Oral Oncology Reports最新文献

{"title":"Radiant advances: The future of brachytherapy in oral oncology","authors":"Shyamaladevi Babu,&nbsp;Madhan Krishnan","doi":"10.1016/j.oor.2024.100654","DOIUrl":"10.1016/j.oor.2024.100654","url":null,"abstract":"<div><div>Brachytherapy has become integral to the treatment of oral cancers, offering the advantage of delivering high doses of radiation directly to tumors while minimizing exposure to surrounding healthy tissues. This review examines recent advancements that have significantly improved the precision and effectiveness of brachytherapy. The integration of high-resolution imaging technologies, such as MRI and CT scans, has enhanced tumor delineation, enabling more accurate placement of radioactive sources. Innovations in radioactive sources, particularly high-dose-rate (HDR) brachytherapy, have optimized radiation delivery, leading to shorter treatment durations and improved patient outcomes. Personalized treatment approaches, guided by genomic and molecular profiling, allow for customized dosimeter, maximizing therapeutic effectiveness while minimizing toxicity. Additionally, combining brachytherapy with other treatment modalities such as surgery, external beam radiation therapy (EBRT), and chemotherapy has demonstrated synergistic benefits, improving local control and reducing recurrence rates. Despite its advantages, brachytherapy faces challenges, including the invasive nature of the procedure, the need for specialized equipment and training, and limitations related to tumor size. Future directions in the field include advancements in imaging and dosimeter, the development of robotic-assisted brachytherapy, and more personalized treatment plans. These innovations promise to refine brachytherapy further and expand its applicability. This review highlights the transformative potential of recent advances in brachytherapy, emphasizing its evolving role in the localized treatment of oral cancers.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100654"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024005004/pdfft?md5=de4d017ee953f597078b5dc22e05f558&pid=1-s2.0-S2772906024005004-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining radiotherapy and systemic therapies in oropharyngeal cancer: A comprehensive review of recent developments","authors":"Madhan Krishnan,&nbsp;Shyamaladevi Babu","doi":"10.1016/j.oor.2024.100659","DOIUrl":"10.1016/j.oor.2024.100659","url":null,"abstract":"<div><div>Oropharyngeal cancer (OPC) has seen significant advancements in treatment modalities, particularly with the integration of radiotherapy and systemic therapies. This review comprehensively examines recent developments in combining these treatments, focusing on their synergistic potential, clinical outcomes, and future prospects. Advances in radiotherapy, including intensity-modulated radiotherapy (IMRT), proton beam therapy (PBT), and stereotactic body radiotherapy (SBRT), have improved targeting and reduced toxicity. Concurrent chemoradiotherapy (CCRT) remains a cornerstone, while the onset of immunotherapy, especially immune checkpoint inhibitors, has transformed systemic treatment. Combining radiotherapy with immunotherapy shows promise in enhancing treatment efficacy. Targeted therapies, such as those targeting the epidermal growth factor receptor (EGFR), are also explored for their potential in OPC management. The review underscores the importance of personalized treatment approaches and highlights ongoing research into novel therapeutic combinations and advanced technologies like artificial intelligence and machine learning. These advancements aim to optimize treatment strategies, improve survival rates, and minimize treatment-related toxicity, heralding a new era in OPC management.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100659"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024005053/pdfft?md5=f9ee3f5b239d8f01f715ac3afe275945&pid=1-s2.0-S2772906024005053-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current advances in immunotherapy for cancer","authors":"Indrajit Desai ,&nbsp;Saee Thakur ,&nbsp;Pradeep Pagariya","doi":"10.1016/j.oor.2024.100652","DOIUrl":"10.1016/j.oor.2024.100652","url":null,"abstract":"<div><div>Recent advances in cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T-cell therapy, have significantly improved the clinical management of various cancers. ICIs, such as PD-1/PD-L1 and CTLA-4 inhibitors, enhance the body's immune response against tumors, offering substantial benefits in cancers like melanoma, non-small-cell lung cancer, and lymphoma. CAR-T cell therapy has demonstrated remarkable efficacy in hematologic malignancies, particularly B-cell leukemias and lymphomas, through the genetic modification of T-cells to target tumor-specific antigens.Despite these successes, several challenges remain, particularly in the treatment of solid tumors. The heterogeneity of tumor antigens, the presence of physical barriers that impede CAR-T cell infiltration, and the immunosuppressive tumor microenvironment limit the effectiveness of these therapies. To address these issues, ongoing research is exploring combination therapies that integrate ICIs with CAR-T cell therapy, improved CAR-T cell engineering, and strategies to modulate the tumor microenvironment to enhance immune cell infiltration and function.