Oral Oncology Reports最新文献_第2页

Molecular mechanisms and diagnostic innovations in HPV-associated head and neck squamous cell carcinomas: Insights into integration, epigenetic modifications, and biomarker applications

Oral Oncology Reports Pub Date : 2024-12-27 DOI: 10.1016/j.oor.2024.100710

Geetha Shanmugam , Gnanaprakash Jeyaraj , Koustav Sarkar

引用次数: 0

Neoadjuvant cytokine (IRX-2) immunotherapy for resectable oral cavity carcinoma: Final results of the INSPIRE trial

Oral Oncology Reports Pub Date : 2024-12-26 DOI: 10.1016/j.oor.2024.100706

Gregory T. Wolf , Emily Bellile , Celine Mauquoi , Ariane Nguyen , Maureen Sartor , Siyu Liu , Laura Rozek , Jonathan B. McHugh

{"title":"Neoadjuvant cytokine (IRX-2) immunotherapy for resectable oral cavity carcinoma: Final results of the INSPIRE trial","authors":"Gregory T. Wolf , Emily Bellile , Celine Mauquoi , Ariane Nguyen , Maureen Sartor , Siyu Liu , Laura Rozek , Jonathan B. McHugh","doi":"10.1016/j.oor.2024.100706","DOIUrl":"10.1016/j.oor.2024.100706","url":null,"abstract":"<div><div>Oral cavity squamous carcinoma is characterized by alterations in cell mediated tumor immunity including a lack of immune reactive tumor infiltrating lymphocytes (TILs). To determine if a novel neoadjuvant injection of a multi-cytokine biologic (IRX-2) can restore immune reactivity and enhance patient survival, a randomized Phase 2 clinical trial was conducted in patients with Stage II-IV OSCC undergoing surgical resection (NCT 02609386).</div><div>The intention-to-treat (ITT) enrollment included 105 previously untreated patients, however 9 were excluded from the secondary endpoint analysis group for wrong histology, no treatment or patient refusal. A total of 96 patients comprised the final analytic group and were randomized (2:1) to receive the IRX-2 regimen (Regimen 1) compared to the identical regimen without IRX-2 cytokines (Regimen 2). Toxicity, tumor and immune responses, event-free (EFS) and overall (OS) survival were determined. Kaplan-Meier estimates for OS and EFS and inferential comparisons and asymptotoic log-rank testing between the two treatments were determined.</div><div>In prior preliminary analysis, significant increases in TILs and DMBT1 gene expression were noted for the IRX arm. No significant correlations of immunologic or tumor responses with survival outcomes were found. For the ITT population (n = 105) there were no significant differences in OS by treatment arm. OS [95 % CI] at 48 mo. was 70.4 [57.6, 80.0] vs 66.3 [47.5, 79.8] mos. (Regimen 1 vs Regimen 2, respectively).</div></div><div><h3>Conclusions</h3><div>Significant differences in survival were not seen, however, the trial demonstrated the feasibility of the neoadjuvant immunotherapy and differing immune modulation in each treatment arm. No correlations of immune biomarkers or tumor size changes with survival outcomes were identified.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100706"},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of ctDNA on metastatic cancer management: Current trends and future directions

Oral Oncology Reports Pub Date : 2024-12-16 DOI: 10.1016/j.oor.2024.100705

Omveer Singh , Usha Kumari Sah , Jay Chandra , Saraswati Patel

引用次数: 0

Extended total semiconservative parotidectomy with skull base resection

Oral Oncology Reports Pub Date : 2024-12-15 DOI: 10.1016/j.oor.2024.100701

Bipin Thomas Varghese

引用次数: 0

Synchronous or metachronous metastatic cutaneous cell carcinoma and lymphoma/cronic lymphocytic leukaemia: Considerations for management

Oral Oncology Reports Pub Date : 2024-12-14 DOI: 10.1016/j.oor.2024.100703

Valentina Terenzi , Veronica Clemenzi , Salvatore Martellucci , Andrea Stolfa , Fiorenza Dal Cortivo , Danilo Di Giorgio , Alberto DellAquila , Mattia Di Bartolomeo , Marco Della Monaca , Andrea Battisti , Paolo Priore , Andrea Gallo , Valentino Valentini , Giulio Pagliuca

{"title":"Synchronous or metachronous metastatic cutaneous cell carcinoma and lymphoma/cronic lymphocytic leukaemia: Considerations for management","authors":"Valentina Terenzi , Veronica Clemenzi , Salvatore Martellucci , Andrea Stolfa , Fiorenza Dal Cortivo , Danilo Di Giorgio , Alberto DellAquila , Mattia Di Bartolomeo , Marco Della Monaca , Andrea Battisti , Paolo Priore , Andrea Gallo , Valentino Valentini , Giulio Pagliuca","doi":"10.1016/j.oor.2024.100703","DOIUrl":"10.1016/j.oor.2024.100703","url":null,"abstract":"<div><div>Cutaneous squamous cell carcinoma is not uncommon in patients affected by malignant lymphoma, mostly in elderly; the contemporary management of these diseases presents some difficulties, since they require different modalities of treatment. Only small case series and single case report are described in literature about synchronous or metachronous metastatic cutaneous cell carcinoma and lymphoma/chronic lymphocytic leukaemia; in addiction, we report our experience in order to illustrate difficulties encountered in the management of these patients. We conclude that these patients need a close follow-up, and that US-guided FNAC and <sup>18</sup>F-fluorodeoxyglucose PET in addiction to MRI are useful for staging. cSCC, having a poorer prognosis, has to be treated first; nevertheless, mortality in these patients is obviously higher than expected in immunocompetent people.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100703"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-driven diagnostics and personalized treatment planning in oral oncology: Innovations and future directions

