Insulin receptor substrate 1 (IRS 1) serum levels in patients with Oral Squamous Cell Carcinoma

Aim

To assess the expression of IRS 1 values in Oral Squamous Cell Carcinoma (OSCC) patients and its association with histological grading, tumor staging, and habits.

Objective

To assess the expression of IRS1 in patients with oral squamous cell carcinoma. To correlate IRS1 values with histological grading, tumor staging, habits, and overall survival in OSCC patients.

Materials and methods

IRS 1 values were assessed in N = 106 patients. IRS 1 values in 53 OSCC patients at preoperative and postoperative 3 months and were compared with 53 healthy controls using the sandwich ELISA method. The IRS 1 values were associated with clinicohistopathological factors. Statistical analysis was carried out using SPSS version 23.0 by IBM. One-way ANOVA and paired student t-tests were carried out and any p-value less than 0.05 was considered significant.

Results

The mean preoperative IRS 1 value in OSCC patients was 0.071 ± 0.013, (p-value <0.001) and the mean postoperative 3 months IRS 1 value was 0.103 ± 0.037 (p-value = 0.025). The mean IRS 1 value of healthy controls was 0.134 ± 0.111 (p-value <0.001). The mean values in preoperative OSCC patients were underexpressed, compared to healthy controls and postoperative OSCC patients.

Conclusion

IRS1 expression was associated with various clinicopathological factors such as habit status, pathological tumor staging, and tumor grading. It was also found that underexpression of IRS1 was associated with poor prognosis of OSCC patients.