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100652"},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004989/pdfft?md5=9b7ce80b933ef99a3f68538ac720b265&pid=1-s2.0-S2772906024004989-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging immune checkpoint inhibitors for the treatment of oropharyngeal squamous cell carcinoma","authors":"Pandiselvi Ravi ,&nbsp;Shyamaladevi Babu","doi":"10.1016/j.oor.2024.100650","DOIUrl":"10.1016/j.oor.2024.100650","url":null,"abstract":"<div><p>Oropharyngeal Squamous Cell Carcinoma (OPSCC) is a challenging subtype of head and neck cancer that traditionally has been associated with poor prognosis and high morbidity due to the limitations of conventional treatments such as surgery, radiation, and chemotherapy. Immune checkpoint inhibitors have revolutionized OPSCC and other cancer therapies. ICIs that target the PD-1 and PD-L1 axis and CTLA-4 have altered cancer action by improving the immune system capacity to detect and kill cancer cells. This paper discusses the significant impact of ICIs like Pembrolizumab and Nivolumab, which have been approved for use in recurrent or metastatic OPSCC and have demonstrated remarkable efficacy in clinical trials. The integration of these therapies into clinical practice has been facilitated by the identification of biomarkers such as PD-L1 expression, which guides personalized treatment strategies. Moreover, ongoing research into combination therapies involving ICIs and other treatment modalities is poised which, leads for further improvement in patient outcomes. Despite the successes, challenges such as immune-related adverse events and resistance mechanisms remain, underscoring the need for continued innovation and exploration in the field. This review highlights the pivotal role of ICIs in redefining OPSCC treatment, offering new hope for sustained survival and improved quality of life.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100650"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004965/pdfft?md5=1bba1c33fd8f844785a4d0d026540be8&pid=1-s2.0-S2772906024004965-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor, “Incidental dose to the oropharynx with involved neck only radiotherapy in squamous cell cancer of unknown primary of the head and neck.”","authors":"Gnanaprakash Jeyaraj","doi":"10.1016/j.oor.2024.100648","DOIUrl":"10.1016/j.oor.2024.100648","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100648"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004941/pdfft?md5=6d662e12d0dcea6c5bcbd82bb662df25&pid=1-s2.0-S2772906024004941-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in image-guided radiotherapy (IGRT): Reducing toxicity while increasing efficacy in oral cancer","authors":"Shyamaladevi Babu,&nbsp;Pandiselvi Ravi","doi":"10.1016/j.oor.2024.100623","DOIUrl":"10.1016/j.oor.2024.100623","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"11 ","pages":"Article 100623"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004692/pdfft?md5=f1a2ecdf34946b408cbeca0642283b68&pid=1-s2.0-S2772906024004692-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Prognostic significance of neutrophil to lymphocyte ratio (NLR) in oral squamous cell carcinoma”","authors":"Elumalai perumal,&nbsp;Jospin Sindya","doi":"10.1016/j.oor.2024.100643","DOIUrl":"10.1016/j.oor.2024.100643","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"11 ","pages":"Article 100643"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004898/pdfft?md5=0a1145f3988d84aa86ff9cbe5ba779f2&pid=1-s2.0-S2772906024004898-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of obturator in restoring quality of life and function in maxillary oncological defect cases- A systematic review","authors":"Neelima Manoj,&nbsp;Ahila Singaravel Chidambaranathan,&nbsp;MuthuKumar Balasubramanium,&nbsp;Ganesh RamKumar Rajapandi","doi":"10.1016/j.oor.2024.100636","DOIUrl":"10.1016/j.oor.2024.100636","url":null,"abstract":"<div><h3>Statement of problem</h3><p>Whether prosthetic rehabilitation significantly affects quality of life and functions of post maxillectomy patients.</p></div><div><h3>Objective</h3><p>Systematically analyze the effects of different types of obturators on post-maxillectomy patients focusing on quality of life and function.