Oral Oncology Reports最新文献

{"title":"A review based study on emotional distress and physical pain in oral and head and neck cancer patients pre- and post-chemotherapy","authors":"Sanya Mehndiratta ,&nbsp;Ravindra Singh ,&nbsp;Saanjli Bhandari ,&nbsp;Mansha Dadhich","doi":"10.1016/j.oor.2024.100637","DOIUrl":"10.1016/j.oor.2024.100637","url":null,"abstract":"<div><p>Emotional distress is a psychological response that occurs in the form of mental suffering to an experience that arises from the any negative event or condition. It commonly occurs in patients who suffer from cancer-related physical pain throughout the treatments. Cancer patients face a lot of exhaustion which makes them physically and mentally dysfunctional in their daily lives. However, the Head and Neck Cancer (HNC) patients face some serious issues due to the site of tumour or surgery itself. The current study aims to describe how chemotherapy and physical pain cause emotional distress in HNC patients. Furthermore, the study aims to determine the association between all three factors (Emotional distress, pain, and chemotherapy) and highlight the relevance of care and remediation needs for HNC patients. The literature related to the concerned topic was investigated including empirical research papers, review papers. In total, the authors identified and reviewed 42 articles related to the above-mentioned variables. These articles were obtained from different databases, such as Google Scholar, PubMed, JSTOR and Research Gate. The authors then assessed the full texts of the selected articles for eligibility and extracted data from them. The study revealed that cancer patients who have tolerated physical pain and witnessed the long-term treatment of the process of chemotherapy experience extremely high emotional distress throughout the course. It was also observed that psychological distress is more common in HNC patients than in patients with cancer in other body parts. The main findings of the result indicated that emotional distress was much higher in females. Psychosocial support and palliative care should be integrated to encourage and improve the abilities of cancer-affected patients.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004837/pdfft?md5=76940f688a095ee37b600515ed907c3b&pid=1-s2.0-S2772906024004837-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of lymph node level IIA & IIB IN N-0 neck of oral squamous cell carcinoma","authors":"Mohd Aswad Khan ,&nbsp;Ghulam Sarwar Hashmi ,&nbsp;Sajjad Abdur Rahman ,&nbsp;Roobina Khan ,&nbsp;Mehtab Ahmad ,&nbsp;Tabishur Rahman","doi":"10.1016/j.oor.2024.100639","DOIUrl":"10.1016/j.oor.2024.100639","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004850/pdfft?md5=ba1b4d30aa18d325f634667456c12971&pid=1-s2.0-S2772906024004850-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low grade mucoepidermoid carcinoma arising from glandular odontogenic cyst: A case report with a brief literature review","authors":"Spoorti Kulkarni ,&nbsp;Adarsh Kudva ,&nbsp;G. Srikanth ,&nbsp;Vyshak Mohan ,&nbsp;Mugdha Francis ,&nbsp;Sunitha Carnelio","doi":"10.1016/j.oor.2024.100644","DOIUrl":"10.1016/j.oor.2024.100644","url":null,"abstract":"<div><p>Low-grade mucoepidermoid carcinoma (MEC) is a salivary gland tumor arising rarely within the jaw bones. It poses a diagnostic challenge due to its considerable overlap of the histopathological features with Glandular odontogenic cyst (GOC). Various theories have been put forward to explain the origin of central low-grade MEC, one of the potential being MEC arising from the lining of GOC. In the present paper we report a case of a multilocular lesion in a 54-year-old female in the mandibular anterior region, which clinically and microscopically had a resemblance to the glandular odontogenic cyst, but the final diagnosis of low-grade MEC was confirmed based on the immunohistochemical appraisal.