Oral Oncology Reports最新文献_第10页

Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples 亚洲头颈癌的基因组状况：对 1016 个样本的综合荟萃分析

Oral Oncology Reports Pub Date : 2024-08-10 DOI: 10.1016/j.oor.2024.100628

Srikanth S. Manda , Nafisa Arfa , Neha Sharma , Aparna R. Parikh , Thomas J. Roberts , Sewanti Limaye , Venkataraman Ramachandran , Kumar Prabhash , Moni A. Kuriakose , Prashant Kumar

{"title":"Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples","authors":"Srikanth S. Manda , Nafisa Arfa , Neha Sharma , Aparna R. Parikh , Thomas J. Roberts , Sewanti Limaye , Venkataraman Ramachandran , Kumar Prabhash , Moni A. Kuriakose , Prashant Kumar","doi":"10.1016/j.oor.2024.100628","DOIUrl":"10.1016/j.oor.2024.100628","url":null,"abstract":"<div><p>Head and neck cancer (HNC) is a diverse group of malignancies arising in the mucosal linings of the oral cavity, pharynx, and larynx, influenced by factors such as tobacco use, alcohol consumption, and human papillomavirus (HPV) infection. This study conducts a comprehensive meta-analysis of the mutational landscape of HNC across Asian cohorts, encompassing India, Korea, Japan, China, Singapore, and Saudi Arabia. The analysis highlights distinct genetic profiles influenced by environmental exposures, lifestyle habits, and genetic predispositions. Notably, the RAF family proteins, enriched in both Indian and Chinese cohorts, present potential therapeutic targets for RAF inhibitors like Vemurafenib. Additionaly, specific mutations like MET in Singaporean patients can be effectively addressed with drugs like Crizotinib, leading to rapid responses in HNSCC. Smokers exhibited high frequencies of CASP8 and FAT1 mutations. Novel driver genes, including RYR2 and ANK2, emerged with significant mutational frequencies in smokers. The RAS signaling pathway was identified as a prominent driver in HNC, contrasting with the globally prevalent PIK3CA/MTOR pathway. This study also underscores the high prevalence of HRAS mutations in Indian and Saudi cohorts. The study emphasizes the necessity for region-specific data to understand the unique molecular differences and develop effective therapies. The identification of NBEA and ANK2 as potential novel driver genes in HNC highlights new avenues for research and targeted therapeutic interventions tailored to the genetic profiles of Asian HNC patients.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"11 ","pages":"Article 100628"},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004746/pdfft?md5=6cbe8b6837cd60e62c63b42b459d39b0&pid=1-s2.0-S2772906024004746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reevaluating clinical staging: Recent advances in AJCC/UICC criteria for nasopharyngeal carcinoma 重新评估临床分期：AJCC/UICC鼻咽癌标准的最新进展

Oral Oncology Reports Pub Date : 2024-08-08 DOI: 10.1016/j.oor.2024.100621

Madhan Krishnan, Shyamaladevi Babu

引用次数: 0

Circulating tumor DNA as a therapeutic approach for HPV (+) oropharyngeal squamous cell carcinoma 将循环肿瘤 DNA 作为治疗 HPV（+）口咽鳞状细胞癌的一种方法

Oral Oncology Reports Pub Date : 2024-08-08 DOI: 10.1016/j.oor.2024.100626

Raghul Murugan

引用次数: 0

Machine learning-driven insights into ctDNA for oral cancer: Applications, models, and future prospects 机器学习驱动的口腔癌ctDNA洞察力：应用、模型和未来展望

Oral Oncology Reports Pub Date : 2024-08-06 DOI: 10.1016/j.oor.2024.100629

Dheeraj Kumar, Saraswati Patel

引用次数: 0

Improving oral cancer diagnosis and management with artificial intelligence: A promising future for patient care 利用人工智能改进口腔癌诊断和管理：患者护理的美好未来

Oral Oncology Reports Pub Date : 2024-08-03 DOI: 10.1016/j.oor.2024.100624

Karthikeyan Elumalai

引用次数: 0

Innovations and advancements in adhesives for maxillofacial prosthesis in carcinoma rehabilitated patients 癌症康复患者颌面假体粘合剂的创新与进步

