Oral Oncology Reports最新文献

{"title":"Programmed cell death ligand 2 (PD-L2) expression is inversely correlated with human papillomavirus status in oropharyngeal squamous cell carcinoma (OPSCC) tumors","authors":"Jeff J. Johnson,&nbsp;Wanrui Wang,&nbsp;Zonggao Shi,&nbsp;Annie Roble,&nbsp;Brian Crowley,&nbsp;Madison McFarland,&nbsp;Jing Yang,&nbsp;Daniel L. Miller,&nbsp;Mark W. Lingen,&nbsp;M. Sharon Stack","doi":"10.1016/j.oor.2026.100800","DOIUrl":"10.1016/j.oor.2026.100800","url":null,"abstract":"<div><div>The incidence of oropharyngeal squamous cell carcinoma (OPSCC) associated with infection by the human papillomavirus (HPV) continues to increase and 71% of OPSCC cases in the United States are HPV+. We have previously performed microRNA profiling of HPV+ <em>vs</em> HPV- OPSCC and identified miR-106b as significantly elevated in HPV + cases (<em>Miller</em> et al.<em>, 2015; Am J Path 185:679-92</em> [1]). MicroRNA target prediction identified the gene <em>PDCD1LG2</em> as a highly ranked target of miR-106b. This gene corresponds to the protein programmed cell death ligand 2 (PD-L2), a high affinity ligand for the programmed cell death protein 1 (PD-1) receptor on T-cells. The objective of this study was to evaluate PD-L2 expression in a panel of HPV+ and HPV- OPSCC tumors. Using tissues from two distinct patient cohorts, results show significantly lower PD-L2 protein expression levels in HPV+ tumors. These data suggest that future research on regulation of PD-L2 expression in HPV+ OPSCC is warranted.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"19 ","pages":"Article 100800"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148994962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to Machine learning-driven insights into ctDNA for oral cancer: Applications, models, and future prospects","authors":"Dheeraj Kumar,&nbsp;Saraswati Patel","doi":"10.1016/j.oor.2025.100777","DOIUrl":"10.1016/j.oor.2025.100777","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"19 ","pages":"Article 100777"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149050738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Machine learning-driven insights into ctDNA for oral cancer: Applications, models, and future prospects” [Oral Oncol. Rep. 11, (September 2024), 100629]","authors":"Dheeraj Kumar,&nbsp;Saraswati Patel","doi":"10.1016/j.oor.2025.100775","DOIUrl":"10.1016/j.oor.2025.100775","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"19 ","pages":"Article 100775"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149050736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IRF1 reduces new genes expression and diminishes cell proliferation and invasiveness in OSCC","authors":"Darius Rupa,&nbsp;Ta-Chun Yuan,&nbsp;Tri Astuti Sugiyatmi,&nbsp;Alfianur,&nbsp;Sela Septima Mariya,&nbsp;Nursia,&nbsp;Etty Wahyuni,&nbsp;Saat Egra","doi":"10.1016/j.oor.2026.100795","DOIUrl":"10.1016/j.oor.2026.100795","url":null,"abstract":"<div><div>IRF1 is a transcription factor, initially identified as part of the interferon response (IFN) pathway. It regulates genes involved in immune responses, cell growth, apoptosis, and DNA damage responses. However, the molecular basis of deregulated metabolism in OSCC progression is unknown. Although the controversial role of IRF1 in cancers has been reported, its function and underlying pathway mechanisms in OSCC cells have yet to be determined. Our studies found that IRF1 was highly expressed in OSCC. Knockdown of IRF1 expression led to reduced proliferation, migration, and invasion in OSCC cells. Furthermore, decreased expression of the IRF1 gene decreases the expression of important genes involved in cancer cell growth and the genes are highly expressed in OSCC tumors, correlating with IRF1 expression. These genes are CA2, NPNT, DPYD, FYB, CROCC, GBP4, and GBP2. Importantly, IRF1 could regulate the expression of key molecules involved in diminishes cell proliferation and invasiveness in OSCC cells. The results revealed the oncogenic role of IRF1 in OSCC cells and its underlying molecular mechanism, which may serve as a novel therapeutic target for treating OSCC.