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004904/pdfft?md5=17a28ea29e11c94ffae63da00905351a&pid=1-s2.0-S2772906024004904-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced functional rehabilitation of maxillary defects post-osteomyelitis: A case study utilizing immediate and definitive obturators","authors":"Divyabharathi Selvam ,&nbsp;Deepika Selvam","doi":"10.1016/j.oor.2024.100647","DOIUrl":"10.1016/j.oor.2024.100647","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277290602400493X/pdfft?md5=91a3417e6261784cc6fc80999c28e5ef&pid=1-s2.0-S277290602400493X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142171617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and neck squamous cell carcinoma epidemiology at diagnosis: A description of public and private health care systems in Brazil regarding tumor location, staging and risk factors","authors":"Heloisa Arantes ,&nbsp;Diego Chaves Rezende Morais ,&nbsp;Maria Aparecida do Carmo Rego ,&nbsp;Paula de Mendonça Batista ,&nbsp;Cicera Pimenta Marcelino ,&nbsp;Milena Falcão Almeida ,&nbsp;Marion Coting Braga ,&nbsp;Paula Cristina Pungartnik ,&nbsp;Angelica Carreira dos Santos ,&nbsp;Juliana Ominelli ,&nbsp;Tharcísio Machado Coelho ,&nbsp;Fernanda Bohns Pruski Ramos ,&nbsp;Marcelo Salgado ,&nbsp;Marina Kelner ,&nbsp;Cristiano Guedes Duque ,&nbsp;Daniel Oliveira Brito ,&nbsp;Carlos Gil Moreira Ferreira ,&nbsp;Pedro Rafael Martins De Marchi","doi":"10.1016/j.oor.2024.100645","DOIUrl":"10.1016/j.oor.2024.100645","url":null,"abstract":"<div><h3>Objectives</h3><p>There is a limited number of updated epidemiological Brazilian data on head and neck squamous cell carcinoma (HNSCC). This study aimed to describe demographic and clinical characteristics of HNSCC patients from Brazilian public and private systems.</p></div><div><h3>Methods</h3><p>This is a retrospective observational study that included patients diagnosed with HNSCC from Brazilian public and private settings from 2016 to 2018. As for the public scenario, data were drawn from the public hospital national cancer registry database. As for the private sector, the data were extracted from medical records of patients from Oncoclinicas, a large Brazilian oncology group.</p></div><div><h3>Results</h3><p>A total of 37,121 patients were included in the study, with 36,914 from the public and 207 from the private system. Patients in the public sector were younger than those in the private sector, with medians ages of 61.2 and 66.9 years, respectively. In both cohorts, a predominance of men with a history of tobacco and alcohol consumption and an advanced locoregional stage at diagnosis was observed. The main site of the primary tumor was the oropharynx in the private sector and oral cavity in the public sector. Among patients with oropharyngeal cancer, only those in the private sector were tested for HPV, with the majority being positive.</p></div><div><h3>Conclusions</h3><p>This real-world data study provides epidemiologic characteristics of patients with HNSCC in two different Brazilian healthcare settings, presenting relevant insights into possible opportunities for improvements in the patient's journey with HNSCC.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004916/pdfft?md5=3753b590b326c428beeb02e8c820046a&pid=1-s2.0-S2772906024004916-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological risk factors of oral second primary tumours","authors":"Jelena Karan ,&nbsp;Miriam P. Rosin ,&nbsp;Lewei Zhang ,&nbsp;Denise M. Laronde","doi":"10.1016/j.oor.2024.100638","DOIUrl":"10.1016/j.oor.2024.100638","url":null,"abstract":"<div><h3>Background</h3><p>Oral second primary tumours (SPTs) have a poor prognosis due to late-stage diagnosis. This study evaluates the demographic and clinicopathological risk predictors of SPTs.</p></div><div><h3>Methods</h3><p>Patients with oral squamous cell carcinoma, carcinoma in situ, or severe dysplasia were accrued into the Oral Cancer Prediction Longitudinal study within one year post-curative treatment. Data on demographics, risk habits, and primary tumour characteristics were collected. Clinical follow-up included assessing the presence of second oral premalignant lesions (SOPLs), clinicopathological features, and the results from toluidine blue staining and fluorescence visualization.