Oral Oncology Reports最新文献

{"title":"Comment on “cancer may be induced by microplastics-sorbed polycyclic aromatic hydrocarbons?”","authors":"Parthasarathy Surya,&nbsp;A. Sundaramanickam,&nbsp;Nithin Ajith","doi":"10.1016/j.oor.2024.100555","DOIUrl":"10.1016/j.oor.2024.100555","url":null,"abstract":"<div><p>Microplastics, pervasive environmental contaminants, pose a potential risk to human health, including the development of oral carcinoma. These minute plastic particles infiltrate various environmental niches and enter the human body through ingestion, inhalation, and dermal exposure. Detected in organs such as the gastrointestinal tract and respiratory system, microplastics may induce inflammation and organ dysfunction. Emerging research suggests their potential to harbor carcinogenic substances, leading to DNA damage and carcinogenesis. Genotoxicity studies inform risk assessment and regulatory decisions. Future research should elucidate the mechanistic pathways linking microplastics to oral carcinoma, focusing on tissue accumulation, inflammation, and DNA damage in the oral cavity. Mitigation strategies should encompass regulatory measures, public awareness campaigns, and advancements in dental care products to address the burgeoning health risks posed by microplastic pollution.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004011/pdfft?md5=360c8c87fc1fd43cfd01dc26ff2b7c94&pid=1-s2.0-S2772906024004011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141397432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Advancements in nanotechnology: mRNA vaccines for infectious diseases and cancer immunotherapy driving the future of global health”","authors":"Surya Parthasarathy,&nbsp;Arumugam Sundaramanickam","doi":"10.1016/j.oor.2024.100556","DOIUrl":"10.1016/j.oor.2024.100556","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004023/pdfft?md5=4ea3f2801d3cb5ee498e4701df5be40a&pid=1-s2.0-S2772906024004023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of socioeconomic factors on survival in non-metastatic head and neck squamous cell cancer","authors":"Chinnasamy Ragavendran","doi":"10.1016/j.oor.2024.100553","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100553","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024003996/pdfft?md5=53ca19715d7296203771d749c4a8f6fe&pid=1-s2.0-S2772906024003996-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformative advancements in immune checkpoint inhibitor therapy for Oropharyngeal Squamous Cell Carcinoma (OPSCC)","authors":"Iadalin Ryntathiang,&nbsp;Mukesh Kumar Dharmalingam Jothinathan","doi":"10.1016/j.oor.2024.100564","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100564","url":null,"abstract":"<div><p>Advancements in Immune checkpoint inhibitor (ICI) treatment have greatly changed the way oropharyngeal squamous cell carcinoma (OPSCC) is treated. This paper examines the crucial advancements and their consequences for clinical practice. Initially, the implementation of ICIs, such as pembrolizumab and nivolumab, has significantly enhanced the rates of survival in cases with recurrent and metastatic OPSCC. Furthermore, the discovery of biomarkers for prognosis such as Human Papilloma Virus (HPV) type and expression of programmed death ligand (PD-L1) has facilitated the development of more individualized and efficacious treatment approaches. Furthermore, the utilization of combination therapies that incorporate ICIs alongside conventional treatment methods like as radiation and chemotherapy has exhibited synergistic outcomes, thereby improving the overall effectiveness of the treatment. Furthermore, current clinical trials are exploring innovative combinations of ICIs and treatment sequences in order to enhance patient outcomes. Finally, progress in comprehending the tumor microenvironment and immune evasion mechanisms is influencing the creation of advanced ICIs and innovative treatment targets. These groundbreaking achievements not only provide exciting opportunities for enhancing patient survival and quality of life but also emphasize the necessity for ongoing research and innovation in the sector.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004102/pdfft?md5=7d9045c5a4094fd2704eff78e5cd2004&pid=1-s2.0-S2772906024004102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Exploring PD-1 methylation in oral cancer: A crucial frontier in immunotherapy”","authors":"Muthupandian Saravanan","doi":"10.1016/j.oor.2024.100558","DOIUrl":"10.1016/j.oor.2024.100558","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004047/pdfft?md5=07b9c87bbc89dc67a628a1a91274f2a1&pid=1-s2.0-S2772906024004047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141404517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An innovative approach for lid design for rehabilitation of maxillary oncological defect using hollow bulb obturator","authors":"Shweta Kumari,&nbsp;Peter John,&nbsp;Ahila Singaravel Chidambaranathan,&nbsp;Muthukumar Balasubramanium","doi":"10.1016/j.oor.2024.100561","DOIUrl":"10.1016/j.oor.2024.100561","url":null,"abstract":"<div><h3>Background</h3><p>Post Maxillectomy, prosthodontic treatment modalities include surgical obturator, interim obturator and followed by definitive obturator. The surgical and interim obturator serves the purpose of providing a matrix on which surgical packing can be placed, reduces the contamination during wound healing, facilitates speech and permits deglutition and lessens the psychological impact of surgery. Local drug delivery techniques at the surgical site and the fabricated prosthesis have an impact on the targeted tissue.</p></div><div><h3>Objectives</h3><p>To design a hollow bulb obturator with a detachable lid with attachments in the palatal surface of the obturator and to facilitate local drug delivery.</p></div><div><h3>Methods</h3><p>Duplication of patient's maxillectomy cast, pre-shaped plaster bolus was incorporated inside the defect space to create the hollow space. After which a wax pattern was fabricated and acrylized. Wax template of the lid design was made and acrylized incorporating pins.