Oral Oncology Reports Pub Date : 2024-08-03 DOI: 10.1016/j.oor.2024.100625

N. Gopi Chander, Neha Venkat, A. Noorul Rizwana

{"title":"Innovations and advancements in adhesives for maxillofacial prosthesis in carcinoma rehabilitated patients","authors":"N. Gopi Chander, Neha Venkat, A. Noorul Rizwana","doi":"10.1016/j.oor.2024.100625","DOIUrl":"10.1016/j.oor.2024.100625","url":null,"abstract":"<div><p>Maxillofacial prosthetics play a crucial role in the rehabilitation of oral cancer patients, significantly enhancing their quality of life by restoring facial structure and function. The success of these prosthetics is dependent on adhesives, that ensures assured attachment and stability. Despite their significance, adhesives have received reduced attention in the literature. This review aims to meet this literature gap by exploring the innovations and advancements in adhesives for maxillofacial prosthetics.</p><p>Traditional adhesives, while widely used, often fall short in terms of durability and biocompatibility, especially under the dynamic conditions of the oral cavity. Recent developments in biocompatible materials and applied technology have introduced new adhesives that offer improved adhesion strength, durability, and patient comfort. Smart adhesives, which respond to environmental stimuli like pH and temperature, present significant advancements, enhancing the adaptive nature of prosthetic attachment.</p><p>Customized adhesive solutions, facilitated by digital printing of prosthesis, provide more accurate prosthesis and reduces the interfacial gap with the skin and prosthesis. This further improving prosthetic performance with a predictable layer of adhesives in the interface. Additionally, new application techniques and tools have enhanced the precision and ease of adhesive use, ensuring consistent and reliable attachment.</p><p>This review highlights the importance of advanced adhesives in managing oral cancer patients, presenting the crucial role they play in the effectiveness and comfort of maxillofacial prosthetics. It also emphasizes the need for these adhesives to be a key focus in future research and clinical practice.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"11 ","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004710/pdfft?md5=6a237bb2f9bbc6ab37bbf5f1646d3c8b&pid=1-s2.0-S2772906024004710-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the mTOR pathway: A new horizon in oral cancer treatment 靶向 mTOR 通路：口腔癌治疗的新视野

Oral Oncology Reports Pub Date : 2024-08-02 DOI: 10.1016/j.oor.2024.100619

Mahalakshmi Devaraji, Punniyakoti V. Thanikachalam

引用次数: 0

The role of liquid biopsy in early detection and monitoring of oral cancer 液体活检在口腔癌早期检测和监测中的作用

Oral Oncology Reports Pub Date : 2024-07-31 DOI: 10.1016/j.oor.2024.100618

Mahalakshmi Devaraji, Lokeshvar Ravikumar

引用次数: 0

Innovations in early detection of oral cancer: Advancing diagnostic technologies and reducing global disparities 口腔癌早期检测的创新：推动诊断技术发展，缩小全球差距

Oral Oncology Reports Pub Date : 2024-07-30 DOI: 10.1016/j.oor.2024.100620

Lokeshvar Ravikumar, Ramaiyan Velmurugan

引用次数: 0

Comparison of clinicopathological characteristics of young and old North Indian patients of oral squamous cell carcinoma 北印度年轻和老年口腔鳞状细胞癌患者临床病理特征的比较

Oral Oncology Reports Pub Date : 2024-07-30 DOI: 10.1016/j.oor.2024.100615

G. Sharma, M. Kamboj, A. Narwal, A. Devi, J. Yadav, M. Sharma

{"title":"Comparison of clinicopathological characteristics of young and old North Indian patients of oral squamous cell carcinoma","authors":"G. Sharma, M. Kamboj, A. Narwal, A. Devi, J. Yadav, M. Sharma","doi":"10.1016/j.oor.2024.100615","DOIUrl":"10.1016/j.oor.2024.100615","url":null,"abstract":"<div><h3>Introduction</h3><p>Oral squamous cell carcinoma (OSCC) ranks among the most prevalent epithelial malignancies in the head and neck region. Although it predominantly affects older individuals, there has been a concerning rise in incidence among the younger population in recent years. This study aimed to compare the clinicopathological features of OSCC at our institution distinguishing between young and older age groups.</p></div><div><h3>Methods</h3><p>In the present retrospective study, histopathologically confirmed cases of OSCC were retrieved and assigned into two groups based on their age. Demographic data along with histopathological parameters were assessed. The data collected were statistically analysed using descriptive analysis, chi-square, kappa and multinomial logistic regression tests. A p-value less than or equal to 0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>Of the 707 OSCC patients, 585 were over 40 years old, while 122 were 40 or younger. Both the groups exhibited comparable observations with a high degree of keratinization, moderate nuclear pleomorphism, type 3 pattern of invasion, low tumor budding, high stromal and low intratumoral infiltration of lymphocytes, except lymphoplasmacytic infiltrate which was marked in a higher number of young cases.</p></div><div><h3>Conclusion</h3><p>OSCC in young and older individuals exhibited similar clinical as well as histopathological findings. Although the increased incidence of OSCC in the young is a cause of concern, so future multicentric studies with a larger sample size are warranted, to shed more light on the behavior and prognosis of OSCC in the young.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"11 ","pages":"Article 100615"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004618/pdfft?md5=143d264da8320b2a571bb461b286f08f&pid=1-s2.0-S2772906024004618-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141961009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0