaluate the CAFs. Kaplan Meier analysis was carried out to evaluate the overall survival of the patients.</div></div><div><h3>Results</h3><div>Progressive increase in the CAF immunostaining was noted from papillary squamous cell carcinoma [mean - 1] to basaloid squamous cell carcinoma [1.6 ± 0.5] to spindle cell carcinoma and squamous cell carcinoma with clear cell changes [2.6 ± 0.5] (p = 0.00 - statistically significant). Patients with abundant CAF expression showed lesser survival rate when compared to patients with scanty or focal CAF immunohistochemical staining.</div></div><div><h3>Conclusion</h3><div>Increased CAF immunoexpression was noted in PDSCCs, VCs turning into SCC, OSCC with clear cell changes and spindle cell carcinoma. This highlights the aggressive nature of these tumors. Screening these tumor for the presence of CAFs will help in treatment planning and will aid in treatment planning and survival analysis.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100696"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fight against cancer with advancement of Schiff base metal complexes: Future prospects 希夫贱金属配合物与癌症的对抗：未来展望

Oral Oncology Reports Pub Date : 2024-11-26 DOI: 10.1016/j.oor.2024.100692

Monika Tyagi, Monika Dubey

引用次数: 0

Application of Bone Ring Technique (BRT) for 3D reconstruction in the anterior aesthetic zone after tumor surgery

Oral Oncology Reports Pub Date : 2024-11-22 DOI: 10.1016/j.oor.2024.100684

Yan-Sheng Zeng , Peng-Yu Lai , Shan Shen

引用次数: 0

Resection of a left carotid body tumor in a young female patient: A case report

Oral Oncology Reports Pub Date : 2024-11-22 DOI: 10.1016/j.oor.2024.100691

Anish P. Kamat , Abhishek Shukla , Mandar Deshpande

引用次数: 0

PD-L1 mediated immune escape in nasopharyngeal carcinoma: Impact of LMP1 and IFN-γ on immune surveillance 鼻咽癌中 PD-L1 介导的免疫逃逸：LMP1 和 IFN-γ 对免疫监视的影响

Oral Oncology Reports Pub Date : 2024-11-19 DOI: 10.1016/j.oor.2024.100688

Madhan Krishnan , Aruna Jothi shanmugam , Shyamaladevi Babu

{"title":"PD-L1 mediated immune escape in nasopharyngeal carcinoma: Impact of LMP1 and IFN-γ on immune surveillance","authors":"Madhan Krishnan , Aruna Jothi shanmugam , Shyamaladevi Babu","doi":"10.1016/j.oor.2024.100688","DOIUrl":"10.1016/j.oor.2024.100688","url":null,"abstract":"<div><div>Nasopharyngeal carcinoma (NPC) is a distinct malignancy in head and neck cancer, notably linked to Epstein-Barr virus (EBV) infections in regions with high prevalence. NPC's tumor microenvironment fosters immune escape mechanisms that support tumor cell survival, with programmed death-ligand 1 (PD-L1) as a key player. PD-L1 expression on NPC cells binds to the programmed death-1 (PD-1) receptor on T cells, thereby creating an immunosuppressive environment that impairs immune surveillance. Two significant modulators of PD-L1 expression in NPC include the EBV-encoded latent membrane protein 1 (LMP1) and the immune cytokine interferon-gamma (IFN-γ). Together, they contribute to the intricate regulation of PD-L1, enhancing immune evasion and complicating the landscape for effective treatment approaches. This review explores the molecular mechanisms underlying PD-L1 upregulation, focusing on LMP1's activation of the NF-κB and JAK/STAT pathways and IFN-γ′s paradoxical role in facilitating immune escape. Clinical evidence indicates that PD-L1 expression correlates with poor prognosis and resistance to standard therapies in NPC patients. Understanding these regulatory pathways may inform potential therapeutic strategies, including immune checkpoint inhibitors, combination therapies, and novel immune-based approaches tailored to NPC's unique etiology. By providing a comprehensive synthesis of existing studies, this review highlights the interplay between PD-L1, LMP1, and IFN-γ, offering a framework for innovative therapeutic strategies targeting immune escape mechanisms. Identifying patients most likely to benefit from immune-targeted approaches and leveraging combination treatments could improve outcomes for NPC patients facing advanced or resistant disease.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100688"},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0