{"title":"Rare case of glandular odontogenic cyst in the posterior mandibular ramus: A case report","authors":"Nasem Jamal Yousef, Issa Saad, Marwan Al-Raeei, Chadi Azmeh, Maya Saad, Zeina Darwich, Maya Jokhadar, Ammar Nasser Agha, Waad Omran, Thayer Marouf","doi":"10.1016/j.oor.2024.100586","DOIUrl":"10.1016/j.oor.2024.100586","url":null,"abstract":"<div><p>The glandular odontogenic cyst is a rare developmental cyst with odontogenic origins that shares similarities with other odontogenic lesions. While generally considered benign, GOCs can exhibit aggressive behavior and may transform into more aggressive lesions like ameloblastoma or mucoepidermoid carcinoma. Therefore, it is crucial to closely monitor and follow up after treatment. With less than 200 reported cases in the literature, GOCs are important due to their propensity for recurrence and potential confusion with other lesions. Oral and maxillofacial radiologists play a key role in diagnosing GOC, given its complex histopathology. In this particular case, a 14-year-old male presented with a well-defined radiolucent lesion in his posterior mandibular ramus, making it the third reported case of GOC in Syria. The discovery of the lesion was incidental, as it was found during a routine panoramic view. The radiolucent lesion extended from the distal border and apex of the lower right first premolar into the ramus, indicating the need for thorough diagnostic evaluation and proper management of the condition. This case report emphasizes the importance of recognizing and addressing such lesions early on to prevent any potential complications. As GOCs can be locally aggressive and have a tendency to recur, timely diagnosis and appropriate treatment are crucial in ensuring the best possible outcome for the patient. Further studies and research are needed to better understand the characteristics and behavior of GOCs in the mandibular ramus region.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004321/pdfft?md5=b4ee69158513ddae47d08f44daa9e24c&pid=1-s2.0-S2772906024004321-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on “Salivary exosomes as potential biomarkers in cancer”","authors":"Muthupandian Saravanan","doi":"10.1016/j.oor.2024.100577","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100577","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004230/pdfft?md5=f317c69d52343e34c64adf002c63bc30&pid=1-s2.0-S2772906024004230-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to editor: Comment on “multi-omics approach reveals promising salivary protein markers for head and neck squamous cell carcinoma prognosis\"","authors":"Gokul Sudhakaran","doi":"10.1016/j.oor.2024.100595","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100595","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004412/pdfft?md5=740753f7f79641d42b1cd07fe83cac30&pid=1-s2.0-S2772906024004412-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the editor, “Depth-dependent PD-L1 sampling of head and neck squamous cell carcinoma (HNSCC) – Implications for PD-1/PD-L1 checkpoint inhibitor immunotherapy.”","authors":"Geetha Shanmugam","doi":"10.1016/j.oor.2024.100579","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100579","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004254/pdfft?md5=a6db3a8194989c6ae5594aa9d9874f58&pid=1-s2.0-S2772906024004254-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics","authors":"Saranya Velmurugan, Gowtham Kumar Subbaraj","doi":"10.1016/j.oor.2024.100584","DOIUrl":"10.1016/j.oor.2024.100584","url":null,"abstract":"<div><p>Oral cancer is a significant public health concern globally, with India reporting a high incidence rate. Genetic factors related to immunity, taste perception, and tooth mineralization are being increasingly studied in the context of dental caries. Beta-defensins, a group of antimicrobial peptides crucial for innate immunity, have been linked to oral cancer development. Studies have shown dysregulation of beta-defensins, particularly hBD-3, may contribute to oral squamous cell carcinoma progression via modulation of inflammation and immune responses. The Beta-defensin index (BDI), which measures hBD-3 and hBD-2 ratios, shows promise as a non-invasive test for early oral cancer detection. Clinical applications include guiding biopsy decisions and prognostication. Further research on beta defensins’ mechanisms and broader oncological implications is crucial for innovative therapeutic strategies.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004308/pdfft?md5=9c7ae401eef14b4cda4526a315639de5&pid=1-s2.0-S2772906024004308-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141630141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the editor, “Prevalence of oral side effects associated with chemo and radiotherapy in head and neck cancer treatment: A cross-sectional study in Egypt”","authors":"Gnanaprakash Jeyaraj","doi":"10.1016/j.oor.2024.100578","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100578","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004242/pdfft?md5=317cde6dc9a51b29d5fae77abad25c74&pid=1-s2.0-S2772906024004242-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"End of life and palliative care decisions in advanced head neck cancer","authors":"Shrikant B. Mali","doi":"10.1016/j.oor.2024.100569","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100569","url":null,"abstract":"<div><p>The complexity of care for patients with advanced head and neck cancer is a significant issue, and current healthcare systems must focus on appropriate referral criteria, increased integration and coordination of care, and robust evaluation of specific care components. Linkage between research and service design delivery across teams, disciplines, and care settings is also important. Palliative care needs of patients with advanced head and neck cancer pose unique complexities due to the impact the illness has on eating, speaking, appearance, and breathing. Specialty palliative care consultation by trained experts helps primary teams facilitate goals of care discussions, symptom management, and medical resource navigation for the terminally ill patient. Early initiation of palliative care results in less invasive and more cost-effective patient-centered care. There is little literature on care practices in this population, and hospital-based care may increase towards the end of life to address potentially reversible conditions or uncertain prognosis. Early advanced care planning and end-of-life care options should be supported alongside continuation of therapy lines.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004151/pdfft?md5=a10e435122de333102e63e386f9366c9&pid=1-s2.0-S2772906024004151-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments”","authors":"Antonyraj Matharasi Perianaika Anahas, Ganapathy Dhanraj","doi":"10.1016/j.oor.2024.100571","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100571","url":null,"abstract":"<div><p>Oral cancer treatment potentially advances with the application of C-phycocyanin (C-PC), a powerful antioxidant produced by cyanobacteria. By triggering mechanisms that impair the metabolism of mitochondria and cause cancer cells to initiate apoptosis, this pigment demonstrates potent apoptotic-inducing potentials. Innovative application for C-PC includes integrating it with fibrous scaffolds for long-term release, stimulating tissue regeneration, and lowering inflammation and oxidative damage after surgery. Surgical implants with C-PC, such stents and sutures, provide focused therapy at the locations of oral cancer. In order to enhance the therapeutic uses of C-PC in oral cancer, further studies may investigate genetically modified microalgae. Validating these therapeutic effects and advancing cyanobacterial pigment-based drugs into clinical applications demand further studies.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004175/pdfft?md5=b86cc38af07f9988a9c4308f83abc51e&pid=1-s2.0-S2772906024004175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Repurposing metformin: Can it revolutionize oral cancer treatment as a neoadjuvant therapeutic agent?","authors":"Deepavalli Arumuganainar, Saravanan Sekaran","doi":"10.1016/j.oor.2024.100575","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100575","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004217/pdfft?md5=6585c1ff3dfb83918bf3eeec1e8dfc5d&pid=1-s2.0-S2772906024004217-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on, “How reliable is the assessment of true vocal cord-arytenoid unit mobility in patients affected by laryngeal cancer? A multi-institutional study on 366 patients from the ARYFIX collaborative group”","authors":"Gokul Sudhakaran","doi":"10.1016/j.oor.2024.100568","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100568","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277290602400414X/pdfft?md5=dedad0c793f344d053410f32dc3fd92a&pid=1-s2.0-S277290602400414X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}