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"19 ","pages":"Article 100795"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148951072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Patterns of facial (Level IX) node metastasis in head and neck cancer: A multicenter retrospective study and a hypothesis-generating IXa/IXb framework” [Oral Oncol. (2026) 100797 19]","authors":"Fabrizio Sanna,&nbsp;Annarita Musu,&nbsp;Sophio Khundadze,&nbsp;Anna Merlotti,&nbsp;Dalila Di Mario,&nbsp;Claudia Crescio,&nbsp;Francesco Bussu,&nbsp;Salvatrice Campoccia","doi":"10.1016/j.oor.2026.100802","DOIUrl":"10.1016/j.oor.2026.100802","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"19 ","pages":"Article 100802"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149050737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What comes after perioperative immunotherapy? Rethinking first-line treatment for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC)","authors":"Lucas Alves da Mota Santana,&nbsp;Lara Góis Floresta,&nbsp;Jefferson Reis Guimarães Andrade,&nbsp;Rajiv Gandhi Gopalsamy,&nbsp;Sasikumar Ponnusamy,&nbsp;Lysandro Pinto Borges,&nbsp;Carlos Eduardo Palanch Repeke","doi":"10.1016/j.oor.2026.100801","DOIUrl":"10.1016/j.oor.2026.100801","url":null,"abstract":"<div><ul><li><span>•</span><span><div>Challenges in Treating Recurrent/Metastatic HNSCC.</div></span></li><li><span>•</span><span><div>Application of Perioperative Immune Checkpoint Inhibition to Improve Outcomes in LA-HNSCC.</div></span></li><li><span>•</span><span><div>Relevance of the KEYNOTE-048 Paradigm in LA-HNSCC After Perioperative IO.</div></span></li></ul></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"19 ","pages":"Article 100801"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148951071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysis” [J Oral Oncol Rep 11 (2024)]","authors":"Lara Krusser Feltraco,&nbsp;Julia Rodrigues Fernandes,&nbsp;Leonardo Francisco Diel,&nbsp;Leonardo da Silva Bittencourt,&nbsp;Lisiane Bernardi,&nbsp;Marcelo Lazzaron Lamers","doi":"10.1016/j.oor.2025.100769","DOIUrl":"10.1016/j.oor.2025.100769","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"19 ","pages":"Article 100769"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149050735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysphagia as a primary predictor of malnutrition in head and neck cancer: Psychometric validation and diagnostic accuracy of the Greek MDADI","authors":"Soultana Papadopoulou ,&nbsp;Kalliopi Megari ,&nbsp;Efrosyni Paparouna ,&nbsp;Sotiria Styliani Moskofidou ,&nbsp;Maria Theodoratou ,&nbsp;Avraam Ploumis","doi":"10.1016/j.oor.2026.100789","DOIUrl":"10.1016/j.oor.2026.100789","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the synergistic impact of radiotherapy-induced xerostomia and dysphagia on malnutrition in Greek Head and Neck Cancer (HNC) survivors compared with matched controls, and to psychometrically validate the Greek version of the MD Anderson Dysphagia Inventory (MDADI).</div></div><div><h3>Materials and methods</h3><div>A cross-sectional, case-control study was conducted with 66 HNC patients (3 months post-RT) and 67 age- and sex-matched healthy controls (Oct 2024–Apr 2025). The study adhered to STROBE guidelines (Ethics No. 37871). Participants completed the MDADI, Xerostomia Inventory (XI), and PG-SGA Short Form. Statistical analyses included Cronbach's alpha for validation, Mann–Whitney U tests, Spearman's ρ, multivariable logistic regression, and Receiver Operating Characteristic (ROC) curve analysis to determine diagnostic accuracy.</div></div><div><h3>Results</h3><div>The Greek MDADI demonstrated excellent internal consistency (α = 0.92) and discriminant validity (Patients: 61.0 vs. Controls: 83.0, p &lt; 0.001). Xerostomia and dysphagia were highly prevalent and strongly correlated (ρ = −0.69, p &lt; 0.001). In the multivariable model, dysphagia emerged as the sole independent predictor of malnutrition (OR = 0.86, 95% CI: 0.77–0.95, p = 0.004), indicating a 14% risk reduction for every 1-point improvement in MDADI. ROC analysis identified an MDADI score of &lt;53 as the optimal cutoff for detecting malnutrition risk (AUC = 0.78, Sensitivity 55%, Specificity 93%).