</p></div><div><h3>Result</h3><p>The weight of the prosthesis is reduced. Due to the lesser weight of the prosthesis retention and physiologic function increases. The decrease in pressure to the surrounding tissue aids in deglutition and encourages the regeneration of tissue. The fabricated lid appears stable and retentive, which can be easily removed and placed back according to the need.</p></div><div><h3>Conclusion</h3><p>Local drug delivery techniques at the surgical site and the fabricated prosthesis has an impact on the targeted tissue.The ability of the drug to reach the appropriate anatomic region will always be important, and has been the subject of much research in the past 5 years. Modified hollow bulb of the obturator in this research can aid in local drug delivery in surgical and interim obturators avoiding the removal of the obturator as the whole.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004072/pdfft?md5=cf17c6974264ab9a6945814c9f32a2e5&pid=1-s2.0-S2772906024004072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141404915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting oral cancer awareness in LGBTQ+ communities - Diversity in oral health","authors":"Gayathri Rengasamy,&nbsp;Vishnu Priya Veeraraghavan","doi":"10.1016/j.oor.2024.100549","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100549","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024003959/pdfft?md5=48233674cb7f0c2e28adc673fd1e6e43&pid=1-s2.0-S2772906024003959-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sexual performance and intimacy with satisfaction in life in head and neck cancer patients: A review","authors":"Ananya Arora ,&nbsp;Ravindra Singh ,&nbsp;Khushi Malik ,&nbsp;Unnati Kestwal","doi":"10.1016/j.oor.2024.100563","DOIUrl":"10.1016/j.oor.2024.100563","url":null,"abstract":"<div><h3>Introduction</h3><p>Head and neck (H&amp;N) neoplasms, both in advanced stages and during their oncologic therapy, cause interferences with wild psycho-physical implications and impact on family and partner life, social, relational, and working dimensions. Many studies were conducted on sexual function in oncology patients with breast, pelvic, or prostate organs. Nevertheless, few studies investigated the sexualities of patients with head and neck cancer.</p></div><div><h3>Purpose</h3><p>of the Study: Head and neck cancer patients are often at risk of sexual problems due to the possibility of disfigurement and body image disturbance. These issues in cancer patients may have a significant effect on their psychological well-being. These issues can cause guilt, low life satisfaction, less intimacy, etc. This study aims to give an insight into the association between intimacy, sexual performance, and life satisfaction in patients with head and neck cancer.</p></div><div><h3>Methods</h3><p>We thoroughly reviewed current literature, examining multiple scholarly articles and journals available online. We used electronic databases and search engines such as PubMed, PsycINFO, Google Scholar, and ResearchGate, using key terms such as \"head and neck cancer,\" \"sexual performance,\" \"life satisfaction,\" \"intimacy,\" and \"oral cancer\" to identify relevant studies. Consistency in the definition of these concepts was maintained by excluding synonymous keywords from our search. A total of 78 papers were initially selected on the basis of the titles. According to the research objectives, a total of 53 papers were selected after thorough investigation of the abstract. Further, we have removed duplicate and inaccessible articles from the review process. Then after thoughtful consideration, it was brought down to 27 articles on the basis of their relevance to the study. Only studies that were published in the last 20 years were taken in review.</p></div><div><h3>Results</h3><p>Our review synthesized findings from some studies examining the association of sexual performance and intimacy with satisfaction in life of head and neck cancer patients. Across the included studies, a consistent pattern emerged, highlighting the significant impact of sexual function and intimate relationships on overall life satisfaction in this patient population. These findings emphasize the importance of incorporating interventions targeting sexual and intimacy-related concerns into the comprehensive care of individuals living with head and neck cancer.</p></div><div><h3>Conclusions</h3><p>In conclusion, the findings highlighted the importance of addressing sexual health and intimate relationship concerns as integral components of comprehensive care for head and neck cancer patients. Healthcare providers should prioritize open communication, psycho education, and support services to help patients navigate the challenges associated with changes in sexual behaviour and intimacy.</p></d","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004096/pdfft?md5=a67b098df66ae3315d6358ba50e5c250&pid=1-s2.0-S2772906024004096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “TGM3 - A novel biomarker as a potential diagnostic target for head and neck squamous cell carcinoma (HNSCC)”","authors":"Muthupandian Saravanan","doi":"10.1016/j.oor.2024.100557","DOIUrl":"10.1016/j.oor.2024.100557","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004035/pdfft?md5=941179209a40e617cf1420eabe724515&pid=1-s2.0-S2772906024004035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into miRNA-based therapeutic strategies for oral cancer: Targeting HIF-1α to enhance patient outcomes","authors":"Geetha Shanmugam","doi":"10.1016/j.oor.2024.100551","DOIUrl":"https://doi.org/10.1016/j.oor.2024.100551","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024003972/pdfft?md5=e1ee7419a3c783dd089bd35ad13c4f67&pid=1-s2.0-S2772906024003972-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}