Milena Fior , Francesco Mazzola , Mario Rigante , Joseph Khazen , Renato Covello , Antonello Vidiri , Raul Pellini
{"title":"异位原发性嗅神经母细胞瘤：极其罕见的临床治疗方法","authors":"Milena Fior , Francesco Mazzola , Mario Rigante , Joseph Khazen , Renato Covello , Antonello Vidiri , Raul Pellini","doi":"10.1016/j.oor.2024.100672","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of neuroectodermal origin. Within an already very rare neoplasm, an even rarer and lesser-known entity is ectopic ONB.</div></div><div><h3>Methods</h3><div>A 57-year-old female patient was evaluated for a smooth ethmoidal mass. A contrast-enhanced MRI identified a lesion with epicenter in the osteo-meatal complex without cribriform plate and olfactory recesses involvement. Endoscopic guided biopsy showed ONB Hyams II. An endoscopic trans-nasal resection was performed.</div></div><div><h3>Results</h3><div>The postoperative course was uneventful. A definitive histologic examination confirmed a Hyams grade II, Kadish B ONB, corroborating the ectopic localization. Due to the tumor stage and grade, no adjuvant treatment was performed. The patient was free of disease at one-year postoperative follow-up.</div></div><div><h3>Conclusions</h3><div>Ectopic ONB should be considered in the differential diagnosis of a sinonasal mass. Olfactory bulb and dura resection should be dictated by the clinical or radiological involvement of the cribriform plate.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ectopic primary olfactory neuroblastoma: Clinical management of an extremely rare entity\",\"authors\":\"Milena Fior , Francesco Mazzola , Mario Rigante , Joseph Khazen , Renato Covello , Antonello Vidiri , Raul Pellini\",\"doi\":\"10.1016/j.oor.2024.100672\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of neuroectodermal origin. Within an already very rare neoplasm, an even rarer and lesser-known entity is ectopic ONB.</div></div><div><h3>Methods</h3><div>A 57-year-old female patient was evaluated for a smooth ethmoidal mass. A contrast-enhanced MRI identified a lesion with epicenter in the osteo-meatal complex without cribriform plate and olfactory recesses involvement. Endoscopic guided biopsy showed ONB Hyams II. An endoscopic trans-nasal resection was performed.</div></div><div><h3>Results</h3><div>The postoperative course was uneventful. A definitive histologic examination confirmed a Hyams grade II, Kadish B ONB, corroborating the ectopic localization. Due to the tumor stage and grade, no adjuvant treatment was performed. The patient was free of disease at one-year postoperative follow-up.</div></div><div><h3>Conclusions</h3><div>Ectopic ONB should be considered in the differential diagnosis of a sinonasal mass. Olfactory bulb and dura resection should be dictated by the clinical or radiological involvement of the cribriform plate.</div></div>\",\"PeriodicalId\":94378,\"journal\":{\"name\":\"Oral Oncology Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral Oncology Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772906024005181\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Oncology Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772906024005181","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Ectopic primary olfactory neuroblastoma: Clinical management of an extremely rare entity
Background
Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of neuroectodermal origin. Within an already very rare neoplasm, an even rarer and lesser-known entity is ectopic ONB.
Methods
A 57-year-old female patient was evaluated for a smooth ethmoidal mass. A contrast-enhanced MRI identified a lesion with epicenter in the osteo-meatal complex without cribriform plate and olfactory recesses involvement. Endoscopic guided biopsy showed ONB Hyams II. An endoscopic trans-nasal resection was performed.
Results
The postoperative course was uneventful. A definitive histologic examination confirmed a Hyams grade II, Kadish B ONB, corroborating the ectopic localization. Due to the tumor stage and grade, no adjuvant treatment was performed. The patient was free of disease at one-year postoperative follow-up.
Conclusions
Ectopic ONB should be considered in the differential diagnosis of a sinonasal mass. Olfactory bulb and dura resection should be dictated by the clinical or radiological involvement of the cribriform plate.
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