Oral Oncology Reports最新文献_第2页

A review based study on emotional distress and physical pain in oral and head and neck cancer patients pre- and post-chemotherapy 基于综述的口腔癌和头颈癌患者化疗前后情绪困扰和身体疼痛研究

Oral Oncology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.oor.2024.100637

{"title":"A review based study on emotional distress and physical pain in oral and head and neck cancer patients pre- and post-chemotherapy","authors":"","doi":"10.1016/j.oor.2024.100637","DOIUrl":"10.1016/j.oor.2024.100637","url":null,"abstract":"<div><p>Emotional distress is a psychological response that occurs in the form of mental suffering to an experience that arises from the any negative event or condition. It commonly occurs in patients who suffer from cancer-related physical pain throughout the treatments. Cancer patients face a lot of exhaustion which makes them physically and mentally dysfunctional in their daily lives. However, the Head and Neck Cancer (HNC) patients face some serious issues due to the site of tumour or surgery itself. The current study aims to describe how chemotherapy and physical pain cause emotional distress in HNC patients. Furthermore, the study aims to determine the association between all three factors (Emotional distress, pain, and chemotherapy) and highlight the relevance of care and remediation needs for HNC patients. The literature related to the concerned topic was investigated including empirical research papers, review papers. In total, the authors identified and reviewed 42 articles related to the above-mentioned variables. These articles were obtained from different databases, such as Google Scholar, PubMed, JSTOR and Research Gate. The authors then assessed the full texts of the selected articles for eligibility and extracted data from them. The study revealed that cancer patients who have tolerated physical pain and witnessed the long-term treatment of the process of chemotherapy experience extremely high emotional distress throughout the course. It was also observed that psychological distress is more common in HNC patients than in patients with cancer in other body parts. The main findings of the result indicated that emotional distress was much higher in females. Psychosocial support and palliative care should be integrated to encourage and improve the abilities of cancer-affected patients.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004837/pdfft?md5=76940f688a095ee37b600515ed907c3b&pid=1-s2.0-S2772906024004837-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced functional rehabilitation of maxillary defects post-osteomyelitis: A case study utilizing immediate and definitive obturators 骨骨髓炎后上颌骨缺损的强化功能康复：利用即刻和最终闭合器的病例研究

Oral Oncology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.oor.2024.100647

引用次数: 0

Clinicopathological risk factors of oral second primary tumours 口腔第二原发肿瘤的临床病理学风险因素

Oral Oncology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.oor.2024.100638

{"title":"Clinicopathological risk factors of oral second primary tumours","authors":"","doi":"10.1016/j.oor.2024.100638","DOIUrl":"10.1016/j.oor.2024.100638","url":null,"abstract":"<div><h3>Background</h3><p>Oral second primary tumours (SPTs) have a poor prognosis due to late-stage diagnosis. This study evaluates the demographic and clinicopathological risk predictors of SPTs.</p></div><div><h3>Methods</h3><p>Patients with oral squamous cell carcinoma, carcinoma in situ, or severe dysplasia were accrued into the Oral Cancer Prediction Longitudinal study within one year post-curative treatment. Data on demographics, risk habits, and primary tumour characteristics were collected. Clinical follow-up included assessing the presence of second oral premalignant lesions (SOPLs), clinicopathological features, and the results from toluidine blue staining and fluorescence visualization.</p></div><div><h3>Results</h3><p>Among 296 patients, 23 (8 %) developed SPTs. Older age at primary cancer diagnosis (P = 0.008) and a history of chewing tobacco or betel nut (P = 0.043) increased the risk of SPTs. Patients with primary tumours located at low-risk sites had an increased risk of SPTs (P = 0.004), which often presented at high-risk sites. The presence of SOPLs (P < 0.001), and multiple lesions (P = 0.017) significantly increased the risk of SPTs. Positive toluidine blue staining indicated a trend toward higher risk of SPTs, whereas fluorescence visualization did not. The median time to SPT diagnosis was 3.25 years post-treatment.</p></div><div><h3>Conclusions</h3><p>Identifying second or multiple oral premalignant lesions is critical for predicting the risk of SPTs regardless of their clinical or histological characteristics. Routine biopsy of these lesions should be prioritized to ensure timely diagnosis. Incorporating these risk predictors into clinical follow-up can enhance early cancer detection and improve patient outcomes.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004849/pdfft?md5=828d81ed8c1e6adabae59d42c3182190&pid=1-s2.0-S2772906024004849-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Head and neck squamous cell carcinoma epidemiology at diagnosis: A description of public and private health care systems in Brazil regarding tumor location, staging and risk factors 头颈部鳞状细胞癌诊断时的流行病学：巴西公共和私营医疗系统在肿瘤位置、分期和风险因素方面的描述

Oral Oncology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.oor.2024.100645

