Oral Oncology Reports最新文献_第9页

Tumor microenvironment in oral squamous cell carcinoma: Implications for novel therapies 口腔鳞状细胞癌的肿瘤微环境：对新型疗法的启示

Oral Oncology Reports Pub Date : 2024-10-03 DOI: 10.1016/j.oor.2024.100666

Shyamaladevi Babu , Maghizh Jemima Manavalan , Shaik hifza jasmine , Madhan Krishnan

{"title":"Tumor microenvironment in oral squamous cell carcinoma: Implications for novel therapies","authors":"Shyamaladevi Babu , Maghizh Jemima Manavalan , Shaik hifza jasmine , Madhan Krishnan","doi":"10.1016/j.oor.2024.100666","DOIUrl":"10.1016/j.oor.2024.100666","url":null,"abstract":"<div><div>Oral squamous cell carcinoma (OSCC) has a complex tumor microenvironment (TME) that modulates tumor growth, metastasis, and treatment response. This review intends to shed light on the key components of the TME, such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), immunological cells, endothelial cells, and the extracellular matrix (ECM), as well as their functions in OSCC biology. We address how interactions within the TME lead to tumor growth, treatment resistance, and immune evasion, focusing on current clinical studies that target these processes. In addition, we evaluate emerging therapeutic methods, such as immune checkpoint inhibitors, CAR-T cell therapy, anti-angiogenic medicines, and ECM remodeling inhibitors, which have shown promise in clinical trials. Despite the obstacles faced by TME heterogeneity and the requirement for robust biomarkers, personalized medicine approaches based on TME profiling hold great promise for improving treatment results. This review underlines the necessity of ongoing research to integrate TME-focused medicines into clinical practice and provides future options for overcoming resistance and improving therapeutic efficacy by targeting both tumor cells and their microenvironment.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100666"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing outcomes in oral carcinoma with prosthesis intervention 通过假体干预优化口腔癌的治疗效果

Oral Oncology Reports Pub Date : 2024-10-03 DOI: 10.1016/j.oor.2024.100665

N. Gopi Chander , M. Senthil Murugan

{"title":"Optimizing outcomes in oral carcinoma with prosthesis intervention","authors":"N. Gopi Chander , M. Senthil Murugan","doi":"10.1016/j.oor.2024.100665","DOIUrl":"10.1016/j.oor.2024.100665","url":null,"abstract":"<div><div>Optimal management of oral carcinoma requires a multidisciplinary approach, particularly in cases involving maxillary gingival carcinoma, where surgical and prosthetic interventions are crucial for restoring function and improving patient quality of life. This case report details the comprehensive treatment of a patient diagnosed with maxillary gingival carcinoma, presenting with pain and discharge. Histopathological examination confirmed carcinoma, necessitating surgical excision. A vascular flap was employed for closure to promote healing and preserve anatomical structures.</div><div>Post-surgical rehabilitation began with the use of an interim flexible obturator, designed to provide immediate support for speech, swallowing, and soft tissue protection during the initial healing phase. This prosthetic intervention optimized early functional outcomes and patient comfort. As healing progressed, the patient transitioned to a definitive cast partial denture obturator, featuring a cobalt-chromium alloy framework for enhanced durability and stability. The prosthesis was designed with a complete palate major connector, mesh-type denture base, and carefully positioned rest seats and retainers to ensure optimal function, aesthetics, and long-term structural support.</div><div>Regular follow-ups demonstrated significant improvements in oral functions, psychological well-being, and overall quality of life. This report underscores the vital role of prosthetic interventions in optimizing outcomes for oral carcinoma patients, highlighting the importance of individualized rehabilitation strategies that integrate surgical and prosthetic care for long-term success.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100665"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct extension from primary tumour to nodes: Can molecular profiling solve the dilemma? 原发肿瘤直接延伸至结节：分子图谱分析能解决这一难题吗？

Oral Oncology Reports Pub Date : 2024-09-28 DOI: 10.1016/j.oor.2024.100664

Gargi Sarode, Dheeraj Meena, Sayali Tungikar, Atharv Shrotri, Sachin Sarode

引用次数: 0

Navigating the omics landscape in precision medicine: A bidirectional approach to patient care 在精准医疗中驾驭全局：患者护理的双向方法

Oral Oncology Reports Pub Date : 2024-09-28 DOI: 10.1016/j.oor.2024.100660

Rui Vitorino

引用次数: 0

How to choose a sampling technique and determine sample size for research: A simplified guide for researchers 如何选择抽样技术并确定研究样本量：研究人员简化指南