</p></div><div><h3>Materials and methods</h3><p>An electronic search was conducted across four databases PubMed, Google Scholar, Cochrane Library, and ScienceDirect in English language from January 1995 June 2024 using the key terms maxillectomy OR hemi-maxillectomy OR palatomaxillary defect OR Aramany OR Brown OR Okay AND obturator OR denture OR prosthetic AND flap OR surgery OR prosthetic rehabilitation. Additionally, a hand search was performed in the institutional library on Journal of Prosthetic Dentistry, Journal of Indian Prosthodontic Society, Journal of Prosthodontics, International Journal of Prosthodontics and Indian Journal of Prosthodontic Research.</p></div><div><h3>Results</h3><p>Seven articles were included in this systematic review. Patient scores from quality-of-life questionnaires and functional ability evaluations were compared across a total of 251 patients, including those with and without obturators. The evaluation included 3 prospective studies, 2 retrospective studies, 1 clinical study, and 1 randomized controlled trial. The results demonstrated a statistically significant improvement in both speech and quality of life for patients using maxillary obturators.</p></div><div><h3>Conclusion</h3><p>Obturator prostheses are not only improved the health-related quality of life (HRQOL) but also enhance overall function of the patient rehabilitated with maxillary oncological defects. They play a crucial role in orofacial rehabilitation by addressing functional and aesthetic challenges faced by individuals with such defects. This positive impact is likely due to the prostheses' ability to restore oral and facial functions, improve speech, and enhance self-esteem and social interactions.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"11 ","pages":"Article 100636"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004825/pdfft?md5=00a0a09c92a0e72a9d18b68ff8673947&pid=1-s2.0-S2772906024004825-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review based study on emotional distress and physical pain in oral and head and neck cancer patients pre- and post-chemotherapy","authors":"Sanya Mehndiratta ,&nbsp;Ravindra Singh ,&nbsp;Saanjli Bhandari ,&nbsp;Mansha Dadhich","doi":"10.1016/j.oor.2024.100637","DOIUrl":"10.1016/j.oor.2024.100637","url":null,"abstract":"<div><p>Emotional distress is a psychological response that occurs in the form of mental suffering to an experience that arises from the any negative event or condition. It commonly occurs in patients who suffer from cancer-related physical pain throughout the treatments. Cancer patients face a lot of exhaustion which makes them physically and mentally dysfunctional in their daily lives. However, the Head and Neck Cancer (HNC) patients face some serious issues due to the site of tumour or surgery itself. The current study aims to describe how chemotherapy and physical pain cause emotional distress in HNC patients. Furthermore, the study aims to determine the association between all three factors (Emotional distress, pain, and chemotherapy) and highlight the relevance of care and remediation needs for HNC patients. The literature related to the concerned topic was investigated including empirical research papers, review papers. In total, the authors identified and reviewed 42 articles related to the above-mentioned variables. These articles were obtained from different databases, such as Google Scholar, PubMed, JSTOR and Research Gate. The authors then assessed the full texts of the selected articles for eligibility and extracted data from them. The study revealed that cancer patients who have tolerated physical pain and witnessed the long-term treatment of the process of chemotherapy experience extremely high emotional distress throughout the course. It was also observed that psychological distress is more common in HNC patients than in patients with cancer in other body parts. The main findings of the result indicated that emotional distress was much higher in females. Psychosocial support and palliative care should be integrated to encourage and improve the abilities of cancer-affected patients.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"11 ","pages":"Article 100637"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004837/pdfft?md5=76940f688a095ee37b600515ed907c3b&pid=1-s2.0-S2772906024004837-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of lymph node level IIA & IIB IN N-0 neck of oral squamous cell carcinoma","authors":"Mohd Aswad Khan ,&nbsp;Ghulam Sarwar Hashmi ,&nbsp;Sajjad Abdur Rahman ,&nbsp;Roobina Khan ,&nbsp;Mehtab Ahmad ,&nbsp;Tabishur Rahman","doi":"10.1016/j.oor.2024.100639","DOIUrl":"10.1016/j.oor.2024.100639","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"11 ","pages":"Article 100639"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004850/pdfft?md5=ba1b4d30aa18d325f634667456c12971&pid=1-s2.0-S2772906024004850-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}