</p></div><div><h3>Results</h3><p>Among 296 patients, 23 (8 %) developed SPTs. Older age at primary cancer diagnosis (P = 0.008) and a history of chewing tobacco or betel nut (P = 0.043) increased the risk of SPTs. Patients with primary tumours located at low-risk sites had an increased risk of SPTs (P = 0.004), which often presented at high-risk sites. The presence of SOPLs (P &lt; 0.001), and multiple lesions (P = 0.017) significantly increased the risk of SPTs. Positive toluidine blue staining indicated a trend toward higher risk of SPTs, whereas fluorescence visualization did not. The median time to SPT diagnosis was 3.25 years post-treatment.</p></div><div><h3>Conclusions</h3><p>Identifying second or multiple oral premalignant lesions is critical for predicting the risk of SPTs regardless of their clinical or histological characteristics. Routine biopsy of these lesions should be prioritized to ensure timely diagnosis. Incorporating these risk predictors into clinical follow-up can enhance early cancer detection and improve patient outcomes.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004849/pdfft?md5=828d81ed8c1e6adabae59d42c3182190&pid=1-s2.0-S2772906024004849-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing programmed death-ligand 1 as a prognostic marker in OSCC: Challenges and opportunities in the era of immunotherapy","authors":"Madhan Krishnan,&nbsp;Shyamaladevi Babu","doi":"10.1016/j.oor.2024.100641","DOIUrl":"10.1016/j.oor.2024.100641","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004874/pdfft?md5=022251cdec70f75510a2e3fab0a8a2df&pid=1-s2.0-S2772906024004874-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142171618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gap between epigenetics and cisplatin resistance: Implications for oral cancer management","authors":"Monisha Prasad,&nbsp;Ameerunnisha Begum","doi":"10.1016/j.oor.2024.100649","DOIUrl":"10.1016/j.oor.2024.100649","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004953/pdfft?md5=c861e29e5c61983140b6670ac2ec7e82&pid=1-s2.0-S2772906024004953-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolution of blood cancer treatment in the oral cavity: Breakthroughs in nanotherapy","authors":"Pavithra Bharathy,&nbsp;Elizabeth Rani E,&nbsp;Punniyakoti V. Thanikachalam","doi":"10.1016/j.oor.2024.100635","DOIUrl":"10.1016/j.oor.2024.100635","url":null,"abstract":"<div><p>This comprehensive review explores the potential of nanotherapy in the treatment of blood cancers, specifically leukemia, lymphoma, and myeloma, in the oral cavity. Nanoparticles (NPs) made from organic and inorganic materials have shown promise in delivering therapeutic substances to cancer cells, enhancing their pharmacological efficacy, and reducing their systemic toxicity. Different types of nanoparticles, such as liposomes, extracellular vehicles, and polymeric nanoparticles, have been studied for their effectiveness in targeting cancer cells. Nanotherapy has also been investigated for overcoming drug resistance, targeting cancer stem cells, bypassing efflux pumps, and gene silencing. Clinical trials and research findings have demonstrated the potential of nanotherapy for improving outcomes in patients with acute myeloid leukemia, chronic lymphocytic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, and multiple myeloma. However, challenges exist in addressing the heterogeneity of blood cancers in the oral cavity, navigating the tumor microenvironment, overcoming drug resistance, and modulating immune evasion. Future directions include individualized treatment plans, multifunctional nanoparticles, combination therapies, and improved nanoparticle design. The translation of these breakthroughs into clinical practice requires collaboration among researchers, physicians, and industry stakeholders. Overall, nanotherapy holds promise for more effective and less invasive treatments for blood cancer in the oral cavity.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004813/pdfft?md5=6846a22d0efea8706080e366bbb7b6b2&pid=1-s2.0-S2772906024004813-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in robotic surgery for oral oncology: Enhanced precision and improved outcomes","authors":"Santosh R. Patil","doi":"10.1016/j.oor.2024.100634","DOIUrl":"10.1016/j.oor.2024.100634","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004801/pdfft?md5=1b094b83ff38ade1b36e5fc2bdeb8a47&pid=1-s2.0-S2772906024004801-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142039677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}