</div></div><div><h3>Conclusions</h3><div>Dysphagia is the primary driver of malnutrition in the early post-RT period. The Greek MDADI is a valid clinical tool, and a score below 53 should serve as a \"red flag\" triggering immediate nutritional and speech-pathology intervention. Integrated management of the xerostomia-dysphagia-malnutrition cluster is essential for survivorship care.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"18 ","pages":"Article 100789"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of worst pattern of invasion (WPOI) with clinicopathological parameters: A retrospective cohort study","authors":"Othman Mounbahij ,&nbsp;Faiçal Slimani","doi":"10.1016/j.oor.2026.100788","DOIUrl":"10.1016/j.oor.2026.100788","url":null,"abstract":"<div><h3>Rationale and objective</h3><div>The worst pattern of invasion (WPOI) has been in the last few years a highly studied pathological parameter. There is a clear trend of non-cohesive WPOI (4-5) to be highly aggressive and to affect outcomes negatively. The aim of this study was to investigate the link between WPOI and other clinicopathological parameters which are the lymph node metastasis (LNM), depth of invasion (DOI) and tumor size (TS).</div></div><div><h3>Methods</h3><div>This was a retrospective cohort study. The patients enrolled in the study were diagnosed with oral squamous cell carcinoma (OSCC) and underwent treatment at the Department of Stomatology, Oral and Maxillofacial Surgery at University Hospital Ibn Rochd (CHU 20th August). The exposure variable was the Worst Pattern of Invasion (WPOI) The outcome variables were LNM, DOI and TS. All statistical analysis was conducted using JASP version 0.19.3.0.</div></div><div><h3>Results</h3><div>A total of 33 patients were included in the study. The mean age was 65.1 years and the sample showed a clear male predominance. The relationship between WPOI and LNM was examined using a chi-squared test. Among patients with non-cohesive WPOI, 6 out of 13 (46.2%) had LNM, compared to 4 out of 20 (20%) in the cohesive WPOI group. Although the percentage of LNM was higher in the non-cohesive group, this difference was not statistically significant (X2(1) = 2.552,p = 0.110). An independent samples <em>t</em>-test was performed to assess the relationship between WPOI and DOI. The mean DOI was greater in the non-cohesive group (12.54 mm, SD = 8.09 mm) compared to the cohesive group (8.80 mm, SD = 5.69 mm). This difference, however, was not statistically significant (t(31) = −1.562,p = 0.129). The relationship between WPOI and TS was analyzed using an independent samples <em>t</em>-test. Interestingly, the mean TS was larger in the cohesive group (42.60 mm, SD = 26.39 mm) than in the non-cohesive group (32.08 mm, SD = 10.63 mm). This difference was also not statistically significant (t(31) = 1.361,p = 0.183).</div></div><div><h3>Conclusion</h3><div>Although the results weren't statistically significant, they should be put into the broader context of the study sample size of (n = 33). The higher incidence of LNM and higher DOI in the non-cohesive group (types 4-5) is in line with the strong correlation found in the literature. Our results, while not statistically significant, corroborate the established link between non-cohesive WPOI and more aggressive disease.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"18 ","pages":"Article 100788"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148167930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining immunotherapy and AlphaFold to improve outcomes in oral squamous cell carcinoma (OSCC) treatment","authors":"Lucas Alves da Mota Santana ,&nbsp;Rajiv Gandhi Gopalsamy ,&nbsp;Sasikumar Ponnusamy ,&nbsp;Leandro Napier de Souza ,&nbsp;Cleverson Luciano Trento ,&nbsp;Wilton Mitsunari Takeshita ,&nbsp;Lysandro Pinto Borges","doi":"10.1016/j.oor.2026.100785","DOIUrl":"10.1016/j.oor.2026.100785","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"17 ","pages":"Article 100785"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}