Oral Oncology Reports Pub Date : 2024-12-13 DOI: 10.1016/j.oor.2024.100704

R. Satheeskumar

{"title":"AI-driven diagnostics and personalized treatment planning in oral oncology: Innovations and future directions","authors":"R. Satheeskumar","doi":"10.1016/j.oor.2024.100704","DOIUrl":"10.1016/j.oor.2024.100704","url":null,"abstract":"<div><div>The increasing incidence and complexity of oral cancers demand advancements in both diagnostic precision and individualized treatment strategies. This study investigates the application of artificial intelligence (AI), particularly through deep learning and machine learning models, to enhance diagnostic accuracy and support personalized treatment planning in oral oncology. Recent advancements in AI-driven diagnostics, particularly using Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs), have significantly improved early detection and treatment prediction for oral cancer. By integrating datasets from medical imaging, clinical records, and histopathological profiles, our AI-driven models achieved a diagnostic accuracy of 93 %, with a sensitivity of 91 % and specificity of 94 %, surpassing traditional diagnostic approaches. Furthermore, our treatment prediction models, employing patient-specific tumour characteristics and clinical variables, demonstrated an 87 % accuracy in forecasting optimal therapeutic responses, effectively tailoring treatment strategies to individual patients. These findings underscore AI's transformative potential in oral oncology, providing a foundation for improved patient outcomes and paving the way for future innovations in personalized medicine, as highlighted by recent studies in the field.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100704"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative optical biopsy assessment during TORS head and neck cancer resections-a novel application of confocal laser endomicroscopy with intravenous fluorescein

Oral Oncology Reports Pub Date : 2024-12-13 DOI: 10.1016/j.oor.2024.100702

Harishanker Jeyarajan , Isha Chaudhary , Andrew Fuson , Sherin James , Akhilesh Wodeyar , Matti Sievert , Miguel Goncalves , Carissa M. Thomas , Jason Warram , Bharat Akhanda Panuganti

{"title":"Intraoperative optical biopsy assessment during TORS head and neck cancer resections-a novel application of confocal laser endomicroscopy with intravenous fluorescein","authors":"Harishanker Jeyarajan , Isha Chaudhary , Andrew Fuson , Sherin James , Akhilesh Wodeyar , Matti Sievert , Miguel Goncalves , Carissa M. Thomas , Jason Warram , Bharat Akhanda Panuganti","doi":"10.1016/j.oor.2024.100702","DOIUrl":"10.1016/j.oor.2024.100702","url":null,"abstract":"<div><div>Margin assessment during transoral robotic surgical (TORS) resections of head and neck mucosal malignancies can be complex, originating in part from discrepancies in definitions of positive or close margins, and the technical difficulty of revising microscopic margins intraoperatively without incurring the functional consequences associated with soft tissue deficits in the oropharynx and larynx. Intraoperative optical imaging modalities, including confocal laser endomicroscopy (CLE), may represent an alternative or adjunctive option to delineate tumor footprint and assess for peripheral margin status. We present a case series describing our use of the Cellvizio® probe-based CLE platform as an intraoperative modality to assess for peripheral mucosal margins in the larynx, oropharynx, and hypopharynx during TORS resections using robotic instrumentation to establish basic feasibility and create the groundwork for future investigations of relative efficacy and impact on local recurrence rates.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100702"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on ‘Sex & marital differences in delayed pharyngeal cancer treatment before and after medicaid expansion’

Oral Oncology Reports Pub Date : 2024-12-11 DOI: 10.1016/j.oor.2024.100700

Nilina James

引用次数: 0

Duplication of internal jugular vein - An incidental finding

Oral Oncology Reports Pub Date : 2024-12-07 DOI: 10.1016/j.oor.2024.100699

Vijayakumar Jain, K.V. Sureka, G. Satheesh, V. Venugopalan, D. Durairaj

引用次数: 0

Predictive identification of oral cancer using AI and machine learning

Oral Oncology Reports Pub Date : 2024-12-04 DOI: 10.1016/j.oor.2024.100697

Saraswati Patel , Dheeraj Kumar

{"title":"Predictive identification of oral cancer using AI and machine learning","authors":"Saraswati Patel , Dheeraj Kumar","doi":"10.1016/j.oor.2024.100697","DOIUrl":"10.1016/j.oor.2024.100697","url":null,"abstract":"<div><div>Oral cancer remains a significant global health issue, often diagnosed late due to limitations in traditional diagnostic methods. This study explores the application of artificial intelligence (AI) and machine learning (ML) to enhance the early detection and diagnosis of oral cancer. We investigated three data cleaning techniques missing value imputation, outlier detection, and normalization and assessed their impact on model performance. Using convolutional neural networks (CNNs), support vector machines (SVMs), and random forests, we compared the effectiveness of these techniques in improving diagnostic accuracy and mean squared error (MSE). The results demonstrated that normalization, specifically min-max scaling, was the most effective method, leading to the highest accuracy (94 %) and the lowest MSE (0.013) for CNN models. Outlier detection also improved performance, achieving 93 % accuracy and an MSE of 0.014, while missing value imputation resulted in a lower accuracy of 92 % and an MSE of 0.015. These findings underscore the importance of normalization in preprocessing for machine learning models, highlighting its role in achieving superior performance in oral cancer detection. This study underscores the potential of AI-driven methods to revolutionize diagnostic practices, offering more accurate and timely detection of oral cancer.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"13 ","pages":"Article 100697"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0