Oral Oncology Reports Pub Date : 2024-09-26 DOI: 10.1016/j.oor.2024.100662

Sirwan Khalid Ahmed

{"title":"How to choose a sampling technique and determine sample size for research: A simplified guide for researchers","authors":"Sirwan Khalid Ahmed","doi":"10.1016/j.oor.2024.100662","DOIUrl":"10.1016/j.oor.2024.100662","url":null,"abstract":"<div><div>An appropriate sampling technique with the exact determination of sample size involves a very vigorous selection process, which is actually vital for any empirical research. It is obvious that these methodological decisions would greatly affect the internal and external validity and the overall generalizability of the study findings. This paper has comprehensively updated the guidelines on sampling methods and sample size calculation, hence giving enough evidence that will be beneficial in assisting researchers to advance the credibility and statistical power of their research work. The differences between probability sampling techniques, including simple random sampling, stratified sampling, and cluster sampling, and non-probability methods, such as convenience sampling, purposive sampling, and snowball sampling, have been fully explained. Probability is the only that can ensure the generalizability, while non-probability sampling is useful in exploratory situations. Another significant process is the determination of an optimal sample size, which, among other things, has to take into account the total population size, effect size, statistical power, confidence level, and margin of error. The paper contributes both theoretical guidance and practical tools that researchers need in choosing appropriate strategies for sampling and validating methodologically appropriate sample size calculations. In sum, such a paper sets the standard for best practice in research methodology that will drive reliability, validity, and empirical rigor across diverse studies.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100662"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing 3D printing prosthesis technology for rehabilitation of oral cancer patients 优化用于口腔癌患者康复的 3D 打印假体技术

Oral Oncology Reports Pub Date : 2024-09-25 DOI: 10.1016/j.oor.2024.100661

N. Gopi Chander, Lakshita Sharma, Amrutha Manoj Kumar, Lakshmi Raj

{"title":"Optimizing 3D printing prosthesis technology for rehabilitation of oral cancer patients","authors":"N. Gopi Chander, Lakshita Sharma, Amrutha Manoj Kumar, Lakshmi Raj","doi":"10.1016/j.oor.2024.100661","DOIUrl":"10.1016/j.oor.2024.100661","url":null,"abstract":"<div><div>Oral cancer patients face significant challenges in prosthetic rehabilitation due to tissue loss from surgical interventions and the lasting side effects of treatments such as radiation therapy. Traditional methods of prosthesis fabrication often struggle to account for the anatomical changes caused by cancer treatments, leading to functional and aesthetic limitations. 3D printing technology, with its ability to produce customized, patient-specific prostheses, presents a promising solution for overcoming these challenges. By employing advanced imaging techniques like CT and MRI, 3D printing allows for the precise modeling of the oral cavity, improving the fit, comfort, and functionality of prostheses.</div><div>In addition to enhancing the accuracy of prosthesis design, 3D printing plays a crucial role in surgical reconstruction by enabling surgeons to plan more precise interventions. This reduces the need for multiple surgeries and improves recovery time. The integration of 3D printing with oncologic care, including collaboration between surgical teams and oncologists, further streamlines treatment and enhances patient outcomes. Despite these advantages, limitations remain, particularly regarding the durability and biocompatibility of 3D printing materials. Future advancements, including bioprinting and the development of smart materials, hold the potential to further revolutionize prosthetic rehabilitation for oral cancer patients.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100661"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142359076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sebaceous adenoma of the parotid gland encasing the facial nerve: Case report and review of the literature 包裹面神经的腮腺皮脂腺瘤：病例报告和文献综述

Oral Oncology Reports Pub Date : 2024-09-25 DOI: 10.1016/j.oor.2024.100663

Bhavik Singh , Kelly R. Magliocca , David Chou , Jennifer H. Gross , Jennifer L. Becker , Nicole C. Schmitt

{"title":"Sebaceous adenoma of the parotid gland encasing the facial nerve: Case report and review of the literature","authors":"Bhavik Singh , Kelly R. Magliocca , David Chou , Jennifer H. Gross , Jennifer L. Becker , Nicole C. Schmitt","doi":"10.1016/j.oor.2024.100663","DOIUrl":"10.1016/j.oor.2024.100663","url":null,"abstract":"<div><h3>Background</h3><div>Sebaceous adenoma of the salivary glands are uncommon benign neoplasms, comprising about 0.1 % of salivary tumors. These tumors can be difficult to recognize with heterogeneous appearance on imaging.</div></div><div><h3>Case report</h3><div>A 67-year-old man presented with a painless, progressively growing left parotid mass. Imaging showed a heterogenous, partially cystic mass in the superficial and deep lobes of the parotid with some areas of adipose density. Intraoperatively, a mass with sebaceous differentiation was found to be encasing the main trunk and pes anserinus of the facial nerve, requiring nerve sacrifice for en bloc resection. Final pathology revealed a sebaceous adenoma with intense xanthomatous reaction compressing the facial nerve.</div></div><div><h3>Conclusion</h3><div>Although benign and associated with little risk of recurrence, sebaceous adenomas may be difficult to recognize on preoperative workup and may be locally aggressive. Complete surgical resection is the mainstay of therapy, but rehabilitation may be required in the event of facial nerve involvement.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100663"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trismus following facial nerve sacrifice and reanimation surgery: Incidence and management 面神经牺牲和再植手术后的三联症：发生率和处理