{"title":"Head and neck squamous cell carcinoma epidemiology at diagnosis: A description of public and private health care systems in Brazil regarding tumor location, staging and risk factors","authors":"","doi":"10.1016/j.oor.2024.100645","DOIUrl":"10.1016/j.oor.2024.100645","url":null,"abstract":"<div><h3>Objectives</h3><p>There is a limited number of updated epidemiological Brazilian data on head and neck squamous cell carcinoma (HNSCC). This study aimed to describe demographic and clinical characteristics of HNSCC patients from Brazilian public and private systems.</p></div><div><h3>Methods</h3><p>This is a retrospective observational study that included patients diagnosed with HNSCC from Brazilian public and private settings from 2016 to 2018. As for the public scenario, data were drawn from the public hospital national cancer registry database. As for the private sector, the data were extracted from medical records of patients from Oncoclinicas, a large Brazilian oncology group.</p></div><div><h3>Results</h3><p>A total of 37,121 patients were included in the study, with 36,914 from the public and 207 from the private system. Patients in the public sector were younger than those in the private sector, with medians ages of 61.2 and 66.9 years, respectively. In both cohorts, a predominance of men with a history of tobacco and alcohol consumption and an advanced locoregional stage at diagnosis was observed. The main site of the primary tumor was the oropharynx in the private sector and oral cavity in the public sector. Among patients with oropharyngeal cancer, only those in the private sector were tested for HPV, with the majority being positive.</p></div><div><h3>Conclusions</h3><p>This real-world data study provides epidemiologic characteristics of patients with HNSCC in two different Brazilian healthcare settings, presenting relevant insights into possible opportunities for improvements in the patient's journey with HNSCC.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004916/pdfft?md5=3753b590b326c428beeb02e8c820046a&pid=1-s2.0-S2772906024004916-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of lymph node level IIA & IIB IN N-0 neck of oral squamous cell carcinoma 口腔鳞状细胞癌 N-0 颈部 IIA 和 IIB 级淋巴结的比较评估

Oral Oncology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.oor.2024.100639

引用次数: 0

Low grade mucoepidermoid carcinoma arising from glandular odontogenic cyst: A case report with a brief literature review 腺性牙源性囊肿引发的低级别粘液表皮样癌：病例报告与文献综述

Oral Oncology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.oor.2024.100644

引用次数: 0

Harnessing programmed death-ligand 1 as a prognostic marker in OSCC: Challenges and opportunities in the era of immunotherapy 利用程序性死亡配体 1 作为 OSCC 的预后标记：免疫疗法时代的挑战与机遇

Oral Oncology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.oor.2024.100641

引用次数: 0

Bridging the gap between epigenetics and cisplatin resistance: Implications for oral cancer management 缩小表观遗传学与顺铂耐药性之间的差距：对口腔癌治疗的影响

Oral Oncology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.oor.2024.100649

引用次数: 0

Revolution of blood cancer treatment in the oral cavity: Breakthroughs in nanotherapy 口腔血癌治疗的革命：纳米疗法的突破

Oral Oncology Reports Pub Date : 2024-08-24 DOI: 10.1016/j.oor.2024.100635

{"title":"Revolution of blood cancer treatment in the oral cavity: Breakthroughs in nanotherapy","authors":"","doi":"10.1016/j.oor.2024.100635","DOIUrl":"10.1016/j.oor.2024.100635","url":null,"abstract":"<div><p>This comprehensive review explores the potential of nanotherapy in the treatment of blood cancers, specifically leukemia, lymphoma, and myeloma, in the oral cavity. Nanoparticles (NPs) made from organic and inorganic materials have shown promise in delivering therapeutic substances to cancer cells, enhancing their pharmacological efficacy, and reducing their systemic toxicity. Different types of nanoparticles, such as liposomes, extracellular vehicles, and polymeric nanoparticles, have been studied for their effectiveness in targeting cancer cells. Nanotherapy has also been investigated for overcoming drug resistance, targeting cancer stem cells, bypassing efflux pumps, and gene silencing. Clinical trials and research findings have demonstrated the potential of nanotherapy for improving outcomes in patients with acute myeloid leukemia, chronic lymphocytic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, and multiple myeloma. However, challenges exist in addressing the heterogeneity of blood cancers in the oral cavity, navigating the tumor microenvironment, overcoming drug resistance, and modulating immune evasion. Future directions include individualized treatment plans, multifunctional nanoparticles, combination therapies, and improved nanoparticle design. The translation of these breakthroughs into clinical practice requires collaboration among researchers, physicians, and industry stakeholders. Overall, nanotherapy holds promise for more effective and less invasive treatments for blood cancer in the oral cavity.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004813/pdfft?md5=6846a22d0efea8706080e366bbb7b6b2&pid=1-s2.0-S2772906024004813-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in robotic surgery for oral oncology: Enhanced precision and improved outcomes 口腔肿瘤机器人手术的进展：提高精准度，改善疗效

Oral Oncology Reports Pub Date : 2024-08-20 DOI: 10.1016/j.oor.2024.100634

引用次数: 0