Oral Oncology Reports Pub Date : 2024-09-21 DOI: 10.1016/j.oor.2024.100658

Lachlan Jackson , Emma Charters , Masako Dunn , Jonathan Clark , Tsu-Hui (Hubert) Low

引用次数: 0

Sex & marital differences in delayed pharyngeal cancer treatment before and after medicaid expansion 医疗补助扩展前后咽癌延迟治疗的性别和婚姻差异

Oral Oncology Reports Pub Date : 2024-09-19 DOI: 10.1016/j.oor.2024.100653

Jason Semprini

{"title":"Sex & marital differences in delayed pharyngeal cancer treatment before and after medicaid expansion","authors":"Jason Semprini","doi":"10.1016/j.oor.2024.100653","DOIUrl":"10.1016/j.oor.2024.100653","url":null,"abstract":"<div><h3>Objective</h3><p>In the United States, pharyngeal cancer has become the most common type of head and neck cancer, with 80 % of cases found in males. Although disparities in treatment delays have been observed in pharyngeal patients, less is known about how policies facilitate timely care. This study aimed to estimate the association between Medicaid expansion and delaying initiation of pharyngeal cancer treatment.</p></div><div><h3>Methodology</h3><p>We extracted Surveillance, Epidemiological, End Results (SEER) case data to analyze pharyngeal cancers diagnosed between 2000 and 2018. The outcome of interest was a binary variable indicating if the patient initiated treatment two or more months after diagnosis. We conducted subgroup analyses by sex, marital status, and type of treatment received (surgery, radiation, chemotherapy, post-operative radiation, systemic therapy). We implemented the Matrix Completion algorithm to account for staggered rollout of Medicaid expansion within our difference-in-differences design.</p></div><div><h3>Results</h3><p>Our sample included 79,433 patients diagnosed with pharynx cancer. Delayed treatment was lowest among married females receiving systemic therapy (5 %), and highest among married males and females not recommended to receive surgery (43 %). Generally, there was no association between Medicaid expansion and changes in delayed treatment. Subgroup analyses show that Medicaid expansion was associated with reduced treatment delays in unmarried females receiving systemic therapy (−4.5%-points), and married males receiving chemotherapy (Est. = −2.6%-points), radiotherapy (Est. = −3.1%-points), and married males not recommended to receive surgery (Est. = −4.6%-points).</p></div><div><h3>Conclusions</h3><p>Given the importance of timely pharyngeal cancer treatment, health systems must identify and address the drivers of treatment delays to advance cancer equity.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100653"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004990/pdfft?md5=664276d5ddc4f7bf3248c61ca505846e&pid=1-s2.0-S2772906024004990-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of flap complications following pectoralis major myocutaneous flap reconstruction for oral cancers 评估胸大肌皮瓣重建治疗口腔癌后的皮瓣并发症

Oral Oncology Reports Pub Date : 2024-09-19 DOI: 10.1016/j.oor.2024.100655

Nadimul Hoda , Aastha Moza , Ankita Saraf , Sravani Bhogaraju , Irfan Ahmed

{"title":"Evaluation of flap complications following pectoralis major myocutaneous flap reconstruction for oral cancers","authors":"Nadimul Hoda , Aastha Moza , Ankita Saraf , Sravani Bhogaraju , Irfan Ahmed","doi":"10.1016/j.oor.2024.100655","DOIUrl":"10.1016/j.oor.2024.100655","url":null,"abstract":"<div><h3>Background</h3><div>Oral cavity cancer is among the leading cause of cancer death in India. Pectoralis major myocutaneous flaps (PMMC) are still widely used for the reconstruction of defects pertaining to head and neck region, though free flaps are considered to be gold standard. The study was aimed to identify the risk factors involved in post - operative complications of PMMC Flap for oral subsites.</div></div><div><h3>Methods</h3><div>A total of 266 patients operated in an oncology institute over 2 years of time was evaluated based on their demographic data, pre and post-surgery details, post-operative flap morbidity were collected retrospectively from master case sheets from January 2022 to January 2024. Factors such as age, gender, stage of disease, diabetic status, and hypoprotenemia and radiation therapy were seen, analysed to find their relation in causing flap complications.</div></div><div><h3>Results</h3><div>Totally 266 patients were included for analysis and 16.9 % had major flap complications. On detailed analysis, it was seen that larger bipaddled flaps had higher flap complication rate, highest being wound infection.</div></div><div><h3>Conclusion</h3><div>PMMC Flap is a viable option for head and neck cancer reconstruction, specifically in cases where free microvascular flaps are not done routinely and patient presents with multiple comorbidities. Careful patient selection, pre – operative optimization, operating surgeon experience and post-operative care are contributing factors to reduce flap complications.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"12 ","pages":"Article 100655"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142359075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0